1107 results about "Polyethylene glycol monomethyl ether" patented technology

The invention relates to an amphiphilic block copolymer and a preparation method thereof, and a micelle drug delivery system formed by the copolymer and an anti-tumor drug. The amphiphilic block copolymer comprises a hydrophilic chain segment and a hydrophobic chain segment, and the end of the hydrophobic chain segment is sealed by hydrophobic radicals. According to the amphiphilic block copolymer disclosed by the invention, methoxy polyethylene glycol (or polyethylene glycol)-polyester segmented copolymer with generally recognized safety is taken as a base material, and terminated hydroxyl hydrophobic radicals of the polyester chain segment are modified, thus the compatibility of hydrophobic chain segments in drug molecules and segmented copolymers is improved, and mutual acting force is increased; through a self-assembling method, the drug can be solubilized in micelle hydrophobic cores of the amphiphilic block copolymer, and the drug molecules are limited in the micelle cores so as not to be likely to be dissolved out, thus drug delivery micelle with high stability is obtained.

The invention relates to a crude oil demulsifier, and discloses a natural polysaccharide macromolecule-modified crude oil demulsifier. The demulsifier is prepared by adopting the following operation steps: (1) conducting halogenation modification, carboxylation modification, amination modification, formylation modification, or isocyanic acid esterification modification on polyethylene glycol monomethyl ether; (2) preparing glycidyl dimethyl alkyl ammonium chloride; (3) preparing quaternized polysaccharide; and (4) reacting the modified polyethylene glycol monomethyl ether with quaternized polysaccharide to obtain a product, namely the natural polysaccharide macromolecule-modified crude oil demulsifier. According to the crude oil demulsifier, as the raw material, the natural polysaccharide macromolecule compound has multiple advantages of being wide in source, natural, non-toxic, sustainable, good in usage safety and the like; and the prepared demulsifier has good demulsifying and dewatering effects; in addition, the molecules of the demulsifier contain a great deal of groups of hydroxyl and the like, which have certain chelating capability to metal ions, thus being capable of removing a certain amount of metal ions while demulsifying.

The invention relates to a polyvinyl alcohol-polypeptide-polyethylene glycol graft copolymer and a preparation method thereof. The molecular weight of polyvinyl alcohol is 20,000-80,000; the molecular weight of a polypeptide chain segment is 4,000-8,000; and the molecular weight of a polyethylene glycol chain segment is 350-750. The preparation method comprises the following steps of: (1) synthesizing a polypeptide homopolymer which contains an end-NCO radical: adding the polypeptide homopolymer, diisocyanate, dibutyltin dilaurate serving as a catalyst and dimethyl sulfoxide serving as a solvent into a reactor for reacting to obtain a target product; (2) synthesizing a polyvinyl alcohol-polypeptide graft copolymer: adding the polypeptide homopolymer which contains the end-NCO radical, the solvent and the catalyst into the reactor, adding polyvinyl alcohol and reacting to obtain a target product; and (3) synthesizing a polyvinyl alcohol-polypeptide-polyethylene glycol graft copolymer: adding the polyvinyl alcohol-polypeptide graft copolymer, the solvent and the catalyst into a drying reactor, adding polyethylene glycol monomethyl ether and reacting to obtain a target product.

The invention belongs to the nanotechnical field, and discloses preparation of a methoxy polyethylene glycol-poly(lactic-co-glycolic acid)-polylysine(mPEG-PLGA-PLL) cationic polymer nano-drug delivery system and application thereof. The nano-drug delivery system can have multi-functional characteristics such as tumor targeting, reversing drug resistance and medical diagnosis functions through modification, and can be used for supporting organic medicaments, water-soluble medicaments, non-water-soluble medicaments, or developers for diagnosis. The preparation method is simple and convenient, is suitable for mass production, and is particularly suitable for the preparation of targeting drug delivery systems.

The invention relates to a preparation method for a chitosan natural polymer modified crude oil desalting demulsifier. The method comprises the following steps: 1) modifying polyethylene glycol monomethyl ether by halogenating; 2) preparing glycidyl dimethyl alkyl ammonium chloride; 3) preparing quaternized carboxy alkyl chitosan; 4) causing the modified polyethylene glycol monomethyl ether to react with the quaternized carboxy alkyl chitosan, thereby obtaining a target product, polyethylene glycol monomethyl ether grafted quaternized carboxy alkyl chitosan. According to the invention, the chitosan natural high-molecular compound is taken as the raw material and has the advantages of wide resource, naturality, non-toxicity, sustainability, excellent biological compatibility of products, degradability, and the like. The demulsifier prepared according to the invention has excellent demulsification dewatering effect; the molecule of the demulsifier contains a large amount of carboxy alkyl groups and quaternary ammonium salt groups and the electronegative ions, including metal cation, naphthene acid radicals, and surfaces are electronegative grains and have strong combining capacity, so that the demulsifier has the capacities of demulsifying while removing oil-soluble salt.

The invention discloses a nonionic waterborne polyurethane dispersoid and a preparation method thereof. The dispersoid is mainly made from raw materials of A) diisocyanate, B) one or more than two polyols containing at least two hydroxy groups, wherein number average molecular weight of the polyols is 1000-4000, C) a small molecule chain extender and / or a small molecule cross-linking agent, D) methoxy polyethylene glycol with medium-low molecular weight, and E) one or more than one polyamines with number average molecular weight smaller than 500. According to the invention, the prepared dispersoid is with a small particle size, has long storage time and has great stabilities of acid tolerance, alkali tolerance and salt tolerance, and the like.

The invention relates to a preparation method of a polyether-grafted chitosan derivative crude oil desalting demulsifier. The preparation method comprises the following specific steps: firstly, performing formylation modification on polyethylene glycol monoethylether; secondly, preparing glycidyl dimethyl alkyl ammonium chloride; thirdly, preparing quaternarization carboxyalkyl chitosan; fourthly, enabling formylation modified polyethylene glycol monoethylether to react with carboxy alkyl chitosan to obtain the polyether-grafted chitosan derivative crude oil desalting demulsifier. The polyether-grafted chitosan derivative crude oil desalting demulsifier disclosed by the invention is prepared by taking chitosannatural polymeric compounds as raw materials, and has the advantages of wide sources, naturalness, no toxicity, sustainability, good biocompatibility of a product, degradability and the like. The prepared demulsifier is good in demulsifying and dehydrating effect; meanwhile, a demulsifying molecule contains a large amount of carboxyalkyl groups and quaternary ammonium salt groups which have strong combining capacity to metal cation, ions with negative electricity such as naphthenic acid radicals as well as particles of which the surfaces are electronegative, so the polyether-grafted chitosan derivative crude oil desalting demulsifier has capacity of removing oil-soluble salts while demulsifying.

The invention discloses an ester slump retaining type polycarboxylate water reducer and a preparation method thereof. The ester slump retaining type polycarboxylate water reducer is made from raw materials comprising the following components in parts by weight: 100 parts of esterified macromer solution by weight, 2-6 parts of unsaturated monomer by weight, 1.5-4 parts of unsaturated phosphate by weight, 1-4 parts of an oxidizing agent by weight, 0.9-3.5 parts of a reducing agent by weight, 1-3 parts of a chain transfer agent by weight, 108 parts of water by weight, and 20 parts of industrial sodium hydroxide solution by weight, wherein the concentration of the esterified macromer solution is 75-85%, and a solute thereof is the mixture of methoxy polyethylene glycol methacrylate, crosslinking monomers triethylene glycol dmethylacrglate and methyl methacrylate; the unsaturated monomer is methacrylic acid, acrylic acid, hydroxyethyl methylacrylate, hydroxyethyl acrylate, hydroxypropyl methacrylate or hydroxypropyl acrylate. The ester slump retaining type polycarboxylate water reducer provided by the invention has good slump retaining performance, good dispersibility, good adaptability and low cost.

The invention relates to a preparation method of an efficient crude oil desalting demulsifier. The preparation method comprises the following specific steps: (1) performing isocyanic acid esterification modification on methoxy polyethylene glycol; (2) preparing glycidyl dimethyl alkylammonium chloride; (3) preparing quaternized carboxyalkyl chitosan; (4) modifying the methoxy polyethylene glycol and the quaternized carboxyalkyl chitosan for reaction to obtain a target product, namely, methoxy polyethylene glycol-grafted quaternized carboxyalkyl chitosan. By taking chitosan type natural macromolecular compounds as raw materials, the efficient crude oil desalting demulsifier has many advantages of wide availability, nature, nontoxicity, sustainability, high biocompatibility, degradability and the like. The prepared demulsifier is good in demulsifying and dehydration effect; meanwhile, molecules of the demulsifier contain a large quantity of carboxy alkyl groups and quaternary ammonium salt groups, so that the demulsifier is extremely high in combination capacity for negatively charged ions such as metal cations and naphthenic acid radicals, and particles with electronegativity on the surfaces, and can remove oil-soluble salt during dehumidification.

The invention relates to a synthesis method of a crude oil desalting demulsifying agent. The method specifically includes the steps of firstly, conducting p-nitrophenyl ester modification on methoxypolyethylene glycol; secondly, preparing glycidyl dimethyl alkyl ammonium chloride; thirdly, preparing quaternized carboxy alkyl chitosan; fourthly, making the modified methoxypolyethylene glycol react with quaternized carboxy alkyl chitosan to obtain a product, namely polyethylene glycol questin grafted quaternized carboxy alkyl chitosan. A chitosan type natural high-molecular compound serves as the raw material and has the advantages of being wide in resource, natural, free of toxin, sustainable, good in product biocompatibility, degradable and the like; The prepared demulsifying agent is good in demulsifying dewatering effect; meanwhile, due to the fact that lots of carboxy alkyl groups and quaternary ammonium salt groups are contained in demulsifying agent molecules and have strong binding capacity with metal cations, naphthenic acid radicals and other ions with negative charges and particles with surface electronegativity, the oil-soluble salt removing capacity is achieved during demulsifying.

The invention relates to a preparation method of a double-ion type crude oil desalting demulsifier. The preparation method specifically comprises the following steps: (1) carrying out esterification modification on polyethylene glycol monomethyl ether; (2) preparing glycidyl dimethyl alkyl ammonium chloride; (3) preparing quaternary ammonium carboxymethyl chitosan; (4) making the modified polyethylene glycol monomethyl ether react with the quaternary ammonium carboxymethyl chitosan to obtain a polyethylene glycol monomethyl ether grafted quaternary ammonium carboxymethyl chitosan. The double-ion type crude oil desalting demulsifier takes natural macromolecular compounds of chitosan as raw materials, thereby having many advantages of wide sources, naturalness, no toxicity, sustainability, good product bio-compatibility and degradation and the like. The prepared demulsifier is good in demulsification and dehydration effects, furthermore, demulsifier molecules contain a large number of carboxyl alkyl groups and quaternary ammonium salt groups, so that the demulsifier has a very strong binding capacity for negatively charged ions such as metal cations, naphthenic acid radicals and particles of which the surfaces are electronegative, thereby further having the removal ability for oil soluble salts while performing demulsification.

The invention relates to a water reducing agent with high efficiency used in polycarboxylate concrete and a synthetic method thereof, which is characterized in that: plyethylene glycol methylacrylic acid single armor esterification (MPEGMA) macromonomer synthesized by (methyl) acrylic and polyethylene glycol monomethyl ether added with catalyst and other (methyl) acrylic or (methyl) allyl sodium monomer are grafted and copolymerizated to synthesize into binary or polybasic copolymer comprising carboxyl, sulfonic group and polyoxyethylene chain side under the effect of initiator and chain transfer agent. The products synthetically prepared by the invention has the advantages of high water reducing ratio, low chlorine and low alkali; the cement mixture is high in fluidity and good in mixability, and can restrain slump loss effectively, when 0.7 to 1.2 percent by weight of cement material is added. The water reducing agent with high efficiency used in polycarboxylate concrete is simple in technology, easy in control of reaction condition and reasonable in cost, does not pollute environment, and can be used as the important component of high performance concrete, marine concrete, nuclear power station concrete and anticorrosion concrete and is widely used in the field of industry, civil building, water conservancy, road traffic and nuclear power engineering.

The invention relates to a method for preparing comb-shaped polymer crude oil desalting demulsifier. The method comprises the following steps: (1) performing acrylatioed modification on methoxy polyethylene glycol; (2) preparing glycidyl dimethyl alkyl ammonium chloride; (3) preparing quaternized carboxyalkyl chitosan; (4) reacting modified methoxy polyethylene glycol with quaternized carboxyalkyl chitosan to obtain the target product demulsifier. The demulsifier is prepared by using chitosan naturalpolymer compounds as raw materials, and has the advantages of wide source, nature, no toxicity, sustainability, good product biocompatibility, degradability and the like. The prepared demulsifier has good demulsification and dehydration effect since the molecular structure is a comb-shaped polymer formed by simultaneously grafting a plurality of linear branched chains on a main chain, and has a strong binding capability on metal cations, naphthenate radicals and other negatively charged ions and particles which are electronegative on surfaces since a great amount of carboxyalkyl groups and quaternary ammonium salt groups on the molecules. Therefore, the demulsifier has capabilities of demulsifying and removing oil-soluble salt.

The invention relates to a preparation method of a polyelectrolyte-type crude oil-desalting demulsifier. The preparation method comprises the following specific steps: (1) performing amination modification on methoxypolyethylene glycol; (2) preparing glycidyl dimethyl alkyl ammonium chloride; (3) preparing quaternized carboxyalkyl chitosan; (4) carrying out a reaction between the modified methoxypolyethylene glycol and the quaternized carboxyalkyl chitosan to obtain a target product methoxypolyethylene glycol-grafted quaternized carboxyalkyl chitosan. The polyelectrolyte-type crude oil-desalting demulsifier takes a natural macromolecule chitosan compound as a raw material, and has the advantages of wide sources, naturalness, non-toxicity, sustainability, good product biocompatibility, biodegradability and the like. The prepared demulsifier has good demulsifying and dehydrating effects; a demulsifier molecule contains a large number of carboxyalkyl groups and quaternary ammonium groups, which have very strong capacity of bonding metal cations, negatively-charged ions such as naphthenic acid radicals, and particles with negative charges on the surfaces, so that besides the demulsifying capability, the demulsifier also has the capability of removing oil-soluble salts.

The invention relates to a method for functionalizing a polymer on the surface of nano graphene oxide. The method comprises the following specific steps: preparing graphene oxide from natural graphite powder by an improved Hummers method, utilizing methoxy polyethylene glycol and pyrene acids to carry out esterification to generate polyethylene glycol with pyrenyl as the terminal group, and finally grafting the polyethylene glycol with pyrenyl as the terminal group on the surface of graphene oxide through pi-pi interaction between pyrenyl and the surface of graphene oxide, thus obtaining the graphene oxide with the functionalized polymer on the surface. The solubility of the prepared graphene oxide with the functionalized polymer on the surface is greatly improved. The method has the following advantages: a main process adopted in the experiment is as follows: a polymer with a complex structure is designed and prepared in advance and then is grafted on the graphene oxide, and the grafting reaction can be carried out at normal temperature and pressure, so the whole experiment process is very simple and convenient. Therefore, the study provides a direct method for modifying the graphene oxide and preparing the functionalized graphene oxide-polymer complex to form a new inorganic-organic hybrid material, thereby promoting the development and application of graphene oxide-based materials.

The invention discloses an amphiphilic polymer pigment wetting dispersant for a water-based coating and a preparation method thereof, and the preparation method comprises the following steps: polymerizing macromer or polyethylene glycol methyl ether methacrylate macromer with polymerizable double bonds with one or two hydrophobic (methyl) polyacrylate monomers in the presence of ARGET ATRP (activators regenerated by electron transfer-atom transfer radical polymerization) to obtain a comb-shaped polymer, and further introducing an anchoring functional group in the comb-shaped polymer for preparing the solid wetting dispersant; or polymerizing the macromer or the polyethylene glycol methyl ether methacrylate macromer with the polymerizable double bonds with the (methyl) polyacrylate monomer with the anchoring functional group in the presence of ARGET ATRP to obtain the comb-shaped polymer which is the solid wetting dispersant. By using the preparation method, the cost can be greatly reduced, the efficiency is improved, and the performances of the product can be greatly improved. The obtained wetting dispersant has good dispersion effect and bright color, and the stability of a dispersion system is high.

The invention which relates to a preparation method of an amphiphilic segmented copolymer belongs to the field of chemical engineering materials. According to the method, polyethylene glycol monomethyl ether with the molecular weight of 200-5000 and alpha-halogenated acyl halide undergo an esterification reaction to obtain a hydrophilic macromolecular initiator; and the segmented copolymer with controllable molecular weight and narrow molecular weight distribution (PDI is equal to or less than 1.5) is obtained by catalyzing ARGET ATRP of a (methyl) acrylic acid ester monomer, a fluorine-containing (methyl)acrylic acid ester monomer or a styrene monomer with the hydrophilic macromolecular initiator as an initiator and a low concentration oxidation state transition metal salt as a catalyst in the presence of an organic reductant. Compared with common atom free radical polymerization methods, the novel atom free radical polymerization method allows the catalyst consumption amount to be less, the sensitivity to a small amount of water and air to be reduced, the obtained polymer to be almost colorless, post-treatment steps to be reduced, even omitted, the production cost to be reduced, and industrialization production requirements to be better satisfied.

The invention provides a copolymer with a structure of a formula (I), a preparation method thereof, glucose sensitive micelle containing the same, glucose sensitive medicine-carrying micelle containing the same and a preparation method of the glucose sensitive medicine-carrying micelle. The copolymer provided by the invention comprises a polyethylene glycol monomethyl ether hydrophilic chain segment and a polyglutamic acid hydrophobic chain segment, wherein the polyglutamic acid hydrophobic chain segment takes polyglutamic acid as a main chain and the branch chain contains phenylboric acid groups. In the copolymer, both polyethylene glycol monomethyl ether and the polyglutamic acid have good biocompatibility, the polyglutamic acid has good biodegradability, the carboxyl group has pH sensitivity, and the phenylboric acid group has glucose sensitivity. The copolymer provided by the invention has good biocompatibility, biodegradability, glucose sensitivity and pH sensitivity.

The invention discloses a method for synthesizing poly (ethylene glycol) methyl ether methacrylate. Methyl methacrylate and PGME are synthesized to generate the poly (ethylene glycol) methyl ether methacrylateby through the ester exchange reaction. The catalyst used in the ester exchange reaction is a base catalyst and has high catalytic activity; an inhibitive substance is added in the reaction system to avoid the polyreaction in the process of reaction and air is put into the reaction system; the reaction temperature is moderate and is between 80 and 85 DEG C; the reaction side product of methanol and a reaction medium form an azeotrope which is taken out of the reaction system, thereby ensuring that the reaction is done completely. The method quantificationally converts the PGME into the poly (ethylene glycol) methyl ether methacrylate, has esterification rate close to 100 percent, avoids the polyreaction and other side reactions, has simple steps and is suitable for the industrial production.

The invention discloses a preparation method of a polylactic acid glycollic acid-polypeptide-polyethylene glycol diblock-grafted copolymer. The method comprises the following steps: 1, adding a polypeptide homopolymer, diisocyanate, a catalyst and a solvent to a dry reactor, reacting in an inert atmosphere under stirring at 50-55DEG C for 40-60min, and removing excess diisocyanate through a dialysis process to obtain a terminal -NCO group-containing polypeptide homopolymer; 2, adding the terminal -NCO group-containing polypeptide homopolymer, the catalyst and the solvent to the dry reactor, adding polylactic acid glycollic acid monolauryl ether, reacting in an inert atmosphere under stirring at 50-55DEG C for 50-70min to obtain a polylactic acid glycollic acid-polypeptide diblock copolymer; and 3, adding the polylactic acid glycollic acid-polypeptide diblock copolymer, a catalyst and the solvent to the dry reactor, adding polyethylene glycol monomethyl ether, and reacting in an inert atmosphere under stirring at 55-58DEG C for 2-4d to obtain the polylactic acid glycollic acid-polypeptide-polyethylene glycol diblock-grafted copolymer. The preparation method is simple.

The invention relates to nonionic self-emulsifying waterborne epoxy resin and a preparation method and application thereof. The nonionic self-emulsifying waterborne epoxy resin is prepared by the following steps of: mixing 15 to 55 parts of diisocyanate, 70 to 150 parts of polyethylene glycol monoethylether and 4 to 10 parts of an acetyl chloride acetone solution together in parts by mass, and then reacting at 35 to 65 DEG C for 1 to 5 hours; and adding 100 to 300 parts of epoxy resin into the mixed system, adding 0.5 to 5 parts of a catalyst into the mixed system, and reacting at 40 to 85 DEG C for 1 to 5 hours after mixing. The invention also provides a method for preparing the waterborne epoxy resin into a waterborne epoxy varnish. According to the nonionic self-emulsifying waterborne epoxy resin, after a polyethylene glycol monomethyl ether chain is introduced into a segment, alkaline water or volatile organic weak monoacid is not needed to be added, so that the application range of an emulsion is wide, and the emulsion is easy to prepare; and after crosslinking curing of the emulsion, the network chain molecular weight is improved, the crosslinking density is reduced, and a formed coating film is toughened.

The invention discloses a preparation method of a poly-carboxylic acid water reducing agent with high performance, the water reducing agent is made in simple process with low mixing amount and high dispersive property. The technical proposal is as the follow: A) methacrylic acid and methoxy polyethylene glycol with a mole ratio of 1 to 1.2: 1 are put into a reactor with catalyst, polymerization inhibitor and water carrying agent being added to be mixed and heated to 100 to 150 DEG C and kept reacting within 8 to 12 hours to obtain polyoxyethylene methacrylate; B) water and initiator are added into the reactor, then a mixing solution containing sodium allylsulfonate, the polyoxyethylene methacrylate and the methacrylic acid is added drop by drop slowly into the reactor, wherein the weight proportion of the water and the mixing solution is 2: 1 to 1.2, the solution is mixed and heated to the temperature of 80 to 120 DEG C. Chain transfer agent is added after reaction of 4 to 6 hours and the adding drop by drop being finished, and the solution is discharged after being kept mixing with heat preserved for 1 to 2 hours, the poly-carboxylic acid water reducing agent with high performance is obtained.

The invention provides a paclitaxel polymer micelle drug-loading system. The polymer is an amphiphilic block copolymer, optimally methoxy polyethylene glycol-poly(D,L) lactide, which is subjected to cationic exchange resin treatment and low in tin content (less than 100ppm); the paclitaxel and the methoxy polyethylene glycol-poly(D,L) lactide are dissolved in an organic solvent and concentrated until being dry, and the residue is hydrated to obtain the micelle; the obtained micelle is lyophilized to obtain lyophilized powder. According to the micelle, the polymer is refined (cationic exchange resin treatment), so that the content of tin in the polymer due to introduce of a catalyst is remarkably reduced, and the grain diameter stability of the paclitaxel polymer micelle prepared from the refined methoxy polyethylene glycol-poly(D,L) lactide is remarkably improved.

The invention belongs to the filed of biopolymer material synthesis, relates to a preparation method of a polyethylene glycol monomethyl ether-dl-polylactic acid block copolymer. The method includes the following steps of: adding a solvent with volume more than 3-6 times of total weight of reagents into a dried reactor, adding stannous octoate as a catalyst, and polyethylene glycol monomethyl ether and dl-lactide whose weight ratio is in the range of 65:35 to 20:80, introducing nitrogen, removing air, then heating and reacting, pouring a product into a compound of petroleum ether-carbon dioxide dry ice, simultaneously, violently stirring, obtaining the needed product after drying a white filtered solid in a vacuum drying oven. The new-type solvent is used in the invention, and a novel purification processing method is provided and is simple and easily controlled, the copolymer with a certain amount of molecular weight can be synthesized according to the specified requirement, and the requirement of further producing a pharmaceutical preparation is met.

The invention discloses a preparation method of a novel polycarboxylic acid type water-reducer. The novel polycarboxylic acid type water-reducer is prepared by the following steps: 1) a unsaturated acid monomer and an amine unsaturated monomer react under the action of a chain transfer agent, an initiator and a reducing agent to obtain a copolymer containing an amino group; 2) excessive diisocyanate is dropwise added into methoxy polyethylene glycol to react under the action of a catalyst so as to obtain methoxypolyethylene glycol mono-isocyanate; 3) the copolymer containing the amino group is added into the methoxypolyethylene glycol mono-isocyanate to react and then pH value is adjusted so as to obtain a novel polycarboxylic acid water-reducer. According to the method, product performance is adjusted by controlling molecular structure / molecular weight of the amine copolymer and molecular weight of methoxy polyethylene glycol. Reactions are fast and efficiency is high. In addition, no organic solvent is used; the water-reducer is nontoxic and pollution-free; and operation is simple. The polycarboxylic acid type water-reducer prepared by the method is a functional polycarboxylic acid type high-efficiency water-reducer, and product performance is stable.

The invention relates to a preparation method of a mud-resistant type polycarboxylate superplasticizer. First, polyethylene glycol monomethyl ether and acrylic acid are used as raw materials and synthetized into polyethylene glycol monomethyl ether methyl acrylate. Then, the prepared polyethylene glycol monomethyl ether methyl acrylate is copolymerized with mixed liquid which is made from the acrylic acid and diacrylamide sodium dimethallyl sulphonate and mixed liquid which is made from ammonium persulfate and mercaptoethanol, alkaline compounds are added to regulate a pH value to 7-8 after reaction, and the mud-resistant type polycarboxylate superplasticizer is obtained. In the preparation method, technical parameters and conditions, such as raw material ratio, the used amount of chain transfer agents and initiators, copolymerization temperature, time and the like are determined. The reaction conditions are mild, the adopted equipment is simple, the equipment investment is small, the technology is reasonable, and the operation is simple and favorable for industrial production.

The invention discloses a method for preparing a polypeptide-polylactic acid-polyethyleneglycol dual-graft copolymer. The method is characterized in that the molecular weight of a polypeptide chain segment in the copolymer is 20000-50000; the molecular weight of a polylactic acid chain segment is 1000-2000; and the molecular weight of a polyethylene glycol chain segment is 500-700. The preparation method comprises the following steps of: 1) synthesizing a polypeptide-polylactic acid graft copolymer, namely, adding a polypeptide homopolymer, polylactic acid lauryl ether, a solvent and a catalyst to a dry reactor, stirring and reacting for 3-4 days under an inert atmosphere at 55-58 DEG C, so as to prepare the target in manners of filtering, dialyzing and drying; and 2) synthesizing the polypeptide-polylactic acid-polyethyleneglycol dual-graft copolymer, namely adding the polypeptide-polylactic acid copolymer, the catalyst, the solvent and the methoxy polyethylene glycol to the dry reactor, stirring and reacting for 2-3 days under the inert atmosphere at 55-59 DEG C, so as to obtain the target in manners of filtering, dialyzing and drying. The method is simple in process; and the obtained target is a novel biodegradable material.

The invention relates to an ultra-hydrophobic nanometer SiO2 / high polymer complex film and a preparation method thereof. The method comprises the following steps: carrying out an ester exchange reaction of MPEG and PEDS to synthesize an MPEG-g-PEDS graft polymer; adding a certain amount of water to the MPEG-g-PEDS graft polymer for a solation-gelation reaction; then, grinding and pulverizing gel, dispersing the gel powder as a filling to a high polymer solution; and coating the solution on a basal material and drying to form a film. The complex film is soaked in a water / alcohol solution, uses a surface dressing agent for the self assembly of surface molecules, uses normal hexane to wash away residual liquid and is dried so as to obtain the ultra-hydrophobic nanometer SiO2 / high polymer complex film.

The invention discloses a preparation method of polycarboxylic acids high efficiency water reducer, which includes steps of firstly synthesizing methoxypoly(ethylene glycol) monomethyl ether acrylate large monomer from methoxypoly(ethylene glycol) monomethyl ether and crylic acid which are used as raw materials, then copolymerizing the esterified large monomer and the acrylic acid to prepare the polycarboxylic acids high efficiency water reducer. In the synthesis of the esterified large monomer, hydroquinones and hydroquinone monomethyl ether are employed to coordinatedly blocking polymerization, thereby reducing failure ratio of unsaturated double bond, increasing effective content of the synthesized water reducer, increasing concrete water reducing ratio, and increasing slump retaining performance.

The invention belongs to the field of medical technology, relates to a high-stability polyethylene glycol-polyester polymer and an application thereof, and particularly relates to an amphiphilic block copolymer having a hydrophilic block and a hydrophobic block with terminal hydroxyl, wherein the terminal hydroxyl of the hydrophobic block is replaced by a cholic acid group. The hydrophilic A block is any one of ethylene glycol monomethyl ether, polyethylene glycol, polyvinyl alcohol and polyvinylpyrrolidone; the hydrophobic B block is any one of polylactide, polylactide-co-glycolide, polyglycollide, polycaprolactone, polylactide-co-caprolactone, polyglycollide-co-caprolactone and polylactide-co-glycolide-cocaprolactone. The polymer provided by the invention can spontaneously form high-stability micelle in a waterborne medium, and can be used as a carrier of various water-insoluble drugs.