Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Sodium houttuyfonate injection and its preparation method

A new houttuyfonate sodium and injection technology, which is applied in anti-inflammatory agents, pharmaceutical formulas, non-central analgesics, etc., can solve the problems of less curative effect than intravenous infusion, affect use and curative effect, and low purity, and achieve enhanced The immune function of the body, the effect of increasing the phagocytosis of white blood cells, and increasing the blood flow

Inactive Publication Date: 2005-04-06
FUKANGREN BIO PHARMA
View PDF1 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because the drug causes pain during intramuscular injection, patients feel fear when using it; at the same time, due to the low purity of raw materials (caused by defects in production technology and testing methods), the drug is easy to separate out during storage; and the curative effect of intramuscular injection is not as good as Intravenous infusion, which affects the use and curative effect of the drug

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0213] prescription:

[0214] New Houttuyniatin Sodium 2000mg

[0215] Tween-80 5g

[0216] Glycerin 50mg

[0217] Add water for injection to 1000ml

[0218] Take about 600ml of water for injection (or glucose isotonic solution), boil it, add a mixture containing 2000mg neohouttuyfonate sodium, 5g Tween-80, and 50mg glycerin, stir to dissolve, add water for injection (or isotonic solution) to 900ml, adjust pH5.0-6.2, stir to dissolve, filter, add water for injection (or isotonic solution) from the container to the total amount, fine filter, test intermediate products, fill (can be small volume injection or large volume Injection, specifications 2ml / bottle, 5ml / bottle, 50ml / bottle, 100ml / bottle, 250ml / bottle, 500ml / bottle), 100 degrees Celsius, 30 minutes sterilization, clarity inspection, packaging, ready to use.

Embodiment 2

[0220] prescription:

[0221] Neohouttuydin Sodium 80mg

[0222] Tween-80 0.1g

[0223] Glycerin 50mg

[0224] Add water for injection to 1000ml

[0225] Take about 600ml of water for injection (or glucose isotonic solution), boil it, add a mixture containing 80mg neohouttuyfonate sodium, 0.1g Tween-80, and 50mg glycerin, stir to dissolve, add water for injection (or isotonic solution) to 900ml, adjust pH5.0-6.2, stir to dissolve, filter, add water for injection (or isotonic solution) from the container to the total amount, fine filter, check the intermediate product, fill (can be small volume injection or large volume injection) Volumetric injection, specifications 2ml / bottle, 5ml / bottle, 50ml / bottle, 100ml / bottle, 250ml / bottle, 500ml / bottle), 100 degrees Celsius, 30 minutes sterilization, clarity inspection, packaging, ready to use.

Embodiment 3

[0227] Weigh 6 g of hydroxypropyl β-cyclodextrin, place in 6 ml of distilled water, and stir to dissolve. Another 0.3 g of neohouttuyfonate sodium was added to the above-mentioned hydroxypropyl β-cyclodextrin solution, and stirred or ground at room temperature for 30 minutes to obtain neohouttuyfonate sodium solution. (The weight ratio of drug to hydroxypropyl β-cyclodextrin is 1:20). Concentrate this solution to 5ml to obtain 60mg / ml neohouttuydin sodium solution.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to vein injection and its preparing method, which contains effective quantity of cosolvent, injected solvent or isoosmotic solution and excipient and pH conditioning agent can be added into if there is need.

Description

Technical field: [0001] The invention relates to a new houttuyfonate sodium intravenous injection and a preparation method thereof. Background technique: [0002] Neo-Houttuyninum sodium (Neo-Houttuyninum) synthesized by chemical method, the chemical name is lauryl acetaldehyde sodium bisulfite, and the active ingredient in natural Houttuyninum (Houttuyninum) sodium houttuydinum, chemical The name is the same series of sodium bisulfite adducts of decanoyl acetaldehyde, and the pharmacological effects and curative effects of the two are basically similar. At present, the preparation made of new houttuyniatin sodium is new houttuyniatin sodium injection, which is now recorded in "Guangdong Provincial Drug Standards" (1987 Edition Volume 2), page 1177-1178, and this variety is an antibacterial and anti-inflammatory drug . It is a chemical synthesis of an aldehyde component in the volatile oil of the whole herb of Houttuynia sulfite. It has obvious inhibitory effect on pneumo...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/08A61K31/255A61P11/00A61P15/00A61P29/00A61P31/04
Inventor 杨青波赵晟郭恒丰李广军付仁芳姚勇敢霍志强李丽娟张晓波聂红梅朱丽华
Owner FUKANGREN BIO PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com