The invention provides silicon-fluorine modified resin and a method for preparing antifouling and easy-clean surface modified coating by utilizing the silicon-fluorine modified resin, wherein the silicon-fluorine modified resin is a modified surface processing agent which has uniform structure, extremely low surface tension, extremely good drainage and antifouling effect and excellent physical and mechanical properties and solvent resistance. The silicon-fluorine modified resin comprises the following raw materials in percentage by weight: 0.1-20 percent of silicon resin, 0-10 percent of fluororesin, 0.1-20 percent of hydroxyl acrylate resin, 20-50 percent of hydroxyl polyurethane resin and 20-70 percent of solvent. Coating slurry comprises the following components by weight part: 100 parts of silicon-fluorine modified resin, 10-40 parts of curing agent, 10-40 parts of accelerating agent and 10-200 parts of solvent, and the coating is constructed through printing, roller painting, spraying, brushing, dip-coating, and the like. The silicon-fluorine modified resin and the coating thereof have excellent antifouling and easy-clean functions and better comprehensive physicochemical property, and can be widely applied to the fields of furniture, automotive trims and seats, clothes, shoe leather, bags, and the like.