33results about How to "Control the dissolution rate" patented technology

The invention relates to a bone implanting and internal fixation appliance with bioactivity and absorbability, which belongs to the field of bio-medical appliances, particularly to the field of medical appliances used for bone wound surgery, reparative and reconstructive surgery and plastic and cosmetic surgery. The appliance includes bone nails and a bone plate made of magnesium and the alloy thereof with bioactivity and absorbability. The bone implanting and internal fixation appliance is a bone internal fixation device, which comprises a blade plate and matched screws, intramedullary nails, a fracture and dislocation fixing device of vertebral column, bone nails or screws having individual fixation effect, wherein the bone internal fixation device is made of magnesium and the alloy thereof with bioactivity and absorbability. The bone internal fixation device can solve the problem in bioactivity of prior bone internal fixation device and promote healing the tissue where the device in implanted. The device also includes a protection layer prepared on the surface of the internal fixation device for controlling the degradation rate of magnesium alloy and the dissolution rate of magnesium ions, thus controlling the bioactivity and the absorption speed of the magnesium alloy device in an organism.

A scaffold of the granular anticancer medicine for treating the benign or malignant stenosis of esophagus and digestive tract is disclosed, which has 4 structures consisting of scaffold, granular anticancer medicine, selective coated film on the surface of scaffold, and selective external protective layer.

The invention relates to a nonionic hydrophobic association and polymerization water soluble polymer prepared by opposite phase microemulsion and a preparation method thereof, and the polymer is copolymerized by a cation monomer having surface activity and a nonionic monomer. The microemulsion system fat phase is formed by mixing vash oil and spans surface active agent with tweens surface active agent; aqueous phase is the aqueous solution of the cation monomer having surface activity and the nonionic monomer. The micro-rubber latex of the polymer is characterized by very low viscosity which is closes to that of the fat phase, and has obvious tyndall effect; the micro-rubber latex of the polymer can quickly disperse in water, and can be directly used, so as to overcome the defects that the traditional hydrophobic association water soluble polymer has slow dissolution rate and poor solubility property. Therefore, the invention relates to the preparation method of the novel nonionic hydrophobic association polymer prepared by opposite phase microemulsion, and the polymer has the advantages of good water-solubility, viscosity increasing property, salt tackification, and the like, thus the method can be applied to the industries such as petroleum extraction, etc.

The slow release bromide biocide for disinfection of industrial water and public places consists of bromochloro dimethyl hydantoin as main component 50-80 wt%, other halogenated hydantoin as supplementary material 15-35 wt% and active adhesive 5-15 wt%, and is prepared into tablet or granule with controlled dissolving rate and thus delayed release function. It has the germicidal advantage of bromide biocide maintained and prolonged biocidal effect. Its slow release function is realized through both stepped reaction to release active components slowly and properly selected adhesive to control dissolving rate.

A hydrophobic, associated and water-soluble composite cationic polymer for recovering petroleum, treating sewage and preparing water-soluble paint is prepared from a great cationic monomer with surface activity, a small cationic monomer and a non-ionic monomer through copolymerizing. Its advantages are high water solubility and high viscosity increasing function.

The invention relates to a composite material of hydrogenated nitrile rubber and polyurethane rubber and a preparation method thereof, and belongs to the technical field of rubber. The composite material of the hydrogenated nitrile rubber and the polyurethane rubber comprises the polyurethane rubber, the hydrogenated nitrile rubber, carbon black, a plasticizer, stearic acid, an antiager, an accelerant, a vulcanizing agent and polyglycolic acid. The soluble rubber composite material can directly lose mechanical properties in water or a well fluid and is eventually dissolved or degraded, so thatthe production efficiency is improved and the working cost is reduced; and the dissolution speed is controlled by adjusting the contents of the hydrogenated nitrile rubber and the polyurethane rubber.

The invention discloses a metoprolol controlled release mixed matrix tablet, belonging to the pharmaceutical field, comprising the following components: 4-60% of metoprolol or metoprolol salt, 0.05-10% of lauryl sodium sulphate, 15-60% of high viscosity hydrophilic polymer and 2-60% of non-disintegration matrix material; the non-disintegration matrix material forms a matrix system with equal gaps; the mixture of the metoprolol or metoprolol salt and the high viscosity hydrophilic polymer is filled in the matrix system. The metoprolol matrix tablet can slowly release for 24 hours and can be taken one time per day; the blood concentration is in the range of the therapeutic window of the metoprolol, which is suitable for the request of the treatment. Simultaneously, the invention provides a method for preparing the metoprolol controlled release mixed matrix tablet; the other auxiliary materials and pharmaceutical preparations are mixed with the insoluble non-disintegration matrix material; the insoluble non-disintegration matrix material can form rigid matrix and effectively control the release speed of the drugs.

The invention specifically relates to a sustained-release oral preparation of brivaracetam, and a preparation method thereof, belonging to the technical field of medicinal preparations containing organic effective components. The sustained-release oral preparation of brivaracetam is composed of brivaracetam, a filler, a disintegrating agent, a lubricant, a flow aid and a binder, wherein special treatment is carried out brivaracetam so as to allow brivaracetam to have an ultrafine particle size, 85% of the treated brivaracetam has a particle size of 30 [mu]m or below, 99% of the treated brivaracetam has a particle size of 50 [mu]m or below, and distribution is narrow, so the dissolvability, stability, dissolving-out and dissolving-out speed of the preparation are greatly improved. The sustained-release oral preparation of brivaracetam can be effectively and rapidly released without any cosolvent, so the bioavailability of brivaracetam is substantially improved; and the preparation method is suitable for large-scale production.

The invention discloses a micro-nano bubble oxygenation irrigation system with precise feedback control, which comprises a nutrient filling unit, a micro-nano bubble generation device and a dissolvedoxygen concentration detection feedback unit, the micro-nano bubble oxygenation irrigation system is characterized in that the right side of the micro-nano bubble generation device is in fixed connection with a venturi feeding device, the upper end of the venturi feeding device is spirally mounted with a first pressure gauge, and the right side of the venturi feeding device in fixed connection with a left-handed gas filling device and a right-handed gas filling device. By mounting the nutrient filling unit, the micro-nano bubble generation device and the dissolved oxygen concentration detection feedback unit, the requirement of oxygenation concentration and oxygen source ratio according to the types of crops and various growth periods can be realized, and oxygenation concentration and thetype of gas sources can be set.

The invention relates to a sustained-dissolved type chemical fertilizer which comprises the following raw materials in parts by weight: 50-60 parts of organic chemical fertilizer, 5-15 parts of alkenyl succinic anhydride starch ester, 10-15 parts of phosphate esterified starch, 5-10 parts of cross-linking starch and 0.1-0.5 part of nucleating agent. Esterified starch of different substitution degrees can be selected according to plant nutrient requiring periods, the dissolution speed can be effectively controlled, and a stable controlled-release function is achieved.

The invention discloses an electropolishing treatment method for stainless steel and belongs to the technical field of stainless steel processing. The electropolishing treatment method for the stainless steel specifically comprises the following steps of (1) conducting cleaning and oil removing, (2) preparing electrolyte, (3) conducting electrolytic treatment and (4) conducting cleaning and drying treatment. The electropolishing treatment method for the stainless steel can effectively improve the polishing quality of the stainless steel, improves the ratio of high-grade products, effectively lowers the production temperature, improves economic benefits and has quite good popularization value.

The invention relates to a coated mineral feed additive and a preparation method thereof. The feed additive includes the following raw materials: lconite, potassium bicarbonate, HPMCP, maltose syrup and starch. The preparation method includes the following steps: (1) weighing the lconite and the starch, mixing the weighed lconite and starch with water to make a paste-like mixture, and putting thepaste-like mixture into an oscillating granulator to make wet granules; (2) soaking the wet granules described in step (1) in the maltose syrup for 2-3 minutes; (3) weighing the potassium bicarbonateand the starch in set dosages, mixing the weighed potassium bicarbonate and starch with water to make a paste-like mixture; (4) putting the wet granules soaked in the maltose syrup obtained in step (2) into the paste-like mixture described in step (3), and putting the mixture into the oscillating granulator to make wet granules; (5) weighing the HPMCP, dissolving the weighed HPMCP with water to obtain coating solution; (6) atomizing the coating solution to be sprayed on the surface of loose granules, carrying out wetting, spreading, coalescence, adhesion and drying until continuous coating-films are formed on the surfaces of the granules, with the weight of the coating-films accounting for 5-10% of the total weight of the tablets; and (7) carrying out mesh-screening and separate-packing, thereby obtaining the finished products.

The invention discloses mixed acid pre-cleaning liquid for thinning a high-generation panel. The mixed acid pre-cleaning liquid is prepared from the components in percentage by weight: 50 to 80 percent of sulfuric acid, 5 to 18 percent of phosphoric acid, 0.01 to 2 percent of hydrochloric acid and / or soluble chloride salt, 1 to 7 percent of nitric acid and the balance of water, wherein the soluble chloride salt is at least one selected from sodium chloride, potassium chloride and ammonium chloride. The mixed acid pre-cleaning liquid for thinning the high-generation panel, disclosed by the invention, is prepared by adopting and mixing the sulfuric acid, the phosphoric acid, the hydrochloric acid and / or soluble chloride salt, the nitric acid and the water; since the sulfuric acid has certain dissolving capacity on some inorganic and organic compounds, dust, fingerprints and the like on the surface of a glass substrate can be effectively removed; by regulating the concentrations of the sulfuric acid, the phosphoric acid, the nitric acid and the hydrochloric acid and / or soluble chloride salt, the dissolving speed of the sulfuric acid on curing glue can be controlled.

The invention discloses a method for synthesizing lithium nickel cobalt manganese oxide by using an active substance separated from a waste lithium power battery as a raw material. The method includesthe following steps: (1) disassembling a power lithium battery to obtain a positive electrode; and immersing the positive electrode in a solvent, filtering, centrifuging the filtrate to obtain a solid precipitate, and drying and crushing the solid precipitate to obtain an active substance; (2) dissolving the active substance into an inorganic weak acid, adding hydrogen peroxide, centrifuging, adding a salt containing nickel ions, a salt containing cobalt ions and a salt containing manganese ions to a supernatant, adjusting the concentration of nickel ions, cobalt ions and manganese ions in the supernatant, and then adding a complexing agent and a precipitating agent, performing centrifugal separation, and drying to obtain a lithium nickel cobalt manganese oxide precursor; and (3) mixing the lithium nickel cobalt manganese oxide precursor with a lithium ion-containing compound, calcining, cooling, crushing, and sieving. According to the scheme of the invention, the rapid and complete separation of a current collector and the active material in the waste power lithium battery can be achieved, and the integrity of the current collector structure can be better maintained.

The invention discloses a method for preparing a high-purity aluminum oxide precursor Al(OH)3, and belongs to the technical field of preparation of high-purity aluminum oxide. The preparation method comprises the following steps: selecting high-purity aluminum as an anode plate, conducting treatment under the action of electric auxiliary conversion and an external field, meanwhile filtering anode impurities by using a porous membrane, so as to obtain an Al(OH)3 product, and filtering, washing and drying the Al(OH)3 product in sequence to obtain a high-purity aluminum oxide precursor. The porous membrane can prevent anode impurities from polluting an electrolysis product Al(OH)3, an external field not only promotes Al<3+> to penetrate through the porous membrane and improves the electrolysis rate and efficiency, but also can control the opportunity that Al(OH)3 falls off from a cathode, prevent the Al(OH)3 from growing, ensure the uniformity of the size and realize the control on the particle size of generated Al(OH)3 particles, and the purity of the product Al(OH)3 is high. Anode mud generated in the production process can be used for preparing a primary aluminum by-product, and the cathode generates a hydrogen by-product, so that the economical efficiency of the technology can be improved.

The invention discloses glycosylated hemoglobin detection test paper and a method for detecting glycosylated hemoglobin by the glycosylated hemoglobin detection test paper. The glycosylated hemoglobindetection test paper comprises a bottom plate, a chromatographic film, a water absorption pad, a partition plate and a cover plate, the chromatography film and the water absorption pad are respectively fixed on the left side and the right side of the top surface of the bottom plate; an optical detection area is arranged on the top surface of the chromatography film; aminophenylboronic acid agarose combined with glycosylated hemoglobin is arranged on the optical detection area; the partition plate is fixed on the top surface of the chromatographic membrane; a hollow part corresponding to the optical detection area is arranged at one end of the partition plate; the inner wall of the hollow part is provided with a high polymer film for sealing and covering the optical detection area, the high polymer film can be dissolved by eluent, the top surface of the partition plate is further provided with a reaction area and an electrode group, and the method for detecting glycosylated hemoglobinby adopting the glycosylated hemoglobin detection test paper comprises the following steps: a) electrochemical detection; b) polymer film dissolution and c) photochemical detection, so that the detection accuracy is high, and the polymer film dissolution speed is controllable.

A composition containing flupirtine or a pharmaceutically acceptable salt thereof and a preparation method thereof. The invention discloses a flupirtine slow-release preparation with strong stability, sustainable release and simple process. Adopting the combination of immediate-release and sustained-release design, the sustained-release preparation contains immediate-release part, sustained-release part, disintegrant, magnesium stearate and micropowder silica gel, and the immediate-release part does not need to be granulated, and the raw material drug can be Tablets are directly compressed with sustained-release granules, and the sustained-release part is prepared by wet granulation, adding special sustained-release framework materials, and directly mixed with other pharmaceutical excipients to avoid drug release caused by uneven coating in dry granulation Problems, the sustained release of the drug is ensured, while the process is simplified and the production cost is reduced.

The invention discloses a method for preparing a high-purity magnesium aluminate spinel precursor, and belongs to the technical field of high-purity magnesium aluminate spinel preparation. The preparation method comprises the following steps: selecting a high-purity aluminum-magnesium alloy as an anode plate, carrying out electric auxiliary conversion and external field action, filtering anode impurities by using a porous membrane to obtain a magnesium-aluminum hydroxide precipitate, and sequentially conducting filtering, washing and drying on the magnesium-aluminum hydroxide precipitate to obtain a high-purity magnesium-aluminum spinel precursor. The porous membrane can prevent anode impurities from polluting an electrolytic product magnesium-aluminum hydroxide, an external field not only promotes Al<3+> and Mg<2+> to penetrate through the porous membrane and improves the electrolysis rate and efficiency, but also can control the opportunity that the magnesium-aluminum hydroxide falls off from a cathode, prevent the magnesium-aluminum hydroxide from growing and ensure the size uniformity, and control over the particle size of generated magnesium-aluminum spinel precursor powder is achieved. Anode mud generated in the production process can be used for preparing an aluminum-magnesium alloy byproduct, a hydrogen byproduct is generated by a cathode, and the economical efficiency of the technology can be improved.

The invention discloses a temperature-resistant and salt-resistant fracturing fluid thickening agent and a preparation method thereof, and relates to a polymer thickening agent in the fracturing process in the field of exploration and development of oil and gas fields. The preparation method comprises the following steps: sulfonating alpha-olefin amine to obtain sulfonic acid alkylamine, reacting with benzaldehyde to obtain benzamide alkyl sulfonic acid, reacting with acryloyl chloride to obtain a temperature-resistant and salt-resistant functional monomer N-benzyl-N-acrylamido-alkyl sulfonic acid (AMBPS), and reacting with acrylamide to obtain the temperature-resistant and salt-resistant functional monomer AMBPS. Mixing and dissolving AMBPS, acrylamide, a chelating agent, a cosolvent, a polymer stabilizer, an initiator and the like, introducing nitrogen, and irradiating the solution under an ultraviolet lamp to prepare the temperature-resistant and salt-resistant fracturing fluid thickening agent. The prepared thickening agent is simple in process and rapid in reaction, and the obtained product is high in molecular weight, high in dissolving speed and high in temperature resistance and salt resistance and has a good application effect in the field of fracturing fluid thickening.

The invention discloses a metoprolol controlled release mixed matrix tablet, belonging to the pharmaceutical field, comprising the following components: 4-60% of metoprolol or metoprolol salt, 0.05-10% of lauryl sodium sulphate, 15-60% of high viscosity hydrophilic polymer and 2-60% of non-disintegration matrix material; the non-disintegration matrix material forms a matrix system with equal gaps; the mixture of the metoprolol or metoprolol salt and the high viscosity hydrophilic polymer is filled in the matrix system. The metoprolol matrix tablet can slowly release for 24 hours and can be taken one time per day; the blood concentration is in the range of the therapeutic window of the metoprolol, which is suitable for the request of the treatment. Simultaneously, the invention provides a method for preparing the metoprolol controlled release mixed matrix tablet; the other auxiliary materials and pharmaceutical preparations are mixed with the insoluble non-disintegration matrix material; the insoluble non-disintegration matrix material can form rigid matrix and effectively control the release speed of the drugs.

The invention provides a controllable full-degradable bridge plug. The controllable full-degradable bridge plug comprises a bridge plug body and a setting sleeve arranged on the bridge plug body, a sealing rubber sleeve, an upper slip and a lower slip are arranged on the setting sleeve, the sealing rubber sleeve is located between the upper slip and the lower slip, the setting sleeve is used for extruding the sealing rubber sleeve before setting, so that the upper slip and the lower slip are fixed to the inner wall of an oil well sleeve, a reaction dissolving cavity is formed in the bridge plug body, chemical substances are arranged in the reaction dissolving cavity, an overflowing hole is formed in the bridge plug body, one end of the overflowing hole communicates with the reaction dissolving cavity, the other end of the overflowing hole is located between two sealing rings arranged on the bridge plug body before setting, and the other end of the overflowing hole communicates with a drainage groove formed in the inner end of the setting sleeve after setting, so that liquid in a shaft enters the reaction dissolving cavity through the drainage groove and the overflowing hole to react with the chemical substances, and heat is generated. The controllable full-degradable bridge plug solves the problems that an existing bridge plug is influenced by the shaft formation temperature and the fracturing flow-back fluid property when being dissolved and the adaptability is limited.

The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition containing digestive enzymes and a preparation method thereof. The composition containing digestive enzymes provided by the present invention is composed of compositions A, B, and C, containing ursodeoxycholic acid and 7 kinds of enzymes, which are pepsin 20-30g, papain 40-60g, amylase 10-20g , 10-20g of cellulose, 40-60g of pancreatic enzymes, which can help digestion of carbohydrates, fats, proteins, and cellulose, and promote intestinal gas excretion and bile secretion. And promote the secretion of pancreatic juice, so as to promote food digestion, expel intestinal gas, and eliminate abdominal fullness.

The invention discloses fertilizer-efficiency-controllable biofertilizer capable of improving heating resistance of plants. The biofertilizer is prepared from raw materials in parts by weight as follows: 36-39 parts of sheep manure, 3-4 parts of an EM agent, 18-22 parts of tobacco residues, 3-4 parts of pullulan, 5-6 parts of dolomite calcium powder, 2-3 parts of polyacrylic acid, 3-4 parts of calcium lactate, 4-6 parts of potassium carbonate, 37-38 parts of rice straw, 32-34 parts of leaves of camphor trees, 9-11 parts of a 30% hydrogen peroxide solution, 0.7-1.0 part of n-tetradecyl trimethylammonium chloride, an appropriate quantity of a sodium hydroxide solution with the concentration of 5 mol / L and an appropriate amount of 45% ethanol water and water. The fertilizer has comprehensive nutrients; with addition of the raw materials such as pullulan, polyacrylic acid and the like with good water solubility, the dissolving-out speed of nutritional ingredients in fertilizer particles can be effectively controlled; longer-period nutrient supplementing and releasing of soil can be realized through matching of utilization of multi-type nutrients and addition of decomposed organic matter, and the condition of nutrient loss and waste caused by high probability of too fast nutrient release of conventional fertilizer is avoided, so that the utilization efficiency of the fertilizer is improved.

The invention discloses a long-acting slow-dissolving composition capable of immediately generating strong oxidation chlorine dioxide when encountering water. The composition comprises sodium chlorate, sodium chloride, maleic anhydride, starch, water, and vegetable oil. First starch and water are put into a first food grade stirrer for stirring, and then crushed with a first food grade crusher, particles with 80 meshes or less are obtained by sieving, and are put into a second food grade stirrer, sodium chlorate, sodium chloride and maleic anhydride are added, stirring is performed, then vegetable oil is added, stirring is performed, the mixture is put into a second food grade crusher for crushing, and then the crushed powder is put into a pressing mold, and is pressed into a cylinder or sphere to obtain a finished product, namely the long-acting slow-dissolving composition capable of immediately generates strong oxidation chlorine dioxide when encountering water. The invention provides the long-acting slow-dissolving composition capable of immediately generating strong oxidation chlorine dioxide when encountering water, the composition does not contain chlorine dioxide during storage, and has no shelf life and hidden danger defects, and a chlorine dioxide gas is generated by a reaction after the composition is soaked into water to kill bacteria, algae, viruses and microorganisms, and oxidize humic layers.