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Preparation method of polylactic acid glycollic acid-polypeptide-polyethylene glycol diblock-grafted copolymer

A technology of poly(lactic-co-glycolic acid) and di-block copolymer, which is applied in the field of biodegradable polymer material preparation, and achieves the effect of simple preparation process

Inactive Publication Date: 2013-07-31
SHANDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This diblock-graft copolymer has not been reported in the literature at present

Method used

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  • Preparation method of polylactic acid glycollic acid-polypeptide-polyethylene glycol diblock-grafted copolymer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1, adopt the following steps:

[0022] 1) Synthesis of Polypeptide Homopolymers Containing Terminal-NCO Groups:

[0023] Add 15 grams of poly(γ-benzyl-L-glutamate) with a molecular weight of 10,000, 4 grams of 2,4-toluene diisocyanate and 250 ml of dimethyl sulfoxide solvent into the dry reactor, and add the above Dibutyltin dilaurate with a total reactant weight of 3‰, under an inert atmosphere, stirred and reacted at 50° C. for 40 minutes, terminated the reaction, removed excess diisocyanate by dialysis to obtain the target object, and the molecular weight of the target object was 10174;

[0024] 2) Synthesis of poly(lactic-co-glycolic acid-polypeptide diblock copolymer):

[0025] Add 10 grams of poly(γ-benzyl-L-glutamate) containing terminal -NCO groups, 30 grams of polylactic acid with a molecular weight of 2000 and a ratio of lactic acid and glycolic acid of 75 / 25 to the dry reactor Glycolic acid monolauryl ether and 300ml dimethyl sulfoxide solvent, a...

Embodiment 2

[0031] 1) Synthesis of Polypeptide Homopolymers Containing Terminal-NCO Groups:

[0032] Add 14 grams of poly(γ-ethyl-L-glutamate) with a molecular weight of 15,000, 3.2 grams of 2,4-toluene diisocyanate and 200 ml of dimethyl sulfoxide solvent into the dry reactor, and add the above reaction Dibutyltin dilaurate with a total weight of 4‰, under an inert atmosphere, stirred and reacted at 52° C. for 50 minutes, terminated the reaction, removed excess diisocyanate by dialysis to obtain the target object, and the molecular weight of the target object was 15174;

[0033] 2) Synthesis of poly(lactic-co-glycolic acid-polypeptide diblock copolymer):

[0034] Add 9 grams of poly(γ-ethyl-L-glutamate) containing terminal -NCO groups, 29.5 grams of poly(lactic acid ethanol) with a molecular weight of 2500 and a ratio of lactic acid and glycolic acid of 75 / 25 to the dry reactor Acid monododecyl ether and 290ml of 1,1,2-trichloroethane solvent, then add dibutyltin dilaurate with a total ...

Embodiment 3

[0039]1) Synthesis of Polypeptide Homopolymers Containing Terminal-NCO Groups:

[0040] Add 12 grams of poly(γ-methyl-L-glutamate) with a molecular weight of 20,000, 2.5 grams of 2,4-toluene diisocyanate and 190 ml of dimethyl sulfoxide solvent into a dry reactor, and add the above reaction Dibutyltin dilaurate of total weight 5‰, under an inert atmosphere, stirred and reacted at 55° C. for 60 minutes, terminated the reaction, removed excess diisocyanate by dialysis to obtain the target object, and the molecular weight of the target object was 20174;

[0041] 2) Synthesis of poly(lactic-co-glycolic acid-polypeptide diblock copolymer):

[0042] Add 8 grams of poly(γ-methyl-L-glutamate) containing terminal -NCO groups, 29.1 grams of poly(lactic acid ethanol) with a molecular weight of 3000 and a ratio of lactic acid and glycolic acid of 75 / 25 to the dry reactor Acid monododecyl ether and 280ml dimethyl sulfoxide solvent, then add dibutyltin dilaurate with a total weight of 5‰ o...

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Abstract

The invention discloses a preparation method of a polylactic acid glycollic acid-polypeptide-polyethylene glycol diblock-grafted copolymer. The method comprises the following steps: 1, adding a polypeptide homopolymer, diisocyanate, a catalyst and a solvent to a dry reactor, reacting in an inert atmosphere under stirring at 50-55DEG C for 40-60min, and removing excess diisocyanate through a dialysis process to obtain a terminal -NCO group-containing polypeptide homopolymer; 2, adding the terminal -NCO group-containing polypeptide homopolymer, the catalyst and the solvent to the dry reactor, adding polylactic acid glycollic acid monolauryl ether, reacting in an inert atmosphere under stirring at 50-55DEG C for 50-70min to obtain a polylactic acid glycollic acid-polypeptide diblock copolymer; and 3, adding the polylactic acid glycollic acid-polypeptide diblock copolymer, a catalyst and the solvent to the dry reactor, adding polyethylene glycol monomethyl ether, and reacting in an inert atmosphere under stirring at 55-58DEG C for 2-4d to obtain the polylactic acid glycollic acid-polypeptide-polyethylene glycol diblock-grafted copolymer. The preparation method is simple.

Description

technical field [0001] The invention relates to a preparation method of poly(lactic-co-glycolic acid-polypeptide-polyethylene glycol diblock-graft copolymer), which belongs to the technical field of preparation of biodegradable polymer materials. Background technique [0002] Polylactic acid glycolic acid is a kind of polymer biomaterial with good biocompatibility and biodegradability, and has been widely used in the field of biomedicine [Qiao Mingxi et al., Chinese patent, application number 200510046409.8]. However, due to the strong acidity of lactic acid, the initial product of polylactic acid degradation, its local accumulation will have a certain stimulating effect on tissues, so its application is limited [Yao Kangde et al., Chinese patent, application number 02155475.7]. [0003] Polypeptide has good biocompatibility, biodegradability and low genetic immunity, and various functional groups can be easily introduced to form polypeptide derivatives. It is an important c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G81/00
Inventor 朱国全王发刚柳玉英高巧春粟常红
Owner SHANDONG UNIV OF TECH
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