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Preparation method of photo-controlled degradable hydrogel

A technology of hydrogel and aqueous solution, which is applied to medical preparations containing non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc. It can solve problems such as the inability to control the degradation rate of the gel in the body, and achieve the effect of simple operation

Active Publication Date: 2018-08-21
NANJING UNIV OF POSTS & TELECOMM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this kind of gel still has the situation that the degradation rate of the gel in vivo cannot be regulated, and its controllable degradation still has certain limitations.

Method used

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  • Preparation method of photo-controlled degradable hydrogel

Examples

Experimental program
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Effect test

Embodiment 1

[0029] Glycopolymer aqueous solution (polymer 1, the number of repeating units is 100, 1mL, 200mg / mL), phenylboronic acid half ester grafted sodium alginate aqueous solution (1mL, 50mg / mL, grafting rate 0.1), photosensitizer aqueous solution (2mg / mL, 0.1mL) and ascorbic acid aqueous solution (2mg / mL, 0.1mL) were quickly stirred and mixed evenly, and left to stand for a period of time to obtain a hydrogel.

[0030] image 3 Photodegradation diagram of the hydrogel prepared in Example 1 of the present invention, it can be seen from the figure that the gel can be used for photodegradation;

[0031] Figure 4 It is the storage modulus and loss modulus statistical chart of the hydrogel prepared in Example 1 of the present invention, it can be seen from the figure that the storage modulus of the prepared hydrogel is much greater than the loss modulus, indicating that the gel At the same time, the storage modulus is as high as 5000, indicating that the gel has high strength

Embodiment 2

[0033] Glycopolymer aqueous solution (polymer 2, the number of repeating units is 100, 1mL, 200mg / mL), phenylboronic acid half-ester grafted sodium alginate aqueous solution (1mL, 50mg / mL, grafting rate 0.1), photosensitizer aqueous solution (2mg / mL, 0.1mL) and ascorbic acid aqueous solution (2mg / mL, 0.1mL) were quickly stirred and mixed evenly, and left to stand for a period of time to obtain a hydrogel.

[0034] Figure 5 The storage modulus and loss modulus statistical diagram of the hydrogel prepared in Example 2 of the present invention, it can be seen from the figure that the storage modulus of the hydrogel prepared in this embodiment is also much higher than the loss modulus , indicating the formation of a gel, while the storage modulus is as high as 3000, indicating that the gel also has a higher strength.

Embodiment 3

[0036] Glycopolymer aqueous solution (polymer 1, the number of repeating units is 200, 1mL, 200mg / mL), phenylboronic acid half ester grafted sodium alginate aqueous solution (1mL, 50mg / mL, grafting rate 0.2), photosensitizer aqueous solution (2mg / mL, 0.1mL) and ascorbic acid aqueous solution (2mg / mL, 0.1mL) were quickly stirred and mixed evenly, and left to stand for a period of time to obtain a hydrogel.

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Abstract

The invention discloses a preparation method of a photo-controlled degradable hydrogel, and belongs to the technical field of biopolymers. The preparation method is simple to operate; the photo-controlled degradable hydrogel is prepared by mixing glycopolymer, benzeneboronic acid hemi-ester grafted sodium alginate, a photosensitizer and ascorbic acid, and has injectability and good biocompatibility; the properties of gel can be regulated by changing the content of each component; the strength of the hydrogel is changed by regulating the configuration of sugar in the glycopolymer, so that the prepared hydrogel has high strength and self-healing property; the hydrogel can be degraded rapidly under irradiation of near-infrared light, has photo-control degradability, provides a new carrier forcontrolled release of anticancer drugs, and has great significance in the field of biomedicine.

Description

technical field [0001] The invention belongs to the technical field of biopolymer materials, and in particular relates to a preparation method of photodegradable hydrogel. Background technique [0002] Hydrogel is a new type of multifunctional polymer material with a three-dimensional network structure. According to the different bonding of the hydrogel network, it can be divided into physical gel and chemical gel. Physical gel is formed by physical force, such as Formed by electrostatic interaction, hydrogen bonding, chain entanglement, etc., this gel is non-permanent and can be converted into a solution by heating the gel, so it is also called pseudogel or thermoreversible gel; chemical gel is formed by The three-dimensional network polymer formed by cross-linking chemical bonds is permanent, also known as true gel. First of all, hydrogel has properties similar to extracellular matrix, which is closer to living tissue than any other synthetic biomaterials; in addition, th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K9/06A61K47/36A61K47/32A61K47/22A61K45/00A61P35/00
CPCA61K9/06A61K41/0042A61K45/00A61K47/22A61K47/32A61K47/36A61P35/00
Inventor 孙鹏飞王笑笑范曲立
Owner NANJING UNIV OF POSTS & TELECOMM
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