69 results about "Glycopolymer" patented technology

The invention relates to the diagnosis, monitoring, prognosis, and / or prediction of cancer utilizing the detection or measurement of glycan-protein interactions, particularly glycan-antibody interactions. The invention relates to carbohydrate-containing molecules that are utilized in bioanalytical systems, methods and kits for detecting neoplasia and methods related thereto and based thereon. In an exemplary embodiment glycans or glycopolymers are carried in an array, on beads or in a microfluidic system for diagnostic screening for risk of neoplasia, the existence of neoplasia in a patient, or for treatment monitoring. In such an embodiment, the bioanalytic system identifies binding interactions between molecules in a patient test sample (e.g., glycan compositions) and the glycans or glycopolymers. The glycan-binding compositions may be used to generate an immune response against cancer cell epitopes. Alternatively, antibody therapeutics can be developed that are useful for binding to glycan compositions on a cell surface.

The present invention discloses a sugar-containing porphyrin complexation photosensitizer and a preparation method thereof. The preparation method comprises the following steps: 1) adopting a sugar-containing monomer, an initiator and a chain transfer agent to carry out a reversible addition fragmentation chain transfer polymerization reaction to obtain a sugar-containing polymer with a regular structure and a controllable molecular weight; and 2) mixing the sugar-containing polymer obtained in the step 1) and porphyrin, adding a catalyst, and then adopting a one-pot method to synthesize to obtain the sugar-containing porphyrin complexation photosensitizer. According to the present invention, water solubility of the sugar-containing porphyrin complexation photosensitizer prepared by using the method is substantially increased, and specific interactions of the sugar-containing component and protein receptors over-expressed on the surface of pathological cells can be adopted to achieve a targeting purpose so as to improve a photodynamic treatment effect.

The present invention relates to a biological method for assaying peptidoglycans (PGN) in a sample, particularly a sample of glucose polymers. The PGN assay includes: a) treating the glucose polymer sample by sonication, heating, and / or alkalizing; b) placing the treated sample or a dilution thereof in contact with a recombinant cell expressing an exogenous TLR2 (toll-like receptor 2) and a reporter gene directly dependent on the signaling pathway associated with the TLR2. The reporter gene codes for a colored or fluorescent protein or for a protein the activity of which is measurable with or without a substrate; c) measuring the reporter gene signal; and d) determining the amount of PGN in the sample using a standard curve of the correlation between the amount or PGN and the strength of the reporter gene signal.

The invention relates to the field of polymer microsphere preparation, in particular to a hydrophilic super-macroporous polymer microsphere and a preparation method thereof. Using self-made amphiphilic diblock macromonomers as surfactants, microspheres were prepared by suspension polymerization. Since the hydrophilic segments will spontaneously arrange on the outer surface of the microspheres facing the water channel during the process of water absorption and swelling, The hydrophobic segment is combined into the microsphere skeleton through the double bond participating in the polymerization reaction, thus realizing the preparation and surface hydrophilic modification of the ultra-macroporous polymer microsphere in one step. The hydrophilic ultra-macroporous polymer microsphere prepared by the present invention has a microsphere skeleton of cross-linked polystyrene, high mechanical strength and good chemical stability, and the outer surface is a sugar-containing polymer or polyvinyl alcohol gel, which is hydrophilic Good and with extra large holes. The hydrophilic ultra-macroporous polymer microsphere has wide application space in the fields of enzyme immobilization and protein rapid separation and purification.