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Preparation method and product of medical porous titanium-tantalum artificial bone and artificial joint

A technology for artificial joints and artificial bones, which is applied in the field of artificial joints and porous titanium-tantalum artificial bones for medical implants. It can solve problems such as difficult tantalum coating, aseptic loosening, and long time consumption, and achieve stable and reliable process and precise pore size. Controllable, guaranteed combined quality effect

Active Publication Date: 2019-05-07
HUAZHONG UNIV OF SCI & TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Due to the characteristics of spraying, the bonding force of the two materials is poor, and it is easy to peel off, and it is difficult to obtain a uniform tantalum coating by spraying on prostheses with complex structures.
The Chinese patent with the publication number CN 102409195 A proposes a method for preparing porous tantalum by laser cladding. In this patent, a layer of high-purity tantalum powder is pre-spread on the surface of the substrate, and then metal tantalum is prepared by laser cladding. Coating, the tantalum coating prepared in this way can form a metallurgical bond with the substrate, but the surface morphology and pore size of the coating are difficult to control, and due to the rapid heating and rapid cooling of the laser treatment, the Ta-Ti alloyed layer is easy to Microcracks are generated, and the investment cost of laser equipment is too high, and the coating preparation process is complicated and time-consuming
The publication number is CN103586641 A. A Chinese patent proposes a method for preparing a titanium-tantalum-platinum composite plate by explosive welding. Although this method can form a solid-phase bond between titanium and tantalum, the explosive welding requires a thicker plate, which is difficult. The production of thin composite boards is not conducive to reducing the amount of tantalum used, thereby controlling costs; at the same time, the quality of explosively welded composite boards is unstable, and there are noise pollution and shock wave pollution, which is not conducive to environmental protection
[0008] In addition, metal titanium and metal tantalum are both biologically inert materials, which cannot form chemical bonds with surrounding bone tissue after implantation, so aseptic loosening is prone to occur in the early stage of implantation
Huang Liping of Shanghai Institute of Ceramics, Chinese Academy of Sciences (Huang Liping, Xie Youtao, Ji Heng, et al. Vacuum plasma spraying HA / Ta composite coating[J]. Thermal Spray Technology, 2013,5(2):10-15 .) A layer of tantalum / hydroxyapatite composite coating was prepared on the surface of metal titanium by plasma spraying, hoping to improve the stability of the implant through the chemical combination of hydroxyapatite and bone tissue, but the composite coating and the matrix The bonding force between them is only 37MPa, and the coating is easy to fall off in the human body

Method used

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  • Preparation method and product of medical porous titanium-tantalum artificial bone and artificial joint
  • Preparation method and product of medical porous titanium-tantalum artificial bone and artificial joint
  • Preparation method and product of medical porous titanium-tantalum artificial bone and artificial joint

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[0044] The preparation method of the invention is used to prepare a highly biocompatible medical metal implant porous titanium tantalum artificial bone and artificial joint. figure 1 It is a flow chart of the preparation method of the present invention, as can be seen from the figure, the inventive method comprises the steps:

[0045] S1: Grind TC4 titanium alloy sheet and pure tantalum sheet step by step with 400 mesh to 1200 mesh sandpaper to remove surface oxide layer and oil stain, and then perform ultrasonic cleaning in acetone, alcohol, and deionized water in sequence;

[0046] S2: Assemble the titanium alloy sheet and the pure tantalum sheet processed in the above step S1 into a billet; the assembly method is: attach the titanium alloy sheet and the pure tantalum sheet, and then use a precision welding machine to spot the side joints. welding fixed;

[0047] S3: heat up the slab assembled in step S2 to 850°C-1050°C, keep it warm for 20-40 minutes, and inert atmosphere ...

Embodiment 1

[0056] This embodiment includes the following steps:

[0057] S1: The titanium alloy sheet and the pure tantalum sheet are successively polished with 400-mesh, 800-mesh, and 1200-mesh sandpaper to remove the surface oxide layer and oil stains, and then ultrasonically cleaned in acetone, alcohol, and deionized water. Titanium alloy sheet is TC4 titanium alloy sheet, TC4 is the grade of titanium alloy, its specific composition is: iron (Fe)≤0.30, carbon (C)≤0.10, nitrogen (N)≤0.05, hydrogen (H)≤0.015, oxygen (O)≤0.20, aluminum (Al) 5.5~6.8, vanadium (V) 3.5~4.5, the balance is titanium (Ti);

[0058] S2: Assemble the titanium alloy sheet and pure tantalum sheet processed in the above step S1 into a rolled billet. The assembly method is: bonding the titanium alloy sheet and pure tantalum sheet, and then using argon tungsten arc welding precision welding repair machine Spot welding at the side joint;

[0059] S3: Heating the slab assembled in step S2 to 850°C and holding it for ...

Embodiment 2

[0069] This embodiment includes the following steps:

[0070] S1: The titanium alloy sheet and the pure tantalum sheet are successively polished with 400-mesh, 800-mesh, and 1200-mesh sandpaper to remove the surface oxide layer and oil stains, and then ultrasonically cleaned in acetone, alcohol, and deionized water. The titanium alloy sheet is TC4 titanium alloy sheet;

[0071] S2: Assemble the titanium alloy sheet and pure tantalum sheet processed in the above step S1 into a rolled billet. The assembly method is: bonding the titanium alloy sheet and pure tantalum sheet, and then using argon tungsten arc welding precision welding repair machine Spot welding at the side joint;

[0072] S3: Heating the slab assembled in step S2 to 1050°C and holding it for 20 minutes, with an inert atmosphere protection during the heating and holding process, and the heating rate is 120°C / min;

[0073] S4: Carry out single-pass or multi-pass rolling on the slab after the heat preservation in s...

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Abstract

The invention discloses a method for preparing porous titanium-tantalum artificial bone and joint and products thereof, and belongs to the field of biological materials. The method comprises the following steps: S1, grinding to-be-bonded surfaces of a titanium alloy sheet and a tantalum sheet, and performing ultrasonic washing sequentially with acetone, alcohol and deionized water; S2, fitting the titanium alloy sheet and the tantalum sheet, heating to 850-1050 DEG C, insulating for 20-40 minutes, pressurizing to perform plastic deformation, and air-cooling to room temperature to form metallurgic bonding between the two materials; S3, quickly preparing pores having a pore size of 300-600mu m in a compound plate by utilizing a solid laser; S4, preparing various artificial bones and joints from the titanium-tantalum compound plate by utilizing a thermal forming technology; and S5, performing alkali and pre-calcifying treatment to improve the biocompatibility of the compound material. Compared with a traditional explosive compound method, the hot-rolling compound method is safer, controllable, convenient and firm in bonding. The product has relatively high biocompatibility.

Description

technical field [0001] The invention belongs to the technical field of biomaterials, and more specifically relates to a method and product for preparing a permanent medical porous metal implant, in particular to a preparation of porous titanium tantalum for medical implants suitable for replacing human bones and human joints Methods and products for artificial bones and artificial joints. Background technique [0002] At present, porous medical metal implant materials have important and special uses in the fields of bone tissue trauma, femoral tissue necrosis, spinal surgery, and dental implants. The porous structure is conducive to the ingrowth of the surrounding biological tissue, so that the implant material and the surrounding bone tissue form a firm mechanical lock, which is conducive to the stability of the implant material in the human body. On the premise of ensuring the mechanical properties of the implanted material, the porosity of the implanted material should b...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/56A61L27/54A61L27/12A61L27/06A61L27/04B23P15/00
CPCA61L27/047A61L27/06A61L27/12A61L27/54A61L27/56A61L2400/18A61L2430/02A61L2430/24B23P15/00
Inventor 胡树兵王文凯
Owner HUAZHONG UNIV OF SCI & TECH
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