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Beta-tricalcium phosphate porous ceramic drug-loading stent and preparation method and application thereof

A technology of tricalcium phosphate and porous ceramics, applied in ceramic products, applications, and other household appliances, etc., can solve the problems of slow tissue repair effect and single function, achieve good bone repair effect, fast release, reduce and avoid inflammation and The effect of the immune response

Inactive Publication Date: 2019-08-06
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the tissue repair effect of β-tricalcium phosphate materials is slow and has a single function. Therefore, by loading functional drugs in β-tricalcium phosphate scaffolds, it is possible to test the accelerated repair of bone tissue and achieve other functional purposes.

Method used

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  • Beta-tricalcium phosphate porous ceramic drug-loading stent and preparation method and application thereof
  • Beta-tricalcium phosphate porous ceramic drug-loading stent and preparation method and application thereof
  • Beta-tricalcium phosphate porous ceramic drug-loading stent and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] (1) 30g of β-tricalcium phosphate, 18g of sodium alginate solution with a mass concentration of 10%, 3g of Pluronic F-127 solution with a mass concentration of 30%, and 7g of ultrapure water were evenly stirred through a ball mill to obtain a 3D printed product. Ink: Put the 3D printing ink into the 3D printing equipment, design a cylindrical printing model with a diameter of 8mm and a height of 10mm, use a nozzle with a diameter of 0.41mm, an air pressure of 0.5MPa, a printing speed of 3mm / s, a layer thickness of 0.4mm, and an adjacent distance of The printing parameters of 0.8mm are printed by 3D printing equipment and dried at room temperature for 24 hours;

[0031] (2) Put the printed stent into the muffle furnace, the sintering system is: 5°C / min from room temperature to 500°C, heat preservation for 0.5 hours; 10°C / min from 500°C to 1100°C, heat preservation for 0.5 hours ;Rapidly cool down to 800°C at 10°C / min, hold for 2 hours, and cool with the furnace to obtain...

Embodiment 2

[0041](1) Mix 44g of β-tricalcium phosphate, 25g of sodium alginate solution with a mass concentration of 20%, 9g of Pluronic F-127 solution with a mass concentration of 20%, and 3g of ultrapure water through a ball mill to obtain a 3D printed product. Ink: Put the 3D printing ink into the 3D printing equipment, design a cylindrical printing model with a diameter of 8mm and a height of 10mm, use a nozzle with a diameter of 0.41mm, an air pressure of 0.5MPa, a printing speed of 3mm / s, a layer thickness of 0.4mm, and an adjacent distance of The printing parameters of 0.4mm are printed by 3D printing equipment and dried at room temperature for 24 hours;

[0042] (2) Put the printed stent into the muffle furnace, the sintering system is: 5°C / min from room temperature to 550°C, heat preservation for 2 hours; 10°C / min from 550°C to 1000°C, heat preservation for 2 hours ;Rapidly cool down to 900°C at 10°C / min, keep it warm for 2 hours, and cool with the furnace to obtain a β-tricalci...

Embodiment 3

[0049] (1) 30g β-tricalcium phosphate, 20g mass concentration of 10% sodium alginate solution, 5g mass concentration of 20% Pluronic F-127 solution are stirred evenly by ball milling to prepare 3D printing ink; 3D printing Put the ink into the 3D printing equipment, design a cylindrical printing model with a diameter of 8mm and a height of 10mm, use the printing parameters of a nozzle diameter of 0.41mm, air pressure of 0.5MPa, printing speed of 3mm / s, layer thickness of 0.4mm, and adjacent spacing of 0.6mm , printed by 3D printing equipment, and dried at room temperature for 24 hours;

[0050] (2) Put the printed stent into the muffle furnace, the sintering system is: 5°C / min from room temperature to 500°C, heat preservation for 1 hour; 20°C / min from 500°C to 1100°C, heat preservation for 2 hours ; 20°C / min rapid cooling to 800°C, heat preservation for 2 hours, and cooling with the furnace to obtain a β-tricalcium phosphate porous bioceramic scaffold with a macroscopic macrop...

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Abstract

The invention relates to a beta-tricalcium phosphate porous ceramic drug-loading stent and a preparation method and an application thereof. The method comprises the following steps: (1) preparing thebeta-tricalcium phosphate porous ceramic drug-loading stent having macroscopic macropores and microscopic small pores therein; (2) preparing a silk fibroin solution, adding a drug to-be-loaded, stirring and mixing the materials uniformly, and obtaining a mixed solution of silk fibroin and the drug; (3) performing ultrasonic treatment of the above mixed solution, and then rapidly injecting the drug-loading silk fibroin solution into the beta-tricalcium phosphate porous ceramic stent after a period of time, after the completion of the perfusion, performing water bath at normal temperature, and waiting for solidifying the silk fibroin solution to gel; and (4) taking an above sample and performing freeze-drying treatment, removing excess silk fibroin on the surface of the beta-tricalcium phosphate porous stent. Compared with the prior art, the beta-tricalcium phosphate porous ceramic drug-loading stent has the beneficial effects that (1) good biocompatibility; (2) better bone repairing effect; and (3) sustained drug release effect.

Description

technical field [0001] The invention relates to a β-tricalcium phosphate porous ceramic drug-loaded support, a preparation method and application thereof, belonging to the field of biological materials. Background technique [0002] Bone tissue engineering is considered to be an effective way to solve the problem of bone tissue regeneration and repair. The main component of β-tricalcium phosphate is composed of calcium and phosphorus, which is similar to the inorganic components of human bone tissue, and has good biocompatibility, osteoconduction and osteoinduction capabilities; β-tricalcium phosphate can be degraded by human tissues, and Calcium and phosphorus components participate in the regeneration and reconstruction of new bone tissue through bone homeostasis regulation. However, the tissue repair effect of β-tricalcium phosphate materials is slow and has a single function. Therefore, by loading functional drugs in β-tricalcium phosphate scaffolds, it is possible to t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/56A61L27/54A61L27/12A61L27/10A61L27/22A61L27/50C04B35/447C04B35/622B33Y10/00C04B38/00
CPCA61L27/10A61L27/12A61L27/227A61L27/50A61L27/54A61L27/56A61L2300/23A61L2300/602A61L2430/02B33Y10/00C04B35/447C04B35/622C04B38/00C04B2235/3212C04B2235/6562C04B2235/6565C04B2235/6567C08L89/00C04B38/0003C04B38/0054C04B38/0051
Inventor 戴红莲马遇乐黄孝龙
Owner WUHAN UNIV OF TECH
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