The invention discloses a preparing method of a craniocerebral operation preoperative intervention drug, comprising the steps of (1) cleaning and purifying fimbristylis dichotoma, grand torreya flower, Abutilon peniculatum Hand. Mazz, mentha spicata, Akebia trifoliate, Laportea sinensis C.H.Wright, stem or leaf of fortune euonymus, Memecylon ligustrifolium Champ. ex Benth and wood or root of pedunculate acronychia in a prescription amount, airing, smashing, distilling with vapor to extract essential oil, collecting and mixing, and uniformly mixing the dregs after extraction; (2) uniformly mixing the dregs of after extraction in the step (1) with herb of knottedflower phyla, Soroseris erysimoides and simon plum root and leaf, adding water, decocting twice, mixing decocting liquid, and standing; then adding alcohol, standing, filtering, centrifuging filtrate, concentrating centrifuged liquid, drying, and smashing to dry paste powder; (3) mixing uniformly the essential oil in the step (1) with the dry paste powder in the step (2), drying, smashing and sieving. The drug is reasonable in prescription, clear in treatment effect, and capable of effectively preventing acute heart failure caused by a craniocerebral operation on a patient with cardiac insufficiency.