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44 results about "Sodium houttuyfonate" patented technology
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Application of new sodium houttuyfonate injection in treating milk cow mastitis
InactiveCN101978946ASimple recipeQuality is safe and reliableOrganic active ingredientsPharmaceutical delivery mechanismActivated carbonAntioxidant
The invention discloses a new sodium houttuyfonate injection and a preparation method thereof, which are used for treating milk cow mastitis and belong to the technical field of animal remedies. The sodium houttuyfonate injection comprises the following components in percentage by weight: 0.01 to 10 percent of new sodium houttuyfonate, 0.1 to 50 percent of solubilizing agent, 0.1 to 50 percent of pH modifying agent, and 0.01 to 0.5 percent of antioxidant. The preparation method comprises the following steps of: fully mixing the new sodium houttuyfonate with the solubilizing agent, and then uniformly grinding the mixture; adding aqueous solution of the antioxidant to adjust the pH to be 4.5 to 6.5; adding activated carbon to remove pyrogen; decarburizing and filtering the mixture; filtering the mixture for degermation by using 0.22 mum microporous filter membrane terminal; and performing nitrogen-filling and sub-package, capping sealing, and sterilized packaging to obtain the injection. The new sodium houttuyfonate injection has a simple formula, safe quality and high stability; and the preparation process is simple and feasible, is convenient to operate, is low in cost, is suitable for industrial production, and has an extensive prospect.
Owner:商丘市康森动物药品研究所
Tildipirosin composition and applications thereof in treating or preventing poultry respiratory tract diseases
ActiveCN104922140AWidely distributedApparent volume of distribution is largeAntibacterial agentsAntipyreticDiseaseTreatment effect
The invention discloses a tildipirosin composition and applications thereof in treating or preventing poultry respiratory tract diseases. The tildipirosin composition comprises tildipirosin / pharmaceutically-acceptable salts of tildipirosin, sodium houttuyfonate, and a pharmaceutically-acceptable carrier; and can be made into different oral dosage forms such as soluble powder, granule, oral liquid, premix, and the like. The provided tildipirosin composition has the characteristics of wide distribution in poultry body, large apparent volume of distribution, long half life, slow elimination, little using amount, and good curative effect, and has a good curative effect on poultry respiratory tract diseases caused by bacteria and mycoplasma.
Owner:LUOYANG HUIZHONG ANIMAL MEDICINE
Skin bacteriostatic composition
InactiveCN104547426ALong-lasting antibacterial and antibacterial effectLess likely to cause allergic reactionsAntisepticsSulfur/selenium/tellurium active ingredientsVitamin CRadix Astragali seu Hedysari
The invention provides a skin bacteriostatic composition which has no irritation to skins and has durable bacteriostatic and antibacterial action. According to the skin bacteriostatic composition, allicin, sodium houttuyfonate, elaterin, rhizoma dioscoreae septemlobae extract and radix astragali seu hedysari extracting liquid which have bacteriostatic and antibacterial action are taken as bacteriostatic and antibacterial main components, camellia oil with antibacterial activity is added, and vitamin C and hyaluronic acid are taken as main skin heat-insulating nutrition components. The skin bacteriostatic composition can be directly applied on the surface of skin, pH value is appropriate, the salinity and water-moisture balance of the skin can be regulated, and the skin bacteriostatic composition has no irritation to the skin and difficultly causes allergic reaction.
Owner:广州靖康生物科技有限公司
Mango couth suppressing capsule and method of preparatuion long effect capsule
A medicine in the form of capsules for treating cough with durable effect is prepared through extracting active components from fresh mango fruit, proportional mixing with sodium houttuyfonate and chlorpheniramine, granulating and loading in capsules.
Owner:徐小彬
Quality control method of composite prepn. of dry mango tree leaves extract
InactiveCN1785219AStrong specificityGood reproducibilityComponent separationRespiratory disorderChlorphenamine maleateSoftgel
A compound medicine in the form of tablet, capsule or softgel is prepared from the dried extract of mango leaf, sodium houttuyfonate and chlorphenamine maleate. Its quality control method features that a thin-layer chromatography is used to identify said three components and an efficient liquid-phase chromatographe is used to measure their contents.
Owner:广西南宁允上医药科技开发有限公司
Temperature-sensitive type gel for curing endometritis of livestock and preparation method for temperature-sensitive type gel
InactiveCN105030660AControl release speedIncrease surface tensionAerosol deliveryOintment deliverySulfamonomethoxineTherapeutic effect
The invention belongs to the technical field of veterinary drug preparations, in particular to temperature-sensitive type gel for curing endometritis of livestock and a preparation method for the temperature-sensitive type gel. The temperature-sensitive type gel comprises the following main drug: one of 5 to 10 percent of ofloxacin, 1 to 2 percent of sodium new houtluyfonate, 1 to 2 percent of sodium houttuyfonate, 5 to 20 percent of sulfadiazine sodium, 5 to 20 percent of sulfamonomethoxine sodium and 10 to 20 percent of lincomycin hydrochloride, the following auxiliary materials: 10 to 30 percent of gel matrix, 1 to 2 percent of release rate regulator, 0.1 to 0.5 percent of antioxygen and 0.5 percent of acetic acid, and balance of water for injection in weight percentage. By fully utilizing the characteristics of good flowability, long resistance time, slow drug release and lasting and stable drug effect of the temperature-sensitive type gel disclosed by the invention, the endometritis of the female livestock is effectively cured, and the curative effect is thorough; meanwhile, the labor strength of a cultivation worker is reduced; the temperature-sensitive type gel is more convenient in therapeutic use.
Owner:张永奎
Sodium houttuyfonate injection and its preparation method
InactiveCN1602852AIncrease blood flowImprove solubilityAntibacterial agentsOrganic active ingredientsSolventVein injection
Owner:FUKANGREN BIO PHARMA
Application of sodium houttuyfonate as synergist of antifungal medicament
InactiveCN101961328AEliminate side effectsReduce doseAntimycoticsAnhydride/acid/halide active ingredientsAntifungal drugsSide effect
The invention relates to the technical field of medicaments, in particular to novel application of sodium houttuyfonate as a synergist of an antifungal medicament. The antifungal medicament is an azole or polyene antifungal medicament; and 1 to 16mu g of sodium houttuyfonate is added into each 1ml of antifungal medicament. Experiments prove that: when the sodium houttuyfonate is combined with the antifungal medicament such as fluconazole, ketoconazole, miconazole or amphotercin B, and the like, the treatment effect of the sodium houttuyfonate on superficial or deep fungal infection can be ensured under the condition of reducing the dosage and the sodium houttuyfonate can make the antifungal medicament recover the effect on medicament-resistant fungi, so the sodium houttuyfonate can be used as the synergist of the antifungal medicament. The sodium houttuyfonate serving as the synergist of the antifungal medicament can reduce the dosage of the azole or polyene antifungal medicament so as to reduce the toxic and side effects of the medicament; and particularly, the sodium houttuyfonate makes the antifungal medicament recover the effect on the medicament-resistant fungi, effectively treats fungal infection, particularly medicament-resistant fungal infection, and has important clinical application value.
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Chinese medicine preparation for treating acute and chronic rhinitis and improvement on preparation method thereof
InactiveCN103816224ANot volatileImprove efficacyHydroxy compound active ingredientsAntisepticsPharmaceutical AidsOral solutions
The invention relates to an improvement on the preparation of a Chinese medicine which is made of Chinese medicines and used for treating acute and chronic rhinitis. The preparation comprises the components of centipeda minima, cocklebur fruits, pogostemon cablin, schizonepeta, scutellaria, radix angelicae, chrysanthemums and the like. A preparation method comprises the following steps: cutting up the pogostemon cablin, the schizonepeta and the centipeda minima; extracting volatile oil by a vapor distillation method; sparing the volatile oil; filtering a water decoction solution; adding water into medicine dregs for decocting for an hour; filtering; combining filtrates; concentrating for standby application; adding the water into the cocklebur fruits, the scutellaria, the radix angelicae and the chrysanthemums for second times; filtering; combining the filtrate and the spared solution; concentrating and chilling; adding ethyl alcohol and quietly placing; getting supernatants; recycling the ethyl alcohol and concentrating the ethyl alcohol into thick paste; drying; adding pig gall paste, chlorpheniramine maleate, sodium houttuyfonate dispersions, peppermint oil, volatile oil and other auxiliary materials to prepare tablets or granules, capsules, oral solutions, pills and nasal drops. Due to the adoption of the preparation, the clinical verifications are carried by hospitals to three hundred of patients with nasosinusitis, nasal obstruction and allergic rhinitis, the total efficiency rate is more than 90%, and no adverse effect is generated during the clinical process.
Owner:广西两面针亿康药业股份有限公司
Skin-care cream and preparation method thereof
InactiveCN108245461APromote absorptionIncreased persistenceCosmetic preparationsToilet preparationsAdditive ingredientUltraviolet
The invention discloses skin-care cream and a preparation method thereof. The skin-care cream disclosed by the invention is prepared from ester mangiferin, sodium houttuyfonate, muriatic berberine, artemisia vulgaris essential oil, orange peel extract, Guangxi sweet tea extract and succinic acid compounding ingredients; the skin-care cream is prepared by microencapsulating main components of the mangiferin and berberine. The skin-care cream prepared by the preparation method disclosed by the invention has the effects of resisting inflammation and bacteria, moisturizing and resisting ultraviolet, is easily absorbed by skin and can be used for preventing and treating skin acne as well as skin itching and redness caused by mosquito bites. The skin-care cream disclosed by the invention is mildin drug properties and is suitable for people with sensitive skin like child skin.
Owner:覃静欣
Compound oil-in-water schizonepeta spike oil nanoemulsion composition and preparation method thereof
InactiveCN102397330APrevention and treatment of cold diseasesGood water solubilityAntiviralsRespiratory disorderNasal cavitySaposhnikovia
The invention discloses a compound oil-in-water schizonepeta spike oil nanoemulsion composition, which consists of the following raw materials in percentage by mass: 0.1 to 6.0 percent of schizonepeta spike oil, 0.1 to 5.0 percent of divaricate saposhnikovia root oil, 0.1 to 5.0 percent of weeping forsythiae capsule oil, 0.1 to 2.0 percent of peppermint oil, 0.01 to 0.65 percent of sodium houttuyfonate, 19.0 to 33.0 percent of surfactant and the balance of distilled water, wherein the total percentage by massweight of the raw materials is 100 percent. The nanoemulsion has the effects of relieving exterior syndrome by diaphoresis, clearing away heat and toxic materials, removing pathogenic wind and raising the nonspecific immunity of an organism, and is used for preventing and treating inappetence, increased temperature, cold intolerance and lack of power, which are caused by cold, and sore throat, cough, rhinorrhea, mucus even purulent secretion and the like fully filled in a nasal cavity, which are caused by upper respiratory tract infection, for livestock and poultryanimals.
Owner:NORTHWEST A & F UNIV
Synthetic method of sodium houttuyfonate
InactiveCN106316892AEasy post-processingEasy to operateOrganic compound preparationSulfonic acids salts preparationReaction speedMarket potential
The invention provides a synthetic method of sodium houttuyfonate. In the synthetic method, undecanone and ethyl formate are subjected to condensation reaction at low temperature and immediately hydrolyzed at low temperature to prepare an intermediate I, then SO2 and the intermediate I are subjected to an addition reaction, and finally the sodium houttuyfonate is prepared through simple aftertreatment. As sodium methylate and sodium ethoxide are adopted as alkali in the synthetic method, aftertreatment is convenient, operation steps are simple, and the requirement for equipment is low; sulfur dioxide is used as an addition agent, the reaction speed is high, reaction is easy to control, raw materials are easy to obtain, and the synthetic method is low in production cost and suitable for large-scale industrial production and has good application prospects and market potential.
Owner:SHANGHAI QINGPING PHARMA CO LTD
Full-function health maintenance conditioning instrument
InactiveCN104161664ASmooth blood circulationPromote blood circulationDevices for heating/cooling reflex pointsRoller massageTemperature controlMassage
The invention discloses a full-function health maintenance conditioning instrument. The instrument comprises a closed box body with a door, a heating device, five-color lamps, a five-tone player, foot sole magnetic energy massage devices and negative ion generators. The instrument further comprises a video, an interphone, a temperature controller and herb purification health maintenance boxes which comprise plastic boxes and health maintenance raw materials. Multiple air holes are formed in the two ends of each plastic box, and the health maintenance raw material are composed of the tomatine, sodium houttuyfonate, the sea buckthorn flavone, the Kuding flavone, the gaultheria yunnansis oil and sublimation agents. The negative ion generators are movable and replaceable negative ion generators and installed on the wall A, the wall B and the wall C of the box body respectively. The interphone and the temperature controller are installed on the wall C of the box body. The problems that in the market, a health maintenance device is single in function and poor in health maintenance effect are solved, and the health maintenance condition instrument integrates multiple functions, comprehensively improves the immunity of the human body and the health maintenance effect and is more convenient to use for a user.
Owner:何水英
Quality control method of composite prepn. of dry mango tree leaves extract
InactiveCN100402048CImprove accuracyTo overcome the deficiency of large measurement deviationComponent separationRespiratory disorderChlorphenamine maleateSoftgel
A compound medicine in the form of tablet, capsule or softgel is prepared from the dried extract of mango leaf, sodium houttuyfonate and chlorphenamine maleate. Its quality control method features that a thin-layer chromatography is used to identify said three components and an efficient liquid-phase chromatographe is used to measure their contents.
Owner:广西南宁允上医药科技开发有限公司
Composition used for killing drug-resistant aspergillus fumigatus and prepared from sodium houttuyfonate and application of composition
InactiveCN107261146ASmall toxicityWide variety of sourcesAntimycoticsAnhydride/acid/halide active ingredientsAntifungal drugsMicroorganism
The invention discloses a composition used for killing drug-resistant aspergillus fumigatus and prepared from sodium houttuyfonate and application of the composition and belongs to the technical field of microorganisms. The composition comprises sodium houttuyfonate and antifungal drug, and the antifungal drug comprises AMB, voriconazole and itraconazole. Concentration of sodium houttuyfonate is 1 / 32XMIC-4XMIC while that of the antifungal drug is 1 / 32XMIC-4XMIC when the composition is in use. Synergistic effect generated by the composition improves antibacterial effect of drug to a drug-resistant aspergillus fumigatus strain and lowers using dosage of the antifungal drug, thereby lowering toxic and side effect, so that the composition is an ideal drug composition for treating infection of aspergillus fumigatus resistant to the antifungal drug.
Owner:GUANGXI MEDICAL UNIVERSITY
Sodium houttuyfonate vaginal expansive suppository and preparation method and test method thereof
ActiveCN103784391AGuaranteed effective concentrationPrevent outflowWeighing by removing componentSuppositories deliveryVaginal SuppositorySecondary Infections
The invention relates to a sodium houttuyfonate vaginal expansive suppository and a preparation method and a test method thereof. The expansive suppository comprises sodium houttuyfonate-containing matrix and an expansive carrier; in the sodium houttuyfonate-containing matrix, acid particles and alkaline particles generate carbon dioxide when meeting water, so as to foam, and in combination with the expansive action of the expansive carrier, sodium houttuyfonate can reach vaginal deep site and fold site to improve the drug action range; ascorbic acid in acid particles has an antioxidant effect to improve the stability of the suppository; buffer salt particles in the sodium houttuyfonate-containing matrix provide an appropriate pH environment which is in favor of the complete effervescence of the suppository and improves the bioavailability of sodium houttuyfonate in the suppository; the hollow effervescent vaginal suppository seals the drug-containing layer in the matrix hollow cavity, so as to improve the stability of the expansive suppository; the sodium houttuyfonate vaginal expansive suppository adopts six original advanced techniques, and has the beneficial effects of prevention of medicinal liquid from flowing out, high stability, lasting therapeutic effect, prevention of secondary infection, and so on.
Owner:哈尔滨田美药业股份有限公司
Injection of compound aminophylline for animal use, and preparation method
InactiveCN1872069AQuick killExpanded antimicrobial spectrumAntibacterial agentsPharmaceutical delivery mechanismEthylenediamineBronchophony
A veterinary compound injection of euphyllin for treating asthma, pneumonia, infectious pleural pneumonia, bronchial pneumonia, atrophic rhinitis, etc of pig is prepared through dissolving sodium houttuyfonate in hot water at 60-90 deg.C, dissolving euphyllin and ethyldiamine in hot water at 60-90 deg.C, mixing them together, adding phenylmethanol, stirring, and adding the water for injection.
Owner:TIANJIN SHENGJI GRP CO LTD
Application of sodium houttuyfonate in preparation of products for prevention and treatment of diabetic cardiopathy
InactiveCN109223744AMetabolism disorderNatural extract food ingredientsDiabetic heartDiabetic retinopathy
The invention discloses Application of sodium houttuyfonate in preparation of products for prevention and treatment of diabetic cardiopathy. Houttuyfonate sodium can be use for preparing product for preventing and treating diabetic heart disease, regulating myocardial energy metabolism disorder, and improving glycolipid metabolism abnormality. The invention has been proved by experiments that: (1)sodium houttuyfonate has preventive and therapeutic effects on diabetic heart disease and cardioprotective effects; (2) It can regulate the disturbance of myocardial energy metabolism; (3) It can reduce the increase of blood lipid caused by diabetes mellitus and has the effect of lowering blood glucose. It has good clinical application prospect in the prevention and treatment of diabetes-inducedcardiac injury, myocardial energy metabolism disorder, glucose and lipid metabolism abnormalities and so on.
Owner:SHANGHAI INST OF TECH +1
Traditional Chinese veterinary medicine for treating avian respiratory infectious disease and preparation method of traditional Chinese veterinary medicine
InactiveCN104474027AGood curative effectAct quicklyAmphibian material medical ingredientsHydroxy compound active ingredientsDiseaseCyclodextrin
The invention relates to a traditional Chinese veterinary medicine for treating avian respiratory infectious disease. In parts by weight, 100 parts of the traditional Chinese veterinary medicines comprise the following crude drugs: 0.3-0.5 part of calculus bovisfactitious, 0.1-0.3 part of venenumbufonis, 1-3 parts of scutellariabaicalensis extracts, 0.1-0.3 part of borneol, 15-20 parts of liquorice extracts, 5-10 parts of folium eucalypti, 0.2-0.6 part of sodium houttuyfonate, 2-8 parts of tween-80, 15-25 parts of cyclodextrin and the balance of sucrose powder with granularity of 100 mesh. The traditional Chinese veterinary medicine for treating avian respiratory infectious disease has the advantages of reliable curative effect, rapid action and low cost, and is convenient to use.
Owner:ZHENGZHOU HOUYI PHARMA
Application of sodium houttuyfonate to preparation of medicament for treating heart failure and/or arrhythmia
PendingCN108210487ALittle side effectsImprove myocardial systolic dysfunctionAnhydride/acid/halide active ingredientsCardiovascular disorderMedicineCardiac muscle
The invention provides application of sodium houttuyfonate to preparation of a medicament for treating heart failure and / or arrhythmia. The invention also provides application of the sodium houttuyfonate to preparation of a medicament for enhancing contractile force of ventricular myocytes. The sodium houttuyfonate increases L-type calcium current (Ica.L), and can improve myocardial systolic dysfunction caused by the reduction of sarcoplasmic reticulum Ca release when the heart failure is occurred. The sodium houttuyfonate blocks peak sodium current (Ina.p) and has the characteristics of class-I antiarrhythmic medicaments, and can also block late sodium current (INa.L) increased by the induction of congestin II (ATX-II) and has the potential of inhibiting the arrhythmia caused by the increment of the INa.L.
Owner:WUHAN UNIV OF SCI & TECH
A skin antibacterial composition
InactiveCN104547426BLong-lasting antibacterial and antibacterial effectLess likely to cause allergic reactionsAntisepticsSulfur/selenium/tellurium active ingredientsVitamin CRadix Astragali seu Hedysari
The invention provides a skin bacteriostatic composition which has no irritation to skins and has durable bacteriostatic and antibacterial action. According to the skin bacteriostatic composition, allicin, sodium houttuyfonate, elaterin, rhizoma dioscoreae septemlobae extract and radix astragali seu hedysari extracting liquid which have bacteriostatic and antibacterial action are taken as bacteriostatic and antibacterial main components, camellia oil with antibacterial activity is added, and vitamin C and hyaluronic acid are taken as main skin heat-insulating nutrition components. The skin bacteriostatic composition can be directly applied on the surface of skin, pH value is appropriate, the salinity and water-moisture balance of the skin can be regulated, and the skin bacteriostatic composition has no irritation to the skin and difficultly causes allergic reaction.
Owner:广州靖康生物科技有限公司
Polymer microneedle patch for treating acne and preparation method of polymer microneedle patch
ActiveCN113143844AControl releaseAchieve procedural releaseAntibacterial agentsMicroneedlesPropanoic acidBacillus acnes
The invention belongs to the field of biomedical materials, and particularly discloses a polymer microneedle patch for treating acne and a preparation method of the polymer microneedle patch. The polymer microneedle patch is composed of a base and needle tips, the base is a cuboid, the needle tips are cones and are evenly distributed on the base, and the needle tips comprise bioactive high-molecular compounds, sodium houttuyfonate and erythromycin. Through the interaction between drugs and the bioactive high-molecular compounds, drug release can be effectively controlled, by combined use of the sodium houttuyfonate and the erythromycin, generation of drug resistance of propionibacterium acnes can be effectively prevented, the treatment effect of the acne is enhanced, meanwhile, the needle tips and the base are separated to achieve the effect that the drug-loaded needle tips are left in the skin, the drugs can achieve programmed release of the drugs, and the effect of treating the acne is further improved.
Owner:GUANGDONG PHARMA UNIV
Compound oil-in-water schizonepeta spike oil nanoemulsion composition and preparation method thereof
InactiveCN102397330BPrevention and treatment of cold diseasesGood water solubilityAntiviralsRespiratory disorderNasal cavitySaposhnikovia
The invention discloses a compound oil-in-water schizonepeta spike oil nanoemulsion composition, which consists of the following raw materials in percentage by mass: 0.1 to 6.0 percent of schizonepeta spike oil, 0.1 to 5.0 percent of divaricate saposhnikovia root oil, 0.1 to 5.0 percent of weeping forsythiae capsule oil, 0.1 to 2.0 percent of peppermint oil, 0.01 to 0.65 percent of sodium houttuyfonate, 19.0 to 33.0 percent of surfactant and the balance of distilled water, wherein the total percentage by massweight of the raw materials is 100 percent. The nanoemulsion has the effects of relieving exterior syndrome by diaphoresis, clearing away heat and toxic materials, removing pathogenic wind and raising the nonspecific immunity of an organism, and is used for preventing and treating inappetence, increased temperature, cold intolerance and lack of power, which are caused by cold, and sore throat, cough, rhinorrhea, mucus even purulent secretion and the like fully filled in a nasal cavity, which are caused by upper respiratory tract infection, for livestock and poultryanimals.
Owner:NORTHWEST A & F UNIV
Compound medicine for preventing and treating porcine reproductive and respiratory syndrome
PendingCN113876930ASolve the problem that it can only treat secondary infection but is not effective for acute PRRSEffective treatmentDispersion deliveryPeptide/protein ingredientsHouttuyninPharmaceutical drug
The invention relates to a compound medicine for preventing and treating porcine reproductive and respiratory syndrome, and belongs to the field of veterinary medicines. The compound medicine is an oral pharmaceutical preparation prepared from macrolide medicines special for animals, sodium houttuyfonate, mannatide and pharmaceutical adjuvants in a certain proportion. The medicine disclosed by the invention can be used for effectively treating acute-stage porcine reproductive and respiratory syndrome, rapidly relieving clinical symptoms of diseased pigs and improving survival rate.
Owner:BEIJING DABEINONG ANIMAL HEALTH TECH +1
Testing method of compound Sijiqing Pian (tablet of folium ilicis chinensis extract)
InactiveCN109799311AImplement a quality evaluation systemComponent separationTheoretical plateTest sample
The invention relates to a testing method of a compound Sijiqing Pian (tablet of folium ilicis chinensis extract). The testing method includes firstly, identifying the compound Sijiqing Pian; secondly, determining content of sodium houttuyfonate of the compound Sijiqing Pian by the steps of of preparing a reference solution, preparing a test sample solution, and determining, to be specific, injecting the reference solution and the test sample solution into a high performance liquid chromatograph by sucking to obtain a chromatogram and then calculating the content of sodium houttuyfonate according to the chromatogram, wherein, chromatographic conditions of the high-performance liquid chromatograph include taking octadecylsilane chemically bonded silica as a filler, taking a solution, containing acetonitrile, 0.01mol / L of tetrabutylammonium bromide and diethylamine of which the ratio being 30 : 40 : 0.028, as a mobile phase, setting the testing wavelength to be 283nm, and controlling thenumber of theoretical plates to be not lower than 3000 by calculating according to the peak of sodium houttuyfonate.
Owner:SHANGHAI YUDAN PHARMA
Application of sodium houttuyfonate as synergist of antifungal medicament
InactiveCN101961328BReduce doseSynergistic effect is obviousAntimycoticsAnhydride/acid/halide active ingredientsAntifungal drugsSide effect
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Method for synthesizing houttuynin Schiff base and copper complex thereof
InactiveCN110092732AImprove biological activityEasy to synthesizeCopper organic compoundsImino compound preparationSodium new houttuyfonateSulfite salt
Houttuynin is the main extract in the volatile oil of Houttuynia cordata, and has excellent antibacterial, antiviral and anti-inflammatory effects, so the houttuynin can be widely applied to medicines. The chemical properties of the houttuynin are unstable, so the medical application of the houttuynin is limited, so it is necessary to carry out chemical modification to synthesize a series of new compounds reserving the original active structure in order to obtain a compound with high activity. Sodium houttuyfonate and its homologues octanoyl acetal sodium sulfite and sodium new houttuyfonate,which are used as raw materials, are chemically modified on the basis of reserving the active group carbonyl group to obtain novel compounds with high or extensive bioactivity, so the future studyingof houttuynin drugs is benefited. The invention discloses a method for synthesizing a series of houttuynin 1,4-butanediamine Schiff bases with different carbon chain lengths, and a copper complex thereof. The formula of the Schiff base is C4H8N2(CnH2n+1)2.
Owner:HUNAN NORMAL UNIVERSITY
Novel sodium houttuyfonate compound as well as preparation method and pharmaceutical composition thereof
InactiveCN103265459AClinical application safetyStable in naturePowder deliveryOrganic chemistryStructural formulaK-alpha
The invention relates to the field of medicines and particularly relates to a novel sodium houttuyfonate compound as well as a preparation method and pharmaceutical composition thereof. The novel sodium houttuyfonate compound provided by the invention is shown as the structural formula (I), and an X-ray powder diffraction map obtained through measuring by using Cu-K alpha rays is shown as the drawing I. The novel sodium houttuyfonate compound provided by the invention is high in purity, good in stability and safe and reliable in clinical application.
Owner:四川省惠达药业有限公司
Application of sodium houttuyfonate in preparation of medicine for preventing and treating nervous system diseases taking Kv7/M channel as target spot
ActiveCN112933067AGood Toxicological SafetyMetabolic stabilityNervous disorderAntipyreticHouttuyninMechanism of action
The invention provides an application of sodium houttuyfonate in preparation of a medicine for preventing and treating nervous system diseases taking a Kv7 / M channel as a target spot, sodium houttuyfonate or any derivative of sodium houttuyfonate, or a natural, synthetic or semi-synthetic sodium houttuyfonate-containing mixture or a sodium houttuyfonate-containing composition of sodium houttuyfonate, and the sodium houttuyfonate or any derivative of sodium houttuyfonate has the effects of increasing the Kv7 / M current, and changing the action mechanism of cell excitability obviously, the Kv7 / M current can be used for preparing medicines for preventing, treating and assisting in treating nervous system diseases and symptoms, the action mechanism of obviously changing the cell excitability by increasing the Kv7 / M current is never reported, and the action mechanism is completely different from the action mechanism of the existing medicine application of sodium houttuyfonate.
Owner:HEBEI MEDICAL UNIVERSITY
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