Preparation method of nano-zinc oxide-doped hydroxyapatite porous ceramic

Abstract

The invention relates to a preparation method of a nano-zinc oxide-doped hydroxyapatite porous ceramic and belongs to the technical field of preparation of biomedical materials. The preparation methodtakes nano-zinc powder and hydroxyapatite powder as the raw materials and comprises weighing out ZnO and HA (hydroxyapatite) at a weight ratio of 1-7%:99%-93%, performing ball milling to obtain composite powder, uniformly mixing and pressing the composite powder and a pore forming agent of ammonium bicarbonate to obtain a blank, and then preparing the nano-zinc oxide-doped hydroxyapatite porous ceramic through a spark plasma sintering method. The prepared nano-zinc oxide-doped hydroxyapatite porous ceramic is pure in composition and achieves a controllable porosity of 40-70%, and added nano-zinc oxide can improve the osteogenic induction capacity of the nano-zinc oxide-doped hydroxyapatite porous ceramic and further improve the bone-forming capacity of parts around an implanted part; by controlling the porosity of the nano-zinc oxide-doped hydroxyapatite porous ceramic, the preparation method can prepare biological ceramics which meet different requirements and are applied to bone scaffold, filling and repair materials.

Description

technical field [0001] This article relates to a preparation method of nanometer zinc oxide doped hydroxyapatite porous bioceramic, which belongs to the technical field of preparation of biomedical materials. Background technique [0002] In recent years, with the rapid development of my country's national economy, the improvement of people's living standards, the aging of the population, and the significant improvement of medical and health standards, more and more orthopedic patients are caused by work-related injuries, traffic accidents, bone tumors, bone tuberculosis and other diseases. The artificial bone materials currently used clinically have delayed union or nonunion of bone graft, mismatch between the degradation of artificial bone and the rate of osteogenesis, fragmentation and deformation of bone graft material, collapse of bone after bone graft leading to loss of bone height, post-graft infection, Long-term sinus tract formation, long-term pain at the bone graft...

AI Technical Summary

Problems solved by technology

The artificial bone materials currently used clinically have delayed union or nonunion of bone graft, mismatch between the degradation of artificial bone and the rate of osteogenesis, fragmentation and deformation of bone graft material, collapse of bone after bone graft leading to loss of bone height, post-graft infection, Long-term sinus formation, long-term pain at the bone graft site, etc.

[0003] The porous hydroxyapatite-based artificial bone materials prepared by the prior art have the following problems: (1) In order to improve the mechanical properties of the material and obtain a stable porous structure, the material needs to be sintered at high temperature for a long time

Excessive sintering temperature and long holding time will cause partial decomposition of hydroxyapatite, resulting in a decrease in the biological activity of the material; (2) In the process of preparing the material, binders (such as polyvinyl alcohol, sodium silicate, etc.) need to be added ), there is a small amount of residue after high temperature sintering

The residual binder will not degrade, which reduces the bioactivity and osteogenic activity of the material, and even produces toxicity; (3) The degradation of the material does not match the osteogenesis rate during the application process, and the role of materials and elements that promote osteogenesis is limited. It is easy to cause delayed union or non-union of bone graft after implantation

Images