Polymer microneedle patch for treating acne and preparation method of polymer microneedle patch
A technology of microneedle patch and polymer, which is applied in the direction of microneedles, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of high cost and drug resistance of new antibiotics, and achieve the preparation method Simple and reasonable, easy to separate, enhance the effect of treatment effect
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[0030] Embodiment, the present invention is used for the polymer microneedle patch of treating acne and its preparation
[0031] Such as figure 1 As shown, the polymer microneedle patch for treating acne of the present invention consists of a base 1 and a needle point 2. The base 1 is a cuboid with a length of 10 cm, a width of 10 cm, and a height of 2 cm; It is a cone, evenly distributed on the base 1 , with a diameter of 300 μm, a height of 600 μm, and a pitch of 600 μm.
[0032] The needle tip is made of bioactive polymer compound, houttuyfonate sodium and erythromycin according to the following mass ratio.
[0033] group Carboxymethyl chitosan (mg) Sodium Houttuyniatin (mg) Erythromycin (mg) Example 1 600 75 150 Example 2 480 80 160 Example 3 600 60 180
[0034] Preparation method: S1. Synthesis of carboxymethyl chitosan: Suspend 10 g of chitosan in 75 mL of isopropanol, add 5 mL of 10 mg / mL NaOH solution every 5 min at 25 ° C,...
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