218 results about "Supramolecular hydrogels" patented technology

The invention discloses a high-strength supramolecular hydrogel and a preparation method and application thereof. The high-strength supramolecular hydrogel is prepared by using acryloyl glycinamide as a monomer and triggering in the presence of an initiator; because of the synergistic effect of hydrogen bonds, the supramolecular hydrogel is high in tensile strength and anti-tear while being compressed, can realize functions of thermoplasticity and self-repair at a high temperature, and is good in biocompatibility.

The invention discloses multi-component super-molecular hydrogel and a preparation method of the multi-component super-molecular hydrogel. The hydrogel is formed by a component containing a strong hydrogen bond, a component containing a weak hydrogen bond and water, wherein the component containing the strong hydrogen bond is one or more of a carbon oxide nano tube, graphene oxide, a carboxylated ferroferric oxide nano particle, a carboxylated silver nano particle, a carboxylated quantum dot, polyacrylic acid, polypropylene glycol, polyvinyl alcohol, polyurethane, polyamide and poly(p-styrene) sodium sulfonate; and the component containing the weak hydrogen bond is a small-molecular compound or a high-molecular compound. A lot of cross-linking force of the hydrogel disclosed by the invention comes from the weak hydrogen bond so that the hydrogel is very sensitive to the stimulation of an external environment; when chemical components are proper, gel-sol conversion can be carried out under the effects of temperature rising, near-infrared light illumination and acids; and the conversion is reversible, namely the gel-sol conversion can be carried out under the effects of temperature reduction, removing of a near-infrared light source and alkalis.

The invention relates to a preparation method of high-strength ion-responsive lubricating hydrogel, belonging to the technical field of ion response. The preparation method combines a high-strength hydrogel material with a synergistic design system of ion-responsive supramolecular hydrogel, and realizes the regulation and control of the surface lubrication of the hydrogel material by regulating the bulk phase of the hydrogel material as well as surface ion species and charged state. On the one hand, the high-strength hydrogel can give good mechanical support to cartilage; on the other hand, the ion-responsive supramolecular hydrogel can undergo gel-sol conversion under the action of external ions, and the factors such as ion species and concentration of the environment in which the hydrogel is located can be further controlled according to complexion situations of different ions by an ion-responsive polymer, so that the purpose of reversible regulation of hydrogel surface lubrication is achieved, and the hydrogel is enabled to automatically adjust the strength and the surface lubrication performance. The high-strength ion-responsive lubricating hydrogel greatly enhances the stability and environmental adaptability of bionic cartilage, thus having a very good medical prospect.

The invention discloses a host-guest supramolecular hydrogel, and a preparation method and an application thereof. The host-guest supramolecular hydrogel is prepared through initiating the copolymerization of free radicals by host-guest supramolecule and methacrylic anhydride gelatin (GelMA) under an ultraviolet light (UV ) condition, and has good mechanical strength and biocompatibility. The host-guest supramolecule is prepared through the host-guest coupling of acryloyloxyethyl isocyanate-modified beta-cyclodextrin (beta-CD) and allyl 1-bromoadamantane. Compared with pure GelMA hydrogel, thehost-guest supramolecular hydrogel has the advantages of good mechanical properties, control of the mechanical strength of the hydrogel by adjusting the concentration of the host-guest supramolecule,and good biocompatibility. The host-guest supramolecular hydrogel also has the advantages of simple preparation process, mild conditions, effective improvement of the mechanical strength, and good application prospect in the field of tissue repair engineering.

The present invention provides supramolecular hydrogels having a three-dimensional, self-assembling, elastic, network structure comprising non-polymeric, functional molecules and a liquid medium, whereby the functional molecules are noncovalently crosslinked. The functional molecules may be, for instance, anti-inflammatory molecules, antibiotics, metal chelators, anticancer agents, small peptides, surface-modified nanoparticles, or a combination thereof. Applications of the present invention include use of the supramolecular hydrogel, for instance, as a biomaterial for wound healing, tissue engineering, drug delivery, and drug / inhibitor screening.

The invention discloses a method for in-situ preparing antibacterial supermolecule aquogel. The method comprises the following operation steps: silver nitrate crystal and polyethyleneglycol-polypropylene glycol-polyethyleneglycol triblock copolymer solution are mixed and stirred to obtain mixed solution; the steps of stirring the mixed solution for 15 minutes and ultrasonically dispersing the mixed solution for 5 minutes are alternatively carried out for 2-4 hours to obtain nano silver sol; and the nano silver sol and Alpha-cyclodextrin solution are mixed, stirred and stands at the room temperature to obtain hydrogel. The hydrogel can be used for preparing injectable drug carriers. The invention has the advantages of simple operation, adjustable gel strength and the gelation time, room temperature forming, no involvement of chemical cross linking reaction and the usage of organic solvent, favorable biocompatibility and antibacterial property of obtained gel, and the like and is prospective to be widely applied in the field of biomedical engineering materials.

The invention discloses applications of multi-component super-molecule hydrogel as a stress response material and a self-healing material. The hydrogel consists of a component with a strong hydrogen bond, a component with a weak hydrogen bond and water, wherein the component with the strong hydrogen bond is one or more of a carbon oxide nano tube, graphene oxide, carboxylic ferroferric oxide nano particles, carboxylic silver nano particles, carboxylic quantum dots, polyacrylic acid, polypropylene glycol, polyurethane, polyamide and poly(sodium-p-styrenesulfonate); and the component with the weak hydrogen bond is a small molecule compound or a macromolecular compound. The hydrogel provided by the invention simultaneously has multiple response and self-healing functions, and environment-dependent reversible adhesion behavior, and can be importantly applied to the fields of sensors, actuators, drug controlled release, self-healing materials, photo-thermal therapy, movable smart adhesion agents and artificial joints.

The invention is applicable to the technical field of hydrogel and provides an injectable cartilage repair supramolecular hydrogel and a preparation method thereof. The supramolecular hydrogel comprises acrylated beta-cyclodextrin, gelatin and chondroitin sulfate, wherein the gelatin and the chondroitin sulfate are connected through an amido bond; the acrylated beta-cyclodextrin is combined with a benzene ring in the gelatin through hydrophobic action subject and object; and the acryloyl groups of the acrylated beta-cyclodextrin form double-bond crosslinking.

The invention belongs to the fields of supramolecular polymer polymer chemistry and drop formation control, and particularly relates to supramolecular hydrogel microsphere modified with cyclodextrin water-solubility polymer and adamantine water-solubility polymer and formed by assembling subjective and objective bodies in a liquid drop, and a preparation method and application thereof. The first purpose of the invention is to provide novel supramolecular hydrogel microsphere formed by assembling subjective and objective bodies and a preparation method thereof method, the second purpose of the invention is to adopt liquid drop as a template to realize supramolecular assembly and achieve uniform particle size and controllable dimension of the supramolecular hydrogel microsphere, and the third purpose of the invention is to provide application of the type of supramolecular hydrogel microsphere in adriacin doxorubicin and taxol water-solubility antitumor drug sustained release, so as to achieve the purpose that a drug can keep a high concentration level for a long time.

The invention provides supermolecular hydrogel containing chitosan and gelatin as well as a preparation method and an application of the supermolecular hydrogel and belongs to the field of biomaterials. The supermolecular hydrogel contains a part formed by combining chitosan modified with a beta-cyclodextrin carboxylated derivative and gelatin under the host-guest interaction; chitosan is graftedwith the beta-cyclodextrin carboxylated derivative through an amide group. The preparation method comprises the steps as follows: the chitosan is grafted with the activated beta-cyclodextrin carboxylated derivative through the amide group, then, the gelatin is added, so that the grafted beta-cyclodextrin carboxylated derivative and an aromatic group of the gelatin are in host-guest interaction, and the supermolecular hydrogel containing the chitosan and the gelatin is obtained. The supermolecular hydrogel containing the chitosan and the gelatin has shear thinning and self-healing characteristics and can be used as an injectable cell or drug carrier. The beta-cyclodextrin group in hydrogel and the aromatic group in the gelatin can be used in cell carriers and tissue engineering materials through the host-guest interaction.

The invention discloses a multi-response supramolecular hydrogel factor, a hydrogel and a preparation method thereof. The method comprises the following operation steps: chemically modifying phenylalanine with activated ferrocene to obtain a ferrocene-phenylalanine hydrogel factor; and diluting a dimethylsulfoxide solution of the gel factor to 0.5%(w / v) with a PBS (phosphate buffer solution) having a pH value of 7.4, thus forming the hydrogel. The hydrogel prepared by the invention is simple and cheap, has multi-response property and simultaneously reserves the reduction-oxidation activity of ferrocene and the bioactivity of amino acid or short peptide, thus being hopefully used widely in the fields of such as medicine slow release, biosensing, response materials and the like.

The invention belongs to the technical field of hydrogel and provides injected supermolecule hydrogel and a preparing method thereof. The injected supermolecule hydrogel comprises beta-cyclodextrin, gelatin and a coupling agent. Beta-cyclodextrin and a benzene ring in gelatin are combined in a subject and object mode by means of the hydrophobicity effect. The coupling agent is a silane coupling agent containing amino and / or epoxy bonds. Gelatin and the end, containing amino or epoxy bonds, of the coupling agent form covalent cross linking. The other end of the coupling agent is subjected to self-crosslinking to form a silicon dioxide network.

Disclosed is sugar response supramolecular gel with a G-quadruplex structure. A preparation method includes: taking sugar response of 2-formylphenylboronic acid as a center; utilizing a vicinal diol structure that vernine has to react with the 2-formylphenylboronic acid to form dynamic covalent bond boron ester bond; enabling primary amine in tri(2-amino ethyl)amine and aldehyde group of the 2-formylphenylboronic acid to form dynamic imine bond; forming the G-quartet structure when potassium ions among basic groups of vernine are stable. The sugar response supramolecular gel can be used for detecting release effect of methylthionine chloride in a glucose solution and an acidic solution. The sugar response supramolecular gel and the preparation method have the advantages that the gel prepared by the method is stable, high in strength, high in sugar response performance and capable of loading a lot of macromolecular / micromolecular gel; raw materials related to the preparation method are simple, and the supramolecular gel can be prepared by utilizing micromolecules while complex synthesis steps are not needed, so that cost is low, production process is simple, products can be stored for a long time without going bad, the raw materials are low in toxicity, and the preparation method is easy to popularize and apply.

The invention belongs to the technical field of regenerative medical materials, and discloses hyaluronic acid supramolecular hydrogel for three-dimensional culture of chondrocytes, and preparation andapplication of the hyaluronic acid supramolecular hydrogel. The method comprises the following steps: with water as a reaction medium, carrying out a copolymerization reaction on methacrylic anhydride modified hyaluronic acid, a double-bond functionalized ureido pyrimidinone functional monomer and 2-(2-methoxyethoxy)ethyl methacrylate under the action of an initiating system, and carrying out subsequent treatment to obtain the hyaluronic acid supramolecular hydrogel. The hydrogel is used in the field of cartilage tissue engineering, and is used for three-dimensional culture of chondrocytes and preparation of cartilage repair materials. The hydrogel disclosed by the invention has sol-gel conversion and self-repairing properties, uniform dispersion of the chondrocytes can be easily realizedby sol at a low temperature, and the sol can undergo phase change to form gel after being conveyed to a cartilage injury part, so in-situ fixation of the chondrocytes is realized; and the formation of a dynamic three-dimensional microenvironment of the hydrogel is beneficial for the maintenance of chondrocyte functions and the secretion of cartilage characteristic matrixes.

The invention belongs to the field of a biological medical polymeric material and relates to a preparation method of biodegradable supermolecular hydrogel with high strength. The preparation method is that firstly, Pluronic block copolymer and stannous octoate are used as coinitiator to initiate Epsilon-caprolactone monomer ring-opening polymerization and acrylate or methacrylate is terminated to obtain a photopolymerisable macromonomer. Then, macromonomer solution which is mixed with micro-photo initiator is mixed with Alpha-cyclodextrin solution of certain concentration to rapidly form the precursor of supermolecular physical gel. The precursor of physical gel can rapidly form the supermolecular hydrogel with high strength in situ after the irradiation of ultraviolet. The preparation method of the invention relates no organic solvent, cross linking agent and related reaction. The preparation method is simple and can be applied rapidly. And the strength and the temperature responsive property of the supermolecular hydrogel can be regulated and controlled. The obtained biodegradable supermolecular hydrogel with high strength can be widely applied to the field of the biological medical engineering material.

The invention belongs to the field of the hydrogel material application and the technical field of novel medical materials and particularly relates to inorganic-organic hybrid three-dimensional interpenetrating network hydrogel materials and a preparation method and an application thereof. The inorganic-organic hybrid three-dimensional interpenetrating network hydrogel materials comprise inorganic material enhanced first supermolecular hydrogel and room temperature in-situ polymerized second polymer hydrogel. Polymer monomers form a second polymer hydrogel network in a first network formed by inorganic materials and dendritic polymers through in-situ polymerization to form the inorganic-organic hybrid three-dimensional interpenetrating network hydrogel and accordingly the mechanical performance of the inorganic-organic hybrid three-dimensional interpenetrating network hydrogel is high. The sol state is transformed into the gel state in the polymerization process due to the in-situ polymerization of the second polymer hydrogel network and accordingly the injection performance of the inorganic-organic hybrid three-dimensional interpenetrating network hydrogel is good. The inorganic-organic hybrid three-dimensional interpenetrating network hydrogel is of a porous microstructure and accordingly the adsorption capability or the load capacity of the inorganic-organic hybrid three-dimensional interpenetrating network hydrogel are high and X-ray developer or small molecule drugs can be loaded.

The invention relates to chiral supramolecular nucleoside hydrogel based on a boron ester bonds as well as a preparation method and application of the chiral supramolecular nucleoside hydrogel, and particularly provides supramolecular hydrogel which is obtained by mixing guanine nucleoside and borate as raw materials in a solvent, wherein the guanine nucleoside is D-guanine nucleoside and / or L-guanine nucleoside. The supramolecular hydrogel has excellent stability, injectability and self-repairability, also has good biocompatibility, does not show obvious acute toxicity in animal bodies, can be degraded in vivo, and can be used as an extracellular matrix for 3D culture of cells. The supramolecular hydrogel provided by the invention has a very good application prospect in the field of tissue engineering as a scaffold material.

The invention discloses an ultra-high-strength polyurethaneurea supermolecular hydrogel and a preparation method thereof. The method comprises the following steps: adding polyethylene glycol (PEG), polyester dihydric alcohol (PBA), a hydrophilic chain extender dihydroxymethyl butyric acid (DMBA) and diisocyanate at the same time and carrying out a reaction for a certain period of time; then carrying out chain extension by using a micromolecular chain extender, e.g., 1,4-butylene glycol (BDO); and further carrying out chain extension by using water as a chain extender so as to obtain the product ultra-high-strength polyurethaneurea supermolecular hydrogel. A mol ratio of PEG to polyester dihydric alcohol to DMBA to BDO to diisocyanate to H2O is 2.5: 2.5: 4: 5: X: X-14. The ultra-high-strength polyurethaneurea supermolecular hydrogel has ultra-high tensile strength as high as 3.3 to 34 Mpa and has tensile elongation at break of 695 to 2411%. The hydrogel has the functional characteristic of shape memory and can be used for preparing fibers through electrostatic or melt spinning.

The present invention pertains to the design and application of a supramolecular hydrogel having a three-dimensional, selfassembling, elastic, network structure comprising non-polymeric, functional molecules and a liquid medium, whereby the functional molecules are noncovalently crosslinked. The functional molecules may be, for instance, anti-inflammatory molecules, antibiotics, metal chelators, anticancer agents, small peptides, surface-modified nanoparticles, or a combination thereof. The design of the hydrogel includes: 1) modifying functional molecules to convert them into hydrogelators while enhancing or maintaining their therapeutic properties and 2) triggering -the hydrogelation process by physical, chemical, or enzymatic processes, thereby resulting in the creation of a supramolecular hydrogel via formation of non-covalent crosslinks by the functional molecules. Applications of the present invention include use of the supramolecular hydrogel, for instance, as a biomaterial for wound healing, tissue engineering, drug delivery, and drug / inhibitor screening.

The invention relates to a method for preparing magnetic DNA (deoxyribonucleic acid) supramolecular hydrogel and application thereof. The magnetic DNA supramolecular hydrogel comprises magnetic oxidized graphene and two types of DNA monomers [Y-type DNA monomers (Y-DNA) and linker DNA monomers (L-DNA)]. The Y-DNA and the L-DNA are hybridized by sticky ends in a complementary manner to form DNA hydrogel; exposed sticky ends of the DNA hydrogel are adsorbed on the surfaces of the magnetic oxidized graphene under pi-pi stacking effects to form the magnetic DNA supramolecular hydrogel. The method and the application have the advantages that the magnetic DNA supramolecular hydrogel prepared by the aid of the method is low in cost, easy to operate and separate and high in reaction speed and universality; the method can be successfully applied to colorimetry and ultraviolet-visible absorption quantitative detection on medicine carriers and adenosine triphosphate (ATP); as compared with existing detection methods, the method is easy and convenient to implement and low in cost and has a broad application prospect, visual detection results can be obtained, and complicated instruments or equipment can be omitted.

The invention discloses a super-molecular hydrogel double-medicament carrier for simultaneously loading hydrophilic and hydrophobic medicaments and a preparation method as well as application thereof. The method comprises the following operating steps of: performing chemical modification on the hydrophobic medicament by using methoxypolyethylene glycol to synthesize a water-soluble macromolecularprodrug; physically mixing prodrug molecules with the hydrophilic medicament; further mixing the mixed solution with an alpha-cyclodextrin solution and stirring; and standing at room temperature to obtain the super-molecular hydrogel double-medicament carrier for simultaneously loading the hydrophilic and the hydrophobic medicaments. The carrier has the advantages of easiness in operation, adjustable gel strength and gelation time, forming at room temperature, no chemical crosslinking reaction or organic solvent, high bioavailability, sustainable and controllable release of the medicament andthe like, and is expected to be widely applied to the field of biomedical engineering materials.

The invention discloses a supramolecular structural hydrogel gene vector material and a preparation method and application thereof. The method comprises the following operation steps: synthesizing a multi-block copolymer with cation chain segments through modification of a terminal group of triblock copolymer of a polyethylene glycol-polypropylene glycol-polyethylene glycol which is modified by polylysine; then, mixing the copolymer with DNA solution to obtain DNA compound micelle; further, mixing and then stirring the micelle solution and solution of alpha-cyclodextrin; and keeping mixed solution at the room temperature to obtain hydrogel. The hydrogel can be used for preparing an injectable gene vector. The method has the advantages that the method has simple operation, can adjust the strength of the hydrogel and the gelatination time, can mold at the room temperature and does not relate to chemical crosslinking reaction and the use of organic solvent; and the obtained hydrogel has the advantages of temperature sensitivity, good bio-compatibility, obvious transfection effect and the like; and the method is hopeful to be widely applied in the field of a biomedical engineering material.

The invention provides a medicament-supported hydrogel system, which comprises a block copolymer modified graphene and / or graphene oxide, medicinal molecules and cyclodextrin hydrogel. The invention also provides a preparation method of the hydrogel system. The preparation method comprises the following steps: (1) adding block copolymer into graphene and / or graphene oxide aqueous solution, and reacting to obtain the block copolymer modified graphene and / or graphene oxide aqueous solution; (2) adding the medicinal molecules into the aqueous solution prepared in the step (1), and supporting the medicinal molecules to the graphene and / or graphene oxide; and (3) adding the solution prepared in the step (2) into the cyclodextrin aqueous solution to obtain the medicament-supported hydrogel system. The hydrogel system provided by the invention has the characteristics of supramolecular hydrogel, and contains a graphene nano-structure in the gel structure, can be used for regulating the medicament releasing process, and has good medicament sustained-release effect.

The invention discloses supermolecular hydrogel and preparation method and application thereof. The preparation method of the supermolecular hydrogel comprises the following steps of: synthesizing a polyethylene glycol modified cation copolymer; mixing with a nucleic acid solution and standing to obtain a copolymer / nucleic acid composite solution; and finally, mixing with alpha-cyclodextrin solution, and standing to obtain the supermolecular hydrogel capable of acting on a gene vector material. In the forming process of the hydrogel disclosed by the invention, a chemical crosslinking reactiondoes not happen, and thus the influence of a byproduct of the chemical crosslinking reaction on the activity of nucleic acid is effectively avoided, an efficient gene transfer effect is realized, andthe transfection efficiency is obviously improved over the conventional gel material; and moreover, the preparation method is convenient and quick, realizes formation at room temperature, imposes relatively low requirements on concentration and temperature, and is favorable for maintaining the biological activity of embedded gene and the biocompatibility of the material.

The invention discloses an enzyme-sensitive supramolecular hydrogel nano material which is easy to synthesize, a gelator and a preparation method of the gelator. The enzyme-sensitive supramolecular hydrogel nano material is characterized in that the gelator is synthesized by simple solid-phase polypeptide synthesis and conventional liquid-phase condensation reaction; gelatinization and gel dissolution are controlled in a manner of regulating pH; and meanwhile, the gelator comprises an oligopeptide sequence for identifying specificity of caspase 3, and thus, the gelator can be cut by the caspase 3 generated in the cell apoptosis process and survival time of cells can be prolonged. Compared with a conventional supramolecular hydrogel nano material, the enzyme-sensitive supramolecular hydrogel nano material disclosed by the invention has the advantages that complex reaction conditions are not required, the gelator is simple to synthesize and the gelatinization condition is easy to control; and the enzyme-sensitive supramolecular hydrogel nano material is sensitive to the specific caspase 3 generated in the cell apoptosis process, has excellent biocompatibility for cells and can be used for detecting activity of a specific enzyme related to apoptosis on the living cell plane and assisting cells to live in the cell culture.

The invention discloses supramolecular hydrogel and also discloses a preparation method and application of the supramolecular hydrogel. The supramolecular hydrogel disclosed by the invention is prepared from a 2-deoxy-2-fluoro-guanosine analogue and silver ions. The silver-ion supramolecular antibacterial hydrogel provided by the invention has the advantages of simplicity in preparation, low toxicity, good biocompatibility, excellent stable performance and the like; the silver ions can be effectively alleviated and the antibacterial activity is good; especially, the silver-ion supramolecular antibacterial hydrogel has relatively high antibacterial activity on methicillin-resistant staphylococcus aureus ATCC25923 and ATCC33591, and fusobacterium nucleatum; the silver-ion supramolecular antibacterial hydrogel is prepared into an antibacterial material and has a relatively good application prospect.

The invention discloses application of a multi-component super-molecule hydrogel as an adhesion agent. The hydrogel consists of a component with a strong hydrogen bond, a component with a weak hydrogen bond and water, wherein the component with the strong hydrogen bond is one or more of a carbon oxide nano tube, graphene oxide, carboxylic ferroferric oxide nano particles, carboxylic silver nano particles, carboxylic quantum dots, polyacrylic acid, polypropylene glycol, polyvinyl alcohol, polyurethane, polyamide and poly(sodium-p-styrenesulfonate); and the component with the weak hydrogen bond is a small molecule compound or a macromolecular compound. When the hydrogel provided by the invention is used as an adhesion agent, the hydrogel is different from a common adhesion agent; and the adhesive power of the gel in the vertical direction is far larger than that in the tangential direction, and thus the hydrogel can play the role of bonding two bones together in an artificial joint, so that the bones can rotate freely along the tangential direction without being separated from each other.

The invention discloses a preparation method and applications of anti-cancer supramolecular hydrogel containing tyroservatide. Pentapeptide NapGDFDFDY with the D-configuration is adopted as the self-assembly gel-forming factor, anti-cancer oligopeptide YSV is bonded to the C terminal of gel pentapeptide through covalent modification, the target product NapGDFDFDYGYSV is obtained through polypeptide solid-phase synthesis, the macroscopically visible hydrogel is formed after heating-cooling, and then the anti-cancer activity of YSV is improved. The microstructure of the anti-cancer supramolecular hydrogel is composed of nanofibers, and a good inhibiting effect for various tumors including liver cancer is achieved in vitro and vivo. The preparation is simple, the yield is high, the cost is low, the biocompatibility and degradability in the body are good, and the conversion towards the clinical direction is easy. Compared with the independent anti-cancer oligopeptide YSV, the obtained nanometer material has the advantages that the capacity in resisting protease degrading and the effect in inhibiting tumor growth can be obviously improved in vitro and vivo, and the application prospectis good.

The invention discloses a hydrogel composite material for 3D printing and a preparing method and application thereof. Firstly, the invention discloses the hydrogel composite material for 3D printing.The hydrogel composite material for 3D printing is prepared from, by mass, 10-40% of PEG modified chitosan, 10-40% of gelatin and 30-60% of alpha-cyclodextrin. The invention further discloses the preparing method and application of the hydrogel composite material. When the hydrogel composite material is used for 3D printing, a dual physical crosslinking mode is adopted and involves that before printing, PEG and alpha-cyclodextrin form a supermolecule hydrogel system, and after printing, remaining aminos in chitosan and aminos and beta-sodium glycerophosphate in the gelatin form ironic crosslinking, so that the strength of a hydrogel model structure after printing is improved, and the hydrogel composite material has good printability, biocompatibility and operability.

The invention relates to the technical field of supramolecular chemistry, and discloses a preparation method of self-repairing multi-photoresponse double-layer supramolecular hydrogel, which comprisesthe following steps: (1) reacting N-isopropylacrylamide, cyclodextrin monomer and graphene oxide aqueous dispersion to obtain a hydrogel layer 1; (2) carrying out a reaction on N-isopropylacrylamide,a cyclodextrin monomer and acryloyloxyethyl trimethyl ammonium chloride to obtain a prepolymer solution of the hydrogel layer 2; and (3) injecting the prepolymer solution into a mold to obtain double-layer hydrogel, and soaking the double-layer hydrogel in an ammonium molybdate tetrahydrate solution to finally obtain the double-layer supramolecular hydrogel. According to the hydrogel, physical crosslinking is realized by utilizing host-guest interaction between cyclodextrin and N-isopropylacrylamide isopropyl, tight connection between double-layer hydrogel is also realized through host-guestinteraction, the double-layer bonding strength is high, and the hydrogel has good self-repairing performance, multiple photoresponse deformation discoloration performance and injectable performance.