338results about How to "Allergenicity reduction" patented technology

The invention provides a fish protein powder which is water soluble with the color between light-yellow and pale-brown meal, wherein, the dry basis protein content of the fish protein powder is more than 80%; and a preparation method is provided for the fish protein powder. The method comprises the following steps: (1) preparing mincedfish seriflux; (2) preparing enzymatic hydrolyzate by the mincedfish seriflux; (3) preparing the fish protein powder by the enzymatic hydrolyzate. The fish protein powder prepared in the invention has the advantages of health, easy digestion, easy absorption, and the like; and can be widely used on protein-enhanced foods; the production process is simple, the production efficiency is high, and the raw materials have wide sources and can be obtained easily, thereby helping save cost.

The invention discloses a method for producing the raw materials of a seasoning product of sea crab; the method comprises the following steps: wastes of the sea crab are smashed; the sea crab is used for processing and cooking the concentrated solution of soup ingredient (namely, sea crab juice), heating is carried out to inactivate the enzyme, the process of mixed acid is used for carrying out deordorization, and filtering is carried out so as to remove the residue, etc. As the invention uses the hydrolyzation of papain to lead the protein in the waste of the sea crab to be decomposed furthest and the allergen to be removed, the fresh substances are released completely, while flavourzyme is adopted to carry out debittering process and inhibit the reproduction of microorganism in the process of enzymolysis; besides, as the invention uses weak acid process of citric acid and malic acid to carry out deodorization to the hydrolyzate or further uses low-temperature concentration and spray drying, the original nutrient ingredients and unique flavor of the product materials are maintained to the utmost degree and the property of the allergen is reduced.

The invention discloses a swelling-type hollow silk fibroin micro-needle drug delivery system and a preparation method thereof. According to the technical scheme of the preparation method, a swelling modified silk fibroin solution is casted in a PDMS mold to be vacuumized, dried and molded as a hollow needle-type housing. After that, a silk fibroin micro-needle array provided with cavities in the hollow needle-type housing is filled with powder-like or solution-like drugs, vacuumizing and drying are carried out to form a drug part. Finally, a layer of modified silk fibroin solution is cast, dried and molded as a cladded coating. The cladded coating is removed to obtain the swelling-type hollow silk fibroin micro-needle drug delivery system. The drugs are wrapped inside the cavities of the silk fibroin micro-needle arrays, so that the system is high in drug loading ratio and low in skin allergenicity and stimulation. The system facilitates the sustained release and the controlled release of micro-needle drugs. Meanwhile, according to the preparation method, since the swelling modified silk fibroin solution is cast, dried and molded in a mild processing condition, the system is low in processing cost and suitable for large-scale production. Drugs are directly wrapped in the cavities of the swelling hollow micro-needles, so that controlled-release drugs are swelled in the micro-needle base material. In this way, the biological activities of the controlled-release drugs are maintained, while the structure of the hollow silk fibroin micro-needle drug delivery system is greatly simplified. The system is better in practicality.

The invention provides a light fasting full nutrition formula brewing instant bar and a preparation method thereof. The formula can brew various components of instant nutrient nutrients according to the suggested configuration of the 'Chinese Dietary Guidelines', foods are diverse, and no preservatives, no sweeteners and no artificial pigments are added; the bar is prepared from, by weight, oil, aquatic eggs, dairy products, soybeans, nuts, cereal potatoes, dietary fibers, fruits and vegetables, nutritional strengthening components and the like, is convenient to eat, and is especially suitablefor meeting the full nutritional needs of a body during light fasting and fat reduction.

The invention discloses a formula for supplementing nutrients of bone and improving functions of bone and a preparation method. The formula comprises the following components in percentage by mass: 30to 70% of bone collagen protein peptide powder, 1 to 10% of L-aspartic acid calcium, 1 to 10% of hydrolyzed II-type collagen, 1 to 10% of casein phosphopeptide powder, 1 to 10% of milk minerals, and0.0002 to 0.005% of vitamin D. The formula has the advantages that according to the cause of bone diseases, several kinds of pure animals and plants are used as the raw materials and are reasonably compounded and scientifically proportioned, so that while the content of calcium in a human body is supplemented, the bone collagen protein is supplemented, and the full absorbing of calcium is accelerated; after the formula is taken for a long time, the demand and intake amount of calcium by the human body can be adjusted, and the formula is especially suitable for patients with osteoporosis or arthritis; any side or toxic effect is avoided, the auxiliary treatment effect is realized on treatment of various bone diseases, the nutrients of the bone can be supplemented, the functions of the bonecan be improved, and the functions of enhancing the immunity of the human body, resisting the aging and resisting the fatigue are realized.

The present invention relates to the field of fermentation media. More specifically, the invention provides a method for preparing a composition useful for culturing microbial cells wherein whole and/or autolysed yeast cells are enzymatically treated to obtain the composition. The microbial cultures obtained have increased stability and are useful in the manufacturing of food, feed and as a pharmaceutical product.

The invention discloses a hydrating and skin rejuvenating mask and a preparation method thereof, and belongs to the technical field of masks. The hydrating and skin rejuvenating mask comprises the following raw materials in percentage by weight: 3 to 10 percent of glycerinum, 1.5 to 4.5 percent of butanediol, 1 to 4 percent of deep-sea fish collagen peptide, 3 to 8 percent of mycose, 0.05 to 2 percent of squalane, 0.15 to 2 percent of sodium hyaluronate, 1 to 5 percent of propylene glycol, 0.02 to 0.35 percent of xanthan gum, 0.02 to 0.45 percent of hydrogenated castor oil, 0.02 to 2 percent of polysorbate, 0.01 to 1 percent of phenoxyethanol, 0.01 to 0.5 percent of methylparaben, 0.1 to 2 percent of beta-glucan, 0.01 to 0.5 percent of a grape seed extract, 0.01 to 3 percent of an aloe extract, 0.01 to 1 percent of dipotassium glycyrrhizinate and the balance of deionized water. The mask provided by the invention promotes the absorption of water by the skin, is favorable for the skin topreserve moisture for a long time, is non-irritant and has a good effect of moisturizing skin.

The invention provides a gelatin composition. The gelatin composition comprises hydroxylated gelatin, microbial glutamine transaminase and protein glutaminase, wherein the hydroxylated gelatin is 20-60%proline-hydroxylated gelatin. The gelatin composition has an extremely-good bleeding stopping effect at a temperature in a range of 4-10DEG C. The invention also discloses a preparation method of the gelatin composition and an application of the gelatin composition.

The present invention discloses one kind of ewe milk beverage with lactic acid bacteria, and belongs to the field of beverage producing technology. Sour ewe milk as the main material is produced into the ewe milk beverage with lactic acid bacteria through mixing with water, sugar or sweetening agent, fruit juice, stabilizer and other components; filtering; sterilizing; homogenizing and other steps. The ewe milk beverage with lactic acid bacteria is healthful, and the production process is simple and suitable for industrial application.

The invention relates to a liquid milk preparation method based on reduction of milk sensitization. The preparation method comprises the following steps: (1) degreasing; (2) preheating; (3) enzymolysis: after the preheating, taking skimmed milk, sequentially adding three protease solutions into the skimmed milk in a dropwise adding manner, and carrying out enzymolysis, wherein the enzymolysis timeis 60-120 min, the temperature is 50-60 DEG C, and the pH value is adjusted in different time periods so as to obtain an enzymatic hydrolysate; and (4) enzyme deactivation. Small peptides with a molecular weight of less than 5000 Daltons in the hypoallergenic liquid milk account for about 99%. The liquid milk preparation method for reducing the milk sensitization is used for reducing the sensitization of a plurality of allergen proteins in the cow milk, and the allergen proteins in the cow milk comprise one or more of casein, alpha s1-casein, alpha s2-casein, beta-casein, k-casein, alpha-lactalbumin, beta-lactoglobulin, immunoglobulin and lactoferrin.

The invention relates to respiratory syncytial virus-like particles, and establishes a novel method of preparing respiratory syncytial virus-like particles for animal immunization. The preparation method comprises the following steps: according to codon bias of mammalian cells, carrying out codon optimization for M, F and G genes which are respectively cloned to a shuttle vector to obtain recombinant adenovirus plasmids, and transfecting to obtain the recombinant adenovirus FGAd-Msyn, FGAd-Fsyn and FGAd-Gsyn; infecting the recombinant adenovirus by use of Vero cells to obtain the virus-like particles; purifying the virus-like particles by adopting a sucrose density gradient centrifugation method; applying the particles to animal immunization. According to the invention, the virus-like particles are prepared by adopting the adenovirus vector, and a novel virus-like particle preparation method is established. The protein expression quantity is improved and the yield of the virus-like particles is improved through codon optimization, so that a better immune effect is obtained, and the respiratory syncytial virus-like particles are relatively safe.

There is described an oil-in-water emulsion free of surfactant agents comprising: A) At least a cross-polymer acrylate/alkyl-acrylate or derivatives thereof, or mixtures thereof in the aqueous phase of the emulsion; b) At least a polyacrylate or derivatives thereof, or mixtures thereof in the oily phase of the emulsion, and c) At least a neutralizing agent. Further, the present invention refers to a process of obtaining a surfactant-free emulsion and its use in cosmetics and pharmaceuticals compositions. The emulsion in question can be applied to all kinds of skin, being also indicated for people with sensitive skin.

The invention discloses a processing method of dried crab meat floss with low allergy, and relates to the field of crab meat processing method. The processing method comprises the following steps: washing crabs to remove sand, mud, and dirt on the surface of crabs, removing crab shell, crab gill, and umbilical part of crab, washing the crab bodies, picking out crab meat; soaking the obtained crab meat in a flavoring liquid, then cooking the flavoring liquid, heating the flavoring liquid by slow fire to keep the flavoring liquid in a boiling state until the flavoring liquid is completely evaporated; baking the crab meat until the water content reaches 50%, tearing the crab meat into filaments, putting the crab filaments into a frying pan containing plant oil, frying the crab meat by slow fire until the crab meat become loose and uniform; baking the obtained crab meat in a preheated baking oven to dry the crab meat floss; sterilizing the dried crab meat floss, packing dried crab meat floss into bags, and finishing to obtain finished products. Polyphenol oxidase and caffeic acid are used to soak crab meat for a short time; at the same time, processing technologies such as boiling, baking, and the like are adopted so as to maximally preserve the unique flavor and nutrients of crab meat; moreover, the allergen of crab meat carries out enzymatic crosslinking reactions, and thus the sensitization is reduced. The processing method has the characteristics of simple operation, low cost, and suitability for massive production.

The present invention provides a remineralizing material for use on a demineralized enamel surface and a preparation method thereof; the remineralizing material is prepared through the following steps: using carboxymethyl chitosan of certain concentration to stabilize hydrogen phosphate ions in supersaturated ionic solution with hydrogen phosphate and calcium ions in supersaturated calcium-containing ionic liquid, so as to form nano amorphous calcium phosphate particles, and adding sodium hypochlorite solution of certain concentration and glycine into sodium hypochlorite solution of certain concentration to obtain the remineralizing material. The demineralized enamel oriented ordered mineralizing material described herein has reasonable structural design, is simple to prepare and can transform quickly into crystal and specifically binds and firmly binds with the demineralized enamel surface; arranging newly-formed hydroxyapatite in a certain direction in order; the material is nontoxic and nonirritating, has good biocompatibility and low allergicity and has ideal result.