Extracting method of 2'-hydroxy-4'-methoxyacetopheone

Abstract

The invention provides an extracting method of 2'-hydroxy-4'-methoxyacetopheone.The method comprises the steps that a water steam distillation and alkali-dissolution and acid-precipitation combined method is adopted to extract 2'-hydroxy-4'-methoxyacetopheone, moutan bark and whole plants of paniculate swallowwort or paniculate swallowwort roots serve as the raw materials, the raw materials are smashed and subjected to water extraction for 10 h-23 h, water steam distillation is conducted, and distillation is stopped when the mass of distillate is 2.5-3 times that of the raw materials; the distillate is cooled and filtered, a product A is obtained, the pH of the raw material and residual liquid in a flask after water steam distillation is conducted is adjusted to be 12-14, and alkali dissolution is conducted; the pH of the solution is adjusted to be 5-7 after alkali dissolution is conducted, acid precipitation is conducted, cooling and filtering are conducted, and a product B is obtained.The method can efficiently extract 2'-hydroxy-4'-methoxyacetopheone, the extraction rate reaches up to 95.3%, and the purity of obtained 2'-hydroxy-4'-methoxyacetopheone reaches up to 98.8%; according to the method, no organic solvent is adopted, environmental pollution is avoided, and environmental friendliness is better achieved.

Description

Technical field [0001] The present invention is an active ingredient and application field in Chinese herbal medicines, and it involves a method of extract for a dehuminol. Background technique [0002] Danol is the root skin that is mainly separated from the root skin of the peony or the Moroic plant of the peony of the peony.It has been found to have a variety of medicinal effects. The main pharmacological effects are sedative, hypnosis, antioxidant, lowering blood pressure, antibacterial, anti -inflammatory and other effects. Danol can reduce the fading of pigments deposited in the skin to increase the skin whitening the skin.It is widely used in cosmetics, toothpaste, ruling liquid, and tooth powder. [0003] The main extraction methods of peony skin or Xu Changqing are the following: 1. Organic solvent immersion method.Kang Yebin, Shang Hongsheng, etc. In the "Optimization of the Craft Optimization of the Solid Method Extraction", the amount of chlorine, tetrachloride, ace...

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Problems solved by technology

[0004] Among the above-mentioned several extraction methods of paeonol at present, the use of chloroform and carbon tetrachloride in the solvent method has high toxicity and heavy pollution, and is not suitable for industrialized production. Although ethanol is weak in toxicity, the efficiency of ethanol extraction is slightly low, even if more The method of extracting several times can also cause the problem of a corresponding increase in the amount of impurities extracted, and still use organic solvents, which is poor in environmental protection

The extraction rate is 88.1% after two extractions using only steam distillation, and the 30min efficiency of the second stage of steam distillation is extremely low, and the energy cost is correspondingly increased, which also has certain problems

while CO 2 Although the extraction of supercritical extraction technology can better bring out the organic matter in the medicinal materials, the content of other organic impurities is also high, and the selectivity is poor.

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