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Inorganic-organic hybrid three-dimensional interpenetrating network hydrogel materials and preparation method and application thereof

A technology of interpenetrating network and organic hybridization, which is applied in the field of inorganic-organic hybrid three-dimensional interpenetrating network hydrogel materials and its preparation, and can solve problems such as side effects infection, sudden death, secondary injury, etc.

Inactive Publication Date: 2015-08-05
FUDAN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these clinical embolic agents are often accompanied by relatively serious side effects (infection, spasm) or complications (sudden death, arterial rupture or embolism recanalization), which are likely to cause serious secondary injuries

Method used

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  • Inorganic-organic hybrid three-dimensional interpenetrating network hydrogel materials and preparation method and application thereof
  • Inorganic-organic hybrid three-dimensional interpenetrating network hydrogel materials and preparation method and application thereof
  • Inorganic-organic hybrid three-dimensional interpenetrating network hydrogel materials and preparation method and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Prepare graphene oxide aqueous solution by following formula:

[0056] ①At room temperature, while stirring in 70 mL of concentrated sulfuric acid, add 3 g of graphite powder spoon by spoon;

[0057] ② Transfer the mixture to an ice bath, add 1.5 g of sodium nitrate spoon by spoon, and stir for 15 min;

[0058] ③ Continue to slowly add 9 g of potassium permanganate in the ice bath, stir for 15 min, then transfer to an oil bath at 36 °C, and react for 1 h;

[0059] ④ Slowly add 150 mL of water via dropper and stir for 15 min;

[0060] ⑤ After stirring, heat up to 90 °C, react until the solution turns yellow, transfer to a 2000 mL large beaker, add 500 mL of water and stir for 30 min;

[0061] ⑥ Add 20 mL of hydrogen peroxide with a mass fraction of 30%, let stand overnight, and settle naturally;

[0062] 7. incline supernatant liquid, be pickling 2 times with the dilute hydrochloric acid solution of 5% with mass fraction;

[0063] ⑧Wash twice with distilled water;

...

Embodiment 2

[0067] Graphene oxide reinforced interpenetrating network hydrogels were prepared by the following formula:

[0068] ① Dissolve 0.833 g of acrylamide monomer in 2.5 mL of graphene oxide solution with a concentration of 9 mg / mL, and ultrasonically homogenize it in the ice-water mixture;

[0069] ②Take 400 μL of 1 mol / L sodium hydroxide solution, 200 μL of 30 mg / mL polyamide-amine dendrimer solution, and 80 μL of 5 mg / mL N,N'- The methylenebisacrylamide solution was added to the mixed solution in the previous step one after another, and after each addition of materials, it was ultrasonically uniform in the ice-water mixture to obtain the original solution of the interpenetrating network hydrogel;

[0070] ③ Add 100 μL ammonium persulfate solution with a concentration of 250 mg / mL to the stock solution of the interpenetrating network hydrogel, stir for 30 s, then add 200 μL freshly prepared gluconolactone solution with a concentration of 200 mg / mL, stir and mix evenly, After...

Embodiment 3

[0073] Injectable graphene oxide-enhanced interpenetrating network hydrogels were prepared by the following formulation:

[0074] ① Dissolve 0.833 g of acrylamide monomer in 1.25 mL of graphene oxide solution with a concentration of 18 mg / mL and 1.25 mL of diatrizoate with a mass fraction of 76% (based on the total amount of diatrizoate and sodium diatrizoate). In the mixed solution of amine injection, ultrasonically homogenize in the ice-water mixture;

[0075] ②Take 400 μL of 1 mol / L sodium hydroxide solution, 200 μL of 30 mg / mL polyamide-amine dendrimer solution, and 80 μL of 5 mg / mL N,N'- Add the methylenebisacrylamide solution to the mixed solution in the previous step one after another, and after each addition of the material, ultrasonically homogenize it in the ice-water mixture to obtain the injection-type interpenetrating network hydrogel stock solution;

[0076] ③Add 100 μL ammonium persulfate solution with a concentration of 250 mg / mL to the stock solution of t...

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Abstract

The invention belongs to the field of the hydrogel material application and the technical field of novel medical materials and particularly relates to inorganic-organic hybrid three-dimensional interpenetrating network hydrogel materials and a preparation method and an application thereof. The inorganic-organic hybrid three-dimensional interpenetrating network hydrogel materials comprise inorganic material enhanced first supermolecular hydrogel and room temperature in-situ polymerized second polymer hydrogel. Polymer monomers form a second polymer hydrogel network in a first network formed by inorganic materials and dendritic polymers through in-situ polymerization to form the inorganic-organic hybrid three-dimensional interpenetrating network hydrogel and accordingly the mechanical performance of the inorganic-organic hybrid three-dimensional interpenetrating network hydrogel is high. The sol state is transformed into the gel state in the polymerization process due to the in-situ polymerization of the second polymer hydrogel network and accordingly the injection performance of the inorganic-organic hybrid three-dimensional interpenetrating network hydrogel is good. The inorganic-organic hybrid three-dimensional interpenetrating network hydrogel is of a porous microstructure and accordingly the adsorption capability or the load capacity of the inorganic-organic hybrid three-dimensional interpenetrating network hydrogel are high and X-ray developer or small molecule drugs can be loaded.

Description

technical field [0001] The invention belongs to the application field of hydrogel materials and the technical field of new medical materials, and specifically relates to an inorganic-organic hybrid three-dimensional interpenetrating network hydrogel material and a preparation method and application thereof. Background technique [0002] In vascular interventional therapy, the embolization of target blood vessels by injection of embolic agents has been widely used because of its safety and high efficiency, such as hemostasis, vascular injury repair, tumor treatment, organ resection, blood redistribution, etc. [0003] As an important means to enhance the mechanical strength of hydrogels, the interpenetrating network structure has gained extensive attention. The interpenetrating network was first described by Alysworth in 1914, and a concept proposed by Millar in 1960, which is defined as a network formed by two or more networks that are at least partially interwoven through n...

Claims

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Application Information

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IPC IPC(8): A61L31/04A61L31/02A61L31/14A61L31/18C08F220/56C08F2/44
Inventor 易涛朱巍陈黎明周峰
Owner FUDAN UNIV
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