The invention discloses a regeneration technology of a V-Ti-based honeycomb SCR denitration catalyst, and an apparatus thereof. A deactivated catalyst in the technology is regenerated through steps of pressurized water spraying, ultrasonic cleaning, secondary pressurized water spraying, air blow drying, active component supplement, secondary air blow drying, step calcining, and the like. Parameters of the regeneration technology, which comprise components of a cleaning solution, a pickling solution and an active supplement solution, are provided. By adopting the technology, the denitration activity of the deactivated catalyst is recovered, the structural strength of the catalyst is maintained, and the SO2 oxidation frequency is reduced. The apparatus used for realizing the technology comprises a pressurized water spraying pool, an ultrasonic cleaning pool, a secondary pressurized water spraying pool, a pickling pool, an air blow drying pool, an active component supplement pool, a secondary air blow drying pool, a calciner and the like which are sequentially arranged, and the device can realize the hoisting transport regeneration of a regeneration module, and has the characteristics of simplicity, convenient operation, and high efficiency.