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Preparation method of biologically absorbable polyphosphate and amino acid copolymer material

A polyphosphate and amino acid technology, which is applied in the field of biomedical degradable materials, can solve the problems of application limitations, uncontrollable degradation rate, and rapid mechanical strength decay, and achieves improved hydrophilicity and degradation performance, high plasticity and application. value, the effect of improving physical and mechanical properties

Active Publication Date: 2017-06-13
SICHUAN GUONA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there are also many bottlenecks and problems, such as poor hydrophilicity and low biological activity; there is an uncontrollable degradation rate in vivo, which belongs to bulk degradation, leading to material collapse, especially when applied to bone-setting materials, the mechanical strength decays too quickly; acidity Degradation products or materials themselves stimulate the body and cause local non-specific inflammatory reactions, etc.
[0006] Nowadays, bioabsorbable polymer materials are getting more and more attention. However, with the gradual diversification of medical technology and the pursuit of higher quality medical models, the traditional bioabsorbable polymer types and material properties can no longer meet the actual needs, especially in compatible Sexuality, acidic degradation products and other issues, resulting in limitations in medical applications

Method used

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  • Preparation method of biologically absorbable polyphosphate and amino acid copolymer material
  • Preparation method of biologically absorbable polyphosphate and amino acid copolymer material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Take 55.17g (0.4875mol), 31.94g (0.2438mol), and 25.14g (0.2437mol) of caprolactam, 6-aminocaproic acid, and γ-aminobutyric acid, respectively, and put them into a 250ml three-necked bottle, add 70ml of distilled water, and pass nitrogen gas protection , stirring and gradually raising the temperature to 150°C to 200°C for slow dehydration. After the dehydration is completed, the prepolymerization reaction is 0.5 hours, and the temperature is raised to 210°C for 1.5 hours of polymerization reaction. Add 7.15g (0.025mol) of cyclic phosphate after calcium chloride dehydration, The temperature was raised to 220°C for ring-opening reaction for 1 h, and then cooled to room temperature under nitrogen protection to obtain 101.4 g of a light yellow solid. The obtained polyphosphate amino acid copolymer is broken into 1-3mm particles. The polyphosphate content in the copolymer was 2.5%.

[0044] The polyphosphate amino acid copolymer was subjected to an in vitro simulated body f...

Embodiment 2-4

[0046] Take respectively 56.01g, 53.75g, 50.92g, 32.42g, 31.11g, 29.48g, 25.52g, 24.49g, 23.20g of caprolactam, 6-aminocaproic acid, and γ-aminobutyric acid into a 250ml three-necked bottle, add 70ml of distilled water, protected by nitrogen gas, stirred and gradually raised to 150°C to 200°C for slow dehydration, pre-polymerized for 0.5 hours after dehydration, heated to 210°C for 1.5 hours of polymerization, added calcium chloride dehydrated cyclic phosphate 2.86g, 14.3g and 28.6g were heated to 220°C for 1 hour of ring-opening reaction and then cooled to room temperature under nitrogen protection to obtain copolymers with different contents of polyphosphate, the contents of which were 1%, 5% and 10% respectively. The obtained polyphosphate amino acid copolymer is broken into 1-3mm particles.

[0047] The polyphosphate amino acid copolymer was subjected to an in vitro simulated body fluid immersion test, a clear water test and an experiment of culturing L929 fibroblasts with...

Embodiment 5

[0049] Take 55.17g, 30.04g, 23.11g, 3g and 5g of caprolactam, 6-aminocaproic acid, γ-aminobutyric acid, lysine and proline, respectively, and put them into a 250ml three-necked bottle, add 70ml of distilled water, and pass nitrogen gas protection , Stir and gradually raise the temperature to 150°C to 200°C for slow dehydration. After the dehydration is completed, the prepolymerization reaction is 0.5 hours, and the temperature is raised to 210°C for 1.5 hours of polymerization reaction. Add 7.15g of cyclic phosphate after calcium chloride dehydration, and heat up to 220°C After ring-opening reaction for 1 h, it was cooled to room temperature under the protection of nitrogen to obtain 103.17 g of light yellow solid. The obtained polyphosphate amino acid copolymer is broken into 1-3mm particles. The polyphosphate content in the copolymer was 2.5%.

[0050] The polyphosphate amino acid copolymer was subjected to an in vitro simulated body fluid immersion test, a clear water test...

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Abstract

The invention discloses a preparation method of a biologically absorbable polyphosphate and amino acid copolymer material. The preparation method comprises the following steps: 1) dehydrating alpha-amino acid and caprolactam under the protection of inert gas at 150 DEG C to 200 DEG C; 2) reacting at 190 DEG C to 260 DEG C and finishing polymerization reaction to form a polymer with a multi-component amino acid amide structure; 3) adding phosphate and reacting at 200 DEG C to 260 DEG C for 0.5h to 2h and finishing ring-opening copolymerization reaction; cooling to room temperature under the protection of the inert gas to obtain a product. A polyphosphate and amino acid copolymer prepared by the method has good hydrophilcity and degrading performance, and good mechanical properties; the pH (Potential of Hydrogen) of a degraded product is 6.5 to 7.5 and stimulation reaction is not caused; the polyphosphate and amino acid copolymer has good effect when being used for in-vivo repairing and has good clinical application prospect.

Description

technical field [0001] The invention relates to a preparation method of a bioabsorbable polyphosphate amino acid copolymer material, belonging to the field of biomedical degradable materials. Background technique [0002] Bioabsorbable materials have been used in medical, environmental protection and other fields for a long time. Especially in the field of medicine and health, biodegradable medical materials have been vigorously developed. Absorbable materials generally referred to, that is, biodegradable materials, are a kind of artificially synthesized polymer organic matter, or natural polymer materials, which undergo hydrolysis and oxidation reactions in the body, and the final product is CO 2 and H 2 O is excreted through the respiratory system or urinary system, does not accumulate in the body, has almost no toxic effects, and does not need to be removed by surgery again. At the same time, its decomposition and absorption cycle varies depending on the molecular struc...

Claims

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Application Information

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IPC IPC(8): C08G79/04C08G69/16C08G69/10A61L31/14A61L31/06
CPCA61L31/06A61L31/14A61L31/148C08G69/10C08G69/16C08G79/04C08G2230/00
Inventor 王鹏刘朋真吕国玉李鸿陈立井淋静
Owner SICHUAN GUONA TECH
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