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Chinese medicine preparation for treating acute and chronic rhinitis and improvement on preparation method thereof

A technology for acute and chronic rhinitis and traditional Chinese medicine preparations, applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, and pill delivery, etc., can solve the problems of reduced drug effect, easy volatility, and storage time affecting drug effects, etc., and achieves remarkable curative effect, The effect of improving the efficacy of the drug

Inactive Publication Date: 2014-05-28
广西两面针亿康药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because houttuyfotin sodium is easy to volatilize in the pharmaceutical process, resulting in a decrease in the efficacy of the drug, even if it is made into oral liquid and nasal drops, the long storage time will also affect the effect of the drug

Method used

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  • Chinese medicine preparation for treating acute and chronic rhinitis and improvement on preparation method thereof
  • Chinese medicine preparation for treating acute and chronic rhinitis and improvement on preparation method thereof
  • Chinese medicine preparation for treating acute and chronic rhinitis and improvement on preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-1

[0085] Grind houttuyfonate sodium with a pulverizer, pass through a 100-mesh sieve, and set aside. The polyethylene glycol water-soluble carrier with a molecular weight of 3500 is heated in a water bath at 40-80°C to make it melt, then it is removed, and the ground and sieved houttuyonin sodium powder is quickly added, and continuously stirred to make the houttuyonin The sodium is fully dispersed in the polyethylene glycol carrier, and the weight of houttuyfonate sodium: polyethylene glycol is 4:1. Then, quickly spread the houttuyfonate sodium-polyethylene glycol dispersion on a clean and dry tray to fully spread (thickness about 5mm). After cooling, Houttuyfonate Sodium-Polyethylene Glycol dispersion is formed, scraped or shoveled Houttuyfonate Sodium-Polyethylene Glycol dispersion with a blade or shovel, pulverized by pulverizer, sieved, and 40 Particles between -80 mesh and fine powder >80 mesh sieve are melted and granulated repeatedly to make Houttuyfonate Sodium-Polyeth...

Embodiment 1-2

[0087] Grind houttuyfonate sodium with a pulverizer, pass through a 100-mesh sieve, and set aside. The polyethylene glycol water-soluble carrier with a molecular weight of 5000 is heated in a water bath at 40-80°C to make it melt, then removed, and quickly added houttuyfonate sodium powder that has been crushed and sieved, and stirred continuously to make houttuyonin The sodium is fully dispersed in the polyethylene glycol carrier, and the weight ratio of houttuyfonate sodium: polyethylene glycol is 3:1. Then, quickly spread the houttuyfonate sodium-polyethylene glycol dispersion on a clean and dry tray to fully spread (thickness about 5mm). After cooling, Houttuyfonate Sodium-Polyethylene Glycol dispersion is formed, scraped or shoveled Houttuyfonate Sodium-Polyethylene Glycol dispersion with a blade or shovel, pulverized by pulverizer, sieved, and 40 Particles between -80 mesh and fine powder >80 mesh sieve are melted and granulated repeatedly to make Houttuyfonate Sodium-P...

Embodiment 1-3

[0089] Grind houttuyfonate sodium with a pulverizer, pass through a 100-mesh sieve, and set aside. The polyethylene glycol water-soluble carrier with a molecular weight of 4000 is heated in a water bath at 40-80°C to melt it, then removed, and quickly added houttuyfonate sodium powder that has been crushed and sieved, and stirred continuously to make houttuyonin The sodium is fully dispersed in the polyethylene glycol carrier, and the weight ratio of houttuyfonate sodium: polyethylene glycol is 1:1. Then, quickly spread the houttuyfonate sodium-polyethylene glycol dispersion on a clean and dry tray to fully spread (thickness about 5mm). After cooling, Houttuyfonate Sodium-Polyethylene Glycol dispersion is formed, scraped or shoveled Houttuyfonate Sodium-Polyethylene Glycol dispersion with a blade or shovel, pulverized by pulverizer, sieved, and 40 Particles between -80 mesh and fine powder >80 mesh sieve are melted and granulated repeatedly to make Houttuyfonate Sodium-Polyet...

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Abstract

The invention relates to an improvement on the preparation of a Chinese medicine which is made of Chinese medicines and used for treating acute and chronic rhinitis. The preparation comprises the components of centipeda minima, cocklebur fruits, pogostemon cablin, schizonepeta, scutellaria, radix angelicae, chrysanthemums and the like. A preparation method comprises the following steps: cutting up the pogostemon cablin, the schizonepeta and the centipeda minima; extracting volatile oil by a vapor distillation method; sparing the volatile oil; filtering a water decoction solution; adding water into medicine dregs for decocting for an hour; filtering; combining filtrates; concentrating for standby application; adding the water into the cocklebur fruits, the scutellaria, the radix angelicae and the chrysanthemums for second times; filtering; combining the filtrate and the spared solution; concentrating and chilling; adding ethyl alcohol and quietly placing; getting supernatants; recycling the ethyl alcohol and concentrating the ethyl alcohol into thick paste; drying; adding pig gall paste, chlorpheniramine maleate, sodium houttuyfonate dispersions, peppermint oil, volatile oil and other auxiliary materials to prepare tablets or granules, capsules, oral solutions, pills and nasal drops. Due to the adoption of the preparation, the clinical verifications are carried by hospitals to three hundred of patients with nasosinusitis, nasal obstruction and allergic rhinitis, the total efficiency rate is more than 90%, and no adverse effect is generated during the clinical process.

Description

technical field [0001] The invention relates to a medicine for treating acute and chronic rhinitis, in particular to the improvement of the traditional Chinese medicine preparation for treating acute and chronic rhinitis which uses Chinese medicine cocklebur, goose herb and the like as raw materials and its production method. Background technique [0002] Acute and chronic rhinitis described in traditional Chinese medicine includes various acute and chronic rhinitis, sinusitis, and allergic rhinitis caused by wind-heat accumulation of toxins. The local ischemia of the respiratory mucosa weakens the local resistance, and viruses and bacteria take the opportunity to invade and cause the disease. After getting rhinitis, people often have nasal congestion, nasal itching, sneezing, runny nose, edema of nasal mucosa, unsmooth breathing, and uncomfortable nasal cavity. Some chronic simple rhinitis and rhinitis can also cause headaches, insomnia, difficulty in concentrating when wor...

Claims

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Application Information

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IPC IPC(8): A61K36/539A61K9/20A61K9/16A61K9/48A61K9/08A61P11/02A61P31/02A61P37/08A61K31/4402A61K31/121A61K31/045A61K35/413
Inventor 王志萍邓志坚王勤何政剑何群冷承先黎立李瑞利熊春媚赖一竹
Owner 广西两面针亿康药业股份有限公司
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