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Nanometer silver far-infrared negative ion magnet therapy sanitary towel and sanitary pad
ActiveCN102600021ANon-irritatingNo allergic reactionElectrotherapyAbsorbent padsFar infraredMagnet therapy
The invention relates to a nanometer silver far-infrared negative ion magnet therapy sanitary towel and a sanitary pad. The sanitary towel comprises a nanometer silver far-infrared negative ion magnet therapy composite core, and a preparation method of the core includes soaking and treating a semi-finished non-woven fabric in nanometer silver antibacterial liquor; then soaking the semi-finished non-woven fabric in far-infrared negative ion liquor; finally taking out the fabric; spraying magnetic powder on the fabric; and drying, purifying and ironing the fabric so as to form the core. The nanometer silver far-infrared negative ion magnet therapy sanitary towel and the sanitary pad have effects of sterilization, bacteriostasis and healthcare.
Owner:深圳市康乐美科技有限公司
Indoor air cleaning agent filled paired components
The present invention discloses a kind of indoor air smell-cleaning agent, including two portions of component A and component B. The compount A is a solid active agent formed from one or several kinds of oxalic acid, tartaric acid, amino acid, citric acid, aminosulfonic acid, isonicotinic acid and camphoric acid, and the component B is a stable solution formed from one or several kinds of potassium chlorate, sodium chlorate, magnesium chlorate, sodium hypochlorite, calcium hypochlorite, sodium chlorite, sodium perchlorate, potassium perchlorate, sodium dichloroisocyanurate and sodium trichloroisocyanurate. The component A can be added in the component B. The substances of nascent state oxygen, nascent state chlorine or chlorinedioxide can be released so as to eliminate harmful smell pollution due to building, decoration and furniture in the room.
Owner:HEBEI ZHONGLU ENVIRONMENTAL PROTECTION
Low-smoke low-halogen flame-retardant conveyor belt covering glue for coal mine and preparation process thereof
InactiveCN108659285AHigh bromine contentImprove thermal stabilityConveyorsComposite ceramicEngineering
The invention discloses low-smoke low-halogen flame-retardant conveyor belt covering glue for a coal mine, and relates to the technical field of conveyor belt covering glue. The covering glue comprises the following chemical components: natural standard rubber, styrene-butadiene rubber SBR1502, cis-butyl BR9000 rubber, polyisobutylene PB1300, an anti-aging agent, zinc oxide, magnesium oxide, stearic acid, a flow release agent, N234 carbon black, nano-aluminum hydroxide, antimony trioxide, decabromodiphenylethane, composite ceramic powder, expanded halogen-free flame-retardant IFR, a multi-purpose synergistic halogen-free flame retardant PNA220, molybdenum salt used as a smoke suppressant, an accelerator and sulfur. The low-smoke low-halogen flame-retardant conveyor belt covering glue disclosed by the invention is used under a coal mine well to meet flame-retardant performance of the conveyor belt, has excellent wear resistance and flame retardancy, and is low in smoke amount and smoketoxicity.
Owner:江苏凯嘉橡胶科技股份有限公司
Anal fistula suppository and preparation method thereof
The invention provides an anal fistula biological suppository and a preparation method thereof. The anal fistula biological suppository uses small intestine submucosa tissues of inbred line animals without cell and DNA (deoxyribonucleic acid) components as the raw material, completely reserves the extracellular matrix component and structure, and has a micropore structure. The preparation method of the anal fistula biological suppository comprises the following operation steps: determination of animal source, pretreatment and rough cleaning of small intestine tissues, virus inactivation, cell removal, DNA removal treatment, formation, packaging and sterilization. The anal fistula biological suppository prepared by the method uses an inbred line animal as an animal source, and thus, the hereditary features are pure, stable and uniform, thereby radically ensuring the stability and uniformity of different batches of products; and the anal fistula biological suppository has fewer animal source DNA residues, completely reserves the three-dimensional structure of natural ECM, and has the advantages of low immune source property and high infection resistance.
Owner:BEIJING BIOSIS HEALING BIOLOGICAL TECH
Nosiheptide-sulfuric acid colimycin premix and preparation and using method thereof
InactiveCN101327314AImprove liquidityReduce the impactAntibacterial agentsAnimal feeding stuffNosiheptideColistin Sulfate
The invention discloses a nosiheptide-colistin sulfate premixed agent which comprises 0.5-4 portions of nosiheptide, 1-10 portions of colistin, and the carriers of calcium carbonate, zeolite powder, corn flour, etc. for the rest in every 100 weight portions. The preparation method is as following. The raw materials are added in a mixing machine by the sequence of the carriers, the colistin sulfate, the nosiheptide and the carriers, and mixed evenly to make into powdery nosiheptide-colistin sulfate premixed agent. Or the nosiheptide and the carriers can be mixed fully firstly, then the colistin sulfate is dissolved in the water and sprinkled evenly on the mixture of the nosiheptide and the carriers. After being granulated, dried and screened, the mixture is made into the granular-typed nosiheptide-colistin sulfate premixed agent, the granularity of which is 30-60 mesh. The nosiheptide-colistin sulfate premixed agent of the invention is added in feedstuffs. The content range of the nosiheptide in every kilogram of overhead price feedstuff is 0.5-20mg, and the content range of the colistin sulfate in every kilogram of overhead price feedstuff is 2-40mg.
Owner:ZHEJIANG ESIGMA BIOTECH CO LTD +1
Aqueous chlorhexidine iodine sterilizing spray and preparation method thereof
InactiveCN102727435ASimple production processReduce high costAntibacterial agentsOrganic active ingredientsIrritationSolvent
The invention relates to aqueous chlorhexidine iodine sterilizing spray and a preparation method thereof. The spray comprises the following materials by weight: 0.1-2% of chlorhexidine iodine, 1-30% of solubilizer, 0.5-5% of cosolvent and the balance of water, and is prepared by dissolving the chlorhexidine iodine, the solubilizer and the coslovent with appropriate amount of water under ultrasonic treatment, adding the rest of water until the sum of the prescription is 100%, mixing, and filling into a spray bottle. The inventive spray has the advantages of no iodine odor, yellow-staining, toxicity, teratogenecity and skin / mucous membrane irritation, low available concentration, strong sterilizing ability, wide antibacterial spectrum, simple preparation process, and easy popularization.
Owner:WUHAN GENERAL HOSPITAL OF GUANGZHOU MILITARY
Novel wound self-healing biological material, preparation method and application thereof
InactiveCN101972489APromotes self-healingGood water solubilityOrganic active ingredientsDigestive systemSelf-healingSolid component
The invention discloses a novel wound self-healing biological material, a preparation method and application thereof, and relates to the technical field of biological materials. The wound self-healing biological material comprises a solid component and a liquid component, wherein the solid component comprises a cationic water-soluble chitin derivative which is a chitin derivative soluble in purified water, and accounts for 0.1 to 100 weight percent of the total weight of solid component. The novel wound self-healing biological material has the advantages that the structure and performance of a molecular scaffold of the cationic water-soluble chitin derivative is close to those of skin and mucosal intercellular matrix mucopolysaccharide (such as hyaluronic acid), and is an excellent matrix material for the growth of skin and mucosal cells, and the self-healing of human skin and mucosal injury is promoted effectively by the antibiotic property of cationic macromolecules.
Owner:吴奕光
Beauty composition containing vaccinium vitis-idaea extract and application thereof
ActiveCN101543525AImprove antioxidant capacityAchieve the beauty effect of anti-wrinkle and anti-agingHydroxy compound active ingredientsDermatological disorderLingonberry extractWrinkle skin
The invention relates to a beauty composition containing a vaccinium vitis-idaea extract and application thereof to skin beauty. The invention provides the vaccinium vitis-idaea extract, which contains components of anthocyanin, procyanidin, resveratrol and polyphenols such as catechin and the like. The invention also relates to the application of the vaccinium vitis-idaea extract to the beauty, including but not limited whitening, color fleck removing, wrinkle removing, skin smoothness strengthening, and skin sensitivity improving. The invention also discloses a medicament, the beauty composition and food which are prepared from the vaccinium vitis-idaea extract. Compared with the prior cosmetics, the vaccinium vitis-idaea extract has better effect and higher safety.
Owner:BEIJING GINGKO GRP BIOLOGICAL TECH CO LTD
Ammonia-free preservative for natural fresh latex
The invention relates to the technical field of natural rubber primary processing, and in particular relates to an ammonia-free preservative for natural fresh latex. An oxidation-type bactericide is selected from a large amount of solid, water-soluble, non-volatile and broad-spectrum bactericides aiming at pollution problems of ammonia and ammonia composite preservatives, and the oxidation-type bactericide is compounded with an alkaline stabilizer to be used as a preservation system of the natural latex. The novel preservation system provided by the invention has the characteristics of a goodpreservation effect, low costs, no ammonia, no volatilization, no irritation, easy solubility in water and convenient use, and can preserve the natural latex for a plurality of days, and the preparedraw rubber has excellent properties, especially has significantly-improved aging resistance; and in addition, the preservative can also be applied to early-stage preservation in the ammonia-free concentrated latex preparation process, and the overall costs are lower than those of a currently-used ammonia and TT / ZnO systems.
Owner:RUBBER RES INST CHINESE ACADEMY OF TROPICAL AGRI SCI
Ultramicro traditional Chinese medicine for preventing and treating lactation reduction and redness and swelling of breasts of dairy cows
InactiveCN105663256AHigh cure rateNo dependencyPowder deliverySexual disorderBaical Skullcap RootToxic material
The invention discloses an ultramicro traditional Chinese medicine for preventing and treating lactation reduction and redness and swelling of breasts of dairy cows. The ultramicro traditional Chinese medicine comprises raw materials in parts by weight as follows: 25-32 parts of dandelions, 18-22 parts of weeping forsythia, 15-25 parts of baical skullcap root, 25-34 parts of cowherb seeds, 18-22 parts of beautiful sweetgum fruits, 8-13 parts of uniflower swisscentaury root, 18-22 parts of Chinese angelica, 8-13 parts of rhizoma chuanxiong, 6-11 parts of bighead atractylodes rhizome, 9-14 parts of frankincense, 6-12 parts of myrrh and 8-11 parts of Chinese honeylocust spines. The ultramicro traditional Chinese medicine has the functions of treating both symptoms and root causes, and can be used for directly inhibiting or killing pathogenic bacteria of mastitis or inhibiting or killing pathogenic bacteria through improvement of body immunity; the medicine formula adopts the principles of heat and toxic material clearing, antisepsis, anti-inflammation, menstrual flow promotion, blood circulation promotion, swelling and pain elimination, collateral activation and lactation promotion, has functions of tonifying qi, raising yang and strengthening body resistance to dispel pathogenic factors, is effective and has a high cure rate, the milk quality of the dairy cows is improved, and the milk amount is remarkably increased. The ultramicro traditional Chinese medicine has controllable quality and the drug dependence is eliminated.
Owner:INNER MONGOLIA HUATIAN PHARMA
Leather cleansing agent
InactiveCN106085630AOdorlessSlightly fragrantNon-ionic surface-active compoundsOrganic detergent compounding agentsCarboxylateSurface-active agents
The invention discloses a leather cleansing agent. The leather cleansing agent is prepared from the following raw materials in parts by weight: 35-56 parts of deionized water, 12-16 parts of natural saponin, 4-7 parts of sodium polystyrene sulfonate, 4-8 parts of alcohol ethoxylate carboxylate, 1-3 parts of ethylene glycol monostearate, 3-7 parts of sophorolipids, 18-22 parts of a cross-linking agent, 5-10 parts of a cross-linking monomer, 7-9 parts of soybean ethylsulfuric acid ethyl ester morpholine, 5-9 parts of hydroxyethyl cellulose, 22-25 parts of ethanediol, 5-8 parts of a surface active agent, and 1-6 parts of castor oil butyl oleate sodium sulphate. The leather cleansing agent disclosed by the invention is free from odour, has light delicately-fragrant flavour, is free from irritability when being in contact with skin, free from teratogenicity and free from potential carcinogenicity, and does not corrode natural leather.
Owner:HUZHOU HONGXIN SILK FACTORY
Wool fabric antibacterial and anti-mold finishing agent
The invention discloses a wool fabric antibacterial and anti-mold finishing agent which consists of the following raw materials in parts by weight: 4-9 parts of cinnamon oil, 12-16 parts of natural saponin, 6-9 parts of alkyl sodium sulfonate, 3-6 parts of a dispersing agent, 7-9 parts of sodium gluconate, 6-9 parts of N-(phosphonomethyl) glycine isopropylamine salt, 2-10 parts of plifenate, 2-4 parts of a cross-linking agent, 13-20 parts of propylene glycol, 2-6 parts of allyl glycidyl ether, 4-7 parts of a surfactant, 9-11 parts of sophorolipid, 5-7 parts of coconut oil amide propyl betaine, 3-5 parts of dodecane pure sodium sulfate and 40-60 parts of water. A wool fabric processed with the wool fabric antibacterial and anti-mold finishing agent has functions of mold resistance, bacterial resistance, deodorization and the like, causes no irritation or allergy to skin, is free of toxin, teratogenicity or potential teratogenicity, and can meet environment protection requirements.
Owner:HUZHOU LINGHU ZHONGZHAO JINHUI SILK WEAVING FACTORY
Antimicrobial moldproof finishing agent for rabbit-hair fabric
InactiveCN105887485ANo stimulationNo allergic reactionBiochemical fibre treatmentAnimal fibresEpoxyIrritation
The invention discloses an antimicrobial moldproof finishing agent for rabbit-hair fabric. The finishing agent is prepared from, by weight, 5-6 parts of sodium polystyrenesulfonate, 3-6 parts of hydroxypropyl xanthan gum, 10-14 parts of emulsifier, 12-16 parts of natural saponins, 5-10 parts of sophorolipid, 3-6 parts of epoxy chloropropane, 5-8 parts of ethyltriethoxysilane, 15-20 parts of 2-methyl-4-isothiazoline-3-ketone, 11-14 parts of dibutyltin dilaurate, 16-22 parts of coupling agent, 1-8 parts of glycerin, 4-8 parts of crosslinking monomers, 8-10 parts of alkylphenol polyoxyethylene and 40-50 parts of deionized water. By means of the antimicrobial moldproof finishing agent for the rabbit-hair fabric, the functions of mold prevention, anti-microbial, deodorization and the like can be given to the rabbit-hair fabric, and the finishing agent is free of irritation to skin, free of allergic reaction and free of toxicity, teratogenicity and potential carcinogenicity and meets the environment-friendly requirement.
Owner:HUZHOU HONGXIN SILK FACTORY
Application of ulinastatin in preparation of drugs for treating prostatic cancer
InactiveCN105816862ASmall toxicityImprove securityPowder deliveryPeptide/protein ingredientsProstate cancerCurative effect
The invention belongs to the technical field of medicine, and specifically discloses an application of ulinastatin in the preparation of drugs for treating prostatic cancer. The test results show that ulinastatin can prominently prevent the weight loss of naked mice with prostatic cancer and inhibit the increasing of tumor volume; and moreover, ulinastatin can increase the expression of TNF-alpha of naked mice with prostatic cancer to promote apoptosis of tumor cells and reduce the expression of NF-kB to reduce the generation of related inflammation factors, and thus finally prevents prostatic cancer. Ulinastatin has the advantages of less adverse reactions, low side and toxic effect, high safety, low cost, and good curative effect on prostatic cancer.
Owner:GUANGDONG TECHPOOL BIO-PHARMA CO LTD
Soft cable sheath material for signal transmission of amphibious special vehicle and preparation method thereof
ActiveCN106883477BImprove low temperature resistanceAlleviate yellowingRubber insulatorsMicrocrystalline waxWear resistant
The invention discloses a flexible cable sheath material for signal transmission of amphibious special vehicles and a preparation method thereof, which is characterized in that the raw materials for the material include: 600-900 parts of neoprene, 100-300 parts of natural rubber, and nano-zinc oxide 30-60 parts, 20-60 parts of magnesium oxide, 10-30 parts of accelerator, 10-40 parts of anti-aging agent, 200-400 parts of high wear-resistant carbon black, 10-30 parts of stearic acid, 20-60 parts of microcrystalline paraffin 80-150 parts of pottery clay, 20-40 parts of dioctyl ester, 300-500 parts of nano-calcium carbonate, 100-150 parts of rubber antifungal agent, and 80-130 parts of anti-yellowing finishing agent. It is not easy to turn yellow, enhances the tensile properties of materials, improves the strength of soft wires, and is lead-free and mercury-free, which meets ROHS requirements. It has the advantages of extremely strong wear-resistant mechanical properties and good low-temperature resistance.
Owner:江西联创电缆科技股份有限公司
Traditional Chinese medicine composition for inhibiting oral infection of helicobacter pylori
ActiveCN114146125AEfficient killingPromote healingAntibacterial agentsCosmetic preparationsToothpastePharmaceutical Aids
The invention belongs to the technical field of traditional Chinese medicine preparations, discloses a traditional Chinese medicine composition for inhibiting oral infection of helicobacter pylori, and particularly relates to a traditional Chinese medicine preparation containing a Huai radix rehmanniae extract and used for killing oral infection of helicobacter pylori. Comprising the following effective components in percentage by mass: 0.005-0.18% of mucous membrane bactericidal factor compounded chlorine type quaternary ammonium salt and the balance of water, 0.1 to 0.5 percent of ligusticum wallichii extract; 0.1%-2.0% of a rehmannia glutinosa extract; and the balance of water and auxiliary materials. The composition can be prepared into oral spray or toothpaste additive. All the components have a synergistic effect, helicobacter pylori in the oral cavity can be efficiently killed, the sterilization rate is 99.99%, meanwhile, the oral mucosa is repaired, and the ecological balance of the oral cavity is maintained. The traditional Chinese medicine composition can treat ulcer and also has the effect of treating halitosis.
Owner:HENAN HEGUIHENG IND CO LTD
Hot spring sanitary wet tissue formula
PendingCN112022753APromote blood circulationImprove the bactericidal effectCosmetic preparationsToilet preparationsNonwoven fabricBiology
The invention discloses a hot spring sanitary wet tissue formula. The hot spring sanitary wet tissue formula comprises the following main components: a piece of non-woven fabric, and wet tissue solution, wherein the wet tissue solution comprises 99% of hot spring water, 0.5% of herbal enzyme and 0.5% of PHMB. According to the hot spring sanitary wet tissue formula in the invention, due to comprehensive compatibility of the components, such as the hot spring water, the herbal enzymes and the PHMB, the effects of promoting skin blood circulation, improving metabolism and killing bacteria are achieved; and thus, the hot spring sanitary wet tissue formula in the invention has the advantages of being high in functionality, capable of improving metabolism and capable of achieving sterilization.
Owner:辽宁佳合晟世医药科技股份有限公司
Non-catalyzed double-reducing-agent NOx removal method and non-catalyzed double-reducing-agent NOx removal device
ActiveCN112879126ANon-carcinogenicNo teratogenicityInternal combustion piston enginesExhaust apparatusAir pumpEngineering
The invention discloses a non-catalyzed double-reducing-agent NOX removal method. The NOX removal is realized by taking ethanol and n-pentane as pre-spraying / post-spraying reducing agents under an oxygenation condition. An adopted aftertreatment device comprises a plurality of spray modules which are arranged on a pipe body in the flowing direction of fluid and are of the same structure, each module comprises a heating piece, a temperature sensor and four nozzles, the heating pieces and the temperature sensors are arranged in an inner cavity of the pipe body, the nozzles are arranged on the wall of the pipe body, and each heating piece is provided with an I-shaped through hole provided with a heating wire; the nozzles located on the same side of the axis of the pipe body on the wall of the pipe body are connected to an oxygen pump through oxygen pressure stabilizing rails, and the nozzles with odd numbers in the nozzles located on the other side of the axis of the pipe body on the wall of the pipe body are connected to an ethanol filtering pump through ethanol pressure stabilizing rails; the four nozzles with even numbers are connected to an n-pentane filter pump through n-pentane pressure stabilizing rails; and all the sensors, the filter pumps and the heating pieces are connected to an automobile electronic control unit. The NOX removal rate is further increased through the multi-modular design.
Owner:TIANJIN UNIV
A kind of non-catalyzed double reducing agent NOx removal method and its device
ActiveCN112879126BNon-carcinogenicNo teratogenicityInternal combustion piston enginesExhaust apparatusEngineeringMechanics
The invention discloses a non-catalytic double reducing agent NO X Removal method to achieve NO with ethanol and n-pentane as pre / post-spray reductants under oxygenated conditions X remove. The post-processing device used includes a plurality of spray modules with the same structure arranged along the fluid flow direction on the pipe body. A single module includes a heating plate and a temperature sensor arranged in the inner cavity of the pipe body and four nozzles arranged on the wall of the pipe body. The heating sheet is provided with an I-shaped through hole with a heating wire installed; the nozzles on the same side of the tube axis on the tube body wall are connected to the oxygen pump through the oxygen stabilizing rail, and on the other side of the tube body axis on the tube body wall The odd-numbered nozzles in the nozzles are all connected to the ethanol filter pump through the ethanol rail; the even-numbered four nozzles are connected to the n-pentane filter pump through the n-pentane rail; each sensor, filter pump and heating sheet Both are connected to the car electronic control unit. The multi-modular design of the present invention further improves the NO X removal rate.
Owner:TIANJIN UNIV
3D printing resin for antibacterial wear-resistant shoes
PendingCN114437298AIncrease coefficient of frictionExcellent low coefficient of frictionAdditive manufacturing apparatusPolymer scienceButadiene Dioxide
The invention provides a 3D printing resin for antibacterial wear-resistant shoes. The 3D printing resin is applied to the field of 3D printing. The 3D printing resin comprises the following raw materials in parts by weight: 20-40 parts of carboxyl-terminated butadiene modified acrylate, 10-30 parts of fluoroalkane modified acrylate monomers, 10-15 parts of a reactive diluent, 1-2 parts of a polymerization inhibitor, 2-3 parts of a photoinitiator, 3-5 parts of a pigment, 10-15 parts of a filler, 0.5-2 parts of an antibacterial finishing agent and 5-10 parts of a silane coupling agent. According to the obtained 3D printing resin for the antibacterial and wear-resistant shoes, the resin is compounded with high elasticity and wear resistance required by shoe materials, meanwhile, the antibacterial property requirement is met, and the 3D printing resin can be used in the field of 3D printing shoes.
Owner:深圳锐沣科技有限公司
A method for treating fish egg hatching water with ultrasonic and electrocatalytic equipment
ActiveCN106746082BNo teratogenicityNo drug residueWater contaminantsWater/sewage treatment with mechanical oscillationsZoologyEgg incubation
The invention relates to a method for treating fish roe hatching water through ultrasonic wave synergistic electrocatalysis equipment, and belongs to the technical field of water treatment in aquaculture cultivation industry. The method has the advantages that the fish roe hatching water is treated through the ultrasonic wave synergistic electrocatalysis equipment, the hatching water is purified in a pure physical mode, pathogene and zooplankters, such as bacteria, algae and Cyclops, can be remarkably killed after a single treatment, a part of organic pollutants can be further degraded, so as to ensure that water is healthier, without drug residues and teratogenicity, the traditional chemicals are replaced, and the disadvantages that the chemicals have teratogenicity and drug residues, pollutes water areas, and standing needs to be performed for a certain period after disinfection to enable the chemicals to be volatilized are overcome.
Owner:TONGWEI
A kind of hrp activity assay and h 2 o 2 Concentration detection kit and its application
ActiveCN107190050BFast color rendering rateGood colorMicrobiological testing/measurementSolventMethyl palmoxirate
The invention relates to a biochemical detection reagent box. The reagent box comprises a reagent A, a reagent B and a reagent C, wherein the reagent A is a SDS / [C2mim][BF4] compound reaction solution, the reagent B is color rendering substrate 3,3'5,5'-tetramethyl benzidine (TMB) solid powder, and the reagent C is a H2O2 solution. According to needs, the reagent box further comprises a reagent D, a reagent E and a reagent F, wherein the reagent D is HRP enzyme liquid, the reagent E is a buffer solution PBS, and the reagent F is a substrate solvent dimethyl sulfoxide (DMSO-d6, 99.9%). According to the reagent box, on the basis of the principle that the SDS / [C2mim][BF4] compound reaction solution can significantly improve the color rendering efficiency of HRP-H2O2-TMB reaction, and the synergism effect is adopted to achieve HRP enzyme activity determination and H2O2 concentration detection. The reagent box has the advantages of being quick, sensitive and stable in color rendering, reagent organisms for detection are non-toxic, the operation is quick and convenient, the cost is low, and the reagent box has commercial potential for large-scale HRP activity determination and H2O2 concentration detection.
Owner:EAST CHINA UNIV OF SCI & TECH
Tpl2-deficient MDCK cell strain as well as construction method and application thereof
InactiveCN111454908AStable growth rateStabilize cell shapeSsRNA viruses negative-senseGenetically modified cellsFrameshift mutationCell strain
The invention provides a Tpl2-deficient MDCK cell strain as well as a construction method and application thereof, and relates to the technical field of biology. In the MDCK cell strain, 239th to 243rd bases of a first exon of a Tpl2 gene are deleted. The Tpl2 gene in the MDCK cell strain is knocked out through frame shift mutation, but the mutation has no influence on the growth rate and cell morphology of an MDCK cell after passage for 10 generations; tests show that the Tpl2-deficient MDCK cell strain provided by the invention can be stably inherited, is safe and reliable, and solves the problem that an existing mutant MDCK cell is unstable or unsafe in heredity. The Tpl2-deficient MDCK cell strain disclosed by the invention can be used for improving the flu virus yield after being inoculated with flu viruses, and compared with conventional MDCK cell culture, the supernatant hemagglutination titer and the supernatant virus TCID50 titer are obviously improved, and the problem of insufficient flu virus yield in the existing MDCK cell culture is solved.
Owner:HARBIN VETERINARY RES INST CHINESE ACADEMY OF AGRI SCI
Reagent box for HRP activity determination and H2O2 concentration detection and application thereof
ActiveCN107190050AFast color rendering rateGood colorMicrobiological testing/measurementSolventEnzyme
The invention relates to a biochemical detection reagent box. The reagent box comprises a reagent A, a reagent B and a reagent C, wherein the reagent A is a SDS / [C2mim][BF4] compound reaction solution, the reagent B is color rendering substrate 3,3'5,5'-tetramethyl benzidine (TMB) solid powder, and the reagent C is a H2O2 solution. According to needs, the reagent box further comprises a reagent D, a reagent E and a reagent F, wherein the reagent D is HRP enzyme liquid, the reagent E is a buffer solution PBS, and the reagent F is a substrate solvent dimethyl sulfoxide (DMSO-d6, 99.9%). According to the reagent box, on the basis of the principle that the SDS / [C2mim][BF4] compound reaction solution can significantly improve the color rendering efficiency of HRP-H2O2-TMB reaction, and the synergism effect is adopted to achieve HRP enzyme activity determination and H2O2 concentration detection. The reagent box has the advantages of being quick, sensitive and stable in color rendering, reagent organisms for detection are non-toxic, the operation is quick and convenient, the cost is low, and the reagent box has commercial potential for large-scale HRP activity determination and H2O2 concentration detection.
Owner:EAST CHINA UNIV OF SCI & TECH
Taxinol-sodium alginate micro ball vascular embolism agent and its preparation
ActiveCN1319525CNo teratogenicityNo reproductive toxicityOrganic active ingredientsSuppositories deliverySide effectBiocompatibility Testing
The preparation process of taxinol-sodium alginate microballoon as vascular embolism agent includes the following steps: preparing taxinol solution, sodium alginate solution and cationic solution of barium chloride, calcium chloride, etc.; mixing the taxinol solution, sodium alginate solution and the cationic solution of barium chloride, calcium chloride, etc. to obtain sodium alginate microballoon containing taxinol as vascular embolism agent. The vascular embolism agent has carrier material of natural extractive and excellent biocompatibility, is biodegradable, has carried medicine with less side effect, and is suitable for tumor blood vessel embolism and chemotherapy.
Owner:BEIJING SHENGYIYAO SCI & TECH DEV
Calcium phosphate bone cement degraded by temperature regulation and its preparation method
ActiveCN108744031BPromote degradationNo toxicityTissue regenerationProsthesisMicrospherePhosphoric acid
The invention discloses a calcium phosphate bone cement subjected to temperature regulation degradation, wherein the preparation raw materials comprise calcium phosphate bone cement liquid phase agentand solid phase powder which are matched when used; the liquid phase agent is a common calcium phosphate bone cement liquid phase agent; the solid phase powder is a mixture of a temperature-sensitiveoxygen generating compound and common calcium phosphate cement solid phase powder; the temperature-sensitive oxygen generating compound is a sodium percarbonate-wax microsphere compound coated with alayer of gelatin on the surface, the sodium percarbonate-wax microsphere compound is a sodium percarbonate microsphere compound coated with a layer of wax on the surface. The invention also disclosesa preparation method of the calcium phosphate bone cement subjected to temperature regulation degradation, the degradation rate of the calcium phosphate bone cement can be accelerated through heat treatment, and the calcium phosphate bone cement has good safety performance and is suitable for mass production.
Owner:吴容思
Use of ulinastatin in preparation of drugs for treating esophageal cancer
InactiveCN105770875ASmall toxicityImprove securityPowder deliveryPeptide/protein ingredientsSide effectTherapeutic effect
The invention belongs to the technical field of medicine and particularly discloses use of ulinastatin in the preparation of drugs for treating esophageal cancer. It is proved herein that by treating a nude mouse with esophageal cancer with ulinastatin, weight reduction of the nude mouse with esophageal cancer can be significantly reduced, dimensional increase of tumors can be significantly inhibited, the weight of esophageal cancer tumors can also be significantly reduced, and high tumor inhibition rate can be achieved; in addition, by increasing the expression of apoptosis-promoting protein Bax and apoptosis terminal cleavage enzyme caspase-3, ulinastatin can reduce the expression of anti-apoptotic protein Bcl-2, accelerate the apoptosis of tumor cells and finally resist esophageal cancer. Ulinastatin described herein causes little adverse response, is low in toxic and side effect, high in safety and low in cost, and is good in therapeutic effect for esophageal cancer.
Owner:GUANGDONG TECHPOOL BIO-PHARMA CO LTD
A controllable and degradable calcium phosphate bone cement and its preparation method
The invention discloses a calcium phosphate bone cement degradable under regulation. The calcium phosphate bone cement is prepared from the following raw materials: a liquid-phase agent and a solid-phase powder. The liquid-phase agent is a common calcium phosphate bone cement liquid-phase agent or a mixed liquid of a two-dimensional black phosphorus nano-material dispersion liquid and the common calcium phosphate bone cement liquid-phase agent, wherein the two-dimensional black phosphorus nano-material dispersion liquid is a mixed liquid of a two-dimensional black phosphorus nano-material anddeionized water. The solid-phase powder is a mixture of a temperature-sensitive oxygen-produced compound and a calcium phosphate bone cement solid-phase powder, wherein the temperature-sensitive oxygen-produced compound is a sodium percarbonate-wax microsphere composite suface-coated with a gelatin layer, and the sodium percarbonate-wax microsphere composite is a sodium percarbonate microsphere composite coated with a wax layer. The invention also discloses a preparation method for the above-mentioned calcium phosphate bone cement degradable under regulation. The calcium phosphate bone cementprepared in the invention can be accelerated in degradation rate through both heat treatment and near-infrared light treatment, and is good in safety and suitable for mass production.
Owner:吴容思
Anal fistula suppository and preparation method thereof
ActiveCN103272276BSmall genetic background differencesGuaranteed stabilityProsthesisBiotechnologyVirus inactivation
The invention provides an anal fistula biological suppository and a preparation method thereof. The anal fistula biological suppository uses small intestine submucosa tissues of inbred line animals without cell and DNA (deoxyribonucleic acid) components as the raw material, completely reserves the extracellular matrix component and structure, and has a micropore structure. The preparation method of the anal fistula biological suppository comprises the following operation steps: determination of animal source, pretreatment and rough cleaning of small intestine tissues, virus inactivation, cell removal, DNA removal treatment, formation, packaging and sterilization. The anal fistula biological suppository prepared by the method uses an inbred line animal as an animal source, and thus, the hereditary features are pure, stable and uniform, thereby radically ensuring the stability and uniformity of different batches of products; and the anal fistula biological suppository has fewer animal source DNA residues, completely reserves the three-dimensional structure of natural ECM, and has the advantages of low immune source property and high infection resistance.
Owner:BEIJING BIOSIS HEALING BIOLOGICAL TECH
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