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Artificial joint prosthesis with biologically activated surface

An artificial joint and bioactivation technology, applied in prosthesis, medical science, coating, etc., can solve problems such as difficult to guarantee effect, hydroxyapatite coating peeling off, etc., to achieve low cost, long-term effect guarantee, stress transfer reasonable effect

Active Publication Date: 2015-01-07
BEIJING JINGHANG BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is still a physical bond between the coating and the substrate. Under the long-term effects of various factors such as cyclic pressure generated during human movement and body fluid corrosion, it is inevitable that the hydroxyapatite coating will fall off.
At present, clinical application results also show that the short-term effect of hydroxyapatite-coated artificial joint prosthesis is good, but the long-term effect is difficult to guarantee

Method used

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  • Artificial joint prosthesis with biologically activated surface
  • Artificial joint prosthesis with biologically activated surface

Examples

Experimental program
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Effect test

Embodiment 1

[0044] Surface Activated Artificial Shoulder Prosthesis

[0045]The humerus component of the artificial shoulder joint prosthesis is made of Ti6Al7Nb alloy to protect the surface that does not contact with bone tissue. The surface is polished, cleaned and then placed in 10mol / l KOH solution and soaked at 80°C for 12h. After cleaning and drying, put it into heat treatment equipment, raise the temperature to 600°C at a rate of 5°C / min, keep it warm for 30 minutes, and cool to room temperature with the furnace.

Embodiment 2

[0047] Surface Activated Artificial Hip Prosthesis

[0048] The femoral stem of the artificial hip joint prosthesis is made of Ti6Al4V alloy to protect the surface that is not in contact with bone tissue. The surface is sandblasted, and then placed in a HCl:H 2 SO 4 :H 2 O in a solution configured at a volume ratio of 2:45:53, soak at room temperature for 30 minutes, wash and dry. Then put it in 5mol / l NaOH solution and soak it at 60°C for 24h. After cleaning and drying the treated femoral stem and acetabular cup, put them into the heat treatment equipment, raise the temperature to 500°C at a rate of 10°C / min, keep it warm for 30 minutes, and cool down to room temperature with the furnace.

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Abstract

The invention belongs to the technical field of surgical implants and relates to an artificial joint prosthesis with biologically activated surface. The biological activation layer formed on the surface of the artificial joint prosthesis has good biocompatibility and bioactivity and forms natural chemical bonding with the bone tissues, thus improving the bond strength between the prosthesis and the bone tissues, ensuring the stress transfer to be more reasonable and reducing the negative effect of stress shielding. The biological activation layer on the surface of the artificial joint prosthesis is formed by chemical reaction and forms chemical bonding with the matrix, therefore, the problem that the biological activation layer on the surface sheds is avoided, thus ensuring the postoperative long-term effect of the prosthesis. The artificial joint prosthesis is biologically fixed; therefore, wear particles produced when bone cement is adopted for fixation are avoided, thus reducing the possibility of occurrence of aseptic loosening. Besides, the artificial joint prosthesis adopts simple raw materials and process, has low cost and is easy to realize.

Description

technical field [0001] The invention belongs to the technical field of surgical implants, and relates to a surface bioactivated artificial joint prosthesis. Background technique [0002] Artificial joint replacement is one of the commonly used methods for the clinical treatment of osteoarthritis, bone and joint tumors and other diseases. Using artificial joint prosthesis to replace the diseased joint tissue can reduce or eliminate the patient's pain, restore the joint function, improve the patient's range of motion, avoid the great physical and psychological damage caused by amputation to the patient, and improve patient's quality of life. However, the artificial joint prosthesis currently used clinically is either fixed by bone cement, or biologically fixed by hydroxyapatite coating or other methods, all of which face problems such as long-term loosening and subsidence of the artificial joint prosthesis. When bone cement is used for fixation, the artificial joint prosthes...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/30A61L27/06A61L27/56
Inventor 李彤梁芳慧熊震国慈华强侯保义张伟黄永玲
Owner BEIJING JINGHANG BIOTECH CO LTD
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