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Taxinol-sodium alginate micro ball vascular embolism agent and its preparation

A vascular embolizing agent, sodium alginate technology, applied in the directions of suppository delivery, cardiovascular system diseases, microcapsules, etc., to achieve the effects of strong hydration, improved curative effect, and reduced toxic and side effects

Active Publication Date: 2007-06-06
BEIJING SHENGYIYAO SCI & TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] At present, there is no precedent at home and abroad that sodium alginate is used as a drug carrier to wrap paclitaxel and apply it to vascular interventional embolization of tumor patients.

Method used

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  • Taxinol-sodium alginate micro ball vascular embolism agent and its preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Preparation of sodium alginate microspheres containing paclitaxel

[0039] 1. Preparations before packing:

[0040] ① Handling of glassware:

[0041] Dry the cleaned glassware in a high-temperature oven at 300 degrees Celsius for 3 hours (sterilize and remove heat source);

[0042] ②Preparation of paclitaxel liquid medicine:

[0043] Take by weighing 1.5 kilograms of commercially available paclitaxel, place in the above-mentioned glass vessel, add dropwise propylene glycol until completely dissolving; the concentration is 10mol / L paclitaxel drug solution;

[0044] ③ Preparation of sodium alginate solution:

[0045] Weigh 2 kg of commercially available sodium alginate, place it in a glass vessel, and add physiological saline while stirring until the sodium alginate is completely dissolved to obtain a sodium alginate solution;

[0046] ④ Prepare 1% calcium chloride solution;

[0047] ⑤ mixing the above-mentioned paclitaxel solution and sodium alginate solution to obt...

Embodiment 2

[0053] Preparation of sodium alginate microspheres containing paclitaxel

[0054] 1. Preparations before packing:

[0055] ① Handling of glassware:

[0056] Dry the cleaned glassware in a high-temperature oven at 300 degrees Celsius for 3 hours (sterilize and remove heat source);

[0057] ②Preparation of paclitaxel liquid medicine:

[0058] Take by weighing 2 kilograms of commercially available paclitaxel, place in the above-mentioned glass vessel, add physiological saline and ethanol dropwise, until all dissolve; obtain paclitaxel drug solution;

[0059] ③ Preparation of sodium alginate solution:

[0060] Weigh 20 kg of commercially available sodium alginate, place it in a glass vessel, and add physiological saline while stirring until the sodium alginate is completely dissolved to obtain a sodium alginate solution;

[0061] ④ Prepare 10% calcium chloride solution;

[0062] ⑤ mixing the above-mentioned paclitaxel solution and sodium alginate solution to obtain a sodium a...

Embodiment 3

[0068] Preparation of sodium alginate microspheres containing paclitaxel

[0069] 1. Preparations before packing:

[0070] ① Handling of glassware:

[0071] Dry the cleaned glassware in a high-temperature oven at 300 degrees Celsius for 3 hours (sterilize and remove heat source);

[0072] ②Preparation of paclitaxel liquid medicine:

[0073] Take by weighing 2 kilograms of commercially available paclitaxel, place in the above-mentioned glass vessel, add acetone dropwise until all dissolve; obtain paclitaxel drug solution;

[0074] ③ Preparation of sodium alginate solution:

[0075] Weigh 150 kg of commercially available sodium alginate, place it in a glass vessel, and add physiological saline while stirring until the sodium alginate is completely dissolved to obtain a sodium alginate solution;

[0076] ④ Prepare 6% barium chloride solution;

[0077] ⑤ mixing the above-mentioned paclitaxel solution and sodium alginate solution to obtain a sodium alginate mixed solution cont...

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Abstract

The preparation process of taxinol-sodium alginate microballoon as vascular embolism agent includes the following steps: preparing taxinol solution, sodium alginate solution and cationic solution of barium chloride, calcium chloride, etc.; mixing the taxinol solution, sodium alginate solution and the cationic solution of barium chloride, calcium chloride, etc. to obtain sodium alginate microballoon containing taxinol as vascular embolism agent. The vascular embolism agent has carrier material of natural extractive and excellent biocompatibility, is biodegradable, has carried medicine with less side effect, and is suitable for tumor blood vessel embolism and chemotherapy.

Description

technical field [0001] The invention relates to a paclitaxel-sodium alginate microsphere vascular embolization agent and its preparation. Background technique [0002] According to the data of the World Cancer Registry, the incidence rate of ovarian cancer is the highest among women in Chile, 21 / 100,000, and the lowest in Japan and India, 3.1 / 100,000 and 3.3 / 100,000 respectively. This shows the harm of this disease to women. degree. In my country, ovarian tumors are also one of the common gynecological diseases, among which malignant tumors account for about 10%, and 70% of patients with ovarian malignant tumors have entered the advanced stage when they are diagnosed, and the mortality rate is the first among female genital malignant tumors. Only 30%-40%, causing great harm to women's health and life. Unfortunately, the incidence is still on the rise year by year, increasing by 3 times in the past 40 years. Studies have shown that the cure rate of paclitaxel for this disea...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/337A61K9/02A61K47/36A61M31/00A61P35/00A61K9/00
CPCA61K9/0019A61K9/1652A61K9/0024A61K31/337A61K47/36A61P9/00A61P35/00A61K9/50
Inventor 李新建洪宏肖光礼
Owner BEIJING SHENGYIYAO SCI & TECH DEV
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