Injected supermolecule hydrogel and preparing method thereof

Abstract

The invention belongs to the technical field of hydrogel and provides injected supermolecule hydrogel and a preparing method thereof. The injected supermolecule hydrogel comprises beta-cyclodextrin, gelatin and a coupling agent. Beta-cyclodextrin and a benzene ring in gelatin are combined in a subject and object mode by means of the hydrophobicity effect. The coupling agent is a silane coupling agent containing amino and / or epoxy bonds. Gelatin and the end, containing amino or epoxy bonds, of the coupling agent form covalent cross linking. The other end of the coupling agent is subjected to self-crosslinking to form a silicon dioxide network.

Description

technical field [0001] The invention belongs to the field of hydrogel technology, in particular to an injectable supramolecular hydrogel and a preparation method thereof. Background technique [0002] Cartilage defect is a common clinical orthopedic disease, arthroscopy found that about 60% of the joints have cartilage defects. If not treated in time, 60%-75% of the lesions can progressively develop into osteoarthritis, seriously affecting the patient's motor function, and even ending his career. Since articular cartilage is not vascularly innervated, its regenerative capacity is very limited. Therefore, in the fields of biomaterials and medicine, cartilage defect repair has always been a research hotspot. So far, cartilage defect repair has not been effectively solved. As the gold standard for the treatment of articular cartilage defects, autologous chondrocyte transplantation has been recognized by scholars, but there are problems such as limited source of seed cells an...

AI Technical Summary

Problems solved by technology

However, due to the limitations of FTIR technology, the results cannot directly prove the occurrence of the hybridization reaction, and the material is only prepared into a two-dimensional structure, and the research is still in the preliminary stage of exploratory research.

However, most foreign studies only predict the molecular structure of the hybrid they prepared, and only use FTIR to detect the type of covalent bond, which cannot verify the inorganic-organic hybrid mechanism of the hybrid

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