32results about How to "Excellent osteoinductive properties" patented technology

The invention relates to a preparation method for a titanium-magnesium double-metal composite of a double-communication netted structure to solve the problems of stress shielding and poor bioactivity caused by a high elasticity modulus of traditional biochemical metal materials such as stainless steel and a titanium alloy. The preparation method comprises the steps that a magnesium alloy with a low elasticity modulus and good osteogenic induction performance is permeated into porous titanium with a low elasticity modulus through a permeation method after being melted; and the titanium-magnesium double-metal composite of the double-communication netted structure is prepared through cooling. The preparation method is used for preparing the titanium-magnesium double-metal composite of the double-communication netted structure.

The invention discloses an injectable strengthened phosphate lime / hydrogel microcapsule tissue engineering bone which is prepared from the following components in percentage by weight: 20-75% of calcium phosphate cement, 20-75% of chitosan, 1-10% of PLGA electric spin and 3-155 of hUCMSCs hydrogel microcapsule. The invention also discloses a preparation method of the tissue engineering bone and application of the tissue engineering bone as a bone defect repairing material. The tissue engineering bone not only maintains original good biocompatibility and osteogenesis inducing property of phosphate lime, but also obviously improved mechanical properties and capability for carrying seed cells. The tissue engineering bone can be used for treating bone defect or bone deficiency caused by various diseases and has the characteristics of easy operation, convenient molding, maximum wound reduction, operation difficulty reduction, patient pain alleviation, less infection danger, less scar formation and the like.

The invention discloses a tetragonal phase BaTiO with micro-nano channel structure 3 The invention discloses a method for preparing / HA hollow microspheres, belonging to the technical field of bioceramic materials. In this method, the BaTiO 3 Complete the atomic-scale mixing with HA and fix it in the form of a liquid precursor, and then the precursor powder after rotary evaporation is subjected to liquid nitrogen wet freeze molding, and after freeze-drying, it is successfully prepared through a high-temperature calcination process. Tetragonal BaTiO 3 / HA microspheres. In the synthesis process of the present invention, common inorganic salts and simple reagents are mainly used, and the cost is low, simple and easy, and the repeatability is good. The synthesized micro-nano channel structure tetragonal BaTiO 3 / HA microspheres have high performance and good stability, are suitable for large-scale production, and can promote the commercialization of bioceramic materials.

The invention discloses a magnetic magnesium-loaded artificial bone and a method for preparing the magnetic magnesium-loaded artificial bone by 3D printing. The artificial bone includes the following components in parts by weight: PLA 6-10, β‑TCP 0.8-1.2, MgSO 4 0.3~0.7, Fe 3 o 4 0.3~0.7. The method uses computer-aided design software to carry out bionic design on the model of the bone scaffold, and then according to the principle of component bionics, PLA, β-TCP, MgSO 4 , Fe 3 o 4 The four raw materials were mixed according to the ratio of 8:1:0.5:0.5, and the obtained powder was centrifuged, washed, dried, and ground to obtain a composite powder. The obtained composite powder was sintered with a 3D printer to prepare a magnetic magnesium-loaded artificial bone.

The invention discloses a small-sized calcium phosphate fiber, a preparation method thereof, and an application in the preparation of a medicament for repairing fractures. The preparation method includes: completely dissolving polyvinyl alcohol in deionized water at 90-100 DEG C, and then cooling to normal temperature to obtain solution A, the mass concentration of polyvinyl alcohol in solution A is 0.5%-1%; Amorphous calcium phosphate is dispersed in absolute ethanol to obtain mixed solution B. The concentration of calcium phosphate in mixed solution B is 5-20 mg / mL; arginine is dissolved in deionized water at room temperature to obtain solution C. The mass concentration of the amino acid is 0.5% to 3%; under stirring, the mixed solution B and solution C are added dropwise to the solution A and evenly mixed, after the dropwise addition is completed, ultrasonic for 20 to 40 minutes, and finally air-dried at room temperature to form a thin film Twist and twist to obtain calcium phosphate fibers of small size; the volume ratio of mixed solution B, solution C, and solution A is 1:1:1.

The invention relates to a preparation method of a porous hydroxyapatite and strontium oxide composite bone repair material, and belongs to the technical field of biomedical material preparation. The method comprises the steps that 88%-99% by mass of hydroxyapatite and 12%-1% by mass of strontium oxide ceramic powder are weighed and ball-milled, and mixed powder is obtained; 40%-70% by mass of the mixed powder and 60%-30% by mass of ammonium bicarbonate pore-forming agent powder are mixed to be uniform and mechanically pressed into a block pressed blank; the pressed blank is put into a graphite mold, then the graphite mold is put into a discharging plasma sintering furnace for sintering, the sintered mold is naturally cooled to room temperature along with the furnace, demolding is conducted, and the porous hydroxyapatite and strontium oxide composite bone repair material is obtained. According to the porous hydroxyapatite and strontium oxide composite bone repair material prepared through the preparation method, any binding agent and templating agent do not need to be added, the components are pure, harmful impurities do not exist, the porosity is controllable between 20% and 50%, the degradation rate is appropriate, good osteogenic induction capacity is achieved, the technology is simple and easy to carry out, and the porous hydroxyapatite and strontium oxide composite bone repair material can be used for a bone defect repair material for hard tissue regeneration or reconstruction of organisms.

The invention discloses a sustained-release antibacterial compound bone grafting material and a preparation method thereof. The sustained-release antibacterial compound bone grafting material is mainly prepared by mixing nanosilver / TMC-207 sustained release microspheres, nano-hydroxyapatite and calcium phosphate cement powder. The preparation method comprises the following steps: firstly, preparing the nanosilver / TMC-207 sustained release microspheres by an O / O emulsion-solvent evaporation method, wherein PLGA is used as a carrier material; secondly, mixing the nanosilver / TMC-207 sustained release microspheres, the nano-hydroxyapatite and the calcium phosphate cement powder, and blending an obtained mixture with deionized water to obtain paste; setting and drying the paste to obtain the slow-release antibacterial compound bone grafting material. The sustained-release antibacterial compound bone grafting material disclosed by the invention has the advantages of long local drug release time, obvious sterilizing effect and high bone repairing capability. The preparation method has the advantages of being simple and convenient to operate and lower in cost.

The invention relates to the technical field of medical bone repair materials, in particular to an injectable bone grafting material, a preparation method and a use method. The bone grafting material is characterized by being prepared from, by weight, 6-10 parts of decalcified bone matrix, 0.8-1.5 parts of PRP, 0.5-2 parts of autologous hemocyte growth factors, 0.5-2 parts of Radix Salviae Miltiorrhizae injection, 0.05-0.2 part of doxycycline and 0.001-0.005 part of scopolamine, decalcified bone matrix, PRP, autologous hemocyte growth factors, doxycycline and scopolamine are mixed in real time during surgery, the mixture is arranged in a 10 ml syringe and compounded into an injectable mixture, and the bone grafting material is injected in an intraoperative bone defect part or the part (such as an intervertebral space) needing bone fusion enhancement, and has the advantages of being good in union effect, resistant to infection, high in osteogenic induction capacity, high in osteogenic strength, and the like.

The invention provides a bioactive ceramic armor with mechanical adaptability and a preparation method thereof. Chitosan, polycaprolactone and hydroxyapatite are used as rigid ceramic units, and polycaprolactone is used as a flexible joint connecting the ceramic units. Partly, through casting technology, in situ biomimetic construction of rigid and flexible bioactive ceramic armor materials. The biologically active armor material prepared by the invention not only has certain mechanical adaptability, but also has good biological activity. Facing the repair of skull injuries in young children, skull repair in complex dynamic mechanical environments such as intracranial hypertension, by implanting this kind of ceramic armor, it can adaptively match the mechanical stretching requirements, and at the same time induce the healthy growth of defective skull tissue to achieve normal repair tissue. form and function.

The invention discloses a preparation method of an anti-osteoporotic and high-bonding-strength micro / nano biomimetic coating of a bone implant. The method comprises: (1) putting the implant into a hydrofluoric acid solution for acid etching; and (2) putting the implant after the acid etching as a matrix into a magnetron sputtering sample introduction chamber, putting anti-osteoporotic strontium salt used as a target material into a main sputtering chamber, vacuumizing the main sputtering chamber and the sample introduction chamber, pre-sputtering the matrix for 20 minutes in the sample introduction chamber, sending the implant matrix into the main sputtering chamber, sputtering for 2-4 hours, taking out the samples from the main sputtering chamber, and performing post-treatment in a heat treatment furnace, with a post-treatment temperature being 300-500 DEG C and an insulation time being 2-4 hours. The coating provided by the invention has characteristics of high adhesion strength with the matrix, osteoporosis resistance, micro / nano biomimetic structure.

The invention discloses a method for preparing a bovine cortical bone grafting material, comprising the following steps: degreasing and decalcifying a cleaned bovine cortical bone block, immersing the bovine cortical bone block in an inhibitor of a bone morphogenetic protein degrading enzyme, then performing deproteinization, and finally obtaining the bovine cortical bone grafting material by freezing and drying. The preparation method has the advantages of simple steps, wide material source, low cost, low antigenicity of the obtained bone grafting material, strong bone formation inducibility, high biomechanical strength.

The invention discloses a preparation method of hydroxyapatite porous bioceramics loaded with nanometer zinc, belonging to the technical field of preparation of biomedical materials. The method of the present invention is to weigh nano-hydroxyapatite (99%-97%) and nano-zinc (1%-7%) powder according to the mass ratio, and then perform ball milling to obtain a composite powder, and mix the composite powder with a pore-forming agent The ammonium bicarbonate is mixed, and after being uniformly mixed, the green body is obtained by pressing, and the porous bioceramics of hydroxyapatite loaded with nanometer zinc is prepared by using the discharge plasma sintering technology. The porous bioceramic prepared by the present invention not only has uniform and pure composition, the porosity of the material is controllable between 40-70%, the compressive strength is 82-162Mpa, and the pore size is 50-600μm; and the addition of zinc can significantly improve the porosity. Osteogenic induction ability of bioceramics, the degradation rate matches the osteogenesis rate; it is suitable for bone scaffolding, filling and repairing materials.

The invention belongs to the field of bone tissue replacement materials, and relates to a porous hydroxyapatite ceramic / graphene composite bone tissue replacement material and a preparation method thereof. The invention provides a method for preparing a hydroxyapatite ceramic / graphene composite bone tissue replacement material, which sequentially comprises: preparing nano-hydroxyapatite / chitosan / graphene slurry, preparing porous hydroxyapatite / graphene Composite support and sintering molding; the method for preparing the composite support is: immerse the polyurethane sponge in the hydroxyapatite / chitosan / graphene slurry, and fill the pores in the polyurethane sponge with the slurry by extruding the polyurethane sponge, Just take it out and carry out vacuum drying; during the vacuum drying process, the vacuum temperature is 40-80°C, and the vacuum degree is 60-90KPa. The obtained bone tissue replacement material has a porous structure, has high mechanical strength and porosity, and can meet the requirements of the bone tissue replacement material.

The invention discloses a titanium-magnesium composite material with a double-connected structure and its preparation method and application, and relates to the technical field of biomedical metal material preparation. The preparation method includes the following steps: uniformly mixing titanium powder and magnesium powder by homogenizing ball milling to obtain titanium magnesium Composite material powder; drying the composite material powder and performing pre-pressing and shaping to obtain a titanium-magnesium composite material rough billet; performing high-temperature and high-pressure sintering on the composite material rough billet to obtain a double-connected structure titanium-magnesium composite material. The invention has a simple process and a short process, and adopts a high-temperature and high-pressure solid-phase sintering process, which solves the problems of microstructure regulation such as magnesium oxidation burning loss and uneven distribution, and the sintering problems of low material density and poor mechanical properties existing in the traditional powder metallurgy method. The double-connected titanium-magnesium composite material prepared by the invention is a novel biomedical composite material integrating excellent mechanical properties, biocompatibility, osteogenic inductivity and osteogenic integration, and has good application prospects.

The invention relates to a bone matrix material containing various proteins secreted by umbilical cord mesenchymal stem cells and a preparation method thereof. The material is an animal bone matrix material with the umbilical cord mesenchymal stem cells inoculated on the surface of a decalcified bone matrix and used for secreting osteogenic induction function proteins to promote osteogenesis. The bone matrix material has natural structures and characteristics of bone tissues and a good osteogenic induction effect, has a better osteogenesis promoting effect in a bone defect repair process, and is helpful for large-scale preparation and clinical application of tissue-engineered bones.