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Biologically composite artificial bone and its preparing process

A kind of artificial bone and biological technology, applied in the direction of medical science, prosthesis, etc., can solve the problems of loss and inability to fully exert effective effects, etc., achieve the effect of bone repair, reduce immune rejection, and increase half-life

Inactive Publication Date: 2005-01-19
上海盈康医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

OPG protein alone is easy to lose with body fluids and cannot fully exert its effective effect, so it needs to be compounded with a carrier to exert its effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Example 1: Application of OPG fusion protein in biocomposite artificial bone

[0046] The biocomposite artificial bone of this example was prepared from a 210:100:1 polylactic acid: hydroxyapatite: OPG fusion protein.

[0047] Its preparation process is as follows: First, hydroxyapatite and OPG fusion protein are pulverized into powder respectively, passed through a standard sieve, and particle powder with a particle size less than 250 μm is taken, and mixed according to the ratio of hydroxyapatite:OPG fusion protein=100:1 Mix well, add an appropriate amount of distilled water and stir to make a suspension; then weigh D, L-type polylactic acid according to the ratio of polylactic acid: hydroxyapatite: OPG fusion protein = 210: 100: 1, and add ethyl acetate to dissolve, ethyl acetate The amount of ester is based on the ability to completely dissolve D, L-type polylactic acid; secondly, add ethyl acetate containing D, L-type polylactic acid to the suspension of hydroxyapati...

Embodiment 2

[0052] Example 2: Application of OPG fusion protein in biocomposite artificial bone

[0053] The biocomposite artificial bone of this example was prepared by the method described in Example 1, but polylactic acid: hydroxyapatite: OPG fusion protein = 250:160:1.

Embodiment 3

[0054] Example 3: Application of OPG fusion protein in biocomposite artificial bone

[0055] The biocomposite artificial bone of this example was prepared by the method described in Example 1, but polylactic acid: hydroxyapatite: OPG fusion protein = 180:120:1.

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PUM

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Abstract

The invention relates to a biological composite artificial bone and its preparation process. The artificial bone is prepared by poly lactic acid, hydroxyapatite(or calcium phosphate) and OPG protein with weight ratio of 180-250 : 100-160 : 0.6-1. The invention mixes poly lactic acid, hydroxyapatite(or calcium phosphate) and OPG protein only once by emulsion cross blend method without changing their chemical structure. The adopted ethyl acetate and absolute ethyl alcohol have no harm to the human body, and the hydroxyapatite(or calcium phosphate) bone conduction function and the osteoclast genesis and activation of the OPG protein are kept. It can also initiate osteoclast apoptosis. The compound product is a biological compound artificial bone for treating bone defection and osteoporosis in clinical practice.

Description

technical field [0001] The invention relates to a biocomposite artificial bone and a preparation process thereof. Specifically, the present invention relates to the preparation of biocomposite artificial bone using OPG protein, polylactic acid and hydroxyapatite by using an emulsion blending method. technical background [0002] As we all know, bone defect and bone trauma are very common clinical diseases, how to repair bone defect and promote the rapid healing of bone defect is an urgent problem to be solved. At present, the commonly used repair materials include autologous bone, allogeneic bone, and synthetic substitutes, all of which have certain deficiencies to varying degrees. For example, autologous bone transplantation, although it has no immune rejection, the cells and bioactive molecules in the transplanted bone can continue to survive at the recipient site and perform corresponding functions to promote the healing of bone defects, which...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/22
Inventor 倪健蒋建平杨武剑罗鹏
Owner 上海盈康医药科技有限公司
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