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Sheet for covering wound

A covering material and wound technology, applied in the field of wound covering sheets of natural or regenerated cellulose fibers, can solve the problems that cannot be used for wound healing, increased strength, poor liquid absorption, etc., and achieve the effect of promoting wound healing

Active Publication Date: 2018-08-31
ASAHI KASEI KK
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The strength of CMC-H is increased, but there is a problem that the liquid absorption is at the same level as that of ordinary cellulose nonwoven fabrics
On the other hand, in the following Patent Document 3, partially protonated CMC is used as an anti-adhesion material, but it has poor liquid absorption and cannot be used for wound healing.

Method used

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  • Sheet for covering wound
  • Sheet for covering wound

Examples

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Comparison scheme
Effect test

Embodiment

[0072] Hereinafter, the present invention will be specifically described with reference to examples, but the present invention is not limited to these examples.

reference example 1

[0074] The regenerated cellulose continuous long-fiber sheet-like structure (copper ammonia fiber sheet-like structure) (width 20cm, basis weight 80g / m) 2 , thickness 0.5mm, density 0.154g / m 3 ), lyocell staple fiber non-woven fabric, or rayon staple fiber non-woven fabric 100g is put into the reaction vessel, then, after adding the ethanol aqueous solution containing sodium hydroxide (water: 875g, ethanol 875g, NaOH: 162.5g) , and stirred at 35°C for 30 minutes. Next, after draining the reagents in the reaction vessel, an aqueous ethanol solution containing sodium monochloroacetate (300 g of water, 960 g of ethanol, and 122.5 g of sodium monochloroacetate) was added, and the mixture was stirred at 30°C or 50°C for 1 to 12 hours. Then, it was dried to obtain a carboxymethylated sheet-like structure. The sheet-like structure obtained above was adjusted to pH 6.0 to 8.0 with an acetic acid-containing ethanol aqueous solution (acetic acid: 37.5 g, distilled water: 375 g, ethano...

reference example 2

[0079] Sections (2 cm×1 cm) were cut out from the CMC sheet-like structure (degree of substitution: 0.55) before protonation obtained by the method of Reference Example 1, and 10 pieces were put into 50 mL plastic tubes. 30 mL of an aqueous methanol solution containing hydrochloric acid (1.2 mol / L hydrochloric acid, 90% methanol) was added to each tube, and incubated at room temperature for 10 minutes, 30 minutes, and 1 hour.

[0080] After incubation, it was washed with 80% methanol aqueous solution and 100% methanol in this order, and then dried to obtain a protonated sheet-like structure. The data of the protonation degree are shown in Table 2 below together with the protonation conditions.

[0081] [Table 2]

[0082]

[0083] It was found that at the concentration of hydrochloric acid in Reference Example 2, almost 100% of the substituents were protonated.

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Abstract

Provided is a novel sheet for covering a wound, which exhibits high liquid absorption and strength. A sheet for covering a wound according to the present invention is a wound covering material that contains carboxymethylated natural or regenerated cellulose fibers, and is characterized in that: the average degree of substitution of hydroxyl groups in a glucose unit that constitutes the cellulose is from 0.3 to 1.0 (inclusive); and from 5% to 80% (inclusive) of carboxymethyl groups are protonated.

Description

technical field [0001] The present invention relates to a wound-covering sheet containing natural or regenerated cellulose fibers containing partially protonated carboxymethyl cellulose (hereinafter abbreviated as CMC). More specifically, the present invention relates to a wound-covering sheet containing natural or regenerated cellulose fibers containing CMC, which can maintain high liquid absorption and maintain morphological stability even after liquid absorption. Background technique [0002] When a wound occurs on human skin or the like, a wound site protective material such as a surgical dressing that protects the wound site and a wound covering material is used. [0003] On the other hand, the following Patent Document 1 describes soluble wound-healing hemostatic cellulose fibers having a substitution degree of CMC of 0.5 to less than 1.0, and also describes that CMC has a cell adhesion promoting effect. In addition, the following Patent Document 2 also describes that...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61F13/00C08B11/12
CPCA61L15/28C08B11/12A61F13/01012C08L1/26C08L5/14A61F13/01042
Inventor 原雄一
Owner ASAHI KASEI KK
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