49results about How to "No inflammation" patented technology

The present invention provides a method for manufacturing a porous three-dimensional support using powder from animal tissue, comprising the steps of making a powder from animal-derived tissue, decellularizing the powder before, after, or simultaneously with the step of making the powder from the animal-derived tissue, and forming the decelluralized powder from the animal-derived tissue into a porous three-dimensional support through a particle leaching method.

The invention provides an aluminum adjuvant used as a vaccine vector. The adjuvant is characterized in that a PEG derivative bio-material and aluminum are compounded to form nano-particles, so that the property of strong Th2 body fluid immunologic adjuvant of aluminum salt is maintained, and the adjuvant can be efficiently transferred to draining lymph nodes in the body and can be easily ingested by dendritic cells to perform effective cross-presentation and induce cellular immunologic response. The aluminum adjuvant has strong Th1 immunologic response.

The invention discloses quaternary ammonium salt type hyperbranched polythioether modified polymer microspheres and a preparation method thereof. The preparation method comprises the following steps of: under a photo-initiation condition, taking polyethylene glycol as a pore-foaming agent, taking alkyl dithiol, propargyl glycidyl ether and 1,7-octadiyne as raw materials, and preparing epoxy groupmicroporous polymer spheres by using a sulfydryl-alkyne addition suspension polymerization method; then, under the condition of 0 DEG C, taking methanol as a solvent, and initiating allyl glycidyl ether and a cysteamine compound by ultraviolet light to react to synthesize an [alpha]-epoxy-[omega]-ammonium-based intermediate; and, in a solvent and under the condition of 60 DEG C, synthesizing the hyperbranched ammonium polythioether modified polymer microspheres from the epoxy group microporous polymer spheres, the [alpha]-epoxy-[omega]-ammonium-based intermediate and sodium methoxide in one step. The obtained product has a good killing effect on escherichia coli, and the modified polymer microspheres can be recycled through simple filtration.

The invention discloses a bio-based hemodialysis membrane and a preparation method thereof. The hemodialysis membrane is prepared from polylactic acid, laminarin, thiolated chitosan, silk fibroin, sodium ascorbyl phosphate, cellulose acetate, dithiothreitol, stachyose, betulin caffeate, ammonium persulfate, ferulic acid, hydroxyethyl starch, N-benzyl glycine hydrochloride, deoxycholic acid, polyhydroxyalkanoate, hexamethylenediamine, hyaluronic acid, benzoperoxide and dimethyl sulfoxide. According to the prepared hemodialysis membrane, the tensile strength is not lower than 7.0 MPa, the transmittance of urea is higher than 86%, the transmittance of beta2 microglobulin is higher than 66%, the rejection rate of macromolecular protein is higher than 95%, the biocompatibility is good, coagulation, thrombus, inflammation, poisoning and other adverse reactions do not exist, and an application prospect is wide.

The invention discloses an MOF composite material with an antibacterial function as well as a preparation method and antibacterial application thereof. The preparation method specifically comprises the following steps: adding a mixed DMF solution of 1-hydroxybenzotriazole (HOBT) and 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC. HCl) into a DMF dispersion solution of molybdenum disulfide carboxylate (MoS2-COOH) nanoparticles; and stirring for 45 + / -5min under an ice bath condition, adding triethylamine (TEA), uniformly stirring, adding UIO-66-NH2 into the solution, stirring for 13 + / -1h under a room temperature condition, carrying out centrifugal separation after the reaction is finished, discarding the supernatant, collecting the precipitate, cleaning the precipitate, and drying to obtain the functionalized MOF nano-material UIO-66-NH-CO-MoS2. The transition metal sulfide and the MOF are combined through an amido bond, the prepared material not only has the capacity of capturing bacteria, but also has catalase activity and a photothermal conversion effect, the antibacterial effect of the transition metal sulfide and the MOF is optimized, and a very good antibacterial effect is achieved.

The invention discloses a bioabsorbable polyphosphoester amino acid copolymer material, which is formed by preparing caprolactam, alpha-amino acid and phosphate, wherein caprolactam and alpha-amino acid are firstly polymerized to form a polybasic amino acid amide structural polymer; the polybasic amino acid amide structural polymer and phosphate are formed to be polyphosphoester amino acid copolymer. The polyphosphoester amino acid copolymer has good hydrophilia and degradation property, excellent physical performance, and can reduce the pH value of the product to 6.5-7.5 without stimulus response; the effect of internal repair is good, and the clinical application prospect is good.

The immune response of an animal to a target immunogen may be enhanced by use of a novel adjuvant which includes low concentrations of killed cells of Mycobacterium avium subspecies avium in combination with mineral oil. The adjuvant may be used in vaccine compositions for the immunization of an animal against any target immunogen, and is particularly preferred for use with immunocontraceptive vaccines such as GnRH and PZP immunocontraceptive vaccines.

The invention, belonging to the field of biomedicine, bio-polymer material and magnesium alloy material, relates to a biodegradable magnesium alloy bile duct stone-dissolving carving stent and a preparation method thereof. The stent is prepared by processing magnesium or magnesium alloy into hollow tubes, carving the hollow tubes under the action of laser to a tubular stent with a porous reticular or spiral tubular structure, and then coating a biodegradable polymer layer containing sodium cholate or / and edetate disodium on the inner surface and outer surface of the tubular stent. Clinical outcomes show that the stone-dissolving bile duct stent of the invention has good radial supporting performance, can keep the bile duct open, can be degraded away in a certain time with no need of removing the stent, has good biocompatibility, and lets almost no internal inflammation generate. Simultaneously, sodium cholate or / and edetate disodium slowly released by the polymer layer containing drugs can dissolve the formed stones and can prevent the re-formation of stones.

The invention discloses application of a biologically absorbable polyphosphate and amino acid copolymer to preparation of a repairing material. The polyphosphate and amino acid copolymer is prepared from caprolactam, alpha-amino acid and phosphate, wherein the caprolactam and the alpha-amino acid are firstly polymerized to form a polymer with a multi-component amino acid amide structure; the polymer with the multi-component amino acid amide structure and the phosphate form the polyphosphate and amino acid copolymer. The invention further discloses a blend formed by the polyphosphate and amino acid copolymer and other materials. The polyphosphate and amino acid copolymer is used as the repairing material and has good hydrophilcity and degrading performance, and good mechanical properties; the pH (Potential of Hydrogen) of a degraded product is 6.5 to 7.5 and stimulation reaction is not caused; the polyphosphate and amino acid copolymer has good effect when being used for in-vivo repairing, and can also form the blend with other materials; the polyphosphate and amino acid copolymer has good clinical application prospect.

The invention discloses Chinese medicinal ointment for treating livestock skin pathological changes and a preparation method thereof. The Chinese medicinal ointment serving as external plasters at least comprises the following medicaments in part by weight: 55 to 65 parts of tung oil, 9 to 11 parts of indigowoad root, 18 to 22 parts of giant knotweed rhizome, 3.6 to 4.4 parts of blackberrykiky rhizome and / or 1.8 to 2.2 parts of vietnamese sophora root, 1.8 to 2.2 parts of figwort root and 1.8 to 2.2 parts of natural indigo, and preferably comprises the following medicaments in part by weight: 60 parts of tung oil, 10 parts of indigowoad root, 20 parts of giant knotweed rhizome, 4 parts of blackberrykiky rhizome, 2 parts of vietnamese sophora root, 2 parts of figwort root and 2 parts of natural indigo. The Chinese medicinal ointment is applied to wounds of livestock continuously for over two days, the livestock can be cured, and particularly, the Chinese medicinal ointment has the obvious curative effect on sore mouth of various degrees.

The invention provides an aqueous suspension injection of cephalosporin medicines, and a preparation method thereof. The aqueous suspension injection comprises the components of 5-20% W / V of a 7-aminocephalosporanic acid derivative, 10-40% W / V of an excipient, 5-25% W / V of a suspending agent, 0.1-0.6% W / V of a suspending aid, 0.1-0.5% W / V of a pH buffer, 0.1-1.0% of an addition amount of a surfactant, and balance of injection water. The 7-aminocephalosporanic acid derivative is micronized, wherein 7-aminocephalosporanic acid derivative particles with size smaller than 100mum account for no lower than 95% by volume of the total volume of the raw materials, and 7-aminocephalosporanic acid derivative particles with size smaller than 20mum and larger than 2mum account for no lower than 90% of the total volume of the raw materials. Compared with oily preparations or powdery preparations of cephalosporin medicines, the aqueous suspension injection of cephalosporin medicines provided by the invention has lower viscosity and better injection performance, such that cephalosporin medicine stability is improved. The viscosity of cephalosporin medicines is reduced, such that injection irritation is reduced.

The invention discloses a biodegradable magnesium alloy carved support capable of preventing bile duct benign and malignant stricture and a manufacture method thereof. The biodegradable magnesium alloy carved support comprises a hollow pipe made of magnesium or a magnesium alloy. The inner diameter of the hollow pipe is 5.5-10 mm, the outer diameter of the hollow pipe is 6.4-10.5 mm, and the length of the hollow pipe is 6-12 cm. The hollow pipe is a pipe of a porous net-shaped structure or a spiral pipe structure and is carved under laser according to a design requirement. A biodegradable polymer layer containing mitomycin or / and paclitaxel is coated on the inner surface and the outer surface of the hollow pipe. Due to the fact that the support is made of magnesium or the magnesium alloy, the radial supporting performance is good, stricture and closing caused by bile duct hyperplasia can be prevented, and a bile duct is kept smooth. The biodegradable magnesium alloy carved support can be degraded and vanished within certain time, is not required to be taken out again, is good in biocompatibility, and almost causes no inflammation during working in vivo. The mitomycin or / and paclitaxel released by the polymer coating layer containing medicine can prevent bile duct benign and malignant hyperplasia stricture, and bile duct obstruction aggravated by stricture generated again by hyperplasia after the support is implanted is prevented.

The invention discloses an annular elastic ring for a medical loop ligation device. The preparation method comprises the following steps: weighing, by mass, 100 parts of medical silicone rubber, 1 to 10 parts of glycerin, 20 to 80 parts of white carbon black and a coupling agent weighing 0 to 2% of the mass of the white carbon black; uniformly mixing the above-mentioned materials on an open mill and putting the obtained mixture in a baking oven for heat treatment; and remilling silicone rubber having undergone heat treatment, adding 0.5 to 5 parts of a cross-linking agent, carrying out uniform mixing, and then successively carrying out hot press molding in a flat vulcanizer and secondary sulfuration in an air blast drying box so as to obtain the annular elastic ring for the medical loop ligation device. The annular elastic ring for the medical loop ligation device overcomes the defect of poor mechanical strength of silicone rubber and provides a nontoxic and harmless annular elastic ring for loop ligation treatment of hemorrhoids. Meanwhile, the annular elastic ring guarantees firm loop ligation, short loop ligation time, a fast tissue shedding speed and no occurrence of infection and inflammations. The preparation method is simple in molding, has low cost and is suitable for large-scale promotion and application.

The invention relates to a vaccine carrier based on aluminum hydroxide nanoparticles. A PEG derivate material and an aluminum salt are compounded into nanoparticles. The vaccine carrier not only remains the property of powerful Th2 humoral immunologic adjuvant of the aluminum salt but also can be effectively in vivo transferred to drainage lymph gland and can be easily absorbed by dendritic cells (DC), can perform effective cross presentation, can induce cellular immunologic response and has strong Th1 immune response.

The invention relates to a biological composite artificial bone and its preparation process. The artificial bone is prepared by poly lactic acid, hydroxyapatite(or calcium phosphate) and OPG protein with weight ratio of 180-250 : 100-160 : 0.6-1. The invention mixes poly lactic acid, hydroxyapatite(or calcium phosphate) and OPG protein only once by emulsion cross blend method without changing their chemical structure. The adopted ethyl acetate and absolute ethyl alcohol have no harm to the human body, and the hydroxyapatite(or calcium phosphate) bone conduction function and the osteoclast genesis and activation of the OPG protein are kept. It can also initiate osteoclast apoptosis. The compound product is a biological compound artificial bone for treating bone defection and osteoporosis in clinical practice.

The invention discloses a preparation method of water-soluble carboxymethyl chitosan, belonging to the technical field of carboxymethyl chitosan preparation. The present invention takes dried poria cocos and heats it in a deionized water bath, filters the filtrate to obtain the rotary evaporation, then adds chloroacetic acid for ultrasonic oscillation and rotary evaporation to prepare modified crystals for later use, then takes chitosan and isopropanol shaking table for oscillation treatment, and mixes with alkali The solution is mixed in a water bath and heated, mixed with the spare modified crystal in a water bath, acid is added for neutralization, and the supernatant is obtained by centrifugation, and the water-soluble carboxymethyl chitosan obtained is obtained through rotary evaporation, washing and drying. The beneficial effects of the present invention are: the preparation steps of the present invention are simple, the bulk density of the obtained product is as high as 0.46-0.56g / mL, the fluidity is good, the degree of substitution is high, and the water-solubility is good; Water-soluble carboxymethyl chitosan is obtained, which effectively solves the problem of product antibacterial activity and moisture retention performance reduction.

The invention provides a degradable biomedical magnesium alloy drug eluting intravascular stent and a preparation method thereof. Wherein the magnesium alloy is prepared from the following components in percentage by weight: 3.0 to 6.0 percent of Gd, 2.5 to 5.5 percent of Y, 1.0 to 3.0 percent of Li, 0.3 to 1.0 percent of Zn, 0.2 to 1.0 percent of Zr and the balance of Mg on the basis that the total weight of the magnesium alloy is 100 percent. The stent has good radial supporting strength and strain dispersion capacity through finite element design. After the protective coating designed by the invention is used, the corrosion resistance of the magnesium alloy stent is greatly improved. The arsenic trioxide or rapamycin and tacrolimus composite drug sustained-release system is used, and is fully adapted to the damage repair process of blood vessels. The implantation result of a large animal shows that the intravascular stent system has a good anti-restenosis treatment effect.

The invention discloses a preparation method of a biologically absorbable polyphosphate and amino acid copolymer material. The preparation method comprises the following steps: 1) dehydrating alpha-amino acid and caprolactam under the protection of inert gas at 150 DEG C to 200 DEG C; 2) reacting at 190 DEG C to 260 DEG C and finishing polymerization reaction to form a polymer with a multi-component amino acid amide structure; 3) adding phosphate and reacting at 200 DEG C to 260 DEG C for 0.5h to 2h and finishing ring-opening copolymerization reaction; cooling to room temperature under the protection of the inert gas to obtain a product. A polyphosphate and amino acid copolymer prepared by the method has good hydrophilcity and degrading performance, and good mechanical properties; the pH (Potential of Hydrogen) of a degraded product is 6.5 to 7.5 and stimulation reaction is not caused; the polyphosphate and amino acid copolymer has good effect when being used for in-vivo repairing and has good clinical application prospect.

Provided is a novel sheet for covering a wound, which exhibits high liquid absorption and strength. A sheet for covering a wound according to the present invention is a wound covering material that contains carboxymethylated natural or regenerated cellulose fibers, and is characterized in that: the average degree of substitution of hydroxyl groups in a glucose unit that constitutes the cellulose is from 0.3 to 1.0 (inclusive); and from 5% to 80% (inclusive) of carboxymethyl groups are protonated.

The invention relates to an anchoring element for a dental prosthetic arrangement, which can be anchored in a jaw bone or implant in a first part-region (TB1) and is suitable for receiving or forming a dental prosthetic element (ZK) in a second part-region (TB2), wherein the anchoring element has a radially projecting collar (KR) between the first part-region (TB1) and the second part-region (TB2), which collar at least partially encloses the circumference of the anchoring element, such that the region above the collar (KR) of the anchoring element is at least in part fully covered a thermoplastic material. The invention further relates to a method for producing an abutment or implant and to a method for producing a dental prosthetic arrangement using the abutment.

The present invention relates to a new wrinkle free injection and the preparation method, which belongs to the tissue engineering field. The injection preparation comprises 105 to 108 newborn umbilical cord dermis fibroblast and the fiber anterior somatic or the mesenchymal cells, 1ml to 8ml limousine with concentration of 0.3 percent, the glucose injection with concentration of 5 percent. The preparation method comprises in vitro cultivation, purification and amplification of the newborn umbilical cord dermis fibroblast and the fiber anterior somatic or the mesenchymal cells. Then the cells are preserved in liquid nitrogen. The cells are massively proliferated during application. According to 105 to 108 newborn umbilical cord dermis fibroblast and the fiber anterior somatic or the mesenchymal cells, 1ml to 8ml limousine with concentration of 0.3 percent and the glucose injection with concentration of 5 percent are added. The present invention has the advantages of no damage to the body with material of newborn umbilical, high survival rate in cell, strong proliferation activity, short amplification time, no side effect, and no pain during injection, wrinkle free effect which is fast, profound, long and natural.

The invention relates to a universal desktop support for laptops and tablet computers, which belongs to computer accessories. One end of a laptop supporting plate is movably connected with a door-shaped frame, the other end of the laptop supporting plate is connected with one end of each of a left T-shaped supporting plate, a right T-shaped supporting plate, a left supporting rod and a right supporting rod through a damping shaft, a screw which can be used for adjusting the length of each supporting rod is embedded in a non-connecting end of each supporting rod, limit clamps are inserted onto the T-shaped supporting plates, a through groove is arranged in the middle of the laptop supporting plate, and a long screw is arranged in the middle of the through groove and provided with a laptop limit clamp. According to the sitting height of a user, the rise range of the laptop supporting plate can be adjusted, so that the center of a laptop screen can be flush with eyes of the user, the user can use the laptop when keeping upright sitting posture, and health potential threats to the neck and the waist of the user caused by the fact that the laptop screen is too low are thoroughly eliminated. Further, the user can easily input information with an external keyboard when wrists are relaxed by the aid of a palm supporting plate.

The invention belongs to the field of massage components, and particularly relates to a should and neck massage device. The should and neck massage device comprises a neck massage component and a shoulder massage component; the neck massage component comprises an arc heart-shaped neck pillow and a first massage machine, the neck pillow is used for coating and wearing the whole set of the first massage machine; the shoulder massage component comprises two shoulder pillows symmetrically arranged at the lower parts of the left side and the right side of the neck pillow and a second massage component; the shoulder pillow comprises an upper curved surface and a lower curved surface, a neck pillow clamping slot is internally sunken in the upper curved surface, the lower surface of the neck pillow is clamped in the neck pillow clamping slot in a dismounting manner; the lower curved surface comprises a first peak and a second peak, the first peak and the second peak are parallel, a shoulder installation part is formed between the first peak and the second peak, the shoulder pillow is worn on the shoulder of a wearer through the shoulder installation part, the opposite surfaces of the firstpeak and the second peak are elastic breathable surfaces; and the should and neck massage device acts on the rear cervical vertebra, the muscle groups around the rear cervical vertebra, the double shoulders and the muscle groups of the double shoulders at the same time, and can massage the rear cervical vertebra and the double shoulders in a targeted way.

The invention, belonging to the field of biomedicine and physical polymer material, particularly relates to a drug eluting stone-dissolving bile duct stent and a preparation method thereof. The stent is prepared by coating a biodegradable polymer layer containing stone-dissolving drug sodium cholate or / and edetate disodium on the inner surface and outer surface of the uncoated stent, wherein the ratio of sodium cholate to edetate disodium is 0-1mol:0-1mol. Clinical outcomes show that the stone-dissolving bile duct stent of the invention has good radial supporting performance, can keep the bile duct open, has good biocompatibility, and lets almost no internal inflammation generate. Simultaneously, sodium cholate or / and edetate disodium slowly released by the polymer layer containing drugs can dissolve the formed stones and can prevent the re-formation of stones.

The invention discloses a fermented turmeric gel and lavender flower water compound essence and a preparation method thereof, the essence is composed of the following components by mass: 1-20% of a compound product, 0-7% of an emulsifier, 0-10% of an emollient, 0-3% of a thickener, 3-10% of a humectant, 0-3% of a skin conditioner, and 50-90% of water, the compound product is obtained by mixing fermented turmeric gel and lavender flower water according to the ratio of 2: (1-6) and then carrying out ultrasonic treatment, wherein the fermented turmeric gel is obtained by fermenting turmeric powder with lactic acid bacteria and carrying out ethanol extraction, vacuum concentration and freeze drying; the preparation method comprises the following steps: mixing water, a humectant and a thickener in proportion, heating, homogenizing and uniformly stirring; adding a skin conditioner during primary cooling, uniformly stirring, adding the compound product during secondary cooling, and uniformly stirring to obtain the aqueous essence. Effective components in the fermented turmeric gel and the lavender flower water synergistically resist bacteria and oxidation, and have the advantages of fast and long-acting acne removal and inhibition and the like.

The present invention provides a novel wound dressing sheet having high liquid absorbency and strength. The wound dressing sheet of the present invention is characterized in that it is a wound dressing material containing carboxymethylated natural or regenerated cellulose fibers, and the average substitution degree of hydroxyl groups in glucose units constituting the cellulose is 0.3 or more and 1.0 or less. , and not less than 5% and not more than 80% of the carboxymethyl groups are protonated.

The invention discloses a preparation method of a biologically absorbable polyphosphate and amino acid copolymer material. The preparation method comprises the following steps: 1) dehydrating alpha-amino acid and caprolactam under the protection of inert gas at 150 DEG C to 200 DEG C; 2) reacting at 190 DEG C to 260 DEG C and finishing polymerization reaction to form a polymer with a multi-component amino acid amide structure; 3) adding phosphate and reacting at 200 DEG C to 260 DEG C for 0.5h to 2h and finishing ring-opening copolymerization reaction; cooling to room temperature under the protection of the inert gas to obtain a product. A polyphosphate and amino acid copolymer prepared by the method has good hydrophilcity and degrading performance, and good mechanical properties; the pH (Potential of Hydrogen) of a degraded product is 6.5 to 7.5 and stimulation reaction is not caused; the polyphosphate and amino acid copolymer has good effect when being used for in-vivo repairing and has good clinical application prospect.