Curcumin microcapsule and preparation method thereof

A technology of curcumin and microcapsules, which is applied in the field of medicine, can solve the problems of low oral absorption rate of curcumin and difficulty in absorbing curcumin by the body

Inactive Publication Date: 2020-05-15
菏泽大树生物工程科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention provides a kind of curcumin microcapsule and preparation method thereof in order to overcome the low defect of existing curcumin oral absorption rate, the present invention utilizes gamma-cyclodextrin and lecithin to improve the hydrophilicity and lipophilicity of curcumin, And it is made into nano-scale microcapsules, which overcomes the problem that curcumin is difficult to be absorbed by the body

Method used

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Examples

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Effect test

preparation example Construction

[0038] The present invention also provides the preparation method of the curcumin microcapsule described in above-mentioned technical scheme, comprises the following steps:

[0039] (1) mixing the water-soluble components in the core material raw materials with water to obtain a water phase; mixing the fat-soluble components in the core material raw materials with the water phase to obtain a mixture;

[0040] (2) Carry out emulsification to mixture successively, homogenize, obtain homogeneous mixture;

[0041] (3) spray-drying the homogeneous mixture to obtain the core material powder;

[0042] (4) Mix the core material powder and the raw materials of the capsule material, stir in vacuum at 40-80° C. until the air bubbles completely disappear, and cool to obtain curcumin microcapsules.

[0043] In the present invention, the water-soluble component in the core material raw material is mixed with water to obtain a water phase; the fat-soluble component in the core material raw ...

Embodiment 1

[0054] In terms of percentage by weight, the raw materials of the core material are: curcumin 8%, γ-cyclodextrin 3%, lecithin 3%, natural borneol 0.3%, linseed oil 20%, walnut oil 10%, glutamine 0.3% , protein 5%, malt syrup 49.2%, compound emulsifier 1.2%. Wherein, the composite emulsifier is monoglyceride, sodium stearoyl lactylate, lecithin, glyceryl tartrate, lauryl alcohol, monoglyceride lactate, and sucrose fatty glyceride in a mass ratio of 32:18:3:8:15:24.

[0055] The preparation steps of curcumin microcapsules are as follows

[0056] ① Weigh curcumin, γ-cyclodextrin, lecithin, natural borneol, glutamine, protein and maltose syrup, stir evenly to obtain the water phase;

[0057] ② Add linseed oil, walnut oil and compound emulsifier to step ①, stir for 5 minutes, and emulsify with stirring;

[0058] ③ Step ② After the emulsification is completed, perform homogenization operation; the pressure is 15-35MPa;

[0059] ④Spray dry the homogeneous mixture; upper air intake...

Embodiment 2

[0063] In terms of percentage by weight, the raw materials of the core material are: curcumin 8%, γ-cyclodextrin 3%, lecithin 3%, natural borneol 0.6%, linseed oil 25%, walnut oil 15%, glutamine 0.3% , 5% protein, 38.25% malt syrup, 1.2% compound emulsifier, 0.15% vitamin E and 0.5% piperine. Wherein, the composite emulsifier is monoglyceride, sodium stearoyl lactylate, lecithin, glyceryl tartrate, lauryl alcohol, monoglyceride lactate, and sucrose fatty glyceride in a mass ratio of 32:18:3:8:15:24.

[0064] The preparation steps of curcumin microcapsules are as follows

[0065] ① Weigh curcumin, γ-cyclodextrin, lecithin, natural borneol, glutamine, vitamin E, piperine, protein and maltose syrup, stir evenly to obtain the water phase;

[0066] ② Add linseed oil, walnut oil and compound emulsifier to step ①, stir for 5 minutes, and emulsify with stirring;

[0067] ③ Step ② After the emulsification is completed, perform homogenization operation; the pressure is 15-35MPa;

[0...

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Abstract

The invention provides a curcumin microcapsule and a preparation method thereof, belonging to the technical field of medicine. The curcumin microcapsule comprises the following raw materials: a capsule material and a core material. The core material comprises, in parts by weight, 3 to 8 parts of curcumin, 1 to 3 parts of gamma-cyclodextrin, 1 to 3 parts of lecithin, 0.2 to 0.5 part of natural borneol, 1 to 5 parts of protein, 0.5 to 5 parts of casein, 1 to 6 parts of sodium caseinate, 0.2 to 0.5 part of glutamine, 10 to 30 parts of linseed oil, 10 to 30 parts of walnut oil, 0.01 to 0.03 part of vitamin E, 0.3 to 0.8 part of piperine and 0.2 to 0.8 part of an emulsifier. The curcumin microcapsule provided by the invention can significantly improve the solubility of curcumin, promote intestinal absorption of curcumin and delay the metabolism speed of curcumin, and also can provide nutrition for patients with tumors.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a curcumin microcapsule and a preparation method thereof. Background technique [0002] In medicine, cancer refers to malignant tumors originating from epithelial tissue, and is the most common type of malignant tumors. Correspondingly, malignant tumors originating in mesenchymal tissue are collectively referred to as sarcomas. There are a few malignant tumors not named according to the above principles, such as Wilms tumor, malignant teratoma, etc. Generally speaking, "cancer" generally refers to all malignant tumors. Cancer has biological characteristics such as abnormal cell differentiation and proliferation, out-of-control growth, invasion, and metastasis. Infection, occupational exposure, environmental pollution, unreasonable diet, and genetic factors are closely related. [0003] With the prolongation of the average life expectancy of human beings, the threat of cancer...

Claims

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Application Information

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IPC IPC(8): A61K9/51A61K47/40A61K47/24A61K47/42A61K47/44A61K31/12A61P35/00
CPCA61K9/5123A61K9/5161A61K9/5169A61K31/12A61P35/00
Inventor 文毅薛冰刘艳飞张瑞红王静武守韬刘艳伟
Owner 菏泽大树生物工程科技有限公司
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