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A kind of bone tissue replacement material and its preparation method

A technology for replacing materials and bone tissue, applied in tissue regeneration, pharmaceutical formulations, pharmaceutical science, etc., can solve the problems of low porosity, poor strength, high production cost, and achieve the effect of high mechanical strength and porosity

Active Publication Date: 2019-12-27
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] There are many technologies and methods that can be used to prepare bone tissue engineering scaffolds, such as: electrospinning, phase separation / freeze drying, solvent casting / particle leaching technology, rapid prototyping technology and gas foaming technology to prepare scaffold materials, However, these technologies have the characteristics of complex preparation process, high production cost, low porosity, and poor strength.

Method used

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  • A kind of bone tissue replacement material and its preparation method
  • A kind of bone tissue replacement material and its preparation method
  • A kind of bone tissue replacement material and its preparation method

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preparation example Construction

[0036] The preparation method of the bone tissue replacement material of the present invention can adopt the following steps:

[0037] (1) Preparation of hydroxyapatite / chitosan slurry: Disperse the hydroxyapatite powder uniformly in the aqueous solution (for example, by ultrasonic for 1 h), then add acetic acid, add chitosan powder while stirring, and then stir and mix well (Generally need to stir for 2h) to obtain hydroxyapatite / chitosan slurry; wherein, the mass ratio of hydroxyapatite to chitosan is: 20-80 parts by weight of hydroxyapatite, 0.5-4 parts by weight of chitosan ;

[0038] (2) Preparation of melamine sponge loaded with hydroxyapatite / chitosan slurry: the melamine sponge is immersed in the hydroxyapatite / chitosan slurry obtained in step (1), and the melamine sponge is extruded by squeezing the melamine sponge. The pores in the sponge are filled with the slurry, and then the melamine sponge loaded with nano-hydroxyapatite / chitosan is taken out for vacuum drying,...

Embodiment 1

[0044] (1) Preparation of CS / HA slurry: Disperse 3g HA nano-hydroxyapatite powder in 10ml aqueous solution, add 200ul acetic acid after ultrasonic for 1h, add CS powder 0.3g after magnetic stirring for 10min and stir for 2h.

[0045] (2) Preparation of melamine sponges of different shapes: Cut the purchased melamine sponges into small cuboids of 0.5cm*0.5cm*1cm with a blade.

[0046] (3) Preparation of melamine sponge loaded with CS / HA slurry: immersing the bulk melamine sponge obtained in (2) in the slurry in (1) and sucking the slurry into the sponge by squeezing the melamine sponge, After taking it out, it was placed in a 60-degree vacuum oven and dried under the condition of a vacuum degree of 80 kPa.

[0047] (4) Sintering and molding: put the dried CS / HA-loaded melamine sponge obtained in (3) in a crucible and sintered under the condition of air. The heating program is to raise the temperature at 5°C / min to 330°C and keep it for 1 hour. After that, the temperature was r...

Embodiment 2

[0051] (1) Preparation of CS / HA slurry: Disperse 6g HA nano-hydroxyapatite powder in 10ml aqueous solution, add 200ul acetic acid after ultrasonic for 1h, add 0.3g CS powder after magnetic stirring for 10min and stir for 2h.

[0052] (2) Preparation of melamine sponges of different shapes: Cut the purchased melamine sponges into small cuboids of 0.5cm*0.5cm*1cm with a blade.

[0053] (3) Preparation of melamine sponge loaded with CS / HA slurry: immersing the bulk melamine sponge obtained in (2) in the slurry in (1) and sucking the slurry into the sponge by squeezing the melamine sponge, After taking it out, it was placed in a 60-degree vacuum oven and dried under the condition of a vacuum degree of 80 kPa.

[0054] (4) Sintering molding: put the dry CS / HA-loaded melamine sponge obtained in (3) in a crucible and sinter under the condition of air. After 1 h, the temperature was raised to 1200 °C at 10 °C / min, and after 2 h, the temperature was naturally lowered to normal tempera...

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Abstract

The invention belongs to the field of bone tissue replacement materials, and in particular relates to a method for preparing a chitosan-graphene-hydroxyapatite composite material as a bone tissue replacement material. The invention provides a method for preparing a bone tissue replacement material. The method comprises sequentially: preparing hydroxyapatite / chitosan slurry, preparing melamine sponge loaded with hydroxyapatite / chitosan slurry, sintering and molding, loading The reduction of graphene oxide and graphene oxide; the method for the preparation of the melamine sponge of the loaded hydroxyapatite / chitosan slurry is: the melamine sponge is immersed in the hydroxyapatite / chitosan slurry by extrusion compaction Amine sponge Fill the pores in the melamine sponge with the slurry, then take it out and vacuum dry it to get the melamine sponge loaded with nano-hydroxyapatite / chitosan; the vacuum temperature is 40-80°C, and the vacuum degree is 60-90KPa . The obtained bone tissue replacement material has a porous structure, has high mechanical strength and porosity, and can meet the requirements of the bone tissue replacement material.

Description

technical field [0001] The invention belongs to the field of bone tissue replacement materials, in particular to a chitosan (CS)-graphene (G)-hydroxyapatite (HA) ternary composite material as a bone tissue replacement material and a preparation method thereof. Background technique [0002] Hydroxyapatite (HA) is the main component of inorganic substances in human bone, and has good biocompatibility and biodegradability. At present, almost all commercial artificial bone materials contain hydroxyapatite, which can be sintered at high temperature to obtain high-strength hydroxyapatite ceramic materials, such as hydroxyapatite bioceramics, coral hydroxyapatite, However, they all have the disadvantages of being difficult to shape, low porosity, insufficient void size, and poor osteoinductive ability. [0003] Chitosan (CS) widely exists in nature, it has good biocompatibility, can be degraded into glucosamine in the body, glucosamine is neutral or weakly alkaline, does not cause...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/12A61L27/08A61L27/56A61L27/58
CPCA61L27/08A61L27/12A61L27/56A61L27/58A61L2400/12A61L2430/02
Inventor 石小军周凯喻鹏杨伟杨鸣波
Owner SICHUAN UNIV
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