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Porous cross pin for operational internal fixation of anterior cruciate ligament for tissue engineering

A body and alloy technology, which is applied in the field of biomedical devices and devices for the treatment of anterior cruciate ligament reconstruction, can solve the problems of not promoting tendon-bone healing, interfering with tendon-bone interface healing, and polylactic acid having no osteoinductive properties, achieving the best results. Therapeutic effect, the promotion of tendon and bone healing, the effect of sustained release of cytokines

Inactive Publication Date: 2016-04-13
张强 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Currently, the fixation device used for the tibial end is an interface screw, and its structure is generally a cylindrical screw; while there are many fixed devices used for the femoral end, commonly used endbutton button plates and Rigid transversal nails; the current Rigid transversal nails are usually polymer screws. Lactic acid material, this material has many disadvantages, for example: polylactic acid does not have osteoinductive properties, does not have the effect of promoting tendon-bone healing, and its metabolites are acidic, and it has been reported in the literature that polylactic acid can be implanted in bone tissue and can be used in tendon-bone Formation of sclerotic tissue at the interface, seriously interfering with tendon-bone interface healing

Method used

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  • Porous cross pin for operational internal fixation of anterior cruciate ligament for tissue engineering
  • Porous cross pin for operational internal fixation of anterior cruciate ligament for tissue engineering
  • Porous cross pin for operational internal fixation of anterior cruciate ligament for tissue engineering

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Effect test

Embodiment 1

[0067] Embodiment 1: as Figure 5 As shown, the adopted specification is Φ2mm*12mm, the range of the two porous areas is: 1mm-3mm, the porosity is 50%-70%, the pore diameter is 1-50μm, and biological factors such as BMP-2, BMSC, and FGF are compounded in the porous area. The surface coating is Ca-P, micro-arc oxidation coating, fluoride coating, alkali heat treatment coating, thermal organic film, phosphating film, hydroxyapatite layer of porous transversal nails. Performed femoral tendon fixation for ACL reconstruction in a beagle dog. On the 4th day, 4th week, 8th week, and 12th week after ACL reconstruction, beagle dogs were anesthetized intravenously with pentobarbital sodium (30 mg / kg), and CT examination was performed to dynamically observe the implanted porous ZK60 magnesium alloy The degradation of the Rigid-fix nail in the body and the surrounding bone formation. At the same time, for the CT results at different time points, the CT display field of view (DisplayField...

Embodiment 2

[0072] The specification is Φ3mm*30mm, the range of the two porous areas is: 3mm-5mm, the porosity is 50%-70%, the pore size is 1-50μm, and the biological factors such as BMP-2, BMSC, FGF are compounded in the porous area, and the surface coating It is a porous transversal nail for Ca-P, micro-arc oxidation coating, fluoride coating, alkali heat treatment coating, thermal organic film, phosphating film, and hydroxyapatite layer. Performed femoral tendon fixation for ACL reconstruction in a beagle dog.

[0073] Twelve weeks after the operation, after intravenous anesthesia with sodium pentobarbital (30 mg / kg), 10 ml of potassium chloride was administered intravenously, the animals were sacrificed, and the knee joints were dissected to obtain specimens. The general appearance of the specimen showed that the anterior cruciate ligament of the knee joint was in place and continuous after transplantation, and the tissue of the original tibial stump had gradually crawled and grown to...

Embodiment 3

[0078] The specification is Φ3.3mm*25mm, the range of the two porous areas is: 1mm-3mm, the porosity is 50%-70%, the pore diameter is 1-50μm, and biological factors such as BMP-2, BMSC, and FGF are compounded in the porous area. The coating is Ca-P, micro-arc oxidation coating, fluoride coating, alkali heat treatment coating, thermal organic film, phosphating film, hydroxyapatite layer of porous transversal nails. Performed femoral tendon fixation for ACL reconstruction in a beagle dog.

[0079] Split the femoral specimen of the knee joint vertically along the top of the pulley, and soak the specimen in 4% formalin solution (PH7.4) according to the standard hard tissue pathology sectioning procedure, and store it in a refrigerator at 4°C for fixation For 48 hours, use different concentrations of alcohol to dehydrate the specimen (70% for 5 days, 75% for 5 days, 80% for 5 days, 90% for 5 days, 95% for 5 days, 100% for 5 days twice, xylene for 5 days and 2 times second), after ...

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Abstract

The invention discloses a degradable and resorbable porous magnesium compound biological factor cross pin for tissue engineering. The cross pin comprises a body which is cylindrical or rhombic magnesium alloy (1), part of the body (1) is provided with a plurality of porous regions used for containing biological factors with bone growth promoting or tendon differentiation effect, one end of the body is sharp and beneficial to cross transplantation of tendons in operation, and a host material of the body is magnesium or magnesium alloy and is subjected to surface modification. The cross pin can improve integration capability between the transplanted tendon and a bone tunnel to stimulate bone growth or induce bone mesenchymal stem cells (BMSC) in the bone tunnel to form tendon differentiation, and the process of tendon-bone healing is accelerated.

Description

technical field [0001] The invention relates to the field of biomedical instruments, and is particularly suitable for the field of instruments for treating anterior cruciate ligament reconstruction. Background technique [0002] The anterior cruciate ligament (ACL) is an important ligament that maintains the anteroposterior, lateral, and rotational stability of the knee joint, and is therefore the main ligament involved in sports injuries. According to statistics, there are 175,000 patients in the United States who need ACL reconstruction surgery every year, and the related surgery cost is as high as 1 billion US dollars. There was no such statistics in China before. In 2009, members of the Orthopedics Branch of the Chinese Medical Association conducted investigations on the number of cases of arthroscopic surgery in the province and other related data, and came up with a relatively accurate figure: 2000 In the past, there were less than 10,000 cases of arthroscopic surgery ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B17/56
CPCA61B17/56A61B2017/00004A61B2017/00933A61B2017/00969A61B2017/564
Inventor 张强王岩傅仰木殷毅冀全博陈旭
Owner 张强
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