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Preparation method for water-soluble carboxymethyl chitosan

A carboxymethyl chitosan, water-soluble technology, applied in the field of preparation of water-soluble carboxymethyl chitosan, can solve the problems of antibacterial activity and moisture retention performance, poor water solubility, low degree of substitution, etc., and achieve fluidity Good, high degree of substitution, good water solubility

Inactive Publication Date: 2016-09-28
董晓
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The technical problem to be solved by the present invention: aiming at the current low bulk density of carboxymethyl chitosan, poor fluidity, low degree of substitution, poor water solubility, resulting in reduced product antibacterial activity and moisturizing performance, a kind of dry poria cocos and poria cocos is provided Deionized water is heated in a water bath, and the filtered filtrate is rotary evaporated, and chloroacetic acid is added for ultrasonic oscillation and rotary evaporation to prepare modified crystals for later use, then chitosan and isopropanol are shaken for treatment, mixed with alkali solution, heated in a water bath, and The spare modified crystals are mixed in a water bath, after being neutralized by adding acid, centrifuged to obtain a supernatant, and the water-soluble carboxymethyl chitosan obtained by rotary evaporation, washing and drying

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0015] First select the dried Poria cocos, crush it and dry it at 65°C for 6 hours, then mix the dried Poria cocos powder with deionized water at a mass ratio of 1:5, heat in a water bath at 65°C for 2 hours, and wait until the water bath heating is completed , let stand to cool to room temperature and filter, collect the filtrate and place it at 70°C for rotary evaporation to 1 / 8 of the original volume to prepare a water-soluble polysaccharide gel; then mix chloroacetic acid with the above-mentioned prepared The water-soluble polysaccharide gel solution was stirred and mixed, then ultrasonically oscillated at 200W for 10 minutes, and then evaporated to dryness at 75°C, and the dried crystals were collected to prepare modified crystals for later use; The polysaccharide and isopropanol were stirred and mixed, and placed in a shaking table at 250r / min for 6h to prepare a chitosan swelling solution, and then the chitosan swelling solution was mixed with 1mol / L sodium hydroxide at ...

example 2

[0018] First select the dried Poria cocos, crush it and dry it at 72°C for 7 hours, then mix the dry Poria cocos powder with deionized water at a mass ratio of 1:5, heat in a water bath at 72°C for 3 hours, and wait until the water bath heating is completed , let it stand to cool to room temperature and filter, collect the filtrate and place it at 75°C for rotary evaporation to 1 / 8 of the original volume to prepare a water-soluble polysaccharide gel; then mix chloroacetic acid with the above-mentioned prepared The water-soluble polysaccharide gel solution was stirred and mixed, then ultrasonically oscillated at 250W for 13 minutes, and then evaporated to dryness at 78°C, and the dried crystals were collected to prepare modified crystals for later use; The polysaccharide and isopropanol were stirred and mixed, and placed in a 275r / min shaker for 7 hours to prepare a chitosan swelling solution, and then the chitosan swelling solution was mixed with 1mol / L sodium hydroxide at a ma...

example 3

[0021]First select the dried Poria cocos, crush it and dry it at 80°C for 8 hours, then mix the dried Poria cocos powder with deionized water at a mass ratio of 1:5, heat in a water bath at 80°C for 3 hours, and wait until the water bath heating is completed , let stand to cool to room temperature and filter, collect the filtrate and place it at 80°C for rotary evaporation to 1 / 8 of the original volume to prepare a water-soluble polysaccharide gel; then mix chloroacetic acid with the above-mentioned prepared The water-soluble polysaccharide gel solution was stirred and mixed, then ultrasonically oscillated at 300W for 15 minutes, and then evaporated to dryness at 80°C, and the dried crystals were collected to prepare modified crystals for later use; The polysaccharide and isopropanol were stirred and mixed, and placed in a 300r / min shaker for 8 hours to prepare a chitosan swelling solution, and then the chitosan swelling solution was mixed with 1mol / L sodium hydroxide at a mass...

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Abstract

The invention discloses a preparation method of water-soluble carboxymethyl chitosan, belonging to the technical field of carboxymethyl chitosan preparation. The present invention takes dried poria cocos and heats it in a deionized water bath, filters the filtrate to obtain the rotary evaporation, then adds chloroacetic acid for ultrasonic oscillation and rotary evaporation to prepare modified crystals for later use, then takes chitosan and isopropanol shaking table for oscillation treatment, and mixes with alkali The solution is mixed in a water bath and heated, mixed with the spare modified crystal in a water bath, acid is added for neutralization, and the supernatant is obtained by centrifugation, and the water-soluble carboxymethyl chitosan obtained is obtained through rotary evaporation, washing and drying. The beneficial effects of the present invention are: the preparation steps of the present invention are simple, the bulk density of the obtained product is as high as 0.46-0.56g / mL, the fluidity is good, the degree of substitution is high, and the water-solubility is good; Water-soluble carboxymethyl chitosan is obtained, which effectively solves the problem of product antibacterial activity and moisture retention performance reduction.

Description

technical field [0001] The invention relates to a preparation method of water-soluble carboxymethyl chitosan, belonging to the technical field of carboxymethyl chitosan preparation. Background technique [0002] Carboxymethyl chitosan is a chemical compound that has appeared in recent years, and it is of great significance in medicine, chemical industry, environmental protection, and health care products. And its stable properties and pharmacological effects such as antibacterial and anti-infection, lipid-lowering and prevention and treatment of arteriosclerosis are destined to play a greater role in the daily life of human beings in the future. Carboxymethyl chitosan is a water-soluble chitosan derivative with many properties, such as strong antibacterial, fresh-keeping effect, and an amphoteric polyelectrolyte. It has many applications in cosmetics, fresh-keeping, medicine, etc. It is also one of the chitosan derivatives that have been studied more in recent years. The a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/08
CPCC08B37/003
Inventor 董晓盛海丰高玉刚
Owner 董晓
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