Preparation method of nosiheptide premix

A technology of nosiheptide and premix, which is applied in the field of preparation of feed antibiotics, can solve problems such as polluting the environment and unfavorable environmental protection, and achieves the effects of small investment in equipment, significant economic benefits, and reduced production costs.

Active Publication Date: 2010-10-27
濮阳泓天威药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] In the method for preparing Nosiheptide premix after separation and extraction of Nosiheptide fermentation liquid, a large amount of organic solvents are used in the Nosiheptide extraction process, which seriously pollutes the environment and is not conducive to environmental protection.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0036] Example 1: The preparation method of powdery nosiheptide premix

[0037]Preparation of nosiheptide fermented liquid: connect the nosiheptide-producing bacterial classification into the seed tank, and through expanded cultivation, connect the fermented tank with an inoculation rate of 6 to 20%, and press the volume ratio of air and fermented liquid to be 1: The amount of 0.6-1 is ventilated, the temperature is controlled at 27-30°C, the stirring speed is 120-140 rpm, and sterile aerobic fermentation is carried out. The fermentation process is based on the sugar, pH value, and bacterial morphology. After culturing for 7-10 days, the fermentation is completed, and each liter of fermentation broth contains 1-3 g of nosiheptide.

[0038] The preparation method of powdery nosiheptide premix:

[0039] a. Pretreatment: Take 1000L of Nosiheptide fermented liquid (the fermentation unit of the fermented liquid is 2g / L) obtained through fermentation above, and add ZC-101 flocculan...

Embodiment 2

[0050] Embodiment 2: basically the same as Embodiment 1, the difference is:

[0051] The difference between the preparation method of powdery nosiheptide premix and embodiment 1 is:

[0052] a. Pretreatment: the added ZC-101 flocculant accounts for 0.05% of the total volume of the fermentation broth;

[0053] B, pressure filtration: the nosiheptide fermented liquid after step a pretreatment is carried out flexible pressing, and the maximum pressing pressure of control is 5.0MPa, obtains the wet filter cake containing nosiheptide after the pressure filtration, i.e. nosiheptide wet filter cake 90kg;

[0054] c, filter cake drying and pulverization: pulverize the Nosiheptide wet filter cake obtained in step b, pass through a 20-mesh sieve, and dry with a fluidized bed after pulverization. During drying, the air inlet temperature is controlled to be 120 to 130° C., and the air outlet temperature is 40~65°C, after drying, 49kg of dried product of Nosiheptide mycelium was obtained;...

Embodiment 3

[0063] Embodiment 3: basically the same as Embodiment 1, the difference is:

[0064] The preparation method of granular nosiheptide premix:

[0065] a. Pretreatment: Add 30kg of filter aid diatomaceous earth to 1000L nosiheptide fermentation liquid;

[0066] B, pressure filtration: the Nosiheptide fermented liquid after step a pretreatment is carried out membrane pressure filtration, and the control pressure filtration pressure is 2.0MPa, obtains the wet filter cake containing Nosiheptide after the pressure filtration, i.e. Nosiheptide wet filter cake 180kg ;

[0067] c. Drying and crushing of the filter cake: The nosiheptide wet filter cake obtained in step b is subjected to spin flash drying, and the temperature of the air inlet is controlled to be 160-180°C during flash drying, and the temperature of the air outlet of the material is 70-80°C to obtain that Sipeptide mycelium dry product 80kg;

[0068] Then the obtained nosiheptide mycelium dry product is pulverized, and ...

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Abstract

The invention discloses a preparation method of nosiheptide premix, which comprises the following steps: adding flocculants or filter aids into nosiheptide fermentation broth obtained by fermenting, fully stirring, and carrying out filter pressing or pressing to obtain nosiheptide filter cakes; drying the nosiheptide filter cakes to obtain dry products of nosiheptide mycelium, smashing to obtain fine powder of the nosiheptide mycelium, adding a powdery carrier into the fine powder and evenly mixing to obtain powdery nosiheptide premix; or granulating the powdery nosiheptide premix in a granulator to obtain granular nosiheptide premix; or adding a carrier, an adhesive and water into the dry products of the nosiheptide mycelium to carry out wet granulation, thus obtaining the granular nosiheptide premix. Preparing the nosiheptide premix by adopting the technical scheme of the invention has low requirement on production capability of equipment and low equipment investment, can effectively reduce production cost and has significant economic benefits; and in addition, no organic solvent is used in the preparation method, thus not generating any pollution on environment and having significant social benefits.

Description

1. Technical field: [0001] The invention relates to a preparation method of feed antibiotics, in particular to a preparation method of non-absorbable nosiheptide premix. 2. Background technology: [0002] Feed safety is the basic point of green and environmentally friendly food. my country has a vast territory and a large population. With the acceleration of reform and opening up, people's living standards have improved, and the demand for livestock, poultry and aquatic products has also increased. In addition, my country is a large agricultural country, and the export volume of livestock and poultry products is very large. However, the problem of drug residues is very serious. Therefore, the research and development of green feed additives is very important for the protection of people's health and the development of my country's agricultural economy. In July 2001, the Ministry of Agriculture issued the notice of "Specifications for the Use of Feed Drug Additives", and lis...

Claims

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Application Information

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IPC IPC(8): A23K1/17A23K20/195
Inventor 陈文成黄振锋郭燕军郑记拴黄玉欣王德玉林建福杨建印孙春领尤敏
Owner 濮阳泓天威药业有限公司
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