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Hydroxyapatite ceramic/graphene composite bone tissue replacement material and its preparation

A composite technology of hydroxyapatite and graphene, applied in tissue regeneration, medical science, prosthesis, etc., can solve the problems of complex preparation process, high production cost, and low porosity, and achieve high porosity, high Mechanical strength, the effect of increasing strength

Active Publication Date: 2020-02-18
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] There are many technologies and methods that can be used to prepare bone tissue engineering scaffolds, such as: electrospinning, phase separation / freeze drying, solvent casting / particle leaching technology, rapid prototyping technology and gas foaming technology to prepare scaffold materials, However, these technologies have the characteristics of complex preparation process, high production cost, low porosity, and poor strength.

Method used

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  • Hydroxyapatite ceramic/graphene composite bone tissue replacement material and its preparation
  • Hydroxyapatite ceramic/graphene composite bone tissue replacement material and its preparation
  • Hydroxyapatite ceramic/graphene composite bone tissue replacement material and its preparation

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preparation example Construction

[0026] The first technical problem to be solved by the present invention is to provide a preparation method of hydroxyapatite ceramic / graphene composite bone tissue replacement material, the preparation method comprising the following steps:

[0027] (1) Preparation of hydroxyapatite / chitosan / graphene slurry: disperse the nano-hydroxyapatite powder in the graphene dispersion, ultrasonically treat the nano-hydroxyapatite to disperse evenly (1h after ultrasonic treatment) Acetic acid, add chitosan powder while stirring, and then stir and mix (generally need to stir for 2h) to get hydroxyapatite / chitosan / graphene slurry; wherein, nano-hydroxyapatite, chitosan and graphene The mass ratio is: 20-80 parts by weight of nano-hydroxyapatite, 0.5-4 parts by weight of chitosan, and 0.05-1 part by weight of graphene;

[0028] (2) Preparation of porous hydroxyapatite composite scaffold: immerse the polyurethane sponge in the hydroxyapatite / chitosan / graphene slurry obtained in step (1) and ...

Embodiment 1

[0035] (1) Preparation of CS / GO / HA slurry: Disperse 3g of HA nanopowder in 10ml of 0.1wt% GO solution, add 0.2ml of acetic acid after ultrasonication for 1h (the purpose of adding acetic acid is to dissolve chitosan) , after magnetic stirring for 10 min, 0.3 g of CS powder was added and stirred for 2 h to obtain CS / GO / HA slurry.

[0036] (2) Preparation of PU with different shapes: Cut the purchased melamine sponge into a cuboid of 3mm×3mm×5mm with a blade.

[0037] (3) Preparation of porous hydroxyapatite composite scaffold: immerse the block-shaped PU sponge obtained in (2) in the slurry in (1) and suck the slurry into the sponge by squeezing the melamine sponge, and then place it on the The porous hydroxyapatite composite scaffold was prepared by drying in a vacuum oven at 60 degrees under the condition of a vacuum degree of 80 kPa.

[0038] (4) Preparation of porous hydroxyapatite composite ceramics: the dry porous hydroxyapatite composite scaffold obtained in (3) was pla...

Embodiment 2

[0040] (1) Preparation of CS / GO / HA slurry: disperse 6g of HA nanopowder in 10ml of 0.1wt% GO solution, add 0.2ml of acetic acid after ultrasonication for 1h, add 0.3g of CS powder after magnetic stirring for 10min and stir again 2h, the CS / GO / HA slurry was obtained.

[0041] (2) Preparation of PU with different shapes: Cut the purchased melamine sponge into a cuboid of 3mm×3mm×5mm with a blade.

[0042] (3) Preparation of porous hydroxyapatite composite scaffold: immerse the block-shaped PU sponge obtained in (2) in the slurry in (1) and suck the slurry into the sponge by squeezing the melamine sponge, and then place it on the The porous hydroxyapatite composite scaffold was prepared by drying in a vacuum oven at 60 degrees under the condition of a vacuum degree of 80 kPa.

[0043] (4) Preparation of porous hydroxyapatite composite ceramics: put the dried porous hydroxyapatite composite scaffold obtained in (3) into a crucible and sinter it under the protection of nitrogen. ...

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Abstract

The invention belongs to the field of bone tissue replacement materials, and relates to a porous hydroxyapatite ceramic / graphene composite bone tissue replacement material and a preparation method thereof. The invention provides a method for preparing a hydroxyapatite ceramic / graphene composite bone tissue replacement material, which sequentially comprises: preparing nano-hydroxyapatite / chitosan / graphene slurry, preparing porous hydroxyapatite / graphene Composite support and sintering molding; the method for preparing the composite support is: immerse the polyurethane sponge in the hydroxyapatite / chitosan / graphene slurry, and fill the pores in the polyurethane sponge with the slurry by extruding the polyurethane sponge, Just take it out and carry out vacuum drying; during the vacuum drying process, the vacuum temperature is 40-80°C, and the vacuum degree is 60-90KPa. The obtained bone tissue replacement material has a porous structure, has high mechanical strength and porosity, and can meet the requirements of the bone tissue replacement material.

Description

technical field [0001] The invention belongs to the field of bone tissue replacement materials, in particular to a porous hydroxyapatite ceramic / graphene composite bone tissue replacement material and a preparation method thereof. Background technique [0002] Hydroxyapatite (HA) is the main component of inorganic substances in human bone, and has good biocompatibility and biodegradability. At present, almost all commercial artificial bone materials contain hydroxyapatite, which can be sintered at high temperature to obtain high-strength hydroxyapatite ceramic materials. Common hydroxyapatite bioceramics, coral hydroxyapatite, However, they all have disadvantages such as difficulty in shaping, low porosity, insufficient void size, and poor osteoinductive ability. [0003] Chitosan (CS) widely exists in nature. It has good biocompatibility and can be degraded into glucosamine in the body. Glucosamine is neutral or weakly alkaline, does not cause local inflammation, and can b...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/12A61L27/10A61L27/08A61L27/50A61L27/56A61L27/58
CPCA61L27/08A61L27/10A61L27/12A61L27/50A61L27/56A61L27/58A61L2430/02
Inventor 杨伟喻鹏石小军周凯杨鸣波
Owner SICHUAN UNIV
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