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Novel wound self-healing biological material, preparation method and application thereof

A biomaterial and self-healing technology, which is applied in pharmaceutical formulation, drug combination, drug delivery, etc., can solve the problem of reduced wound repair activity of chitosan quaternary ammonium salt, and achieve good water solubility, promote self-healing, and significant curative effect Effect

Inactive Publication Date: 2011-02-16
吴奕光
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The hydrogel material is composed of a relatively large amount of synthetic hydrophilic polymer compound, chitosan quaternary ammonium salt and water, has a certain strength and is not easily deformed, but the cross-linked structure of the material will make the chitosan quaternary ammonium salt Reduced in wound repair activity

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] The water-soluble chitin quaternary ammonium salt 2'-O-HTACCt with a deacetylation degree of 10%, a substitution degree of 65%, and a molecular weight of 1.5 million is mixed with starch and glucose in a mass ratio of 2:1:2 to make a capsule .

Embodiment 2

[0017] The water-soluble chitin quaternary ammonium salt 2'-O-HTACCt with a deacetylation degree of 20%, a substitution degree of 80%, and a molecular weight of 1.5 million is mixed with starch and glucose in a mass ratio of 3:3:4 to make a capsule .

Embodiment 3

[0019] The water-soluble chitin quaternary ammonium salt 2'-O-HTACCt with a deacetylation degree of 10%, a substitution degree of 65%, and a molecular weight of 1.5 million is mixed with glucose at a mass ratio of 1:1 to make a capsule.

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PUM

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Abstract

The invention discloses a novel wound self-healing biological material, a preparation method and application thereof, and relates to the technical field of biological materials. The wound self-healing biological material comprises a solid component and a liquid component, wherein the solid component comprises a cationic water-soluble chitin derivative which is a chitin derivative soluble in purified water, and accounts for 0.1 to 100 weight percent of the total weight of solid component. The novel wound self-healing biological material has the advantages that the structure and performance of a molecular scaffold of the cationic water-soluble chitin derivative is close to those of skin and mucosal intercellular matrix mucopolysaccharide (such as hyaluronic acid), and is an excellent matrix material for the growth of skin and mucosal cells, and the self-healing of human skin and mucosal injury is promoted effectively by the antibiotic property of cationic macromolecules.

Description

technical field [0001] The invention relates to the technical field of biomaterials, in particular to self-repairing materials for human skin and mucous membrane damage. Background technique [0002] The repair of damaged wounds is affected by various factors, among which bacterial infection has the most significant impact on wound healing. Infected wounds are usually treated with various antiseptics. The natural biological antibacterial substance chitin and its deacetylated product chitosan have good biocompatibility, non-toxicity, biodegradability and low immunogenicity. Many studies and clinical reports have shown that chitin and Its derivatives have excellent wound healing effects, can promote the growth of macrophages, fibroblasts, and vascular endothelial cells, and regenerate connective tissue, which is helpful for the recovery of granulation tissue and epithelial tissue and scab. It is a new type of Wound biological dressings. Water-soluble cationic chitin derivat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/722A61K9/00A61P15/00A61L15/62A61P17/02A61P1/02A61K9/70A61L15/44A61P1/00A61L15/28C08L5/08
Inventor 吴奕光陈群英
Owner 吴奕光
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