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Method for preparing polypeptide-polylactic acid-polyethyleneglycol dual-graft copolymer

A technology of graft copolymer and polyethylene glycol, which is applied in the field of preparation of biodegradable polymer materials, achieves the effect of simple preparation method

Inactive Publication Date: 2013-08-14
SHANDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, this double-graft copolymer has not been reported in the literature.

Method used

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  • Method for preparing polypeptide-polylactic acid-polyethyleneglycol dual-graft copolymer

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1, adopt the following steps:

[0018] 1) Synthesis of polypeptide-polylactic acid graft copolymer

[0019] Add 8 grams of poly(γ-benzyl-L-glutamate) with a molecular weight of 20000, 6.1 grams of poly(L-lactic acid) monolauryl ether with a molecular weight of 1000, and 1.75 grams of para Toluenesulfonic acid, then add 200 milliliters of 1,1,2-trichloroethane solvent, under inert atmosphere, stir and react at 55°C for 3 days, terminate the reaction, then obtain the target object by filtration, dialysis, and drying. The molecular weight is 25235.

[0020] 2) Synthesis of polypeptide-polylactic acid-polyethylene glycol double graft copolymer:

[0021] Add 7 grams of polypeptide-polylactic acid graft copolymer, 2.8 grams of polyethylene glycol monomethyl ether with a molecular weight of 500 and 1.21 grams of p-toluenesulfonic acid into the drying reactor, and then add 140 milliliters of 1,1,2-tris Ethyl chloride solvent, under an inert atmosphere, stirred and...

Embodiment 2

[0025] 1) Synthesis of polypeptide-polylactic acid graft copolymer

[0026] Add 7 grams of poly(γ-ethyl-L-glutamate) with a molecular weight of 30,000, 7 grams of poly(L-lactic acid) monolauryl ether with a molecular weight of 1500, and 1.21 grams of p-toluene into the dry reactor. Sulphonic acid and 180 milliliters of dimethyl sulfoxide solvent, under inert atmosphere, stirred and reacted at 56 ° C for 4 days, terminated the reaction, and then obtained the target object by filtration, dialysis, and drying. The molecular weight of the target object was 35644.

[0027] 2) Synthesis of polypeptide-polylactic acid-polyethylene glycol double graft copolymer:

[0028] Add 6 grams of polypeptide-polylactic acid graft copolymer, 2.6 grams of polyethylene glycol monomethyl ether and 0.91 grams of p-toluenesulfonic acid with a molecular weight of 600 in the drying reactor, and then add 130 milliliters of dimethyl sulfoxide solvent, Under an inert atmosphere, stirred and reacted at 57°...

Embodiment 3

[0031] 1) Synthesis of polypeptide-polylactic acid graft copolymer

[0032] Add 9 grams of poly(γ-methyl-L-glutamate) with a molecular weight of 50,000, 8.8 grams of poly(L-lactic acid) monolauryl ether with a molecular weight of 2000, and 1.35 grams of p-toluene into the dry reactor. Sulphonic acid and 250 milliliters of 1,1,2-trichloroethane solvent, under an inert atmosphere, stirred and reacted at 58° C. for 3 days, terminated the reaction, and then obtained the target object by filtration, dialysis, and drying. The molecular weight of the target object was 56756.

[0033] 2) Synthesis of Polypeptide-Polylactic Acid-Polyethylene Glycol Double Graft Copolymer

[0034] Add 8 grams of polypeptide-polylactic acid graft copolymer, 2.8 grams of polyethylene glycol monomethyl ether with a molecular weight of 700 and 1.05 grams of p-toluenesulfonic acid into the drying reactor, and then add 150 milliliters of 1,1,2-tris Ethyl chloride solvent, under an inert atmosphere, stirred ...

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Abstract

The invention discloses a method for preparing a polypeptide-polylactic acid-polyethyleneglycol dual-graft copolymer. The method is characterized in that the molecular weight of a polypeptide chain segment in the copolymer is 20000-50000; the molecular weight of a polylactic acid chain segment is 1000-2000; and the molecular weight of a polyethylene glycol chain segment is 500-700. The preparation method comprises the following steps of: 1) synthesizing a polypeptide-polylactic acid graft copolymer, namely, adding a polypeptide homopolymer, polylactic acid lauryl ether, a solvent and a catalyst to a dry reactor, stirring and reacting for 3-4 days under an inert atmosphere at 55-58 DEG C, so as to prepare the target in manners of filtering, dialyzing and drying; and 2) synthesizing the polypeptide-polylactic acid-polyethyleneglycol dual-graft copolymer, namely adding the polypeptide-polylactic acid copolymer, the catalyst, the solvent and the methoxy polyethylene glycol to the dry reactor, stirring and reacting for 2-3 days under the inert atmosphere at 55-59 DEG C, so as to obtain the target in manners of filtering, dialyzing and drying. The method is simple in process; and the obtained target is a novel biodegradable material.

Description

technical field [0001] The invention relates to a preparation method of a polypeptide-polylactic acid-polyethylene glycol double graft copolymer, belonging to the technical field of biodegradable polymer material preparation. Background technique [0002] Polypeptide has good biocompatibility, biodegradability, low genetic immunity, non-toxicity, and no side effects. Various functional groups can be easily introduced to form polypeptide derivatives. It is an important carrier for the preparation of sustained-release drug systems. It is widely used in pharmacy and biomedicine [Yin Jingbo et al., Chinese patent, application number 200610116386.8]. However, the poor hydrophilicity of the peptide material also affects its application. [0003] Polylactic acid is a polymer biomaterial with good biocompatibility and biodegradability, and has been widely used in the field of biomedicine. However, due to the strong acidity of lactic acid, the initial product of polylactic acid deg...

Claims

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Application Information

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IPC IPC(8): C08G81/00
Inventor 朱国全王发刚柳玉英高巧春粟常红
Owner SHANDONG UNIV OF TECH
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