The invention discloses a laser lighting assembly using hollow alumina microspheres and a manufacturing method thereof, and relates to the field of lighting. The laser lighting assembly is formed by mixing hollow alumina microspheres, low-melting-point glass powder, fluorescent powder and volatile organic matters, wherein the hollow alumina microspheres serve as a light scattering medium, the inner diameter of the hollow alumina microspheres is 50-500 nm, the outer diameter of the hollow alumina microspheres is 400 nm to 1 micron, and the melting point range of the low-melting-point glass powder is 500-650 DEG C. The method comprises the following steps: uniformly mixing hollow alumina microspheres, low-melting-point glass powder, fluorescent powder and volatile organic matters to prepareslurry; coating the surfaces of sapphires with the slurry, sintering at high temperature, cooling, and removing a sintered flaky substance containing the hollow alumina microspheres, the fluorescent powder and the low-melting-point glass from the surfaces of the sapphires for supporting, namely obtaining the laser lighting assembly using the hollow alumina microspheres.