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Digestive tract stent with anti-cancer medicinal particles

An anticancer drug and digestive tract technology, which is applied in the field of components in the field of medicine and medical equipment technology, can solve problems such as the influence of drug loading, large toxic and side effects of anticancer drugs, and slow drug release, so as to increase drug loading and improve Dissolution behavior, effect of improving transmembrane absorption

Inactive Publication Date: 2006-06-28
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, traditional metal stents and covered stents have at least two deficiencies: ① they do not have a real local therapeutic effect, and only play a palliative role in mechanical support and short-term symptom reduction, and are powerless to prevent restenosis caused by tumor growth; Although membrane stents can prevent tumor ingrowth to a certain extent, they still cannot prevent tumor longitudinal overgrowth and compressive restenosis
②After the metal stent is implanted, it still needs to cooperate with systemic drug treatment, but the blood concentration of cancer tissue after systemic drug administration is low, and it is difficult to achieve an effective therapeutic concentration; if the therapeutic effect is to be achieved, long-term high-dose drug therapy is necessary However, most anticancer drugs have serious side effects, and it is not advisable for most patients with advanced digestive tract cancer who have already developed organ lesions or are extremely weak.
"Its deficiencies are as follows: one is that the loading amount of the drug in the polymer material is not enough (too high drug loading will affect the mechanical properties of the film), and the other is that the release rate of 5-fluorouracil in the silicone rubber film is relatively slow. Slow, after being covered with a controlled-release membrane, the release of the drug will be slower and it is difficult to reach the therapeutic dose; finally, the silicone rubber layer with holes is used as the controlled-release layer, which is easily damaged during the delivery of the stent, so that the release rate of the drug be affected to a greater extent

Method used

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  • Digestive tract stent with anti-cancer medicinal particles
  • Digestive tract stent with anti-cancer medicinal particles
  • Digestive tract stent with anti-cancer medicinal particles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045]Such as figure 1 and figure 2 As shown, the present invention includes: a stent 1 , anticancer drug particles 3 , and the anticancer drug particles 3 are directly carried on the stent 1 .

[0046] The anticancer drug particles 3 are implanted dosage forms, the carrier material used is glycolide / lactide copolymer, and the anticancer drug is 5-fluorouracil. The anticancer drug particles 3 are tied to the alloy wire of the stent 1 through surgical sutures.

[0047] The stent prepared by the present invention is used for the treatment of stenosis caused by malignant esophageal tumors. It not only has a mechanical expansion effect, but also can directly act on the diseased tissue or its vicinity with the released drug, so as to perform local slow and long-term administration. Treatment of strictures caused by malignancy of the esophagus.

Embodiment 2

[0049] Such as image 3 and Figure 4 As shown, the present invention includes: a stent 1, a coating 2 and anticancer drug particles 3, the coating 2 is wrapped on the surface of the stent 1, the coating 2 is close to the stent 1, and the anticancer drug particles 3 are carried on the coating 2 Above, the protective layer 4 is set on the anticancer drug particle 3 layer.

[0050] The material of the envelope 2 is polyurethane.

[0051] The anticancer drug particles 3 are microspheres, the carrier material is starch, and the antitumor drug is cisplatin. Anticancer drug particles adhere to the envelope 2 through acrylic pressure-sensitive adhesive.

[0052] The stent prepared by the present invention is used for the treatment of stenosis caused by malignant esophageal tumors. It not only has a mechanical expansion effect, but also can directly act on the diseased tissue or its vicinity with the released drug, so as to perform local slow and long-term administration. Treatmen...

Embodiment 3

[0054] Such as Figure 5 and Figure 6 As shown, the present invention includes: a stent 1 , anticancer drug particles 3 , and a protective layer 4 , and the anticancer drug particles 3 are directly carried on the stent 1 . The protective layer 4 is set on the anticancer drug particle 3 layer.

[0055] The anticancer drug particles 3 are nanospheres, the carrier material is albumin, and the antitumor drug is hydroxycamptothecin. The anticancer drug particles 3 are directly bonded to the wire of the stent 1 through a medical adhesive.

[0056] The protective layer 4 is a water-soluble film of polyvinylpyrrolidone.

[0057] The stent prepared by the present invention is used for the treatment of stenosis caused by malignant tumors of the biliary tract. It not only has a mechanical expansion effect, but also can directly act on the diseased tissue or its vicinity with the released drug, so as to perform local slow and long-term administration. Treatment of strictures caused b...

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Abstract

A scaffold of the granular anticancer medicine for treating the benign or malignant stenosis of esophagus and digestive tract is disclosed, which has 4 structures consisting of scaffold, granular anticancer medicine, selective coated film on the surface of scaffold, and selective external protective layer.

Description

technical field [0001] The invention relates to a component in the technical field of medicine and medical equipment, in particular to a digestive tract bracket for anticancer drug particles. Background technique [0002] Gastrointestinal benign and malignant strictures are clinically common diseases. Among them, malignant stenosis of the digestive tract caused by malignant tumors of the esophagus, stomach, intestinal tract, and biliary tract is a high-incidence disease in patients with digestive tract cancer. In addition to surgical resection, radiotherapy and chemotherapy, commonly used interventional methods mainly include balloon dilatation (mainly for benign strictures) and stent placement. For patients with advanced digestive tract cancer, stent implantation is a very important palliative treatment method, which can effectively improve the quality of life and prolong the survival time of patients with advanced digestive tract cancer. However, traditional metal stents...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/00A61F2/04A61K31/00A61L27/44A61L29/00A61M29/00A61M31/00A61P35/00
Inventor 郭圣荣郭庆海刘炯王忠敏
Owner SHANGHAI JIAO TONG UNIV
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