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Biodegradable magnesium alloy bile duct stone-dissolving carving stent and preparation method thereof

A technology of magnesium alloy and degrading polymer, applied in biopolymer materials and magnesium alloy materials, biomedical field, can solve problems such as inability to carry out long-term continuous treatment, avoid adverse effects, good biocompatibility, prevent bile duct closed effect

Inactive Publication Date: 2012-10-17
SHANGHAI FIRST PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, the above-mentioned drugs can only be administered through local perfusion, and can only be used in surgical operations or postoperative drainage tubes, and cannot be used for long-term continuous treatment.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The biodegradable magnesium alloy fused stone engraved scaffold was prepared by the following steps:

[0028] (1) Using magnesium-aluminum alloy with a magnesium mass content of 99.9% as a raw material, it is processed into a hollow tube with an inner diameter of 6.4mm, an outer diameter of 8.8mm, and a length of 100mm; the hollow tube is engraved into a porous network by laser Structural tubular support;

[0029] (2) Dissolve polycaprolactone in acetone at a ratio of 20mg: 1ml to make a solution, and uniformly disperse sodium cholate and disodium edetate with a mass ratio of 1mol: 1mol in the polycaprolactone The solution is sprayed and placed on the surface of the engraved tubular stent prepared in the above step (1) to make a biodegradable magnesium alloy bile duct litholytic engraved stent.

Embodiment 2

[0031] Preparation of biodegradable magnesium alloy fused stone engraved scaffold:

[0032] (1) Using a magnesium-zinc alloy with a magnesium mass content of 99.0% as a raw material, it is processed into a hollow tube with an inner diameter of 7.5mm, an outer diameter of 9.5mm, and a length of 90mm; the hollow tube is engraved into a porous network by laser Structural tubular support;

[0033] (2) Dissolve polylactic acid in methylene chloride at a ratio of 30mg: 1ml to make a solution, and uniformly disperse sodium cholate and disodium edetate with a mass ratio of 1mol: 2mol in the polylactic acid solution , placed on the surface of the engraved tubular stent prepared in the above step (1) through soaking treatment, to make a biodegradable magnesium alloy bile duct litholytic engraved stent.

Embodiment 3

[0035] Using a magnesium-zirconium alloy with a magnesium mass content of 99.5% as a raw material, it is processed into a hollow tube with an inner diameter of 7mm, an outer diameter of 9mm, and a length of 80mm; the hollow tube is engraved into a tubular bracket with a spiral tubular structure by using a laser; and then According to the ratio of 40mg: 1ml, polyglycolic acid is dissolved in chloroform to make a solution, and sodium cholate and disodium edetate with a mass ratio of 2mol: 1mol are uniformly dispersed in the polyglycolic acid The solution is sprayed and placed on the surface of the engraved tubular stent prepared above to make a biodegradable magnesium alloy bile duct litholytic engraved stent.

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Abstract

The invention, belonging to the field of biomedicine, bio-polymer material and magnesium alloy material, relates to a biodegradable magnesium alloy bile duct stone-dissolving carving stent and a preparation method thereof. The stent is prepared by processing magnesium or magnesium alloy into hollow tubes, carving the hollow tubes under the action of laser to a tubular stent with a porous reticular or spiral tubular structure, and then coating a biodegradable polymer layer containing sodium cholate or / and edetate disodium on the inner surface and outer surface of the tubular stent. Clinical outcomes show that the stone-dissolving bile duct stent of the invention has good radial supporting performance, can keep the bile duct open, can be degraded away in a certain time with no need of removing the stent, has good biocompatibility, and lets almost no internal inflammation generate. Simultaneously, sodium cholate or / and edetate disodium slowly released by the polymer layer containing drugs can dissolve the formed stones and can prevent the re-formation of stones.

Description

technical field [0001] The invention belongs to the fields of biomedicine, biopolymer materials and magnesium alloy materials, and in particular relates to a biodegradable magnesium alloy bile duct litholytic carving bracket and a preparation method thereof. Background technique [0002] According to clinical medical statistics, bile duct stones have a very high incidence rate. The traditional treatment method mainly adopts surgery, but the trauma is large, the complications are many, and the recurrence rate is high; Other diseases and cannot tolerate surgical treatment. In recent years, with the development of endoscopic technology, endoscopic pancreaticobiliary interventional stone removal technology (ERCP technology) has gradually become the main treatment method for bile duct stones, and has achieved good therapeutic effects. However, for some patients with difficult to remove bile duct stones (such as multiple, huge, hard or special bile duct stones), or patients who c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/16A61L31/10A61L31/02A61F2/88A61F2/90
Inventor 宛新建袁广银张伟星
Owner SHANGHAI FIRST PEOPLES HOSPITAL
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