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Micro-nano channel structure tetragonal phase batio 3 The preparation method of /ha hollow microspheres

A technology of pore structure and hollow microspheres, which is applied in the field of bioceramic materials, can solve the problems of reduced flexural strength and fracture toughness, HA fracture toughness, and mechanical properties of flexural strength, which cannot be satisfied, and achieve excellent biocompatibility , Degradation rate ideal effect

Active Publication Date: 2022-06-07
XIAN UNIV OF TECH
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  • Description
  • Claims
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Problems solved by technology

[0004] The mechanical properties such as fracture toughness and flexural strength of pure HA are inferior to those of human bones, and its reliability as a bone substitute material is poor, and its flexural strength and fracture toughness will be further reduced after being made into porous microsphere materials, which cannot meet the requirements of human bone. Requirements for bone replacement in weight-bearing parts of the human body

Method used

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  • Micro-nano channel structure tetragonal phase batio <sub>3</sub> The preparation method of /ha hollow microspheres
  • Micro-nano channel structure tetragonal phase batio <sub>3</sub> The preparation method of /ha hollow microspheres
  • Micro-nano channel structure tetragonal phase batio <sub>3</sub> The preparation method of /ha hollow microspheres

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preparation example Construction

[0031] see Figure 1-4 , the present invention provides a technical solution: tetragonal BaTiO with micro-nano pore structure 3 / HA hollow microsphere preparation method, such as figure 1 As shown in the process flow chart, the specific operation steps are as follows:

[0032] Step 1, Formulation of BaTiO 3 Precursor solution: BaCl 2 ·2H 2 O and C 16 H 36 O 4 Ti is used as raw material, ethanolamine is used as reaction chelating agent, and BaTiO is obtained by reaction under high-concentration alkaline conditions 3 Precursor solution; the BaCl 2 ·2H 2 The weight of O is 1.8-10.5g, C 16 H 36 O 4 The weight of Ti is 3.5-21g, the weight of ethanolamine is 0.6-3.6g, the high-concentration alkaline condition selects NaOH aqueous solution, and the weight of NaOH is 2.5-25g;

[0033] Step 2, prepare HA solution: commercial HA nano-powder is dispersed in dehydrated alcohol to obtain HA solution; the weight of described commercial HA nano-powder is 10g, and the volume of d...

Embodiment 1

[0039] Step 1, Formulation of BaTiO 3 Precursor solution: first weigh 1.8g BaCl 2 ·2H 2 Add 10 mL of deionized water and stir until completely dissolved, and add 0.6 g of ethanolamine by weighing and stir to obtain a barium salt solution; then weigh 3.5 g of C 16 H 36 O 4 Dissolve Ti in 5 mL of absolute ethanol, stir evenly to obtain a titanium salt solution; finally weigh 2.5 g of NaOH and slowly dissolve it in 10 mL of deionized water to obtain a strong alkali solution; mix the barium salt solution, titanium salt solution and strong alkali solution. , a white turbid liquid is obtained, which is BaTiO 3 presomatic solution;

[0040] Step 2, prepare HA solution: take 10g of commercial HA nanopowder and dissolve it in 50mL absolute ethanol, stir to obtain HA solution;

[0041] Step 3, prepare PVA binder: according to the weight ratio of PVA and deionized water is 1:100, weigh 1 g of PVA into a beaker and add 100 mL of deionized water, and stir under heating in a water bat...

Embodiment 2

[0046] Step 1, Formulation of BaTiO 3 Precursor solution: first weigh 7.5g BaCl 2 ·2H 2 Add 30 mL of deionized water and stir until completely dissolved, and add 1.8 g of ethanolamine to it, and stir to obtain a barium salt solution; then weigh 10.5 g of C 16 H 36 O 4 Dissolve Ti in 15 mL of absolute ethanol, stir evenly to obtain a titanium salt solution; finally weigh 7.5 g of NaOH and slowly dissolve it in 30 mL of deionized water to obtain a strong alkali solution; mix and stir the barium salt solution, titanium salt solution and strong alkali solution evenly , a white turbid liquid is obtained, which is BaTiO 3 presomatic solution;

[0047] Step 2, prepare HA solution: take 10g of commercial HA nanopowder and dissolve it in 50mL absolute ethanol, stir to obtain HA solution;

[0048] Step 3, prepare PVA binder: according to the weight ratio of PVA and deionized water is 1:100, weigh 1 g of PVA into a beaker and add 100 mL of deionized water, and stir under heating in...

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Abstract

The invention discloses a tetragonal phase BaTiO with micro-nano channel structure 3 The invention discloses a method for preparing / HA hollow microspheres, belonging to the technical field of bioceramic materials. In this method, the BaTiO 3 Complete the atomic-scale mixing with HA and fix it in the form of a liquid precursor, and then the precursor powder after rotary evaporation is subjected to liquid nitrogen wet freeze molding, and after freeze-drying, it is successfully prepared through a high-temperature calcination process. Tetragonal BaTiO 3 / HA microspheres. In the synthesis process of the present invention, common inorganic salts and simple reagents are mainly used, and the cost is low, simple and easy, and the repeatability is good. The synthesized micro-nano channel structure tetragonal BaTiO 3 / HA microspheres have high performance and good stability, are suitable for large-scale production, and can promote the commercialization of bioceramic materials.

Description

technical field [0001] The invention relates to the field of bioceramic materials, in particular to a tetragonal BaTiO with a micro-nano pore structure 3 / HA hollow microsphere preparation method. Background technique [0002] Hydroxyapatite (Ca 10 (PO4) 6 (OH) 2 , HA) is the main inorganic component of human bone tissue, with good biocompatibility, bioactivity and osteoconductivity, widely used in the differentiation and mineralization of bone cells and bone tissue regeneration engineering and other biomaterial fields, known as It is one of the most potential replacement materials for human hard tissue. HA in natural bone minerals mainly exists in the form of nanometer size, and these nanometer HAs are arranged in order to constitute the mechanical properties of bone tissue. Compared with conventional HA, it has better biocompatibility and osteoconductivity. [0003] Human bone tissue is a special "piezoelectric material", and its remarkable piezoelectric effect can pr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C04B38/06C04B38/00C04B35/447C04B35/622C04B35/634A61L27/10A61L27/12A61L27/56A61L27/50A61L27/54A61K9/16A61K47/04A61K47/02
CPCC04B38/00C04B38/067C04B35/447C04B35/63416C04B35/622A61L27/10A61L27/12A61L27/56A61L27/50A61L27/54A61K9/1611C04B2235/3236A61L2430/02A61L2300/112A61L2300/102A61L2300/60
Inventor 焦华靳洁晨赵康汤玉斐张鑫媛周雪蕊
Owner XIAN UNIV OF TECH
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