The invention relates to a low-friction-coefficient antiblocking smooth coating and a preparation method thereof. The low-friction-coefficient antiblocking smooth coating contains the following components in parts by weight: 90-110 parts of styrene-acrylic emulsion, 15-25 parts of ion exchange silica sol, 10-15 parts of large-particle-size silica sol, 15-25 parts of water, 30-50 parts of ethanol, 2-4 parts of n-butyl alcohol and 0.4-0.6 part of sodium polystyrene sulfonate. The preparation method comprises the following steps: a, by taking styrene-acrylic emulsion with the pH value of 8-9 as a base material, slowly doping silica sol, stirring for 1 hour at a rotating speed of 500rpm, and uniformly mixing materials; b, then adding mixed solution of water and ethanol, slowly adding a n-butyl alcohol defoaming agent, and stirring for 20 minutes at a low speed; and c, finally adding water diluted solution of sodium polystyrene sulfonate, stirring for 10 minutes at a low speed, then filtering by virtue of a 300-mesh filter net, standing, and defoaming for later use. Therefore, the coating has multiple advantages of antistatic property, antiblocking property, good weather resistance, high printing color density, low flexibility and improved paper feeding passing rate of a printing medium, the coating is easy to process and manufacture, and batch production can be carried out.