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Testing method of compound Sijiqing Pian (tablet of folium ilicis chinensis extract)

A detection method and technology for green tablets, which can be applied to measuring devices, instruments, scientific instruments, etc., can solve the problems of large differences in physical and chemical properties of compound Sijiqing tablets and no determination of component content.

Inactive Publication Date: 2019-05-24
SHANGHAI YUDAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, due to the large variety of chemical components in Compound Sijiqing Tablets and the large differences in physical and chemical properties, the prior art has not carried out content determination of relevant components

Method used

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  • Testing method of compound Sijiqing Pian (tablet of folium ilicis chinensis extract)
  • Testing method of compound Sijiqing Pian (tablet of folium ilicis chinensis extract)
  • Testing method of compound Sijiqing Pian (tablet of folium ilicis chinensis extract)

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Experimental program
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Embodiment 1

[0109] Determination of Houttuyfonate Sodium in Compound Sijiqing Tablets:

[0110] Step 1, preparation of reference substance solution Accurately weigh about 8 mg of houttuyfonate sodium reference substance dried to constant weight by phosphorus pentoxide, put it in a 100ml volumetric flask, add an appropriate amount of 0.2mol / L sodium hydroxide solution to dissolve, Add water to the mark, shake well, take 4.0ml and put it in a 10ml volumetric flask, add mobile phase to dilute to the mark, shake well, and you get it.

[0111]Step 2, preparation of the test solution Take 20 tablets of this product, grind finely, accurately weigh an appropriate amount (about the weight of 1 tablet) and put it in a stoppered Erlenmeyer flask, accurately add 100ml of 0.2mol / L sodium hydroxide solution , densely plugged, weighed, ultrasonically treated for 30 minutes (power 250W, frequency 30kHz), placed at room temperature, weighed again, supplemented with 0.2mol / L sodium hydroxide solution to lo...

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Abstract

The invention relates to a testing method of a compound Sijiqing Pian (tablet of folium ilicis chinensis extract). The testing method includes firstly, identifying the compound Sijiqing Pian; secondly, determining content of sodium houttuyfonate of the compound Sijiqing Pian by the steps of of preparing a reference solution, preparing a test sample solution, and determining, to be specific, injecting the reference solution and the test sample solution into a high performance liquid chromatograph by sucking to obtain a chromatogram and then calculating the content of sodium houttuyfonate according to the chromatogram, wherein, chromatographic conditions of the high-performance liquid chromatograph include taking octadecylsilane chemically bonded silica as a filler, taking a solution, containing acetonitrile, 0.01mol / L of tetrabutylammonium bromide and diethylamine of which the ratio being 30 : 40 : 0.028, as a mobile phase, setting the testing wavelength to be 283nm, and controlling thenumber of theoretical plates to be not lower than 3000 by calculating according to the peak of sodium houttuyfonate.

Description

Technical field: [0001] The present invention relates to a detection method of pharmaceutical preparations, in particular to a detection method of Compound Sijiqing Tablets Background technique: [0002] Compound Sijiqing tablet is a traditional Chinese medicine preparation prepared from dried Sijiqing extract and decanoyl acetaldehyde (synthetic houttuyonin) as the active ingredients. For anemopyretic cold, cough with excessive phlegm, sore throat. It is a sugar-coated tablet or a film-coated tablet. After the coating is removed, the core of the tablet is brown; the taste is fishy and astringent. The method of administration is: take orally, 2 to 4 tablets at a time, 3 times a day. [0003] The preparation method is as follows: take the dry leaves of Sijiqing, add water and decoct twice, each decoction for 1 hour, combine the decoction, stand still, filter, concentrate the filtrate into a thick paste, dry at low temperature, and pulverize. Take Sijiqing dry extract powde...

Claims

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Application Information

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IPC IPC(8): G01N30/90
Inventor 朱飞进李湘
Owner SHANGHAI YUDAN PHARMA
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