74results about How to "Does not affect release" patented technology

The invention relates to a desloratadine grain and a preparation method thereof. The preparation method comprises the steps: fully coating a medicine and proper auxiliary materials (such as a stabilizing agent, a cosolvent, a PH adjusting agent, a filling agent and the like) into a water-soluble high molecular material; and adding a proper opacifier into a coating material, so that the medicine can be isolated from the light and the external moist air when the medicine is stored, and the stability of the medicine can be adequately guaranteed when the medicine is stored under the room temperature; mixing the coated grain with a proper flavoring agent and soluble auxiliary materials to obtain the desloratadine granular formulation; and properly adding a small quantity of edible coloring agent and fruity essence to increase the novelty to the children, and improve the taking compliance.

A scaffold of the granular anticancer medicine for treating the benign or malignant stenosis of esophagus and digestive tract is disclosed, which has 4 structures consisting of scaffold, granular anticancer medicine, selective coated film on the surface of scaffold, and selective external protective layer.

The invention relates to diatom ooze capable of releasing anions and a preparation method of the diatom ooze. The diatom ooze is prepared from the following raw materials in percentage by weight: 10-50% of kieselguhr, 10-40% of composite tourmaline powder, 0.5-5% of rare earth oxide, 5-30% of titanium dioxide, 5-30% of a cementing material, 1-15% of redispersible powder and 0.1-2% of cellulose, wherein the composite tourmaline powder is mainly prepared from the following raw materials in percentage by weight: 50-80% of tourmaline powder, 10-40% of nanometer titania, 1-10% of sodium silicate and 0.5-1% of a surfactant. The diatom ooze is capable of continuously releasing the anions and a far infrared ray, has good air purification effect and human health effect, is high in purification efficiency and purification persistence and has good adhesive force.

The invention provides a novel drug eluting balloon catheter. The novel drug eluting balloon catheter comprises a catheter body, a balloon body (1) and a balloon surface (2) and further comprises a hydrophilic and lipophilic bottom layer (3) and a drug loading coating layer (4). The hydrophilic and lipophilic bottom layer (3) is arranged on the upper surface of the balloon surface (2), the drug loading coating layer (4) is arranged on the upper surface of the hydrophilic and lipophilic bottom layer (3), and the drug loading coating layer (4) is composed of polymer and drug. The novel drug eluting balloon catheter has the advantages of simple structure, simple production process and procedures, low drug loss during delivery and low drug residues on the balloon after interventional operation.

The invention provides a Fuzzy Vault encrypting method based on secrete sharing. The method combines Fuzzy Vault and a secrete-sharing system to protect messages. In the process of encryption, the sender generates a master encryption key and a master decryption key; the master encryption key encrypts a message and makes use of the master decryption key to produce n sub decryption keys via the secrete sharing system; and n receivers sharing messages respectively provide a group of fingerprint minutiae information sets and construct n Fuzzy Vault systems to bind the sub decryption key. In the process of decryption, when m receivers sharing messages provide fingerprint minutiae information sets used in the process of encryption and input the minutiae information sets into the corresponding Fuzzy Vault systems in encryption to decrypt and recover m sub decryption keys, the secrete sharing system uses the m sub decryption keys to recover the master decryption key. The Fuzzy Vault encrypting method solves the problem of message deadlock in Fuzzy Vault systems of single biological trait, realizes the indirect protection over fingerprint minutiae information, and effectively protects the safety of shared information.

The invention provides a composite coating having antibacterial performance and biocompatibility. The composite coating includes an antibacterial coating and a biocompatibility coating, wherein the antibacterial coating is 2-1000nm thick; and the biocompatibility coating is 2-500nm thick. With the application of a mode of combining the antibacterial coating and the biocompatibility coating, the service life of the coating (the composite coating) is prolonged; the composite coating, which is simple in process, can be continuously and rapidly prepared by a large area; a better antibacterial effect can be achieved, so that antibacterial elements can be released at moderate speed; the biocompatibility coating, under the conditions, can avoid influence to release of antibacterial elements and development of antibacterial performance; and therefore, the composite coating is an ideal coating of implantable medical apparatuses.

The invention belongs to the technical field of manufacturing of oriented silicon steel, and in particular relates to a high-temperature annealing method of low-temperature and high-magnetic-inductionoriented silicon steel. The method comprises the following steps: providing a steel coil to be annealed at a high temperature; placing the steel coil to be annealed at the high temperature on a bottom plate; laying an anti-adhesion layer on the upper end of the steel coil placed on the bottom plate, and covering the anti-adhesion layer with a cover plate; assembling a sealing ring on the bottom plate at the periphery of the steel coil, centering the sealing ring and the steel coil, and filling the part between the sealing ring and the steel coil with a sealing layer; then, additionally arranging an inner cover on the steel coil, putting in a furnace and annealing. The method can improve the quality of the steel coil.

The invention provides a winding device and a fuelling vehicle. The winding device comprises a winding frame, a guide assembly mounted on the winding frame and a damping device mounted on the guide assembly, wherein the winding frame comprises a central shaft and a baffle plate; the guide assembly comprises a two-way lead screw and a guide element which sleeves the two-way lead screw, and cable-pipe inlet and outlet are formed in the guide element; the damping device comprises a U-shaped damping roller, a spring connected with the U-shaped damping roller and the guide element, respectively, and a locking device for controlling the angle of rotation of the U-shaped damping roller with an end thereof as a rotation point. The damping device, under the control of the locking device, is capable of applying resistance to a cable or a pipe on the winding device according to requirements, so that the cable or the pipe can be tightly wound around a central shaft of the winding device when being reeled, and when the cable or the pipe is unreeled, the cable or the pipe can be quickly unreeled without being affected by the resistance. The winding device is capable of keeping the cable or the pipe wound around the central shaft regular and tidy, and also capable of guaranteeing quick unreeling of the cable or the pipe.

The invention discloses desloratadine critrate disodium particles. Based on 100 percent, the desloratadine critrate disodium particles comprise the following raw materials in percentage by weight: 0.1 to 2 percent of desloratadine critrate disodium, 20 to 90 percent of filler, 1 to 10 percent of sweetener, 0.1 to 5 percent of PH conditioner, 0.1 to 2 percent of essence and 0 to 0.05 percent of food coloring, wherein the desloratadine critrate disodium serves as an active ingredient; and the filler, the sweetener, the PH conditioner, the essence and the food coloring serve as minor ingredients. The prepared desloratadine critrate disodium particles have good mouth-feel, and are fresh red, attractive, convenient to take, fast in absorption and high in bioavailability; and a child can compliantly take the particles.

The invention discloses a lansoprazole enteric-coated tablet and a preparation method thereof. The preparation method comprises the following steps: preparing lansoprazole and pharmaceutic adjuvants comprising starch, lactose, microcrystalline cellulose, hydroxypropyl cellulose, sodium carboxymethyl starch, calcium hydrogen phosphate, povidone K30, sodium hydroxide, magnesium stearate and the like into a tablet core; coating the tablet core with an isolated layer, and finally coating the tablet core with an enteric-coated layer so as to obtain the lansoprazole enteric-coated tablet. According to the method, the solubility and releasing rate of the lansoprazole are effectively improved, so that the oral bioavailability of the lansoprazole is improved. The formula process for preparing the lansoprazole enteric-coated tablet is simple, convenient and stable, and is suitable for mass industrial production.

The invention relates to bupropion hydrochloride sustained release tablets, which contain the following components: bupropion hydrochloride, a sustained release framework material, an acid environment regulator, a diluent, a bonding agent, a flow aid and a lubricant. The sustained release tablets are characterized in that: the acid environment regulator is aerosil. The invention also provides a method for preparing the bupropion hydrochloride sustained release tablets. The invention overcomes the defects of large tabletting difficulty, large difference among product batches, easy environmental pollution in the production process, easy corrosion on production equipment, no contribution to industrial production and the like of the conventional bupropion hydrochloride sustained release tablets, and provides new bupropion hydrochloride sustained release tablets which use the aerosil as the acid environment regulator so as to overcome the defects. The sustained release tablets can at least keep 90 percent labeled amount of bupropion hydrochloride after being stored for one year at room temperature under the condition that the relative humidity (RH) is 35 to 60 percent.

The invention relates to a cylindrical battery cell module. The cylindrical battery cell module comprises a battery pack formed by combining a plurality of cylindrical battery cells arranged in an array manner, two electrode assemblies and a top cover; the two electrode assemblies are arranged in parallel, and are respectively positioned at the positive electrode end and the negative electrode endof the battery pack, a plurality of battery cell fixing grooves are arranged at one side, close to the battery pack, of every electrode assembly, the positive electrode ends and the negative electrode ends of the cylindrical battery cells are positioned in the battery cell fixing grooves, and the two electrode assemblies are fixedly connected through a connecting piece; and two sides of the top cover are respectively connected with the two electrode assemblies. The plurality of small-capacity cylindrical battery cells are connected in parallel to form the large-capacity battery pack, and thebattery pack is wrapped with the two electrode assemblies to form the cylindrical battery cell module, so the cylindrical battery cell module has the advantages of simple structure, safety and reliability in connection, good protection, short development period, and meeting of the large-capacity requirements of electric automobiles; and a plurality of cylindrical battery cell modules can be connected in a mutual insertion manner to form a module group having the advantages of difficulty in making mistakes of connection, convenience in routing, reliability in connection, and good resistance toshock and impact.

The invention aims at providing a novel aorta inner branch type covered stent. The novel aorta inner branch type covered stent is composed of a metal frame and a covering film. The novel aorta inner branch type covered stent comprises an anterior arch area, an arch area and a posterior arch area. Multiple inner branch stents are arranged on the big bend side of the arch area, a round open hole located in the big bend side is formed in the top of any inner branch stent, any inner branch stent can comprise an upper part and a lower part, the upper part of any inner branch stent is of a bowl-shaped structure, the diameter of the top section of the upper part is larger than that of the bottom section of the upper part, the lower part of any inner branch stent is of a cylindrical structure, andthe diameter of the cross section of the cylindrical structure of the lower part of any inner branch stent is not larger than that of the bottom section of the bowl-shaped structure of the upper partof any inner branch stent. The novel aorta inner branch type covered stent in the design has the effect that the open holes in the tops of the inner branch stents can correspond to branch arteries ofthe top end of an arch artery. The novel aorta inner branch type covered stent has the advantages that the problem of blood leakage between the aorta covered stent and branch covered stents can be effectively solved, the structures of the inner branch stents adapt to most blood vessel anatomical structures, and alignment with branch artery blood vessels is convenient.

The invention provides an oral dry suspension composition capable of realizing controllable drug-release speed through modification combination design and a preparation method thereof. The oral dry suspension composition comprises a pharmaceutically acceptable excipient and a modified medicine-ion exchange resin compound. The medicine-ion exchange resin compound comprises a compound formed by combining a pharmaceutically acceptable active medicine and pharmaceutically acceptable ion exchange resin, and a polymer system which can be dissolved in water for modifying the compound. The invention provides a medical resin compound preparation and modification method as well as a preparation method of a dry suspension containing the compound; better taste masking effect is realized, the drug release speed is controllable according to different treatment requirements, and the dry suspension has the characteristics of small particles and no gritty mouthfeel, and is especially suitable for a children preparation.

The present invention discloses a method for preparing a plasterboard capable of purifying air. The method comprises: adding negative ion powder to a plasterboard, wherein the adding amount of the negative ion powder is 1-5 parts by weight based on 100 parts by weight of desulfuration gypsum for preparing the plasterboard, the negative ion powder is added to a material slurry for preparing the plasterboard from a material slurry outlet, and negative ion powder aqueous solutions prepared from the negative ion powder are sprayed onto the inner surfaces of upper surface protection paper and lowersurface protection paper of the plasterboard. According to the present invention, the obtained plasterboard can release negative ions into the air, and has good and long-lasting air purifying ability, and the surface of the plasterboard has the three-dimensional shape and the embossed hole with a certain shape so as to achieve the beautiful and elegant characteristics.

The invention discloses a charging pile with a cable stored conveniently, and relates to the technical field of electrical equipment. The charging pile comprises a support, the cable, a charging gun movably inserted into the support, a wire winding shaft and a wire winding cylinder on the periphery of the wire winding shaft; the wire winding cylinder is provided with a wire winding cavity, the twoends of the wire winding cylinder are connected with the support through bearings, and the two ends of the wire winding shaft extend out of the wire winding cavity and are fixedly connected with thesupport; a volute spiral spring is further arranged in the wire winding shaft, and the two ends of the volute spiral spring are fixedly connected with the wire winding shaft and the wire winding cylinder respectively; and one end of the cable is connected with the charging gun, the other end of the cable is wound around the wire winding cylinder, penetrates through the wire winding cylinder and extends into the wire winding cavity, the end, extending into the wire winding cavity, of the cable is wound around the wire winding shaft, and the end, wound around the wire winding shaft, of the cableextends out of the wire winding cavity to be fixed in the support. The charging pile has the advantages that the length of the cable can be adjusted, the cable can be stored and recycled, the structure is simple and practical, and the cable electric leakage caused by abrasion of the cable can be effectively avoided.

The invention discloses a heat-not-burn plant particle with a damp-proof layer and a preparation method of the heat-not-burn plant particle. The heat-not-burn plant particle is prepared from the following components in parts by weight: 40-80 parts of plant particles, 10-40 parts of fragrant substances, 10-50 parts of a smoke agent and 10-20 parts of the damp-proof layer. The preparation method comprises the following steps: taking medicinal and edible plants, crushing, sieving, granulating and drying to obtain plant particles; mixing the plant particles with a fragrant substance and a smoke agent, uniformly spraying the moisture-proof coating liquid on the surfaces of the plant particles, and drying at low temperature to obtain the heat-not-burn plant particles with the moisture-proof layer. The obtained heat-not-burn plant particles are good in moisture-proof effect, do not affect aerosol release, are simple in process and have certain industrial application value, and a coating material is easy to obtain.

The invention provides a micro catheter which comprises a catheter base and a catheter body connected with the catheter base. The catheter body comprises a main body of the catheter body and a tip catheter section which is arranged at the end, far away from the catheter base, of the main body of the catheter body; the outer diameter of the end, far away from the main body of the catheter body, of the tip catheter section is smaller than that of the main body of the catheter body, the inner diameter of the tip catheter section is larger than the outer diameter of a guide wire, and cracks which can enable the tip catheter section to crack outwards in the radial direction are formed in the inner cavity wall of the tip catheter section. During application, when a support enters the tip catheter section, the support can exert acting force on the inner cavity wall of the tip catheter section, the cracks crack, and the tip catheter section cracks outwards in the radial direction, so that the support is sent out; meanwhile, due to the fact that the outer diameter of the far end of the tip catheter section is smaller than that of the main body of the catheter body, the size difference between the far end of the tip catheter section and a narrow lesion is larger, the micro catheter can easily penetrate through the narrow lesion under the guidance of the far end of the tip catheter section, therefore, by means of the micro catheter, it can be guaranteed that the support can be smoothly released from the micro catheter, and meanwhile the difficulty for the micro catheter to penetrate through the narrow lesion is reduced, so that the operation difficulty is reduced.

The invention provides an automatic water supplementing method for valve control lead acid battery, and the battery is composed of one or more unit cell; a pole plate is produced from lead-antimony alloy; the unit cell is installed with water containing capsules which are made of starch-base polypropylene or polylactic acid-base degraded plastic; after cover of the capsule is degraded, automatic water supplement of the battery is realized, thereby the battery has a longer usage life in uncertain scenes, random over charge, or over-discharge, high temperature, wind or light energy storage utilization, abnormal commercial power, equator adjacency and other occasions.

The invention provides a preparation method of novel salmonella bacteriophage microencapsulated microspheres. The method comprises the following steps of mixing a cationic etherified starch solution and a bacteriophage suspension, and uniformly stirring to obtain a first mixed solution; uniformly stirring and mixing the first mixed solution, a sodium alginate solution, a xanthan gum solution and a nano TiO2 solution to obtain a second mixed solution; and dropwise adding the second mixed solution into a calcium chloride solution to form calcium alginate gel, filtering and collecting bacteriophage microspheres, putting the bacteriophage microspheres into a cationic chitosan oligosaccharide solution, coating for 30 minutes, and filtering and collecting the bacteriophage microencapsulated microspheres. In actual use, after the bacteriophage microspheres enter gastric juice, the bacteriophage surface coated material can effectively resist erosion of gastric acid and prolong the survival time of bacteriophage, and after the bacteriophage microspheres enter intestinal juice, the bacteriophage surface coated material can react with the intestinal juice and is cracked to release the bacteriophage in the material so as to achieve the sterilization effect. The method has the advantages that microencapsulation preparation is carried out at room temperature, the process is simple, the application range is wide, and the cost is low; and the raw materials are wide in source, cheap and easy to obtain, and the bacteriophage in the product is high in activity and encapsulation efficiency and can be directly applied to feed addition.

The invention provides a tea tree essential oil enteric coating pellet as well as a preparation method and application thereof, and belongs to the technical field of animal husbandry feeds. The tea tree essential oil enteric coating pellet is prepared from the following components in parts by weight: 40-50 parts of a pellet core, 25-35 parts of a tea tree essential oil-auxiliary material mixture and 25-35 parts of a coating solution. Raw materials for preparing the pill core comprise cellulose, an excipient and water. The coating liquid is prepared from the following raw materials: a methacrylic acid-ethyl acrylate copolymer, inorganic filler, a photolysis resistant material, a coating material, a plasticizer and water. The product can effectively solve the problem that tea tree essentialoil volatilizes easily and special essential oil smell affects animal food intake, effectively reduce the incidence rate of diarrhea and other diseases, remarkably increase the animal food intake, improve the feed conversion efficiency, and is high in safety and free of drug resistance. The product can be added into feed to replace the use of growth-promoting antibiotics in feed additives.

The invention discloses an enzyme and microecological preparation composite agent and a preparation method thereof. The enzyme and microecological preparation composite agent is prepared by mixing a bacillus subtilis mixed solution, a saccharomyces cerevisiae mixed solution and a lactobacillus acidophilus mixed solution to obtain a bacterium and enzyme mixed solution, and then mixing the bacterium and enzyme mixed solution with a protective agent. The obtained composite agent can regulate the ecological balance of animal intestinal tracts, prevent diseases, promote digestion and improve the utilization rate of feed nutrient substances, and can reach a to-be-released position on the premise of completely protecting each component in the agent from being influenced by the outside or an in-vivo environment.

A tissue retractor for use in oral cavity operations is disclosed. The tissue retractor includes an elastic retracting ring capable of deformation retracting and a placement structure. The tissue retractor is characterized in that the front end of the placement structure is a placement unit for the retracted elastic retracting ring; the elastic retracting ring is retracted in the placement unit; the area of cross section of the placement unit is smaller than the area of the elastic retracting ring after the elastic retracting ring extends; a forward pushing structure is arranged behind the placement unit; the area of cross section of the forward pushing structure is not smaller than the area of middle gap of the retracted elastic retracting ring; a forward pushing bar is arranged behind the forward pushing structure; a pushing bar setting unit is arranged at the rear end of the placement structure, and is provided with a pushing bar passage having a size same as that of the forward pushing bar, inside; and the rear end of the pushing bar is connected to a forward pushing button pushing the forward pushing bar. The forward pushing button can be disposed in a pushing button moving slot of a pushing bar placement unit, or disposed in an rear-end groove, or is provided with an extending segment connected to the forward pushing button. In addition, the rear end of the pushing bar setting unit is provided with a rear-end perpendicular segment arranged in a separated manner. Angles of all parts can be adjusted according to operation needs, thus facilitating strength exerting. Thetissue retractor is reasonable in structure setting and convenient to use.

The invention discloses a worm-resistant bookmark manufacturing method. The worm-resistant bookmark manufacturing method comprises the following steps: (1) selecting dry lavender flowers, pulverizing the dry lavender flowers, screening the pulverized dry lavender flowers with a 10-mesh filter screen and screening the screened dry lavender flowers with a 50-mesh filter screen to obtain plus-sieve pulverized dry lavender flowers and minus-sieve pulverized dry lavender flowers; and grinding cymbopogon distans, saponin, alum and bletilla striata into powder, adding the minus-sieve pulverized dry lavender flowers, and performing uniform mixing to obtain worm-resistant powder; (2) adding glue into the worm-resistant powder, and performing uniform stirring to obtain worm-resistant powder glue for later use; (3) pasting two pieces of bookmark paper with the worm-resistant powder glue, then pressing into a bookmark and performing airing; and (4) coating the surface of the bookmark with a layer of the plus-sieve pulverized dry lavender flowers, and pressing an air-permeable plastic film on the bookmark by a laminator to obtain the worm-resistant bookmark. The worm-resistant bookmark manufacturing method not only can prevent book worms from destroying books but also carries faint lavender fragrance, and therefore improves the reading experience of people.

The invention belongs to the field of genetic engineering and cell biology, and relates to a chimeric antigen receptor T cell expressing an IL-6R blocking antibody and targeting CD19, a preparation method and an application of the T cell. Specifically, a dual expression carrier targeting a CD19 chimeric antigen receptor and an IL-6R blocker tocilizumab is constructed. The dual expression carrier targeting the CD19 chimeric antigen receptor and the IL-6R blocker tocilizumab is transduced to the T cell by a lentivirus mediated method. The pHR-antiCD19CAR-Tocilizumab-T cell enable the cells to autocrine the IL-6R blocker tocilizumab through a genetic engineering technology under the condition of not affecting the characteristics of phenotype, killing, cytokine release and the like of the pHR-antiCD19CAR-Tocilizumab-T cell, and thus the generation of CRS side effects is controlled, and the safety is improved.

The present invention discloses a plasterboard capable of purifying air, wherein the plasterboard comprises negative ion powder, the adding amount of the negative ion powder is 1-5 parts by weight based on 100 parts by weight of desulfuration gypsum for preparing the plasterboard, the negative ion powder is added to a material slurry for preparing the plasterboard from a material slurry outlet, and the negative ion powder aqueous solutions are prepared, and are sprayed onto the inner surfaces of upper surface protection paper and lower surface protection paper of the plasterboard. According tothe present invention, the obtained plasterboard can release negative ions into the air, and has good and long-lasting air purifying ability, and the surface of the plasterboard has the three-dimensional shape and the embossed hole with a certain shape so as to achieve the beautiful and elegant characteristics.

The invention discloses a cold hydrogenation wet-process dust removal slag slurry discharging system and method, relating to the field of polysilicon cold hydrogenation dust removal equipment. The system comprises a washing tower and a slag slurry treatment device, and is characterized by also comprising a slag slurry receiving tank, wherein the slag slurry receiving tank is arranged between the washing tower and the slag slurry treatment device; the top end of the slag slurry receiving tank is provided with a slag slurry inlet valve; the slag slurry inlet valve is fixedly connected with the bottom of the washing tower; the top end of the slag slurry receiving tank is also provided with a balance valve and an emptying valve; and the bottom of the slag slurry receiving tank is provided with a slag slurry outlet valve. The bottom of the cold hydrogenation washing tower is provided with the slag slurry receiving tank, and the system pressure is relieved by using the slag slurry receiving tank instead of a disk valve, thereby reducing the system abrasion and lowering the failure rate.

The invention discloses lappaconitine hydrobromide orally disintegrating tablets. The lappaconitine hydrobromide orally disintegrating tablets consist of the following ingredients in part by weight: 5 to 10 parts of lappaconitine hydrobromide, 3 to 10 parts of disintegrating agent, 30 to 100 parts of filling agent, 2 to 10 parts of flavoring agent, 0 to 60 parts of adhesive, 0 to 3 parts of lubricating agent and 0 to 50 parts of stomach-soluble acrylic resin. The lappaconitine hydrobromide orally disintegrating tablets which do not comprise the stomach-soluble acrylic resin in the formula canbe prepared by a wet pelleting tabletting method, a dry pelleting tabletting method or a direct tabletting method; and the lappaconitine hydrobromide orally disintegrating tablets which comprise the stomach-soluble acrylic resin in the formula are prepared by the steps of preparing the lappaconitine hydrobromide into smell concealing particles by using the stomach-soluble acrylic resin and then preparing the orally disintegrating tablets by the wet pelleting tabletting method, the dry pelleting tabletting method or the direct tabletting method. The lappaconitine hydrobromide orally disintegrating tablets have good mouthfeel, do not influence medicament release, have a simple preparation process, high yield and low cost, and are suitable for industrialized production.

The invention discloses a landscape lake water supplementing and purifying process, which belongs to the technical field of sewage treatment, and comprises the following steps of: removing organic pollutants and suspended matters in sewage by adopting a microbial purification method, oxidizing ammonia nitrogen into nitrate under the oxidation action of microorganisms, and removing the nitrate. According to the selected method, nitrate is denitrified into nitrogen in an anoxic environment, and high-efficiency removal of ammonia nitrogen is completed. Calcium carbonate is selected to be added when phosphorus in sewage is removed, hydroxyl calcium phosphate is generated by calcium ions of calcium carbonate and phosphate ions in water, hydroxyl calcium phosphate precipitates downwards, releaseof calcium ions by calcium carbonate on the lower layer is not affected, the method is scientific and reasonable, use is safe and convenient, no filtering device needs to be placed in the treatment process. The replacement cost of the filtering device is reduced, and meanwhile, the cleaning time of the filtering device is also saved.

The invention discloses a packaging structure and a forming method thereof. The packaging structure comprises a wafer which comprises a chip region and a peripheral region which surrounds the chip region; a first wiring layer distributed on the wafer of the chip region in a discrete manner; an upper passivation layer covering the top and the side wall of the first wiring layer and extending to thewafer; and an isolation layer located on the upper passivation layer, arranged on the chip region and extending to a part of the peripheral region, wherein an isolation groove surrounding the chip region is formed in the isolation layer on the peripheral region, and the isolation groove penetrates through a part of the thickness of the isolation layer. The isolation groove can block the conduction of the internal stress action of the isolation layer to realize the release of the internal stress action of the isolation layer, thereby reducing the cracking probability of the upper passivation layer, reducing the occurrence of the exposure phenomenon of the first wiring layer, and improving the performance of the packaging structure.