32results about How to "Excellent osteoinductive properties" patented technology

The invention relates to a preparation method for a titanium-magnesium double-metal composite of a double-communication netted structure to solve the problems of stress shielding and poor bioactivity caused by a high elasticity modulus of traditional biochemical metal materials such as stainless steel and a titanium alloy. The preparation method comprises the steps that a magnesium alloy with a low elasticity modulus and good osteogenic induction performance is permeated into porous titanium with a low elasticity modulus through a permeation method after being melted; and the titanium-magnesium double-metal composite of the double-communication netted structure is prepared through cooling. The preparation method is used for preparing the titanium-magnesium double-metal composite of the double-communication netted structure.

The invention discloses an injectable strengthened phosphate lime / hydrogel microcapsule tissue engineering bone which is prepared from the following components in percentage by weight: 20-75% of calcium phosphate cement, 20-75% of chitosan, 1-10% of PLGA electric spin and 3-155 of hUCMSCs hydrogel microcapsule. The invention also discloses a preparation method of the tissue engineering bone and application of the tissue engineering bone as a bone defect repairing material. The tissue engineering bone not only maintains original good biocompatibility and osteogenesis inducing property of phosphate lime, but also obviously improved mechanical properties and capability for carrying seed cells. The tissue engineering bone can be used for treating bone defect or bone deficiency caused by various diseases and has the characteristics of easy operation, convenient molding, maximum wound reduction, operation difficulty reduction, patient pain alleviation, less infection danger, less scar formation and the like.

The invention discloses a magnetic magnesium-loaded artificial bone and a method for preparing the magnetic magnesium-loaded artificial bone by 3D printing. The artificial bone includes the following components in parts by weight: PLA 6-10, β‑TCP 0.8-1.2, MgSO 4 0.3~0.7, Fe 3 o 4 0.3~0.7. The method uses computer-aided design software to carry out bionic design on the model of the bone scaffold, and then according to the principle of component bionics, PLA, β-TCP, MgSO 4 , Fe 3 o 4 The four raw materials were mixed according to the ratio of 8:1:0.5:0.5, and the obtained powder was centrifuged, washed, dried, and ground to obtain a composite powder. The obtained composite powder was sintered with a 3D printer to prepare a magnetic magnesium-loaded artificial bone.

The invention discloses a small-sized calcium phosphate fiber, a preparation method thereof, and an application in the preparation of a medicament for repairing fractures. The preparation method includes: completely dissolving polyvinyl alcohol in deionized water at 90-100 DEG C, and then cooling to normal temperature to obtain solution A, the mass concentration of polyvinyl alcohol in solution A is 0.5%-1%; Amorphous calcium phosphate is dispersed in absolute ethanol to obtain mixed solution B. The concentration of calcium phosphate in mixed solution B is 5-20 mg / mL; arginine is dissolved in deionized water at room temperature to obtain solution C. The mass concentration of the amino acid is 0.5% to 3%; under stirring, the mixed solution B and solution C are added dropwise to the solution A and evenly mixed, after the dropwise addition is completed, ultrasonic for 20 to 40 minutes, and finally air-dried at room temperature to form a thin film Twist and twist to obtain calcium phosphate fibers of small size; the volume ratio of mixed solution B, solution C, and solution A is 1:1:1.

The invention relates to the technical field of medical bone repair materials, in particular to an injectable bone grafting material, a preparation method and a use method. The bone grafting material is characterized by being prepared from, by weight, 6-10 parts of decalcified bone matrix, 0.8-1.5 parts of PRP, 0.5-2 parts of autologous hemocyte growth factors, 0.5-2 parts of Radix Salviae Miltiorrhizae injection, 0.05-0.2 part of doxycycline and 0.001-0.005 part of scopolamine, decalcified bone matrix, PRP, autologous hemocyte growth factors, doxycycline and scopolamine are mixed in real time during surgery, the mixture is arranged in a 10 ml syringe and compounded into an injectable mixture, and the bone grafting material is injected in an intraoperative bone defect part or the part (such as an intervertebral space) needing bone fusion enhancement, and has the advantages of being good in union effect, resistant to infection, high in osteogenic induction capacity, high in osteogenic strength, and the like.

The invention provides a bioactive ceramic armor with mechanical adaptability and a preparation method thereof. Chitosan, polycaprolactone and hydroxyapatite are used as rigid ceramic units, and polycaprolactone is used as a flexible joint connecting the ceramic units. Partly, through casting technology, in situ biomimetic construction of rigid and flexible bioactive ceramic armor materials. The biologically active armor material prepared by the invention not only has certain mechanical adaptability, but also has good biological activity. Facing the repair of skull injuries in young children, skull repair in complex dynamic mechanical environments such as intracranial hypertension, by implanting this kind of ceramic armor, it can adaptively match the mechanical stretching requirements, and at the same time induce the healthy growth of defective skull tissue to achieve normal repair tissue. form and function.

The invention discloses a preparation method of hydroxyapatite porous bioceramics loaded with nanometer zinc, belonging to the technical field of preparation of biomedical materials. The method of the present invention is to weigh nano-hydroxyapatite (99%-97%) and nano-zinc (1%-7%) powder according to the mass ratio, and then perform ball milling to obtain a composite powder, and mix the composite powder with a pore-forming agent The ammonium bicarbonate is mixed, and after being uniformly mixed, the green body is obtained by pressing, and the porous bioceramics of hydroxyapatite loaded with nanometer zinc is prepared by using the discharge plasma sintering technology. The porous bioceramic prepared by the present invention not only has uniform and pure composition, the porosity of the material is controllable between 40-70%, the compressive strength is 82-162Mpa, and the pore size is 50-600μm; and the addition of zinc can significantly improve the porosity. Osteogenic induction ability of bioceramics, the degradation rate matches the osteogenesis rate; it is suitable for bone scaffolding, filling and repairing materials.

The invention discloses a titanium-magnesium composite material with a double-connected structure and its preparation method and application, and relates to the technical field of biomedical metal material preparation. The preparation method includes the following steps: uniformly mixing titanium powder and magnesium powder by homogenizing ball milling to obtain titanium magnesium Composite material powder; drying the composite material powder and performing pre-pressing and shaping to obtain a titanium-magnesium composite material rough billet; performing high-temperature and high-pressure sintering on the composite material rough billet to obtain a double-connected structure titanium-magnesium composite material. The invention has a simple process and a short process, and adopts a high-temperature and high-pressure solid-phase sintering process, which solves the problems of microstructure regulation such as magnesium oxidation burning loss and uneven distribution, and the sintering problems of low material density and poor mechanical properties existing in the traditional powder metallurgy method. The double-connected titanium-magnesium composite material prepared by the invention is a novel biomedical composite material integrating excellent mechanical properties, biocompatibility, osteogenic inductivity and osteogenic integration, and has good application prospects.

The invention relates to a bone matrix material containing various proteins secreted by umbilical cord mesenchymal stem cells and a preparation method thereof. The material is an animal bone matrix material with the umbilical cord mesenchymal stem cells inoculated on the surface of a decalcified bone matrix and used for secreting osteogenic induction function proteins to promote osteogenesis. The bone matrix material has natural structures and characteristics of bone tissues and a good osteogenic induction effect, has a better osteogenesis promoting effect in a bone defect repair process, and is helpful for large-scale preparation and clinical application of tissue-engineered bones.