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Preparation method of bovine cortical bone grafting material

A technology of cortical bone and bone materials, applied in bone implants, medical science, prostheses, etc., can solve the problems of poor mechanical properties and low osteogenic factors, and achieve low cost, low antigenicity, and retained osteogenesis active effect

Active Publication Date: 2009-03-11
胡懿郃
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, after treatment, the mechanical properties are poor and the osteogenic factors are low.

Method used

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Examples

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Embodiment

[0014] A bovine cortical bone graft material of the present invention is prepared by the following method:

[0015] (1) Material collection and cleaning treatment: Under clean conditions, take the long tubular bones of calves (1-3 years old) that have passed the inspection (tested by BSE) and slaughtered within 6 hours, and cut off the metaphysis on both sides with a chainsaw , bone knife to clean the surrounding soft tissue, periosteum and bone marrow, and finally cut into cortical bone pieces with a size of about 3mm long x 3mm wide x 5mm high with an electric saw; wash the fat and blood on the surface of the bovine cortical bone pieces with warm water at 40°C to 50°C clean, drain;

[0016] (2) Degreasing: Put a chloroform-methanol mixed solution (abbreviated as degreasing solution) with a volume ratio of chloroform and methanol of 1:1 in a sealable glass container, and clean the bovine cortical bone pieces according to the bone fluid volume ratio of about 1:1. 1:3 into a g...

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PUM

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Abstract

The invention discloses a method for preparing a bovine cortical bone grafting material, comprising the following steps: degreasing and decalcifying a cleaned bovine cortical bone block, immersing the bovine cortical bone block in an inhibitor of a bone morphogenetic protein degrading enzyme, then performing deproteinization, and finally obtaining the bovine cortical bone grafting material by freezing and drying. The preparation method has the advantages of simple steps, wide material source, low cost, low antigenicity of the obtained bone grafting material, strong bone formation inducibility, high biomechanical strength.

Description

technical field [0001] The invention belongs to the field of bone tissue engineering, and in particular relates to a preparation method of a bone implant material. Background technique [0002] The repair of bone defects due to trauma, bone disease, etc. has always been a difficult problem in orthopedic treatment. Autologous bone and allogeneic bone transplantation are widely used and have good curative effect, but both have certain limitations. The source of autologous bone is limited, affecting the function of the donor site, increasing surgical trauma and infection; the source of allogeneic bone is also limited, and there is a risk of HIV, hepatitis and other diseases. The pore structure, degradation ability and biological performance of artificial bone are far inferior to natural bone. As a kind of biological tissue, xenograft bone has the advantages of wide sources, low price, and easy to obtain in large quantities. It has a natural porous network structure and good b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/36A61F2/28
Inventor 胡懿郃董松庚刘华
Owner 胡懿郃
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