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Bracket material of bone tissue engineering of self-promoting vascularizing strontium-doped calcium polyphosphate and preparation method

A technology of strontium calcium polyphosphate bone and tissue engineering scaffold, which is used in medical science, prosthesis, etc.

Inactive Publication Date: 2012-11-14
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main problem in bone tissue engineering is the vascularization of tissue engineered bone. At present, there are two main methods to promote the vascularization of tissue engineered bone, one is the tissue presetting method, and the other is the growth factor method. Placement methods include vascular bundle implantation method, vascular pedicle fascia flap wrapping method and muscle flap prefabrication method. Insufficient tissue prefabrication will lead to deformity or trauma in other parts, and prolong the treatment time
[0003]Studies have proved that strontium-doped calcium polyphosphate (SCPP) bone tissue engineering scaffold material has good biocompatibility and biodegradability, because polyphosphate is in the degradation process The free strontium ions produced in the medium will combine with the bone in the form of ion exchange, which will increase the mineral density of the bone, and at the same time have the effect of promoting the growth of osteoblasts and inhibiting the formation of osteoclasts. However, whether it has the effect of "self-promoting vascularization" still unclear

Method used

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  • Bracket material of bone tissue engineering of self-promoting vascularizing strontium-doped calcium polyphosphate and preparation method
  • Bracket material of bone tissue engineering of self-promoting vascularizing strontium-doped calcium polyphosphate and preparation method
  • Bracket material of bone tissue engineering of self-promoting vascularizing strontium-doped calcium polyphosphate and preparation method

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Experimental program
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Effect test

Embodiment 1

[0030]Weigh strontium carbonate and calcium carbonate according to a strontium / calcium molar ratio of 5.0%, mix strontium carbonate and calcium carbonate with phosphoric acid 1.5 times their weight and react at about 15°C to prepare strontium dihydrogen phosphate and dihydrogen phosphate Calcium mixture, the molar concentration of phosphoric acid is 13mol / L, and the reaction time is about 3 hours. After the reaction is completed, the mixture of strontium dihydrogen phosphate and calcium dihydrogen phosphate is washed with absolute ethanol until the pH value of the filtrate is about 6.5, and the mixed Put the salt into the crucible and calcine at about 450°C to make strontium dihydrogen phosphate and calcium dihydrogen phosphate polymerize to prepare a mixture of strontium polyphosphate and calcium polyphosphate. After calcination for about 4 hours, the polymerization reaction is completed Finally, the mixture of strontium polyphosphate and calcium polyphosphate is quickly coole...

Embodiment 2

[0032] Strontium carbonate and calcium carbonate react with phosphoric acid 1.7 times their weight respectively at about 30°C to prepare strontium dihydrogen phosphate and calcium dihydrogen phosphate. The molar concentration of phosphoric acid is 15mol / L, and the reaction time is about 2 hours. After the reaction is finished, wash the strontium dihydrogen phosphate and calcium dihydrogen phosphate with absolute ethanol until the pH value of the filtrate is about 7.0, weigh the strontium dihydrogen phosphate and calcium dihydrogen phosphate according to the molar ratio of strontium / calcium 7.5%, mix and place Put it into a crucible, and calcine it at about 550°C to make strontium dihydrogen phosphate and calcium dihydrogen phosphate polymerize, and prepare strontium polyphosphate and calcium polyphosphate mixture. The calcination time is about 3 hours. After the polymerization reaction is completed, the mixture of strontium polyphosphate and calcium polyphosphate is rapidly coo...

Embodiment 3

[0034] Strontium carbonate and calcium carbonate react with phosphoric acid 2.0 times their weight respectively at about 43°C to prepare strontium dihydrogen phosphate and calcium dihydrogen phosphate. The molar concentration of phosphoric acid is 16mol / L, and the reaction time is about 1.5 hours. After the reaction is completed, wash the strontium dihydrogen phosphate and calcium dihydrogen phosphate with absolute ethanol until the pH value of the filtrate is about 7.5, and put it in a crucible for calcination at about 600°C to make strontium dihydrogen phosphate and dihydrogen phosphate Calcium hydrogen produces a polymerization reaction to prepare strontium polyphosphate and calcium polyphosphate. The calcination time is about 1 hour. After the polymerization reaction is completed, the strontium polyphosphate and calcium polyphosphate are quickly cooled and quenched with ice water, and dried and ground. Powder, weigh strontium polyphosphate and calcium polyphosphate powder b...

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Abstract

The invention discloses a bracket material of bone tissue engineering of self-promoting vascularizing strontium-doped calcium polyphosphate and a preparation method. The bracket material mainly consists of strontium polyphosphate and calcium polyphosphate according to mol ratio of strontium and calcium of 0.5-10% and is in a porous block structure. The preparation method comprises the following steps of: proportioning the strontium polyphosphate and calcium polyphosphate according to the mol ratio of strontium and calcium determined by the bracket material of bone tissue engineering, adding 30-50% of a cavity-inducing agent based on the proportional weight of the strontium polyphosphate and calcium polyphosphate, preparing blocks with designed shapes after adequately mixing; sintering for1-3 hours at 820-950 DEG C, and cooling along with the sintering device to environmental temperature, thus, the bracket material having the self-promoting vascularizing function is obtained. The bracket material of the bone tissue engineering disclosed by the invention has favorable self-promoting vascularizing function, good biodegradability, bone conductivity, bone inductivity and biocompatibility, and is reliable for repairing and treating the bone for bone defect patients.

Description

1. Technical field: [0001] The invention relates to the technical field of biomedical materials, in particular to the technical field of biomedical engineering scaffold materials suitable for repairing human hard tissue defects. 2. Background technology: [0002] Every year around the world, a large number of patients suffering from bone defects, bone tumors, osteomyelitis and other diseases are waiting for treatment. Compared with such a huge demand, the current biomedical materials and products for bone repair are insufficient to meet the needs of clinical operations. Bone grafting has long been the mainstay of treatment for defective or missing bone tissue. Autologous bone grafting is the most commonly used therapy at present, but the limitation of donors limits its application and increases the suffering of patients. Allograft bone has antigenicity, especially when the implant is large, the implant often fails due to severe immune rejection. At present, more and more ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/12A61L27/56
Inventor 余喜讯任大伟万昌秀刘菲张旭
Owner SICHUAN UNIV
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