64 results about "Digestive tract cancer" patented technology

Elevated Hedgehog (Hh) pathway activity, including ligand stimulated Hh pathway activity, was detected in digestive tract cancers, including esophagus, stomach, biliary tract, and pancreatic cancer, and determined to be associated with growth and proliferation of the cancer cells. Accordingly, methods are provided for treating a digestive tract cancer associated with elevated Hh pathway activity by reducing or inhibiting the Hh pathway activity. Also provided are methods of determining the responsiveness of a digestive tract tumor to treatment with an Hh pathway antagonist.

The invention relates to an optical fiber detecting probe head, in particular to an optical fiber detecting probe head for a portable raman spectrometer. The optical fiber detecting probe head for the portable raman spectrometer is characterized by comprising a probe head component and a plurality of collecting optical fibers (9), wherein one ends of the collecting optical fibers (9) are simultaneously connected with the probe head component, and another ends of the collecting optical fibers (9) are simultaneously connected with an FC (fiber channel) probe head; and the optical fiber detecting probe head for the portable raman spectrometer further comprises an exciting optical fiber (10), wherein one end of the exciting optical fiber (10) is connected with the probe head component, and another end of the exciting optical fiber (10) is connected with an SMA905 interface. Therefore, the optical fiber detecting probe head has the advantages that the optical fiber detecting probe head is mini, efficient, and suitable for the clinic detection of the early digestive tract cancer, and the raman light collecting efficiency at the side wall of the upper digestive tract can be improved.

The invention discloses capsules for treating respiratory tract and digestive tract cancers. The capsules are prepared by taking the following traditional Chinese medicines in parts by weight as active pharmaceutical ingredients: 40-60 parts of ginseng, 8-14 parts of calculus bovis factitious, 40-60 parts of pseudo-ginsheng, 10-15 parts of hairyvein agrimonia herb and bud, 8-10 parts of solanum lyratum, 25-45 parts of Chinese Paris rhizome, 25-45 parts of membranous milkvetch root, 25-45 parts of radix sophorae flavescentis, 8-15 parts of ganoderma, 10-30 parts of dried mushroom, 10-30 parts of glabrous greenbrier rhizome, 40-75 parts of longhairy antenoron herb, 8-12 parts of common dysosmatis rhizome and root, 25-45 parts of barbed skullcap herb, 15-21 parts of salvia chinensis, 18-25 parts of spreading hedyotis herb, 10-15 parts of baical skullcap root, 8-12 parts of licorice, 6-14 parts of Indian Iphigenia bulb, 35-55 parts of indigo, 10-15 parts of black nightshade herb, 10-15 parts of asparagus and 8-10 parts of paniculate swallowwort root. The medicament disclosed by the invention is finely extracted from pure Chinese herbal medicines and has obvious analgesic, calmative and anti-cancer effects; the effect of suppressing respiratory tract and digestive tract tumors can achieve 45%; and the medicament is low in price and is a safe and effective treatment way.

The invention discloses health sprouted coarse cereal meal and a preparation method thereof. The prescribed grouted coarse cereal meal with a nutritional health function is enriched with various functional ingredients by sprouting 15 kinds of coarse cereals which serve as raw materials in a scientific means, is produced by process procedures of puffing, grinding, screening, blending, packaging and the like in a proportional formula, and is suitable for people eating. The health sprouted coarse cereal meal is rich in gamma-aminobutyric acid, alkaloid, general flavone, glucan, amino acid, minerals, vitamins, superoxide dismutase, dietary fibers, glutathione, ferulic acid, oryzanol, phytosterol, ascorbic acid, riboflavin, carotene and other multiple active substances with special physiological functions. The health sprouted coarse cereal meal has multiple health functions, such as reducing the incidence rate of cardiovascular diseases, preventing diabetes mellitus and digestive tract cancer, relieving senescence and the like.

The invention belongs to the technical field of intelligent processing of medical images, and specifically relates to a method of detecting and identifying lesions of a gastrointestinal endoscope, based on a sliding window. Early screening through endoscopy is an effective means of reducing the morbidity and mortality of cancers of the digestive tract. In traditional diagnostic methods, the diagnosis of a doctor is entirely a subjective judgment process, so that diagnosis is limited and influenced by the experience and knowledge level of the diagnostic doctor. Therefore, the method of detecting and identifying lesions of a gastrointestinal endoscope, based on a sliding window includes the steps: applying deep learning to lesion detection of a gastrointestinal endoscope, making a sample based on the frame of a lesion area marked by a doctor, and training a classifier; and proposing a candidate area in a gastrointestinal endoscope image to be detected, inputting the candidate area into the classifier, and performing post-processing on the classification result to achieve the purpose of lesion detection. The experiment result shows that the method of detecting and identifying lesionsof a gastrointestinal endoscope, based on a sliding window can accurately detect the lesion position of the gastrointestinal endoscope image so as to provide a reference for the doctor, thus showing that the artificial intelligence-assisted diagnosis and treatment of early digestive tract cancer has irreplaceable superiority.

The invention discloses a functional cereal grain paste and a preparation method thereof. Specifically, 5-8% of germinated peas, 3-5% of germinated chickpeas, 6-9% of germinated giant embryo black rice, 6-9% of germinated black waxy corn, 7-10% of germinated oat, 5-8% of germinated sorghum, 6-9% of germinated seed of Job's tears, 8-11% of germinated lotus seeds, 14-20% of germinated sesame, 4-6% of germinated sunflower seeds, 5-7% of skim milk powder, 6-7% of isomaltose hypgather and 6-8% of maltodextrin are taken as the solid raw materials, and are subjected to production according to proportion and formula, packaging and other production processes, thus obtaining the functional health care cereal grain paste suitable for adults to eat. The cereal grain paste is rich in gamma-aminobutyric acid, protein, amino acids, mineral matters, vitamins and other active substances with special physiological functions, has the health care functions of reducing the incidence of cardiovascular and cerebrovascular diseases, preventing digestive tract cancer, defying aging and the like, and has certain significance to supplement human body nutrition, prevent diseases and promote body health.

The invention discloses germination rice and wheat nutrition powder and a preparation method therefor. Nine kinds of functional brown rice and five kinds of wheat seeds are employed as raw materials, the brown rice and wheat germinate in certain germination conditions, functional component enrichment is carried out, according to a scientific proportion formula, processes of puffing, crushing, sieving, blending, packaging and the like are carried out, and formula rice and wheat nutrition powder suitable for adults and with health care functions is produced. The nutrition powder is rich in a plurality of active substances with special physiological functions such as gamma-aminobutyric acid, proteins, amino acids, mineral matters, vitamins, dietary fibers, glutathione, oryzanol, carotene, cardiac glycoside and the like, and has a plurality of health care functions of lowering the cardio cerebrovascular disease incidence, preventing digestive tract cancers, anti-aging and the like.

The invention discloses a medicine for treating digestive tract cancers, relating to traditional Chinese medicines. The medicine comprises a medicine A and a medicine B or / and a medicine C, wherein the medicine A is prepared from the following raw materials: 1-3g of borneol, 2-4g of stiff silkworm, 2-4g of natural indigo, 5-7g of musk, 3-5g of glycyrrhiza, 3-5g of cattail pollen, 1-3g of lasiosphaera seu calvatia and 5-7g of mirabilite; a preparation method of the medicine A comprises the steps of grinding the raw materials and sieving the powder with a sieve with mesh number more than 60; the medicine B is prepared by decocting coptis root, weeping forsythia capsule, baical skullcap root, cape jasmine fruit, mint, divaricate saposhnikovia root, platycodon root, amur corktree bark, common anemarrhena rhizome, great burdock achene, rhubarb root and rhizome, glycyrrhiza, figwort root and mirabilite with water; the medicine C is prepared by decocting caulis perillae, dried tangerine peel, officinal magnolia bark, rhizoma arisaematis, pinellia tuber, Indian bread, immature bitter orange, immature tangerine peel, fructus amomi, medicated leaven, sharpleaf galangal fruit, areca catechu and gingers with water. The medicine has the beneficial effects that the medicine has good treatment effects; according to observation of the treatment outcomes of 47 patients with esophageal cancers, cardiac cancers and gastric cancers, the total effective rate of the medicine is 97.9%.

A powder injection for treating pneumonia, appendicitis, cellular tissue inflammation, bacterial dysentery, tumors, etc is prepared from glabrous sarcandra herb through extracting, mixing it with cosolvent and excipient and freeze drying.

An enzyme having an activity of transferring N-acetylglucosamine to the non-reducing end of a Galβ1-4Glc or Galβ1-4GlcNAc-group via a β-1,3 bond; a nucleic acid encoding the same; and a method of diagnosing cancer and / or tumor, in particular, digestive cancer and / or tumor using the expression dose of a gene of the above enzyme as an indication. A gene of a novel enzyme having an activity of transferring N-acetylglucosamine to the non-reducing end of a Gal β1-4Glc or Gal β1-4GlcNAc-group via a β-1,3 bond is cloned from human stomach cells and its base sequence is determined. Then this enzyme is expressed. Since this enzyme is scarcely or never produced in cancer and / or tumor, in particular, digestive cancer and / or tumor cells, cancer and / or tumor can be diagnosed with the use of the expression of the enzyme gene as an indication.

An enzyme having an activity of transferring N-acetylglucosamine to the non-reducing end of a Gal β1-4Glc or Gal β1-4GlcNAc-group via a β-1,3 bond; a nucleic acid encoding the same; and a method of diagnosing cancer and / or tumor, in particular, digestive cancer and / or tumor using the expression dose of a gene of the above enzyme as an indication. A gene of a novel enzyme having an activity of transferring N-acetylglucosamine to the non-reducing end of a Gal β1-4Glc or Gal β1-4GlcNAc-group via a β-1,3 bond is cloned from human stomach cells and its base sequence is determined. Then this enzyme is expressed. Since this enzyme is scarcely or never produced in cancer and / or tumor, in particular, digestive cancer and / or tumor cells, cancer and / or tumor can be diagnosed with the use of the expression of the enzyme gene as an indication.

The invention relates to plaster for treating digestive tract cancer, and belongs to the field of Chinese medicinal preparations. The plaster is prepared from the following raw materials in part by weight: 1 to 5 parts of ground beetle, 1 to 5 parts of dragon's blood, 1 to 5 parts of frankincense, 1 to 5 parts of myrrh, 2 to 4 parts of Chinese lobelia herb, 2 to 4 parts of spreading hedyotis herb, 2 to 4 parts of Indian Iphigenia bulb, 1 to 5 parts of honeycomb, 2 to 4 parts of cochinchina momordica seed, 2 to 4 parts of Chinese angelica, 2 to 4 parts of sea horse, 2 to 4 parts of Pallas pit viper, 1 to 5 parts of euphorbia kansui, 1 to 5 parts of bezoar, 1 to 5 parts of musk, 1 to 5 parts of snail, 1 to 5 parts of Mongolian dandelion herb and 1 to 5 parts of Philippine violet herb. The plaster has a scientific formula, obvious and definite curative effect on esophageal cancer and low cost, and is rich in raw materials, wide in medicinal sources, and easy to produce and take; in addition, the plaster has certain curative effect on breast cancer and mammary gland hyperplasia.

The invention relates to a Chinese medicament for preventing and treating digestive tract cancer and process for preparation, wherein the medicament is prepared from astragalus root, green tangerine orange peel, banksia rose, linaloe, clove, zedoary, burred tuber, Ligusticum wallichii, pinellia tuber, white mustard seed, euphorbia helioscopia, radical lobelia, barbat skullcap, oldenlandia, selfheal, dried body of ground beetle, leeches and water.

The invention relates to a method for preparing injection of traditional Chinese medicine glabrous sarcandra herb. The injection is prepared from a medicinal material, namely the glabrous sarcandra herb. The method comprises the following steps of: decocting the medicinal material glabrous sarcandra herb in water, depositing with ethanol, adding a special substance for filtering, and regulating pH value with a pH regulator to obtain the injection. The glabrous sarcandra herb injection has the effects of clearing heat and detoxicating, and dispersing swelling and dissipating stagnation, is used for treating pneumonia, appendicitis, cellulitis, bacillary dysentery and abscess caused by mumps, and can also be used for treating digestive tract cancer, pancreatic cancer, liver cancer and the like by combining glabrous sarcandra herb tablets.

The present invention discloses a Chinese patent medicine for curing carcinoma of esophagus and cardiac cancer. It includes two prescriptions, its main prescription includes 6 Chinese medicinal materials of musk, astragalus root, crataegus fruit, jujube, ovate atractylodes root and ginseng, and its auxiliary prescription is formed from 6 Chinese medicinal materials of purple ganoderma, qitan, aquilaria wood, centipede, pinellia tuber and bovine bezoar.

The present invention provides a pharmaceutical composition for treating digestive tract cancers, belongs to the technical field of drugs and an application of FTY720 or a combination of the FTY720 with JTE-013 in preparation of 5-fluorouracil (5-FU) drug resistance reversal agents. The provided pharmaceutical composition for treating the digestive tract cancers comprises 5-fluorouracil and at least one of the following 5-fluorouracil drug resistance reversal agents: FTY720 and JTE-013. The present invention also provides use of SphK2 and S1PR2 in screening drugs for reversing drug resistanceof fluorouracil compounds for the digestive tract cancers. The SphK2 up-regulates DPD expression-induced fluorouracil primary drug resistance and S1PR2 translocation-induced fluorouracil acquired drugresistance, and besides, the SphK2 and S1PR2 can be used as new molecular targets by designing targeted drugs to solve a drug resistance problem of the fluorouracil and derivatives thereof in cancertreatment processes.

The invention belongs to the technical field of traditional Chinese medicaments, and provides a traditional Chinese medicament for treating digestive tract cancers. The traditional Chinese medicament is prepared from the following components by weight: 20-40g of purpurea halitium, 20-40g of borneol, 50-70g of aconite, 50-70g of arisaema cum bile, 50-70g of potassium nitrate and 10-15g of nux vomica. The traditional Chinese medicament has the advantages of exact curative effect, low relapse rate and high safety.

The invention provides a stomach-strengthening medicinal and edible composition for assisting in treatment of advanced digestive tract cancer. The composition is prepared from the following raw materials by weight of 500 g of rhizoma dioscoreae, 500 g of semen nelumbinis, 500 g of semen euryales, 500 g of yellow millet and 500 g of semen coicis. According to the composition, the medicinal and edible traditional Chinese medicinal materials are used as main materials and combined with the nutrient-rich yellow millet, and the composition has good curative effect on the advanced digestive tract cancer as an adjuvant therapy, significantly improves the life quality of patients and reduces the side effects of chemotherapy. The rhizoma dioscoreae, the semen euryales, the semen nelumbinis and the semen coicis are selected as the medicinal and edible traditional Chinese medicinal materials, are rich in nutritional ingredients and functional ingredients, have various pharmacological activities and good health-care functions, and can increase nutrition intake and resist tumors when being used for the patients with digestive tract cancers. The composition has a clinic guiding effect.

The invention relates to a method for preparing a preparation for treating gastric cancer. The gastric cancer, one of the most common malignant tumors, is among the top of the digestive tract cancers and in the third place of systemic cancers, clear regional disparities of incidence exist in that China is a high-incidence country for gastric cancer whose causes and patheogenesis are not yet clear, the gastric cancer is relevant to factors such as living habits, dietary structures and genetic predisposition, gastric helicobacter pylori, atrophic gastritis, gastric ulcer and gastric polyps are all basic elements causing the gastric cancer, the gastric cancer causes personal pain and brings harm to the families and burden to the society. According to the method, the traditional Chinese medicinal theory is integrated with the modern biotechnology, effective anticancer substances are extracted from traditional Chinese medicinal materials of animals and herbs and prepared by means of mixed fermentation enzymatic hydrolysis at a low temperature. Due to mixed fermentation, the anti-cancer substances contained in the medicinal materials differ from one another, decomposition of the anticancer substances is favorably promoted under the action of digestion biochemical effect, active anti-cancer ingredients are more likely to obtain, anticancer probability is improved, and treatment effectiveness of the gastric cancer can be improved.

The invention discloses a gastroscopic image screening system. The gastroscopic image screening system comprises the following parts: a preprocessing module, which is used for acquiring gastroscopic image information and preprocessing an obtained gastroscopic image; a comparison module, which is used for comparing the preprocessed gastroscopic image with gastroscope type attributes pre-stored in acomputer; and a judgment module, which is used for judging whether a current image and a contrast image are similar images or not by utilizing a neural network according to similarity between the features of the current image and the features of the contrast image. Whether the two images are similar images or not is judged according to the similarity of the image features, and parameters do not need to be manually set, so image screening accuracy is greatly improved; and therefore, a primary medical technology is improved, the homogenization level of digestive endoscopy doctors is improved, and the detection rate of early digestive tract cancer is increased.

The invention discloses health colorful caramel treats and a preparation method thereof. The colorful caramel treats which have yellow, black, green and red colors and have a health function are prepared by using sprouted soybeans, sprouted black soybeans, sprouted green soybeans, sprouted giant-embryo black rice, sprouted red rice, sprouted green rice, sprouted glutinous millet, sprouted black waxy corn, sprouted yellow waxy corn, sprouted white waxy corn, sprouted red waxy corn, sprouted red wheat, sprouted white wheat, sprouted black wheat, sprouted tartary buckwheat, sprouted barley, sprouted oat, sprouted rye, sprouted red sorghum, sprouted black sesame and sprouted white sesame as main raw materials with eggs, glucose syrup, baking powder, skimmed milk powder, edible salt, white granulated sugar, isomaltooligosaccharide, honey, sodium bicarbonate and water. The caramel treats have attractive appearance and unique flavor, are rich in gamma-aminobutyric acid, amino acid, minerals and other multiple physiological active substances, and have health functions of reducing cardiovascular and cerebrovascular diseases, preventing digestive tract cancer, relieving senescence and the like.

Ligands of nuclear receptors PPAR's (peroxisome proliferator-activated receptors) which are compounds selected from the group consisting of ascofuranone; and ascofuranone homologs and ascochlorin homologs having at least an orcyl aldehyde moiety wherein the hydrogen atom(s) of the hydroxyl group(s) at the 2-position and / or the 4-position of the orcyl aldehyde moiety are substituted by C1-15 alkyl, C1-15 alkenyl, CH2COOH, CH2COO(C1-15 alkyl), C(C=O)(C1-15 alkyl), C(=O)(CH2)1-15COOH, nicotinoyl, isonicotinoyl, etc. These ligands are usable in preventing and / or treating diabetes; hypertension or cerebrovascular disorders; arteriosclerosis; complications of diabetes; chronic inflammation; cachexia; digestive cancers, etc.

An oral pharmaceutical composition for the treatment of digestive tract cancers contains an effective amount of a camptothecin derivative dissolved in a non-aqueous solvent. The camptothecin derivative is administered at a dose of about 0.05 to about 1 mg / kg body weight / day. The pharmaceutical composition is particularly suitable for use in low-dose-long-term regimens for colorectal cancers.

The invention discloses a digestive tract cancer cell collector comprising an outer shell and a main body with a spherical structure. The main body is arranged inside the outer shell; a connecting earis arranged on the main body, and a medical suture line is fixedly connected on the connecting ear and is sleeved with more than one scraping sheet; the surface and the bottom surface of the scrapingsheet are each provided with more than one groove with an annular structure; the upper end and the lower end, located on the scraping sheet, of the medical suture line are each sleeved with a fixingring; each of the opposite faces of each fixing ring presses against the outer wall face of the scraping sheet. The digestive tract cancer cell collector has simple structure; because the weight of the main body is larger than the weight of the scraping sheet and the medical suture line, the main body can be set downwards and enters an intestinal tract in advance, and thus the medical suture lineon the main body is straightened by the main body (relatively in the unfolding state), the scraping sheet on the medical suture line makes contact with the inner wall of the intestinal tract comprehensively, the contact area with the intestinal tract is increased, and scraping of cells on the intestinal tract is facilitated; and meanwhile, distinguishing can be easy because of different colors ofthe main body.

The invention provides an application of a recombinant oncolytic virus in the preparation of drugs for treating digestive tract cancer, belongs to genetic engineering and oncology, and relates an application of a human IL-33-carrying recombinant oncolytic vaccinia virus in treating cancer. Through the effective combination of gene therapy for malignant tumors and viral therapy, an oncolytic vaccinia virus capable of efficiently expressing IL-33 can be prepared; and compared with simple gene therapy or viral therapy, killing abilities on tumors can be enhanced; through the adopting of a tumor targeted therapy strategy, tumor cells can be effectively targeted, and specific proliferation can be achieved, so that the safety of an oncolytic vaccinia virus vector can be greatly enhanced; throughthe adopting of the mode of virus replication related gene deletion, the intratumoral specific replication of the virus can be ensured, and the safety of the oncolytic vaccinia virus vector can be greatly enhanced; and through the construction of the human IL-33 carried recombinant oncolytic vaccinia virus, good anti-gastric, colon and pancreatic cancer effects can be achieved.

The invention discloses a colorectal cancer blood detection marker and application thereof, and belongs to the field of tumor detection. The colorectal cancer blood detection marker is a combination of BEND5 and TFPI2 genes, and the marker or a methylation detection reagent thereof can be used for preparing a colorectal cancer or precancerous lesion detection kit. When the marker is used for detecting colorectal cancer, high sensitivity and specificity are achieved, in a plasma sample, the sensitivity of BEND5 and TFPI2 methylation combination detection on I / II stage colorectal cancer is larger than 71%, the sensitivity of BEND5 and TFPI2 methylation combination detection on III / IV stage colorectal cancer is larger than 89%, and meanwhile the combination can effectively avoid false positive generated by gastric cancer, esophageal cancer and other digestive tract cancer species. The invention provides a new idea for noninvasive diagnosis of colorectal cancer.

An upper and lower digestive tract cancer screening testing kit includes a sample bottle, a test box, and a sampling solution. The test box is provided with an antibody and a colloidal gold complex which can be combined with occult blood and Helicobacter pylori in feces, and also includes a sample cell unit and an inspection cell unit. The inspection cell unit has a first result zone, a second result zone, and at least one control zone. The first result zone has a first antibody that can be combined with the Helicobacter pylori. The second result zone has a second antibody that can be combinedwith the occult blood. The control zone has a control antibody that can be combined with the antibody and the colloidal gold complex. The sampling solution has a pH of 8.0, and includes trimethylmethyl-aminomethane hydrochloride with the concentration of 10 mM, sodium azide with the concentration of 0.05% by weight, and sodium hydroxide used to adjust the pH to 8.0. A user only needs to sample once and make a drop test once to obtain two test results at the same time. The detection is very convenient.

The invention discloses a targeted drug delivery device for cancer in the digestive tract, which includes a stainless steel cylinder and an injection needle. A medicine storage device is installed on one side of the stainless steel cylinder, and an injection needle is connected to one end of the medicine storage device. One end of the injection needle is provided with a liquid outlet, an LED video processor is installed on the side wall of the stainless steel end, and one side of the LED video processor is fixedly connected with a wireless communication module, and a battery is installed at one end of the stainless steel cylinder. A piston is installed inside the medicine storage, and a connecting rod is fixedly connected to the end of the piston. The present invention combines the camera device with the drug injection device. By installing the camera on the injection needle, it is convenient to find the tumor accurately, and the drug can be accurately injected to the tumor position. At the same time, the surface of the drug storage device is provided with a scale line, which can be injected quantitatively. Thereby expanding the scope of treatment, reducing the cost of treatment, reasonable structure, practical function, suitable for wide promotion.