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Application of biologically absorbable polyphosphate and amino acid copolymer material

A polyphosphate and amino acid technology, applied in the field of biomedical degradable materials, can solve problems such as application limitations, uncontrollable degradation rate, and excessive mechanical strength attenuation, so as to improve hydrophilicity and degradation performance, large plasticity and application Value, effect of improving physical and mechanical properties

Inactive Publication Date: 2017-06-13
SICHUAN GUONA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there are also many bottlenecks and problems, such as poor hydrophilicity and low biological activity; there is an uncontrollable degradation rate in vivo, which belongs to bulk degradation, leading to material collapse, especially when applied to bone-setting materials, the mechanical strength decays too quickly; acidity Degradation products or materials themselves stimulate the body and cause local non-specific inflammatory reactions, etc.
[0006] Nowadays, bioabsorbable polymer materials are getting more and more attention. However, with the gradual diversification of medical technology and the pursuit of higher quality medical models, the traditional bioabsorbable polymer types and material properties can no longer meet the actual needs, especially in compatible Sexuality, acidic degradation products and other issues, resulting in limitations in medical applications

Method used

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  • Application of biologically absorbable polyphosphate and amino acid copolymer material
  • Application of biologically absorbable polyphosphate and amino acid copolymer material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042]Take 55.17g (0.4875mol), 31.94g (0.2438mol), and 25.14g (0.2437mol) of caprolactam, 6-aminocaproic acid, and γ-aminobutyric acid, respectively, and put them into a 250ml three-necked bottle, add 70ml of distilled water, and pass nitrogen gas protection , stirring and gradually raising the temperature to 150°C to 200°C for slow dehydration. After the dehydration is completed, the prepolymerization reaction is 0.5 hours, and the temperature is raised to 210°C for 1.5 hours of polymerization reaction. Add 7.15g (0.025mol) of cyclic phosphate after calcium chloride dehydration, The temperature was raised to 220°C for ring-opening reaction for 1 h, and then cooled to room temperature under nitrogen protection to obtain 101.4 g of a light yellow solid. The obtained polyphosphate amino acid copolymer is broken into 1-3mm particles. The polyphosphate content in the copolymer was 2.5%.

[0043] The polyphosphate amino acid copolymer was subjected to an in vitro simulated body fl...

Embodiment 2-4

[0045] Take respectively 56.01g, 53.75g, 50.92g, 53.75g, 50.92g of caprolactam, 6-aminocaproic acid, and γ-aminobutyric acid.

[0046] Add 32.42g, 31.11g, 29.48g, 25.52g, 24.49g, 23.20g into a 250ml three-neck flask, add 70ml of distilled water, protect with nitrogen, stir and gradually raise the temperature to 150℃~200℃ for slow dehydration, pre-polymerization after dehydration is completed React for 0.5 hours, heat up to 210°C and polymerize for 1.5 hours, add 2.86g, 14.3g and 28.6g of cyclic phosphate esters after dehydration with calcium chloride, heat up to 220°C for ring-opening reaction for 1h, then cool to room temperature under nitrogen protection , to obtain copolymers with different contents of polyphosphate, the contents of which are 1%, 5% and 10% respectively. The obtained polyphosphate amino acid copolymer is broken into 1-3mm particles.

[0047] The polyphosphate amino acid copolymer was subjected to an in vitro simulated body fluid immersion test, a clear wat...

Embodiment 5

[0049] Take 55.17g, 30.04g, 23.11g, 3g and 5g of caprolactam, 6-aminocaproic acid, γ-aminobutyric acid, lysine and proline, respectively, and put them into a 250ml three-necked bottle, add 70ml of distilled water, and pass nitrogen gas protection , Stir and gradually raise the temperature to 150°C to 200°C for slow dehydration. After the dehydration is completed, the prepolymerization reaction is 0.5 hours, and the temperature is raised to 210°C for 1.5 hours of polymerization reaction. Add 7.15g of cyclic phosphate after calcium chloride dehydration, and heat up to 220°C After ring-opening reaction for 1 h, it was cooled to room temperature under the protection of nitrogen to obtain 103.17 g of light yellow solid. The obtained polyphosphate amino acid copolymer is broken into 1-3mm particles. The polyphosphate content in the copolymer was 2.5%.

[0050] The polyphosphate amino acid copolymer was subjected to an in vitro simulated body fluid immersion test, a clear water test...

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Abstract

The invention discloses application of a biologically absorbable polyphosphate and amino acid copolymer to preparation of a repairing material. The polyphosphate and amino acid copolymer is prepared from caprolactam, alpha-amino acid and phosphate, wherein the caprolactam and the alpha-amino acid are firstly polymerized to form a polymer with a multi-component amino acid amide structure; the polymer with the multi-component amino acid amide structure and the phosphate form the polyphosphate and amino acid copolymer. The invention further discloses a blend formed by the polyphosphate and amino acid copolymer and other materials. The polyphosphate and amino acid copolymer is used as the repairing material and has good hydrophilcity and degrading performance, and good mechanical properties; the pH (Potential of Hydrogen) of a degraded product is 6.5 to 7.5 and stimulation reaction is not caused; the polyphosphate and amino acid copolymer has good effect when being used for in-vivo repairing, and can also form the blend with other materials; the polyphosphate and amino acid copolymer has good clinical application prospect.

Description

technical field [0001] The invention relates to the application of a bioabsorbable polyphosphate amino acid copolymer material, which belongs to the field of biomedical degradable materials. Background technique [0002] Bioabsorbable materials have been used in medical, environmental protection and other fields for a long time. Especially in the field of medicine and health, biodegradable medical materials have been vigorously developed. Absorbable materials generally referred to, that is, biodegradable materials, are a kind of artificially synthesized polymer organic matter, or natural polymer materials, which undergo hydrolysis and oxidation reactions in the body, and the final product is CO 2 and H 2 O is excreted through the respiratory system or urinary system, does not accumulate in the body, has almost no toxic effects, and does not need to be removed by surgery again. At the same time, its decomposition and absorption cycle varies depending on the molecular struct...

Claims

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Application Information

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IPC IPC(8): A61L27/58A61L27/18A61L27/54A61L27/56A61L31/14A61L31/06A61L31/16A61L17/10A61L17/00
CPCA61L27/58A61L17/005A61L17/10A61L27/18A61L27/54A61L27/56A61L31/06A61L31/148A61L31/16A61L2430/02C08L77/02
Inventor 王鹏刘朋真吕国玉李鸿陈立井淋静
Owner SICHUAN GUONA TECH
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