57results about How to "Nature impact" patented technology

Belonging to the technical field of medicines, the invention discloses a doxorubicin liposome and its preparation method. The doxorubicin liposome is composed of doxorubicin, a phospholipid substance, cholesterol, and a PEG lipid derivative, etc. The doxorubicin liposome prepared by a pH gradient method in the invention has an encapsulation rate higher than 96%, ethanol content not greater than 10%, and almost constant related parameters. The preparation and its preparation method provided in the invention can control the ethanol content during liposome preparation, and ensures that the residual ethanol has no substantial influence on liposome property in the preparation process, thus providing reference for liposome preparation and ethanol content control in industrial production.

A process of manufacture of polytrimethylene ether glycol comprising: (a) polycondensing reactant comprising diol selected from the group consisting of 1,3-propanediol, 1,3-propanediol dimer and 1,3-propanediol trimer or mixtures thereof in the presence of acid polycondensation catalyst to form polytrimethylene ether glycol; (b) adding water to the polytrimethylene ether glycol to form an aqueous mixture; (c) heating the aqueous mixture to hydrolyze acid esters formed during the acid catalyzed polycondensation; (d) adding to the hydrolyzed aqueous mixture organic solvent that is miscible with polytrimethylene ether glycol to form (i) organic phase containing the polytrimethylene ether glycol and residual acid polycondensation catalyst from the polycondensing and (ii) aqueous phase; (e) separating the aqueous phase and the organic phase; (f) adding base to the separated organic phase to neutralize the residual acid polycondensation catalyst by forming salts of the residual acid polycondensation catalyst; (g) separating the organic phase into (i) liquid phase comprising the polytrimethylene ether glycol, the organic solvent and any residual water, and (ii) solid phase comprising the salts of the residual acid polycondensation catalyst and the base which is unreacted; and (h) removing the organic solvent and the residual water from the liquid phase to obtain polytrimethylene ether glycol.

The embodiment of the invention provides an air bridge structure and a manufacturing method thereof, and a superconducting quantum chip and a manufacturing method thereof. According to the air bridge structure and the manufacturing method thereof, a bridge support structure is formed by using an inorganic material, and the shape of the bridge support structure can be adjusted by adjusting a first photoresist structure, so that the air bridge structure with the shape conforming to the expectation is obtained. The temperature in the process of forming the bridge support structure is not too high, so that the problem that the photoresist is difficult to remove due to the property change caused by the high temperature can be avoided, and the influence of the high temperature on the property of a temperature sensitive device can also be avoided; meanwhile, the empty bridge structure is obtained in a mode of stripping a second photoresist structure, and the air bridge material layer does not need to be etched, so that the air bridge structure at the bottom is prevented, and the performance of a product with the air bridge structure can be effectively improved.

The invention discloses an edible film with a continuous antioxidant function and a preparation method and application thereof. Preparation parameters of tea polyphenol-chitosan hydrochloride nanoparticles are adjusted, and the prepared chitosan hydrochloride nanoparticles with different tea polyphenol encapsulation rates and particle sizes are added to a natural edible biological macromolecular film formation matrix so as to form the film. On one hand, the different encapsulation rates can change the proportion of free tea polyphenol to encapsulated tea polyphenol in the film; on the other hand, the nanoparticles in different sizes can adjust structure compactness of the film, and therefore release of the tea polyphenol in the film is coordinated and controlled. According to the edible film with the continuous antioxidant function and the preparation method and the application of the edible film, when the antioxidant film is prepared, release of active substances can be adjusted under the condition that the concentration of the active substances is definite, and the use rate of the active substances in the film is increased.

A soft capsule comprises content and soft capsule skin as well as a layer of inner coating membrane which is located between the content and the soft capsule skin. The inner coating membrane comprises solute and solvent, the solute consists of liquid paraffin 25-50, polyvidone K30 5-15, polyacrylic acid resin II 10-20, polyving akohol 400 10-30 and citric acid 2.5-10 according to mass percentage;the solvent is salad oil, the content of which is 60-130% of the content of the solute. The invention aims at solving the problem of influence on the activity of effective constitutes in traditional Chinese medicine and soft capsule skin deterioration, leakage and partial deformation caused by reaction between the soft capsule skin and natural acid or natural aldehyde ketone in the traditional Chinese medicine after the soft capsule wraps the traditional Chinese medicine content in the prior art, thus providing the soft capsule capable of separating the soft capsule skin from the content and ensuring the activity of effective constitutes in traditional Chinese medicine and no soft capsule skin deterioration, or no leakage or no partial deformation.

The invention belongs to the technical field of solar battery packaging assemblies and particularly relates to a solar battery back film subject to low-temperature plasma treatment. The solar battery back film is mainly formed by adhering a base layer and a fluorine-based film layer, wherein the surface of the base layer is provided with a plasma-treated film layer II or a plasma treatment surface grafting copolymer layer II, the surface of the fluorine-based film layer is provided with a plasma-treated film layer I, and the surface of the plasma-treated film layer I is provided with a plasma treatment surface grafting copolymer layer I. The invention further provides a preparation method of the solar battery back film. As the plasma-treated film layers and the plasma treatment surface grafting copolymer layers assist in blocking water vapor, the solar battery back film has the characteristics of better weather resistance, good chemical resistance and excellent electrical insulation. The preparation method is very quick in response, can achieve an expected purpose in a few seconds, is very suitable for a circulation system and facilitates continuous production of the solar battery back film.

The invention provides a preparation method of globefish skin gelatin. The preparation method concretely comprises the following steps: selecting globefish skins, cleaning the globefish skins, removing impurities, and chopping the cleaned globefish skins; adding a sodium hydroxide and hydrogen peroxide composite solution, immersing the chopped globefish skins in the composite solution for 5-10h, and washing the immersed globefish skins with water until the pH value is 7-9 in order to obtain alkali treated globefish skins; adding an aqueous detergent solution with the concentration of 0.1-2%, and immersing the globefish skins for 5-10h; adding an acetic acid solution with the concentration of 0.01-1.0mol / L to carry out extraction; centrifuging the obtained solution, and collecting the obtained supernatant; adding a sodium chloride solution with the concentration of 2.0-3.0mol / L to carry out salting-out; centrifuging the obtained solution, and collecting the obtained precipitate; adding acetic acid with the concentration of 0.01-1.0mol / L to dissolve the precipitate, and carrying out dialysis to obtain a gelatin solution; and freeze-drying the gelatin solution to obtain the globefish skin gelatin. The extraction mode and the extraction conditions are mild, and reagents used in the invention are friendly to environment and have low prices, so the production cost of the globefish skin gelatin is effectively reduced, pollution is reduced, and the high-output and high-quality gelatin product is prepared.

The invention discloses a capillary monolithic column for the separation of benzene homologues and a preparation method thereof. The mixed liquid obtained by dissolving GCC in ethanol is added into a sample bottle equipped with MOF-5 according to a certain amount, and the obtained suspended The liquid is injected into the ploy (GMA-co-EDMA) monolithic post activated by ethylenediamine to obtain the capillary monolithic column MOF-5@ploy (GMA-co-EDMA); the present invention uses the surface covalent immobilization method to MOF‑5 is immobilized on the surface of GMA‑EDMA monolithic column, MOF‑5 is dispersed in a mixture of DCC and ethanol, and the epoxy functional groups on the surface of polymethacrylate (PMMA) are opened by ethylenediamine to make MOF‑5 covalent Immobilized on the surface of the polymer in the monolithic column, since MOF-5 is covalently connected to the monolithic column, it will not cause aggregation and separation of MOFs materials, and the properties of MOFs materials will not be greatly affected.