63 results about "Nosiheptide" patented technology

The invention discloses a 817 miscellaneous chicken feed, which comprises the following components in parts by weight: 500-565 parts of corn, 80-150 parts of wheat, 120-270 parts of soya bean dregs, 20-50 parts of 40% cotton dregs, 0-40 parts of peanut dregs, 30-55 parts of DDGS, 15-35 parts of oil, 11-13 parts of rock powder, 6-13 parts of calcium hydrogen phosphate, 2-3 parts of salt, 1.2-1.5 parts of methionine, 4-6.5 parts of lysine sulphate, 0.6-1.0 part of choline chloride, 1.6-2.0 parts of compound trace elements and 0.4 part of compound vitamin. The feed can also comprise the following components in parts by weight: 0.4 part of betaine, 0.2 part of threonine, 0.1 part of enzyme preparation, 0.1 part of ethoxyquinoline, 0.2 part of nosiheptide, 0-0.5 part of dinitolmide and 0.05 part of alpha-aminobutyric acid. The 817 miscellaneous chicken feed provided by the invention is obtained after years of practice and nutritive additives are added into the feed, thus significantly increasing the immunity of the 817 miscellaneous chickens and significantly reducing the feed conversion ratio.

The invention discloses a laying duck feed which comprises the following components in parts by weight: 100-150 parts of mono-dicalcium phosphate, 200-250 parts of mountain flour, 40-60 parts of salt, 20-40 parts of sodium sulfate, 15-20 parts of choline, 40-45 parts of composite trace elements, 8-10 parts of compound vitamins, 20-30 parts of methionine, 5-8 parts of betaine, 200-250 parts of pine needle meal, 200-300 parts of medical stone, and 8.2 parts of additive, wherein the additive comprises the following components: 1 part of nosiheptide, 2 parts of phytase, 2 parts of compound enzyme preparation, 0.2 part of carophyll red, 1 part of chromium picolinate and 2 parts of probiotics. According to the invention, nutritional additives and the like are added into the feed, so that the feed can meet the needs of laying ducks for high egg laying rate, long egg laying peak time, bright color of egg yolks, and the like, thereby bringing obvious economic benefits.

The invention discloses a method for producing nosiheptide from active streptomyces by virtue of fermentation. The method comprises the following three steps: performing spore culture on a slant culture medium, performing strain culture on a seed tank culture medium, and performing fermentation on a fermentation tank culture medium; and culture or fermentation parameters of each step are optimized. Compared with the prior art, by adopting the method disclosed by the invention, the activation of active streptomyces can be optimized, and the biological activity of the active streptomyces can be improved by virtue of different stages of culture; and the yield of nosiheptide can be increased by more than 60%.

The invention discloses a method for preparing nosiheptide powder, which comprises the following steps: a. carrying out metallic membrane filtration on fermentation liquid containing nosiheptide obtained in fermentation by using a metal pipe type membrane separator and carrying out concentration treatment to remove 20-35 percent of water in the fermentation liquid to obtain concentrated liquid; b. carrying out spray drying treatment on the obtained concentrated liquid to obtain powder containing nosiheptide; adding auxiliary materials into the nosiheptide powder and diluting the nisiheptide powder level by level to prepare nosiheptide preparations with different forms. The invention has the advantages that nosiheptide can be completely extracted from the fermented liquid of nosiheptide, and the method has high yield, low cost and no environmental pollution.

The invention discloses a method for producing nosiheptide employing fermentation of streptomyces actuosus. The method comprises the following three steps: carrying out spore cultivation on a slant culture-medium; carrying out bacterial culture on a seed tank culture medium; and fermenting on a fermentation tank culture medium, wherein culture or fermentation parameters of various steps are optimized. Compared with the prior art, the activation of the streptomyces actuosus is optimized; the biological activity is improved through cultivation of the streptomyces actuosus at different stages; and the yield of the nosiheptide is increased by over 60%.

The invention relates to a preparation method of pure nosiheptide. The method comprises the steps that nosiheptide flashing powder is used as raw materials, a solvent is added for digestion, the temperature is controlled within 20-60 DEG C, and stirring is performed at the uniform rotating speed of 50-300 r / min for 1-3 h; a leaching solution obtained after the raw materials are processed is separated from solid mushroom dregs, the leaching solution is concentrated on a rotary evaporator at the temperature of 30-70 DEG C, and the organic solvent is recycled to obtain a concentrated solution; water and an elution agent are added into the concentrated solution, stirring is performed at the rotating speed of 100-400 r / min for 1-5 h, and then suction filtration is performed to obtain filter cakes; the filter cakes are placed into a vacuum drying oven, drying is performed at the temperature of 20-70 DEG C and the vacuum degree of minus 0.09 MPa for 6-16 h, and smashing is performed to obtain the pure nosiheptide. The method has the advantages that the production technology is simple, operation is convenient, the production efficiency is high, the product purity is high, and economy and environmental protection are achieved; the extracted nosiheptide can be prepared to obtain nosiheptide raw drugs or nosiheptide premixing agents of different specifications.

The invention provides a system and method for preparing nosiheptide premix particles. The system comprises a storage tank, a vacuum rake dryer and an air compressor, wherein a concentrated solution obtained by removing partial moisture from a nosiheptide fermentation liquid and a binder mixed uniformly with the concentrated solution are filled in the storage tank; a carrier is stored in the vacuum rake dryer; the storage tank and the vacuum rake dryer are connected by the air compressor; the uniformly mixed liquid of the nosiheptide and the binder in the storage tank is delivered into the vacuum rake dryer by the air compressor; then the mixed liquid is uniformly sprayed onto the carrier in the vacuum rake dryer by a nozzle on the vacuum rake dryer; and the carrier with the mixed liquid is dried and mixed in the vacuum rake dryer.

The invention provides a feedstuff for increasing weight of weaned young rabbits. The feedstuff comprises the following constituents by weight percent: 20% of corn, 14% of bean pulp, 4% of yeast powder, 38% of grass meal, 20.5% of bran, 2% of calcium hydrophosphate, 0.5% of table salt and 1% of trace additive, wherein the trace additive is composed of trace elements, multivitamins and defatted rice bran. In the feedstuff for increasing weight of weaned young rabbits provided by the invention, arginine and Nosiheptide are added, so that the feedstuff can improve immune performance and health condition of the rabbits. After using the feedstuff, average weight of the young rabbits at the age of 42 days is more than 900g, daily weight gain is 23-27g, the daily weight gain of the weaned young rabbits fed by normal feedstuff is 16-20g, so the feedstuff provided by the invention improves 35-65%, moreover, arginine and Nosiheptide are added in the feedstuff provided by the invention, thus, the feedstuff can improve organism immune performance and enhance the growth performance. The diet formula for increasing weight of weaned young rabbits provided by the invention has the characteristics of enhancing the immune performance of the young rabbits, improving the health condition of the young rabbits, increasing the weight of the young rabbits after weaning, and the like.

The invention discloses feed for laying hens in a brood period. The feed consists of the following components in parts by weight: 50-80 parts of MDCP, 80-100 parts of stone powder, 20-30 parts of salt, 10-20 parts of baking soda, 8-10 parts of choline, 20 parts of compound trace elements, 4-5 parts of compound vitamin, 0.5-1 part of vitamin C, 15-20 parts of methionine, 20-30 parts of lysine, 100-200 parts of fish meal, 100-200 parts of cottonseed meal, 150-250 parts of bone meal, 100-200 parts of corn germ meal, 30-110 parts of zeolite powder, 1-2 parts of nosiheptide, 0.5-1 part of chloroguanide, 1-2 parts of phytase and 1-2 parts of complex enzyme preparation. The feed provided by the invention is obtained after years of practice, and the invention provides the feed for laying hens in the brood period. After laying hens take the feed provided by the invention, the immunity of the laying hens is significantly enhanced, and the weight and shank length of 70-day laying hens exceed breeding standards.

The invention discloses marine Streptomyces sp. and an application of Streptomyces sp. in preparation of nosiheptide. The marine Streptomyces sp. SCSIO 1682 is preserved in the CCTCC (China Center for Type Culture Collection) in Wuhan University, Wuhan City, China on June 6, 2016 and has the preservation number being CCTCC NO: M2016307. A fermentation culture of the marine Streptomyces sp. SCSIO 1682 can be used for preparing nosiheptide shown in the formula (I). A biological preparation method is provided for production and preparation of nosiheptide, and the marine Streptomyces sp. has broad application prospect.

The invention relates to an oil-in-water type neomycin sulfate nosiheptide nanoemulsion antimicrobial medicine which is a nanoemulsion preparation taking neomycin sulfate and nosiheptide as effective components. The antimicrobial medicine comprises the following components in parts by weight: 1 to 20 parts of neomycin sulfate, 15 to 35 parts of surfactant, 0 to 20 parts of cosurfactant, 1 to 25 parts of nosiheptide, 1 to 25 parts of oil and 20 to 70 parts of distilled water. The antimicrobial medicine has a good pharmacological function and an excellent antimicrobial effect via combination of neomycin sulfate and nosiheptide, and is very simple in preparation method and easy to popularize.

The invention relates to an extraction method of nosiheptide. The extraction method comprises the following process steps: nosiheptide fermentation liquid atomizing and drying, composite solvent extraction and centrifugation, macroporous resin absorption, acid water hydrolysis, brine precipitation, washing, depressurization and drying. The invention provides a process for extracting the nosiheptide by utilizing composite solvent extraction and macroporous resin de-coloration and purification. According to the method provided by the invention, the extraction efficiency can be improved by 6.5 percent or more, the product purity reaches 96 percent or above, and the economic benefits are favorably improved. According to the method provided by the invention, the wastewater discharge amount is reduced, and the environmental protection treatment is facilitated. The extraction method provided by the invention has the benefits that the solvent corrosion is low, the toxicity is low, the equipment maintenance is facilitated, and the occupational health is facilitated.