37 results about "Aseptic loosening" patented technology

The invention discloses a polyethylene artificial joint capable of improving biocompatibility and tribological property and a preparation method thereof. The polyethylene artificial joint comprises a joint head and a superhigh molecular weight polyethylene cotyle, wherein a bionic polymer brush layer is grafted on the surface of the superhigh molecular weight polyethylene cotyle rubbed with the joint head; and the bionic polymer brush layer is a brush-shaped structure formed by connecting a super-lubricant and hydrophilic polymer chain on the surface of polyethylene. The high-biocompatibility polymer brush layer is grafted on the surface of the artificial joint polyethylene by simulating a brush-shaped structure and a lubricating antifriction function of a natural joint cartilage epilimmion synovial cavity, so that the biocompatibility and the tribological property of the artificial joint are obviously improved, and tissue reaction and aseptic loosening are relieved; and the polymer brush molecular chain is chemically bonded on the surface of the superhigh molecular weight polyethylene firmly by an ultraviolet grafting technique. The artificial joint prepared by the method has high wettability and biocompatibility on the friction surface and low friction coefficient, and can relive aseptic loosening and prolong service life.

The invention belongs to the technical field of surgical implants and relates to an artificial joint prosthesis with biologically activated surface. The biological activation layer formed on the surface of the artificial joint prosthesis has good biocompatibility and bioactivity and forms natural chemical bonding with the bone tissues, thus improving the bond strength between the prosthesis and the bone tissues, ensuring the stress transfer to be more reasonable and reducing the negative effect of stress shielding. The biological activation layer on the surface of the artificial joint prosthesis is formed by chemical reaction and forms chemical bonding with the matrix, therefore, the problem that the biological activation layer on the surface sheds is avoided, thus ensuring the postoperative long-term effect of the prosthesis. The artificial joint prosthesis is biologically fixed; therefore, wear particles produced when bone cement is adopted for fixation are avoided, thus reducing the possibility of occurrence of aseptic loosening. Besides, the artificial joint prosthesis adopts simple raw materials and process, has low cost and is easy to realize.

The invention discloses a titanium alloy artificial joint with a bio-lubrication surface layer, wherein the titanium alloy artificial joint is composed of a titanium alloy substrate and the bio-lubrication surface layer, and the bio-lubrication surface layer is a polymer electrolyte layer prepared by a layer-by-layer self-assembly technology. A preparation method of the joint comprises the following steps: (1) preparing a polycationic electrolyte solution and a polyanionic electrolyte solution; (2) carrying out hydroxylation treatment of the titanium alloy substrate to form a hydroxylated substrate; and (3) carrying out layer-by-layer self-assembly of the polyelectrolyte layer to form the bio-lubrication surface layer; and completing preparation of the titanium alloy artificial joint. Theartificial joint has good lubrication effect, can effectively reduce abrasive debris, improve tribological properties, achieve the effects of osteolysis inhibition and aseptic loosening, and prolong the service life of the artificial joint.

The invention relates to a design method of a bionic porous gradient artificial hip joint matrix. According to the design method of the bionic porous gradient artificial hip joint matrix, a low-density area, a medium-density area and a high-density area with ordered porous gradient properties are separately constructed on basis of three basic units, including a low-density area, a medium-density area and a high-density area; and then, the three units are combined so as to construct a matrix part of an artificial hip joint model. The design method of the bionic porous gradient artificial hip joint matrix utilizes a bone joint matrix with porous gradient properties as a bionic template; and bionic design is performed on arrangement ways and spatial layouts of the three basic units with different structures and density characteristics so as to obtain a bionic artificial hip joint matrix which is relatively close to a bone joint before replacement in terms of mechanical properties, so thatcomplications of aseptic loosening in previous artificial joint replacement operation can be effectively avoided so as to improve service life and reliability of the artificial joint.

The invention discloses a coating for improving bioactivity of a stainless-steel bone lamella and a bone nail. The Ti / TiB2 composite coating grows on the surface of a stainless-steel bone lamella and bone nail matrix (1), and the thickness of the Ti / TiB2 composite coating ranges from 500nm to 5mum; the inner layer of the composite coating, close to the bone lamella and bone nail matrix, is a pure-metal Ti layer (2) serving as a transition layer; and an external layer, namely a TiB2 layer (3), grows on the pure-metal Ti layer and serves as a function film layer. According to the invention, the pure-metal Ti layer grows on the surface of the bone lamella and bone nail matrix (1) by an ultrahigh vacuum magnetron sputtering method, and the TiB2 layer grows on the pure-metal Ti layer, so that the composite coating has better biocompatibility, frictional wear resistance and chemical stability, can effectively inhibit dissolution and seepage of toxic elements in stainless-steel matrix materials, and can reduce tissue reaction and aseptic loosening of the matrix, prolong the service life of the matrix and enhance the reliability of the matrix.

The invention discloses a method for preparing an antifriction wear-resistant F-DLC film on a titanium alloy surface. A plate hollow cathode HP-PECVD method is adopted. According to the plate hollow cathode HP-PECVD method, on the basis of a traditional PECVD method, a sample disk for carrying samples in an existing deposition system reaction chamber is changed into two parallel plates; a base body is placed between the two plates; negative bias voltage is applied to the space between the two plates to form a hollow cathode effect. The method specifically comprises the following steps of (1) pretreatment; (2) sputter cleaning; (3) deposition of a Si transition layer; and (4) deposition of the F-DLC film. The F-DLC film deposited on the titanium alloy surface through the method has the antifriction wear-resistant function, the tribology performance of titanium alloy in the vivo environment can be improved, and the problem that aseptic loosening complications caused by frictional wear of titanium alloy artificial joints is solved.

The present invention provides methods of preventing, treating, managing or ameliorating periodontal disease, Gorham-Stout disease, Wilson's disease, chronic otitis media, hypertrophic pulmonary osteoarthropathy or aseptic loosening of joint replacement (prostheses), or conditions associated therewith, utilizing antagonists of integrin alphavbeta3. The present invention encompasses the use of methods of preventing, treating, managing or ameliorating periodontal disease, Gorham-Stout disease, Wilson's disease, chronic otitis media, hypertrophic pulmonary osteoarthropathy, or aseptic loosening of joint replacement (prostheses), or conditions associated therewith, utilizing an integrin alphavbeta3 antagonist in combination with another therapy (e.g., another prophylactic or therapeutic agent). In particular, the present invention provides methods of preventing, treating, managing or ameliorating periodontal disease, Gorham-Stout disease, Wilson's disease, chronic otitis media, hypertrophic pulmonary osteoarthropathy or aseptic loosening of joint replacement (prostheses), or conditions associated therewith, comprising administering to a subject in need thereof at least one antagonist of integrin alphavbeta3 and at least one other therapy. The present invention encompasses compositions and articles of manufacture for use in preventing, treating, managing or ameliorating periodontal disease, or aseptic loosening of joint replacement (prostheses), Gorham-Stout disease, Wilson's disease, chronic otitis media, hypertrophic pulmonary osteoarthropathy or conditions associated therewith.

The invention provides a knee joint prosthesis. The knee joint prosthesis comprises a prosthesis body. The prosthesis structure further comprises a protection coating wrapping the outer surface of the prosthesis body. The knee joint prosthesis comprises the prosthesis body and the protection coating wrapping the prosthesis body, as the outer surface of the prosthesis body is coated with the protection coating, the protection coating can wrap the outer surface of the prosthesis body made of Ti6Al4V alloy, the situation of aseptic loosening of the prosthesis due to separation of Al and V ions can be avoided, and the service life of the prosthesis is prolonged; besides, damage of Al ions and V ions to the human body is avoided, and the use safety and reliability of the prosthesis are improved.

An animal intraosseous foreign body particle releasing device comprises an outer cylinder with one end open and the middle provided with a cavity communicated with an opening. The cavity is provided with inducing particles formed by at least one component of an artificial joint. The wall of the outer cylinder is provided with a plurality of release holes communicated with the cavity with the diameter less than the induced particles. The opening of the outer cylinder is sealed through a sealing member. The device can be used for preparation and basic research of a prosthesis aseptic loosening animal model and has the advantages of rapidness, stability and high repeatability.

The invention discloses a pressurized endosseous implant prosthesis, which comprises a hollow in-marrow body with internal threads, wherein the lower end of the in-marrow body has a mushroom-like structure; a draw bar with a belleville spring is arranged in a hollow cavity in the upper end of the in-marrow body; the end, which extends out of the in-marrow body, of the draw bar is connected with an in-marrow fixing piece through threads; and the side face of the in-marrow fixing piece has staggered pores matched with a cortical nail. In the invention, the pressurized endosseous implant prosthesis is firmly fixed by an internal pressurizing spring, the mechanical compatibility problem of the bone and the implant is solved effectively, and thus, the sclerotin absorption by the implant in a long-term implant state due to a stress shielding effect leads to sterile looseness of the implant is solved.

The present invention relate to a distal tibial prosthesis including a distal base and a distal handle, the distal handle comprises a bearing part and a bone trabecular structure layer A arranged on the outer surface of the bearing part, the upper end of the bearing part is connected with the bottom surface of the distal abutment, the top surface of the distal abutment is provided with an anti-rotation table, the top surface of the anti-rotation table is provided with an outer cone, the cross section of the distal handle is elliptical, and the outer surface of the bottom of the distal abutmentis provided with a bone trabecular structure layer B. As the distal handle of the invention is divided into a bearing weight part and a surface bone trabecular structure, the bearing weight part canmeet the load-bearing requirement and promote bone growth, thereby achieving medium-and long-term stability; the cross section of the distal stem is elliptical, which can increase the contact area between the distal tibial medullary cavity and the prosthesis surface, and also can prevent the prosthesis from rotating. It can achieve the initial stability without screw fixation, greatly shorten theoperation time and reduce the difficulty of operation. It can solve the problems of aseptic loosening, initial interface healing and periprosthetic fracture when the distal fixation length of cement tibial shaft prosthesis is insufficient.

The invention relates to the use of gene therapy in the treatment of aseptic loosening of orthopaedic prostheses and discloses methods of refixing such prostheses without open revision surgery. In particular, it provides adenoviral vectors and prodrugs for simultaneous, separate or sequential use in the destruction of interface tissue allowing subsequent recementing of loose prostheses in a minimally invasive manner.

The invention provides a prosthesis structure comprising a prosthesis main body and further comprising a protective coating applied to the outer surface of the prosthesis main body. The prosthesis structure comprises the prosthesis and the protective coating covering the prosthesis main body; the protective coating is applied to the outer surface of the prosthesis main body, so that the protective coating can cover the outer surface of the prosthesis main body made of Ti6Al4V alloy, the phenomenon of aseptic loosening of the prosthesis caused by Al and V ion release is avoided, the service life of the prosthesis is prolonged, damage to human bodies caused by Al ions and V ions can be prevented and the safety and reliability of using the prosthesis are improved.

The invention discloses a preparation process of a soft-soft contact-type bionic joint, and belongs to a preparation process of a bionic material. The preparation process comprises the following steps: 1) manufacturing an artificial knee femoral condyle, an artificial knee tibial liner, an artificial hip joint femoral head and an artificial hip joint acetabulum from medical polyethylene; 2) crosslinking the surface of a test sample with a PAMPS-PDMAAm composite hydrogel bionic cartilage material; 3) again crosslinking the test sample obtained in the step 2 with a PVA / HA-PAA composite hydrogel bionic cartilage material; and 4) again crosslinking the test sample obtained in the step 3 with a PVA hydrogel bionic cartilage material to finally obtain the soft-soft contact-type bionic joint. The bionic joint has a relatively low elastic modulus, high deformability, and excellent lubrication and wear resistance, can effectively reduce the impact, absorb the oscillation and reduce the impact and the wear during joint movement, and solves the problems of wear and aseptic loosening of an artificial joint.

The invention discloses a femoral stem prosthesis, and belongs to the technical field of orthopedic implants. The femoral stem prosthesis comprises a stem body, the outer side of the stem body is provided with a notch, an auxetic structure is arranged in the notch. Stress shielding on the inner side and the outer side of the proximal femur can be well reduced, bone resorption of the proximal femur is avoided, and the problem of aseptic loosening of the femoral stem caused by stress shielding after total hip replacement is solved. In addition, the auxetic structure is also a porous structure, pores communicated each other in the auxetic structure are beneficial to transportation of nutrient substances and metabolites, so that bone ingrowth can be promoted, and the medium and long-term stability of the prosthesis is further improved.

The invention discloses an artificial joint with a self-repairing textured composite film structure and a preparation method. The artificial joint comprises a radiation cross-linked ultra-high molecular weight polyethylene joint cup and a zirconia ceramic joint head, a circular hole micro-texture is processed on the inner surface of the joint cup, a capillary texture is processed on the surface of the joint head, and a layer of self-repairing textured composite film is grafted on the inner surface of the joint cup in friction with the joint head. The texturing adopted by the invention can improve the storage performance and the self-lubricating performance of the lubricating liquid to a great extent, and meanwhile, the self-repairing textured composite film can also enhance the adhesive force on the surface of the joint cup and is firm in combination; and the artificial joint is good in wear resistance and has the functions of self-repairing and sterile loosening prevention, and the service life of the artificial joint is prolonged.

The invention relates to the use of gene therapy in the treatment of aseptic loosening of orthopaedic prostheses and discloses methods of refixing such prostheses without open revision surgery. In particular, it provides adenoviral vectors and prodrugs for simultaneous, separate or sequential use in the destruction of interface tissue allowing subsequent recementing of loose prostheses in a minimally invasive manner.

The invention discloses a method for preparing an antifriction wear-resistant F-DLC film on a titanium alloy surface. A plate hollow cathode HP-PECVD method is adopted. According to the plate hollow cathode HP-PECVD method, on the basis of a traditional PECVD method, a sample disk for carrying samples in an existing deposition system reaction chamber is changed into two parallel plates; a base body is placed between the two plates; negative bias voltage is applied to the space between the two plates to form a hollow cathode effect. The method specifically comprises the following steps of (1) pretreatment; (2) sputter cleaning; (3) deposition of a Si transition layer; and (4) deposition of the F-DLC film. The F-DLC film deposited on the titanium alloy surface through the method has the antifriction wear-resistant function, the tribology performance of titanium alloy in the vivo environment can be improved, and the problem that aseptic loosening complications caused by frictional wear of titanium alloy artificial joints is solved.

The invention discloses an application of rhoifolin in preparation of a drug for preventing and treating osteolytic diseases. In-vitro experiments show that the rhoifolin can significantly inhibit theosteoclast formation and bone absorption induced by RANKL and also inhibit the expression of osteoclast-related genes. Western blotting experiments show that the rhoifolin can inhibit NF-[kappa]B andMAPK signaling pathways and two transcription factors of NFATc1 and c-fos; further studies show that the rhoifolin can inhibit P65 from entering nucleus and the activity of NFATc1 and NF-[kappa]B cells. In-vivo experiments show that the rhoifolin can reduce the number of TRAP-positive osteoclasts and bone destruction of skull in a titanium particle-induced skull model. Therefore, the rhoifolin can improve osteolysis induced by osteoclasts, and can become a potential drug for treatment of joint prosthesis loosening, and provides a new treatment option for aseptic loosening of prosthesis.

The invention belongs to the technical field of surgical implants and relates to an artificial joint prosthesis with biologically activated surface. The biological activation layer formed on the surface of the artificial joint prosthesis has good biocompatibility and bioactivity and forms natural chemical bonding with the bone tissues, thus improving the bond strength between the prosthesis and the bone tissues, ensuring the stress transfer to be more reasonable and reducing the negative effect of stress shielding. The biological activation layer on the surface of the artificial joint prosthesis is formed by chemical reaction and forms chemical bonding with the matrix, therefore, the problem that the biological activation layer on the surface sheds is avoided, thus ensuring the postoperative long-term effect of the prosthesis. The artificial joint prosthesis is biologically fixed; therefore, wear particles produced when bone cement is adopted for fixation are avoided, thus reducing the possibility of occurrence of aseptic loosening. Besides, the artificial joint prosthesis adopts simple raw materials and process, has low cost and is easy to realize.

The present invention pertains to certain ketones and reduced ketones and derivatives thereof which, inter alia, inhibit osteoclast survival, formation, and / or activity; and / or inhibit bone resorption, and more particularly to compounds of the formulae and pharmaceutically acceptable salts, amides, esters, and ethers thereof, wherein: Ar1, Ralk, —ORO, and -Q are as defined herein:The present invention also pertains to pharmaceutical compositions comprising such compounds. The compounds inhibit osteoclast survival, formation, and / or activity, and inhibit conditions mediated by osteoclasts and / or characterised by bone resorption, and are useful in the treatment of bone disorders such as osteoporosis, rheumatoid arthritis, cancer associated bone disease, Paget's disease, aseptic loosening of prosthetic implants, and the like; and / or in the treatment of conditions associated with inflammation or activation of the immune system.

The present invention relates generally to the field of implant related risk of revision, in particular implant related risk of revision not caused by an infection or metal on metal reaction. The present invention provides methods of diagnosing implant related risk of revision, use of kits for such diagnostic purposes and compositions for use in the treatment of implant related risk of revision, in particular implant related risk of revision not caused by an infection or metal on metal reaction.

A joint fluid drainage system provides a solution to the aseptic loosening problem resulting from the utilization of total joint prostheses, lowering the pressure inside the joint capsule and draining the joint fluid comprising particles. The system includes a canal outlet starting from the articulation surface. This high pressure joint fluid with particles causing the loosening is drained from the capsule to the outside of the bone through a drainage path starting from this canal outlet, continuing in the prosthesis and the bone, and opening to the outer surface of the bone. The system also includes a silicone tube mounted to the canal outlet of the prosthesis by using the canal disposed in the bone. The tube is placed inside the fatty porous tissue located between the muscle groups outside the bone and the joint fluid is discharged into this area through this canal system by drainage.

The invention provides a femoral stem prosthesis which is internally provided with a cavity, one end of the femoral stem prosthesis is provided with a communication hole communicated with the cavity,a porous structure is embedded in the outer side wall of the femoral stem prosthesis, and holes in the porous structure are communicated with the cavity. After the femoral stem prosthesis is insertedinto a femoral medullary cavity, blood and nutrient substances can enter the femoral stem prosthesis from the communicated holes and are exchanged with external human sclerotin through the porous structure so that circulation of blood and nutrient substances is realized, local tissue necrosis is avoided, bone ingrowth is facilitated, osteoporosis or dissolution around the prosthesis is avoided, and postoperative aseptic loosening and ostealgia caused by postoperative aseptic loosening are eliminated, meanwhile, human bones can grow into holes in the porous structure, so that the implantation stability of the femoral stem prosthesis is greatly improved, in addition, due to the fact that hollowing and topological optimization are conducted on multiple positions of the femoral stem prosthesis, light weight is achieved, and the advantage of being light in weight is achieved.

The present invention relates generally to the field of implant related risk of revision, in particular implant related risk of revision not caused by an infection or metal on metal reaction. The present invention provides methods of diagnosing implant related risk of revision, use of kits for such diagnostic purposes and compositions for use in the treatment of implant related risk of revision, in particular implant related risk of revision not caused by an infection or metal on metal reaction.

The invention discloses a titanium alloy artificial joint with a biological lubricating surface layer, which is composed of a titanium alloy base and a biological lubricating surface layer. The biological lubricating surface layer is a polymer electrolyte layer prepared by layer-by-layer self-assembly technology. And the preparation method of the above-mentioned joint, the steps are as follows: (1) preparing a polycation electrolyte solution and a polyanion electrolyte solution; (2) carrying out hydroxylation treatment on the titanium alloy substrate to form a hydroxylation substrate; (3) self-assembling polyelectrolyte layer by layer layer, formed as the bio-lubricating surface layer; and the preparation of the titanium alloy artificial joint is completed. The artificial joint has a good lubricating effect, can effectively reduce wear debris, improve tribological properties, achieve the effect of inhibiting osteolysis and aseptic loosening, and effectively prolong the service life of the artificial joint.

The present invention relates to a femoral implant for an animal, and more particularly, to a femoral implant for an animal, which enables hip replacement for an animal, and which can be firmly fixed to the femur of the animal by means of spontaneous bone growth of the animal, so as to prevent the occurrence of complications such as aseptic loosening that may occur when bone cement is used, and bone resorption that occurs around the cement, etc. A plurality of gaps are formed in the porous part, the porous part is relatively weak in strength, and the porous part is protected by the support part which forms a solid surface and is relatively strong in strength, so that damage problems such as fragmentation or bending caused by friction or external force between the edge of the porous part and a bone are prevented in the process of inserting the femoral implant into the animal femur; the present invention relates to a femoral implant for animals, and more particularly, to a femoral implant for animals, which prevents various inflammatory reactions and the like caused by penetration of porous particles into blood vessels, said porous particles being likely to occur when a porous part is damaged.